Jason H Y Wu
Affiliation: Harvard University
- Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiuJason H Y Wu
Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circ Cardiovasc Genet 6:171-83. 2013..These results expand our knowledge of genetic factors relevant to de novo lipogenesis and fatty acid biology...
- Effect of fish oil on circulating adiponectin: a systematic review and meta-analysis of randomized controlled trialsJason H Y Wu
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 98:2451-9. 2013..Adiponectin is a robust marker for insulin sensitivity and adipocyte function. Whether n-3 PUFAs affect adiponectin in humans is unknown...
- Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysisJason H Y Wu
Department of Epidemiology, Harvard School of Public Health, Boston, 665 Huntington Ave, Kresge Building 913, Boston MA 02115, USA
Br J Nutr 107:S214-27. 2012..Reasons for potential heterogeneity of effects, which could include true biologic heterogeneity, publication bias, or chance, deserve further investigation...
- Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health StudyJason H Y Wu
Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 94:431-8. 2011..DNL could affect coronary heart disease (CHD) or sudden cardiac arrest (SCA) via generation of specific fatty acids. Whether these fatty acids are prospectively associated with SCA or other CHD events is unknown...
- Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health studyJason H Y Wu
Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 125:1084-93. 2012..Prior studies evaluating fish or n-3 PUFA consumption from dietary questionnaires and incident AF have been conflicting. Circulating levels of n-3 PUFAs provide an objective measurement of exposure...
- Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of AtherosclerosisMarcia C de Oliveira Otto
Department of Epidemiology, Harvard School of Public Health, Boston, MA
J Am Heart Assoc 2:e000506. 2013..However, some controversy remains about benefits of PUFAs, and most prior studies have relied on self-reported dietary assessment in relatively homogeneous populations...
- Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trialJason H Y Wu
Department of Epidemiology, Harvard School of Public Health, Boston, MA
J Am Heart Assoc 2:e000397. 2013..However, whether presupplementation habitual plasma phospholipid n-3 PUFA, or achieved or change in n-3 PUFA level postsupplementation are associated with lower risk of PoAF is unknown...
- α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysisAn Pan
Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 96:1262-73. 2012..Prior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results...
- Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health StudyWenjie Ma
From the Department of Epidemiology, Harvard School of Public Health, Boston, MA WM, QW, and DM the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA DM the Divisions of Aging LD and Cardiovascular Medicine and Channing Division of Network Medicine DM, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA the Boston Veterans Affairs Healthcare System, Boston, MA LD the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA KJM The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia JHYW the Cardiovascular Health Research Unit, Departments of Medicine RNL and DSS, Epidemiology DSS, and Biostatistics MLB, and the Collaborative Health Studies Coordinating Center JAD, University of Washington, Seattle, WA the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA XS the Department of Internal Medicine, University of New Mexico, Albuquerque, NM IBK and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY JRK
Am J Clin Nutr 101:153-63. 2015..Few prospective studies have used fatty acid biomarkers to assess associations with type 2 diabetes...
- Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE ConsortiumDariush Mozaffarian
From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA DM the Divisions of Cardiovascular Medicine DM and PMR, Genetics DIC, Preventive Medicine LW, DIC, AYC, and PMR, and Aging LD and the Channing Division of Network Medicine DM, QS, EBR, FBH, Brigham and Women s Hospital and Harvard Medical School, Boston, MA the Departments of Epidemiology DM, EBR, and FBH and Nutrition DM, QS, H Wu, MKJ, EBR, and FBH, Harvard School of Public Health, Boston, MA the Department of Medicine COJ, RNL, BMP, and DSS, School of Medicine, and the Departments of Biostatistics BM, Epidemiology DSS and BMP, and Health Services BMP, School of Public Health, University of Washington, Seattle, Georgia
Am J Clin Nutr 101:398-406. 2015..g., relating to incorporation, metabolism, or intercompetition with other fatty acids) that could alter circulating concentrations and possibly modulate or mediate impacts on health...
- Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studiesLiana C Del Gobbo
Department of Nutrition, Harvard School of Public Health, Boston MA, USA
Am J Clin Nutr 98:160-73. 2013..However, whether or not circulating or dietary magnesium at usual concentrations or intakes influences the risk of cardiovascular disease (CVD), including fatal ischemic heart disease (IHD), is unclear...
- (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?Dariush Mozaffarian
Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
J Nutr 142:614S-625S. 2012....
- Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysisLuc Djousse
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
Clin Nutr 31:846-53. 2012..We systematically reviewed the evidence on the association of omega-3 fatty acids and fish intake with the incidence of heart failure in this meta-analysis...
- Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortiumCaren E Smith
Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Mol Nutr Food Res 59:1373-83. 2015..We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid...
- Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical eventsDariush Mozaffarian
Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 58:2047-67. 2011..National and international guidelines have converged on consistent recommendations for the general population to consume at least 250 mg/day of long-chain n-3 PUFA or at least 2 servings/week of oily fish...