Yong Guang Yang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
  2. ncbi request reprint The role of interleukin-12 and interferon-gamma in GVHD and GVL
    Y G Yang
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston 02129, USA
    Cytokines Cell Mol Ther 6:41-6. 2000
  3. ncbi request reprint Role of Interferon-gamma in GVHD and GVL
    Yong Guang Yang
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital, Harvard Medical School, MGH East, Building 149, 13th Street, Boston, 02129, USA
    Cell Mol Immunol 2:323-9. 2005
  4. ncbi request reprint Application of xenogeneic stem cells for induction of transplantation tolerance: present state and future directions
    Yong Guang Yang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, Building 149, 13th Street, Boston, MA 02129, USA
    Springer Semin Immunopathol 26:187-200. 2004
  5. pmc Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice
    Yong Guang Yang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 114:695-700. 2004
  6. ncbi request reprint T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model
    Hiroshi Eguchi
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 13th Street, Boston, MA 02129, USA
    Transplantation 78:1609-17. 2004
  7. ncbi request reprint Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier
    Masahiro Abe
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 99:3823-9. 2002
  8. ncbi request reprint Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 103:3964-9. 2004
  9. pmc Attenuation of phagocytosis of xenogeneic cells by manipulating CD47
    Hui Wang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, Bldg 149 5102, 13th St, Boston, MA 02129, USA
    Blood 109:836-42. 2007
  10. pmc An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation
    Wannee Asavaroengchai
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Blood Marrow Transplant 13:46-55. 2007

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
    ..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function...
  2. ncbi request reprint The role of interleukin-12 and interferon-gamma in GVHD and GVL
    Y G Yang
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston 02129, USA
    Cytokines Cell Mol Ther 6:41-6. 2000
    ....
  3. ncbi request reprint Role of Interferon-gamma in GVHD and GVL
    Yong Guang Yang
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital, Harvard Medical School, MGH East, Building 149, 13th Street, Boston, 02129, USA
    Cell Mol Immunol 2:323-9. 2005
    ..Paradoxically, IFN-gamma facilitates graft-versus-leukemic (GVL) effects. Thus, IFN-gamma blockade is likely deleterious in patients after allogeneic hematopoietic cell transplantation, and not beneficial as previously suggested...
  4. ncbi request reprint Application of xenogeneic stem cells for induction of transplantation tolerance: present state and future directions
    Yong Guang Yang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, Building 149, 13th Street, Boston, MA 02129, USA
    Springer Semin Immunopathol 26:187-200. 2004
    ..This review article focuses on the barriers to porcine hematopoietic engraftment in highly disparate xenogeneic species and the possible application of mixed hematopoietic chimerism to xenograft tolerance induction...
  5. pmc Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice
    Yong Guang Yang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 114:695-700. 2004
    ....
  6. ncbi request reprint T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model
    Hiroshi Eguchi
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 13th Street, Boston, MA 02129, USA
    Transplantation 78:1609-17. 2004
    ..In this article, the authors address these questions in a presensitized pig-to-mouse transplantation model using porcine cytokine-transgenic mice...
  7. ncbi request reprint Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier
    Masahiro Abe
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 99:3823-9. 2002
    ..Thus, mixed chimerism is capable of inducing tolerance in a highly disparate xenogeneic combination and may have clinical potential to prevent xenograft rejection. (Blood. 2002;99:3823-3829)..
  8. ncbi request reprint Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 103:3964-9. 2004
    ..This study proves the principle that porcine chimerism induces tolerance of xenoreactive human T cells...
  9. pmc Attenuation of phagocytosis of xenogeneic cells by manipulating CD47
    Hui Wang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, Bldg 149 5102, 13th St, Boston, MA 02129, USA
    Blood 109:836-42. 2007
    ....
  10. pmc An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation
    Wannee Asavaroengchai
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Blood Marrow Transplant 13:46-55. 2007
    ..These data show that IFN-gamma negatively regulates the CD8 T cell response by inhibiting cell division and promoting cell death and suggest that blockade of IFN-gamma could augment the severity of GVHD in patients undergoing allo-HCT...
  11. ncbi request reprint Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells
    Toshiyasu Kawahara
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 171:5406-14. 2003
    ..These findings demonstrate that peritoneal cavity Mac-1(+) B-1 cells are precursors of Mac-1(-) splenic IgM Ab-secreting cells...
