Affiliation: Harvard University
- Hopping between differentiation states in lung adenocarcinomaHideo Watanabe
Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
Cancer Cell 23:707-9. 2013..The work by Cheung and colleagues, in this issue of Cancer Cell, demonstrates another example of how lineage-specific transcriptional regulators of differentiation, GATA6 and HOPX, can control the fate of lung adenocarcinoma progression...
- Dynamic epigenetic regulation by menin during pancreatic islet tumor formationWenchu Lin
Department of Medical Oncology, Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts High Magnetic Field Laboratory, Chinese Academy of Sciences, 350 Shushanhu RD, Hefei, Anhui Province, 230031, P R China
Mol Cancer Res 13:689-98. 2015..Taken together, these data demonstrate that loss of Men1 in pancreatic islet cells alters the epigenetic landscape of its target genes...
- Identification of focally amplified lineage-specific super-enhancers in human epithelial cancersXiaoyang Zhang
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Nat Genet 48:176-82. 2016..Our results suggest that genomic amplification of super-enhancers represents a common mechanism to activate cancer driver genes in multiple cancer types. ..
- Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional targetHideo Watanabe
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
Genes Dev 27:197-210. 2013..Our findings provide new insight into the transcriptional regulatory network of NKX2-1 and suggest that LMO3 is a transcriptional signal transducer in NKX2-1-amplified lung adenocarcinomas...