SCOTT T contact WEISS

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Implementing Personalized Medicine in the Academic Health Center
    Scott T Weiss
    Partners Center for Personalized Medicine, Partners Health Care, Boston, MA 02115, USA
    J Pers Med 6:. 2016
  2. pmc Infrastructure for Personalized Medicine at Partners HealthCare
    Scott T Weiss
    Partners Personalized Medicine, Partners HealthCare System, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Pers Med 6:. 2016
  3. pmc Vitamin D related genes in lung development and asthma pathogenesis
    Alvin T Kho
    Harvard Medical School, Boston, MA, USA
    BMC Med Genomics 6:47. 2013
  4. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
  5. doi request reprint New approaches to personalized medicine for asthma: where are we?
    Scott T Weiss
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 129:327-34. 2012
  6. pmc Expression analysis of asthma candidate genes during human and murine lung development
    Erik Melen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Respir Res 12:86. 2011
  7. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
  8. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
  9. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
  10. pmc Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    BMC Med Genet 12:150. 2011

Research Grants

Detail Information

Publications144 found, 100 shown here

  1. pmc Implementing Personalized Medicine in the Academic Health Center
    Scott T Weiss
    Partners Center for Personalized Medicine, Partners Health Care, Boston, MA 02115, USA
    J Pers Med 6:. 2016
    ..Recently we at Partners Health Care had a series of articles in the Journal of Personalized Medicine describing how we are going about implementing Personalized Medicine in an academic health care system [1-10].[...]. ..
  2. pmc Infrastructure for Personalized Medicine at Partners HealthCare
    Scott T Weiss
    Partners Personalized Medicine, Partners HealthCare System, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Pers Med 6:. 2016
    ..These components are united by (5) a common IT system that brings researchers, clinicians, and patients together for optimal research and patient care. ..
  3. pmc Vitamin D related genes in lung development and asthma pathogenesis
    Alvin T Kho
    Harvard Medical School, Boston, MA, USA
    BMC Med Genomics 6:47. 2013
    ..We hypothesized that vitamin D pathway genes are developmentally active in the fetal lung and that these developmental genes would be associated with asthma susceptibility and regulation in asthma...
  4. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
    ..We sought to determine whether common genetic variants were associated with AHR severity...
  5. doi request reprint New approaches to personalized medicine for asthma: where are we?
    Scott T Weiss
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 129:327-34. 2012
    ..It is anticipated that this will dramatically increase over the next 10 years as personalized medicine becomes more of a reality for asthma patients...
  6. pmc Expression analysis of asthma candidate genes during human and murine lung development
    Erik Melen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Respir Res 12:86. 2011
    ..Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung function...
  7. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
    ..However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy...
  8. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  9. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
    ..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...
  10. pmc Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    BMC Med Genet 12:150. 2011
    ..Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease...
  11. pmc Diversity of the gut microbiota and eczema in early life
    Erick Forno
    Channing Laboratory Boston, MA, USA
    Clin Mol Allergy 6:11. 2008
    ..A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results...
  12. pmc Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system
    Qing T Zeng
    Decision Systems Group, Brigham and Women s Hospital, Boston, MA, USA
    BMC Med Inform Decis Mak 6:30. 2006
    ..The text descriptions in electronic medical records are a rich source of information. We have developed a Health Information Text Extraction (HITEx) tool and used it to extract key findings for a research study on airways disease...
  13. pmc Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers
    Mousheng Xu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:90. 2011
    ..We hypothesized that the use of random forests classifiers to select SNPs would result in an improved predictive model of asthma exacerbations. We tested this hypothesis in a population of childhood asthmatics...
  14. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  15. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
    ..We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data...
  16. pmc Platform dependence of inference on gene-wise and gene-set involvement in human lung development
    Rose Du
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Bioinformatics 10:189. 2009
    ..0 and the Illumina HumanRef-8 v2 Expression Bead Chips, for comparability in a biological system in which changes may be subtle, namely fetal lung tissue as a function of gestational age...
  17. ncbi request reprint Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program
    S T Weiss
    Brigham and Women s Hospital, Channing Laboratory, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 162:50-6. 2000
    ..001), and longer duration of asthma (r = -0.11, beta = -0.20, p < 0.002). These data provide evidence that the degree of airway responsiveness is linked to disease severity in children with mild to moderate asthma...