  12. pmc Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury
    Hui Wang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical, Boston, MA 02129, USA
    Blood 113:3612-9. 2009
    ..Furthermore, the magnitude of GVL is correlated with the strength of LGVHR, and IFN-gamma reduces the potential of this alloreactivity to cause epithelial tissue GVHD...
  13. ncbi request reprint Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells
    Yong Guang Yang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 99:4207-15. 2002
    ..These data show for the first time that GVHD-inducing activity and GVL effects of allogeneic CD8 T cells can be separated by a single cytokine, IFN-gamma. (Blood. 2002;99:4207-4215)..
  14. pmc CD47 is required for suppression of allograft rejection by donor-specific transfusion
    Hui Wang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 184:3401-7. 2010
    ....
  15. pmc Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts
    Ichiro Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 86:601-10. 2008
    ..In this study, we assessed the diversity of the human T cell repertoire generated in porcine thymic xenografts. We also examined the ability of porcine thymus grafts to coexist with human thymus grafts...
  16. pmc Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death
    Changhong Xing
    Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
    J Neurochem 108:430-6. 2009
    ..We conclude that CD47 mediates neuronal cell death through caspase-dependent and caspase-independent pathways...
  17. ncbi request reprint Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization
    Frederic I Preffer
    Department of Pathology, Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Stem Cells 20:417-27. 2002
    ..Thus, human blood SP cells, although rare, may serve as a source of selected leukocyte progenitor cells. The immunophenotype of circulating SP cells may provide clues to their seeding and homing capacity...
  18. pmc Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs
    Takashi Onoe
    Transplantation Biology Research Center, Massachusetts General Hospital, and Department of Surgery, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 184:6756-65. 2010
    ..Because lymphopenia affects clinical outcomes, this model, which will allow detailed investigation of the effects of lymphopenia in patients, is of clinical significance...
  19. pmc Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model
    Takashi Onoe
    Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:3895-903. 2011
    ..These studies demonstrate the utility of this humanized mouse model for the study of human Treg ontogeny, immunobiology and therapy...
  20. doi request reprint Pig islet xenograft rejection in a mouse model with an established human immune system
    Noriko Tonomura
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 15:129-35. 2008
    ..A better understanding of the human immune response to pig islets would help develop effective strategies for preventing graft rejection...
  21. pmc CD47 gene knockout protects against transient focal cerebral ischemia in mice
    Guang Jin
    Department of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02129, USA
    Exp Neurol 217:165-70. 2009
    ..We conclude that CD47 is broadly involved in neuroinflammation, and this integrin-associated-protein plays a role in promoting MMP-9 upregulaton, neutrophil extravasation, brain swelling and progression of acute ischemic brain injury...
  22. ncbi request reprint No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo
    Andreas Lechner
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Diabetes 53:616-23. 2004
    ..Thus our study results did not support the concept that bone marrow contributes significantly to adult pancreatic beta-cell renewal...
  23. pmc Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model
    Noriko Tonomura
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, Boston, MA 02129, USA
    Blood 111:4293-6. 2008
    ..These results confirm that a functional human immune system can be established in immunodeficient mice through cotransplantation of human fetal thymus/liver tissues and CD34(+) hematopoietic stem/progenitor cells...
  24. pmc Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells
    Hui Wang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 104:13744-9. 2007
    ..The findings highlight the potential importance of nonhematopoietic cells in the regulation of macrophage function, and suggest a previously uncharacterized mechanism of macrophage tolerance...
  25. ncbi request reprint Xenotransplantation: current status and a perspective on the future
    Yong Guang Yang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Rev Immunol 7:519-31. 2007
    ..This Review highlights the major obstacles impeding the translation of xenotransplantation into clinical therapies and the potential solutions, providing a perspective on the future of clinical xenotransplantation...
  26. ncbi request reprint Elimination of porcine hemopoietic cells by macrophages in mice
    Masahiro Abe
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    J Immunol 168:621-8. 2002
    ..Because injection of M-liposomes i.v. mainly depletes splenic macrophages and liver Kupffer cells, the spleen and/or liver are likely the primary sites of porcine cell clearance in vivo...
  27. pmc A model for personalized in vivo analysis of human immune responsiveness
    Hannes Kalscheuer
    Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Sci Transl Med 4:125ra30. 2012
    ..This "personalized immune" mouse provides a new model for individualized analysis of human immune responses that may provide new insights into not only T1D but also other forms of immune function and dysfunction as well...