  18. ncbi request reprint COPD: problems in diagnosis and measurement
    S T Weiss
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J Suppl 41:4s-12s. 2003
    ....
  19. pmc Creating and evaluating genetic tests predictive of drug response
    Scott T Weiss
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Rev Drug Discov 7:568-74. 2008
    ....
  20. ncbi request reprint Obesity and asthma: directions for research
    Scott T Weiss
    Channing Laboratory, Brigham and Women s Hospital, and Harvard School of Public Health, 181 Longwood Avenue, Boston, MA 02110, USA
    Am J Respir Crit Care Med 169:963-8. 2004
  21. ncbi request reprint Asthma genetics 2003
    Scott T Weiss
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 13:R83-9. 2004
    ..These discoveries open new avenues for research in asthma and allergy, and highlight the power (and limitations) of positional cloning for the identification of asthma genes, and complex trait genes in general...
  22. doi request reprint Asthma genetics and genomics 2009
    Scott T Weiss
    Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Genet Dev 19:279-82. 2009
    ..For asthma genetics to begin to have an impact on clinical medicine we need to consider epistatic interaction...
  23. ncbi request reprint Epidemiology and heterogeneity of asthma
    S T Weiss
    Harvard Medical School, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 87:5-8. 2001
    ..The primary objective of this review is to discuss the prevalence, risk factors, and natural history of asthma and its relationship to chronic airflow obstruction...
  24. doi request reprint FDA LABA warning: is there anything new here?
    S T Weiss
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Pharmacol Ther 87:638-9. 2010
    ..The FDA advisory on long-acting beta-agonists (LABAs) is not based on new data but on ongoing safety concerns about this class of medication. Not to be ignored are the potential safety risks of short-acting beta-agonists (SABAs)...
  25. pmc Environmental tobacco smoke exposure and asthma in adults
    S T Weiss
    Harvard Medical School, Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 107:891-5. 1999
    ..It addresses methodological barriers that limit the available data and evaluates the adequacy of the data for risk assessment...
  26. ncbi request reprint Obesity: insight into the origins of asthma
    Scott T Weiss
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:537-9. 2005
  27. doi request reprint What genes tell us about the pathogenesis of asthma and chronic obstructive pulmonary disease
    Scott T Weiss
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 181:1170-3. 2010
    ..This Pulmonary Perspective discusses what we are learning from genome-wide association studies, where the field of genetics and genomics is headed, and how this knowledge will ultimately be put to use in clinical medicine...
  28. pmc Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica
    John M Brehm
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:765-71. 2009
    ..Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood...
  29. pmc Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005
    ..03). Although some evidence for replication was found for SFTPB and HMOX1, none of the previously published COPD genetic associations was convincingly replicated across both study designs...
  30. ncbi request reprint DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma
    Rebecca M Baron
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:927-32. 2002
    ..This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population...
  31. pmc Variants in TGFB1, dust mite exposure, and disease severity in children with asthma
    Sunita Sharma
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 179:356-62. 2009
    ..Polymorphisms in the gene for transforming growth factor-beta1 (TGFB1) have been associated with asthma, but not with airway responsiveness or disease exacerbations in subjects with asthma...
  32. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  33. ncbi request reprint Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:1671-7. 2005
    ..The Met772-AC9 polymorphism represents one of most likely several multi-gene polymorphisms along the receptor-relaxation axis, which together may provide for a composite pharmacogenetic index for asthma therapy...
  34. pmc Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000197. 2008
    ....
  35. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
    ..Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation...
  36. ncbi request reprint TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples
    Ross Lazarus
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 170:594-600. 2004
    ..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk...
  37. ncbi request reprint On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice
    David Fardo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 31:376-82. 2007
    ..The guidelines are illustrated by an application to an asthma study...
  38. ncbi request reprint Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program
    Edwin K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 112:870-6. 2003
    ..Beta2-adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies...
  39. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  40. ncbi request reprint Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  41. ncbi request reprint Pharmacogenetics of asthma
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 165:861-6. 2002
  42. pmc Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 122:921-928.e4. 2008
    ..Among asthmatic subjects, bronchodilator response (BDR) to inhaled beta(2)-adrenergic agonists is variable, and the significance of a consistent response over time is unknown...
  43. ncbi request reprint Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children
    J Paola Contreras
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 112:1072-7. 2003
    ..The early childhood allergen-induced immune responses associated with atopic disease and IgE production in early life are not well understood...
  44. ncbi request reprint A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 110:736-42. 2002
    ..It has been postulated that exposure to bacterial endotoxins and animals early in life might confer protection against the development of asthma and allergies...
  45. doi request reprint Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 122:93-8, 98.e1-5. 2008
    ..The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10)...
  46. pmc Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
    Audrey H Poon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pharmacogenet Genomics 18:373-82. 2008
    ..We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma...
  47. pmc Lack of reproducibility of linkage results in serially measured blood pressure data
    Sanjay R Patel
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
    BMC Genet 4:S37. 2003
    ....
  48. pmc Predictors of mucoid Pseudomonas colonization in cystic fibrosis patients
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital, Boston, Massachusetts, USA
    Pediatr Pulmonol 43:463-71. 2008
    ..aeruginosa acquisition...
  49. pmc Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline
    Florence T Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:1210-5. 2007
    ..As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship...
  50. pmc TLR2 and TLR4 stimulation differentially induce cytokine secretion in human neonatal, adult, and murine mononuclear cells
    Bianca Schaub
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Interferon Cytokine Res 24:543-52. 2004
    ..Therefore, TLR2 and TLR4 stimuli differentially influence IL-13 and IFN-gamma secretion in neonates, adults, and mice, supporting a critical role for innate stimuli in the modulation of cytokine responses...
  51. pmc IL1B polymorphisms modulate cystic fibrosis lung disease
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital, Boston, MA, USA
    Pediatr Pulmonol 44:580-93. 2009
    ....
  52. ncbi request reprint Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 13:1353-9. 2004
    ....
  53. ncbi request reprint Predictors of cord blood IgE levels in children at risk for asthma and atopy
    Christina V Scirica
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:81-8. 2007
    ..Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels...
  54. ncbi request reprint An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation
    Kersten M Small
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0564, USA
    Pharmacogenetics 13:535-41. 2003
    ..Identification of a common AC9 variant that confers reduced enzyme activity reveals an additional polymorphism that should be considered in pharmacogenetic studies of beta-agonist therapy of asthma...
  55. pmc PRKCA: a positional candidate gene for body mass index and asthma
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:87-96. 2009
    ..6 x 10(-)(5)). PRKCA is a pleiotropic locus that is associated with both BMI and asthma and that has been identified via linkage analysis of BMI in a population ascertained on asthma...
  56. ncbi request reprint The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006
  57. pmc Parsing the effects of individual SNPs in candidate genes with family data
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 69:91-103. 2010
    ..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati...
  58. ncbi request reprint The role of indoor allergen sensitization and exposure in causing morbidity in women with asthma
    Sarah A Lewis
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 165:961-6. 2002
    ..07), with adjustment for race and poverty. We conclude that cockroach and cat allergens may contribute to asthma morbidity in sensitized women...
  59. ncbi request reprint Determinants of maximally attained level of pulmonary function
    Xiaobin Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:941-9. 2004
    ..To the degree that these factors diminished plateau phase pulmonary function, they may be important predictors of chronic obstructive pulmonary disease in later life...
  60. pmc 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pharmacogenet Genomics 19:244-7. 2009
    ..Thus, the lung function response to zileuton is modulated by several of the loci that also influence montelukast response...
  61. ncbi request reprint ADAM33: where are we now?
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 31:1-2. 2004
  62. pmc Minimal haplotype tagging
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 100:9900-5. 2003
    ..This result seems to provide further evidence that a severe bottleneck occurred during the founding of Europe and the conjectured "Out of Africa" event...
  63. pmc Prenatal, perinatal, and heritable influences on cord blood immune responses
    Ben M Willwerth
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 96:445-53. 2006
    ..Maternal and perinatal environmental exposures, as well as inherited factors, may influence neonatal immune responses...
  64. pmc In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
    J Allergy Clin Immunol 126:491-7. 2010
    ..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma...
  65. ncbi request reprint Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma
    Angela J Rogers
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1332-7. 2007
    ..The role of these mutations in the development of asthma is less clear, particularly in patients who do not have coincident atopic dermatitis...
  66. pmc Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
    John M Brehm
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 126:52-8.e5. 2010
    ..Vitamin D status might play a role in preventing asthma exacerbations...