  28. pmc T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    Priti Kumar
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:577-86. 2008
    ..Moreover, scFvCD7-9R could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Thus, siRNA therapy for HIV infection appears to be feasible in a preclinical animal model...
  29. pmc Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine
    Patricia S Cho
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Blood 110:3996-4004. 2007
    ..These results suggest the possibility of developing a transplantable tumor model in this large-animal system...
  30. pmc Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras
    Hui Wang
    Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    PLoS ONE 7:e47120. 2012
    ..Thus, donor BM-derived T cells are an important factor in determining the risk of GVHD and therefore, offer a potential therapeutic target for preventing and ameliorating GVHD in the setting of delayed DLI in established mixed chimeras...
  31. pmc CD47 in xenograft rejection and tolerance induction
    Yong Guang Yang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Xenotransplantation 17:267-73. 2010
    ..This review is focused on recent findings regarding the role of CD47, a ligand of an immune inhibitory receptor SIRPalpha, in xenograft rejection and induction of xenotolerance...
  32. pmc Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice
    Diana M Brainard
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 83:7305-21. 2009
    ....
  33. pmc Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro
    Changhong Xing
    Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci Res 87:2571-7. 2009
    ..We conclude that CD47 signaling can negatively affect the viability and function of cerebral endothelial cells, further supporting the notion that CD47 may be a potential neurovascular target for stroke and brain injury...
  34. pmc Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47
    Aseda A Tena
    1 Transplantation Biology Research Center, MGH, Boston, MA 2 Harvard Medical School, Boston, MA 3 Columbia Center for Translational Immunology, Columbia University, New York, NY 4 Pathology Service, Massachusetts General Hospital MGH, Boston, MA
    Transplantation . 2016
    ..However, pig CD47 has previously been shown to be ineffective in transducing signals through primate signal regulatory protein α...
  35. doi request reprint CD47 deficiency improves neurological outcomes of traumatic brain injury in mice
    Song Zhao
    Departments of Orthopedic and Neurosurgery, The First Bethune Hospital of Jilin University, Changchun, Jilin, China Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2401, Charlestown, MA 02129, USA Electronic address
    Neurosci Lett . 2016
    ..We conclude that CD47 may play pathological roles in brain neutrophil infiltration, progression of brain tissue damage, impairment of cerebrovascular remodeling and functional recovery after TBI...
  36. doi request reprint Non-mitogenic form of acidic fibroblast growth factor protects against graft-versus-host disease without accelerating leukemia
    Yi Wang
    Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, PR China Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Int Immunopharmacol 23:395-9. 2014
    ..Our data indicate that the tumor-promoting, but not GVHD-protecting, effect of aFGF largely depends on its mitogenic activity, and suggest that naFGF may provide a safer approach to inhibiting GVHD in patients with malignancies. ..
  37. pmc Activated CD8 T cells acquire NK1.1 expression and preferentially locate in the liver in mice after allogeneic hematopoietic cell transplantation
    Yi Wang
    Key Laboratory of Biotechnology Pharmaceutical Engineering of Zhejiang Province, School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou 325035, China
    Immunol Lett 150:75-8. 2013
    ..1 expression upon activation in allo-HCT recipients and that these NK1.1(+)CD8(+) NKT-like cells maintain an effector/memory phenotype and persist in the recipients with preferential localization in the liver...
  38. ncbi request reprint Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures
    Maria A Giovino
    Immerge BioTherapeutics Inc, Cambridge, Mass, USA
    Exp Hematol 33:363-70. 2005
    ..Here we explore the role of beta1 integrins in maintenance of human vs porcine hematopoiesis within a human hematopoietic environment...
  39. pmc Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages
    Kentaro Ide
    Department of Surgery, Division of Frontier Medical Science, Hiroshima University, Hiroshima 734 8551, Japan
    Proc Natl Acad Sci U S A 104:5062-6. 2007
    ..Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection...
  40. ncbi request reprint Stem cell activity of porcine c-kit+ hematopoietic cells
    Annie C Le Guern
    BioTransplant, Incorporated, Charlestown, Mass, USA
    Exp Hematol 31:833-40. 2003
    ..In this study, we examined the HSC activity of porcine c-kit+ bone marrow cells (BMCs)...