  67. pmc A Bayesian approach to genetic association studies with family-based designs
    Melissa G Naylor
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 34:569-74. 2010
    ..We then applied the approach to a genome-wide association scan to search for associations between single nucleotide polymorphisms and body mass index in the Childhood Asthma Management Program data...
  68. ncbi request reprint Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Hum Mol Genet 12:1199-210. 2003
    ..This study has also identified several genomic regions that could contain loci regulating BDR in early-onset COPD families...
  69. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
    ..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children...
  70. pmc A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphism
    Jen hwa Chu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Syst Biol 3:55. 2009
    ..Estimation of such networks has been a challenging problem when the genes considered greatly outnumber the samples, and the situation is exacerbated when one wishes to consider the impact of polymorphisms (SNPs) in genes...
  71. ncbi request reprint Day care attendance, respiratory tract illnesses, wheezing, asthma, and total serum IgE level in early childhood
    Juan C Celedon
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 156:241-5. 2002
    ..It has been hypothesized that day care--related infections may explain the inverse relation between day care attendance in early life and asthma in childhood...
  72. ncbi request reprint Health-care use among Puerto Rican and African-American children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 130:463-71. 2006
    ....
  73. ncbi request reprint Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes
    Edwin K Silverman
    Channing Laboratory, Division of Pulmonary and Critical Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 11:623-32. 2002
    ..In smokers only, the maximum two point LOD score for mild airflow obstruction was 3.14. These observations provide suggestive evidence that there is a locus on chromosome 12p which contributes to susceptibility to early-onset COPD...
  74. pmc Inflammatory markers of lung disease in adult patients with cystic fibrosis
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital Boston, Boston, Massachusetts, USA
    Pediatr Pulmonol 42:256-62. 2007
    ..We hypothesized that levels of serum biomarkers would correlate with clinical course of CF as defined by pulmonary function testing (FEV1)...
  75. pmc Mouse exposure and wheeze in the first year of life
    Wanda Phipatanakul
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 94:593-9. 2005
    ..Studies have found that exposure to mice is highly prevalent among children with asthma living in urban areas...
  76. pmc Endotoxin exposure and eczema in the first year of life
    Wanda Phipatanakul
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 114:13-8. 2004
    ..The objective of this study was to examine the relation between endotoxin exposure in early life and eczema in the first year of life in children with parental history of asthma or allergies...
  77. ncbi request reprint Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups
    Ross Lazarus
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 80:223-8. 2002
    ..No SNP caused amino acid changes. Differences in pairwise linkage-disequilibrium (LD) patterns and in SNP and haplotype frequency distributions among the three populations may be of potential importance for disease association studies...
  78. ncbi request reprint FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1285-91. 2007
    ..Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations...
  79. pmc Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children
    Elsie M Taveras
    Obesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    J Allergy Clin Immunol 121:1161-1166.e3. 2008
    ..Few prospective data link early childhood adiposity with asthma-related symptoms...
  80. pmc Cost-effectiveness of omalizumab in adults with severe asthma: results from the Asthma Policy Model
    Ann C Wu
    Department of Ambulatory Care and Prevention, Harvard Medical School and Children s Hospital, Boston, MA 02215 5301, USA
    J Allergy Clin Immunol 120:1146-52. 2007
    ..Given the high acquisition cost of omalizumab, its role and cost-effectiveness in disease management require definition...
  81. ncbi request reprint Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:72-5. 2002
    ..4; OR for two or more versus no courses of antibiotics, 0.9; 95% CI, 0.5 to 1.4). Our findings do not support the hypothesis that antibiotic use in early life is associated with the subsequent development of asthma and atopy in childhood...
  82. ncbi request reprint Cost-effectiveness of inhaled steroids in asthma: impact of effect on bone mineral density
    Anne L Fuhlbrigge
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:359-66. 2006
    ..The effects of inhaled corticosteroid (ICS) preparations on bone health have been debated. Multiple analyses have been published examining the question, with mixed results...
  83. ncbi request reprint Apolipoprotein E genotype predicts 24-month bayley scales infant development score
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusett 02115, USA
    Pediatr Res 54:819-25. 2003
    ..These results suggest that subjects with the E4 isoform of APOE may have advantages over those with the E2 or E3 isoforms with respect to early life neuronal/brain development...
  84. ncbi request reprint Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 90:422-8. 2003
    ..To confirm these findings, we tested the hypothesis that serum cytokines are associated with longitudinal lung function decline...
  85. ncbi request reprint A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 56:10-7. 2003
    ..The practical importance of our testing strategy is illustrated by applications to the Childhood Asthma Management Program asthma data sets...
  86. pmc Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:325-31. 2008
    ..Airway responsiveness is a prognostic marker for asthma symptoms in later life...
  87. ncbi request reprint A multivariate family-based association test using generalized estimating equations: FBAT-GEE
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 4:195-206. 2003
    ..Application of the proposed test to an asthma study illustrates the power of the approach...
  88. ncbi request reprint Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 12:1973-9. 2003
    ..Fine mapping efforts for these loci are warranted...
  89. pmc Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records
    Blanca E Himes
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    J Am Med Inform Assoc 16:371-9. 2009
    ..Identify clinical factors that modulate the risk of progression to COPD among asthma patients using data extracted from electronic medical records...
  90. ncbi request reprint Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort study
    Rosalind J Wright
    Department of Pulmonary and Critical Care Medicine, The Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Respir Crit Care Med 165:358-65. 2002
    ..These findings suggest a more direct mechanism may be operating between stress and wheeze in early childhood. Stress may contribute significantly to the population burden of preventable childhood respiratory illness...
  91. pmc Using canonical correlation analysis to discover genetic regulatory variants
    Melissa G Naylor
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 5:e10395. 2010
    ..We assess the potential of applying canonical correlation analysis to partitioned genomewide data as a method for discovering regulatory variants...
  92. pmc On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls
    Jessica Lasky-Su
    Channing Laboratories, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 86:573-80. 2010
    ..We illustrate the approach by an application to a GWAS of attention deficit hyperactivity disorder parent-offspring trios and publicly available controls...
  93. pmc Development of a Pharmacogenetic Predictive Test in asthma: proof of concept
    Ann Chen Wu
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215 5301, USA
    Pharmacogenet Genomics 20:86-93. 2010
    ..To assess the feasibility of developing a Combined Clinical and Pharmacogenetic Predictive Test, comprised of multiple single nucleotide polymorphisms (SNPs) that is associated with poor bronchodilator response (BDR)...
  94. ncbi request reprint Eotaxin polymorphisms and serum total IgE levels in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:298-305. 2006
    ..Family-based association studies of CCL11 genetic variants have not been reported to date...
  95. pmc A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma
    Sunita Sharma
    Channing Laboratory, Center for Genomic Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:328-36. 2010
    ..Animal models demonstrate that aberrant gene expression in utero can result in abnormal pulmonary phenotypes...
  96. pmc Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Respir Res 10:67. 2009
    ..We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20)...
  97. ncbi request reprint Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 360:781-2. 2002
    ..There was no association between wheezing and exposure to dog or dog allergen, and the father's allergy status had no effect on the relation between childhood wheezing and cat exposure...
  98. ncbi request reprint Bottle feeding in the bed or crib before sleep time and wheezing in early childhood
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 110:e77. 2002
    ..We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life...
  99. ncbi request reprint Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease
    Ross Lazarus
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 190:9-25. 2002
    ..These and other factors must be taken into account in the design and analysis of disease association studies...
  100. ncbi request reprint A novel approach to defining the relationship between lung function and symptom status in asthma
    Karen M Kuntz
    Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, Boston, MA, USA
    J Clin Epidemiol 55:11-8. 2002
    ..Functional relationships between FEV(1) percent predicted and asthma-related symptoms can be useful for inferring the effect on the symptoms of a population associated with overall improvements in lung function...
  101. pmc ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008
    ..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients...

Research Grants3

  1. DIET, IMMUNE MODULATION, AND ASTHMA IN EARLY LIFE
    Scott Weiss; Fiscal Year: 2002
    ....
  2. The Genetic Epidemiology of Asthma in Costa Rica
    Scott Weiss; Fiscal Year: 2005
    ..Thus, this proposal will greatly contribute to our understanding of the pathogenesis of a significant public health problem among Hispanic Americans: bronchial asthma. ..
  3. ADMINISTRATIVE/EDUCATION CENTER FOR INNATE IMMUNITY PGA
    Scott Weiss; Fiscal Year: 2004
    ..abstract_text> ..