Hongjun Wang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Bilirubin can induce tolerance to islet allografts
    Hongjun Wang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 147:762-8. 2006
  2. doi request reprint Bilirubin promotes de novo generation of T regulatory cells
    Fredy Rocuts
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Transplant 19:443-51. 2010
  3. ncbi request reprint Donor treatment with carbon monoxide can yield islet allograft survival and tolerance
    Hongjun Wang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, RN 361, Boston, MA 02215, USA
    Diabetes 54:1400-6. 2005
  4. ncbi request reprint Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells
    Soo Sun Lee
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215 USA
    FASEB J 21:3450-7. 2007
  5. ncbi request reprint Toll-like receptor 4 suppression leads to islet allograft survival
    Alyssa Goldberg
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    FASEB J 21:2840-8. 2007
  6. pmc Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation
    Huansheng Dong
    Department of Surgery H D, X Y, D S K, A s, K D C, D B A, H Wa, Medical University of South Carolina, Charleston, South Carolina 29425 Departments of Endocrinology, Diabetes, and Metabolism H H, Y B K and Surgery Y Y, L E O, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215 Department of Medicine H Wu, Section of Endocrinology, Tulane University, New Orleans, Louisiana 70112 and Department of Kinesiology and Physiology H H, East Carolina University, Greenville, North Carolina 27858
    Endocrinology 155:818-28. 2014
  7. doi request reprint Activation of peroxisome proliferator-activated receptor γ prolongs islet allograft survival
    Hongjun Wang
    Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Transplant 21:2111-8. 2012
  8. ncbi request reprint Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    Kenichiro Yamashita
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 20:776-8. 2006
  9. doi request reprint Cell-Permeable Peptide Blocks TLR4 Signaling and Improves Islet Allograft Survival
    Huansheng Dong
    Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
    Cell Transplant 25:1319-29. 2016
  10. doi request reprint Carbon monoxide suppresses membrane expression of TLR4 via myeloid differentiation factor-2 in betaTC3 cells
    Fredy Rocuts
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 185:2134-9. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Bilirubin can induce tolerance to islet allografts
    Hongjun Wang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 147:762-8. 2006
    ..Preincubation of betaTC3 cells with bilirubin also protected the cells from lipid peroxidation. Our data suggests that the potent antioxidant and antiinflammatory actions of bilirubin may contribute to islet survival...
  2. doi request reprint Bilirubin promotes de novo generation of T regulatory cells
    Fredy Rocuts
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Transplant 19:443-51. 2010
    ..Bilirubin treatment promotes de novo generation of Treg cells that might account for the protective effects of bilirubin given to recipients...
  3. ncbi request reprint Donor treatment with carbon monoxide can yield islet allograft survival and tolerance
    Hongjun Wang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, RN 361, Boston, MA 02215, USA
    Diabetes 54:1400-6. 2005
    ..Our present findings show that induction of HO-1 in, or administration of CO to, only the donor, islets, or the recipient or combinations of such treatments improve allogeneic islet survival...
  4. ncbi request reprint Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells
    Soo Sun Lee
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215 USA
    FASEB J 21:3450-7. 2007
    ....
  5. ncbi request reprint Toll-like receptor 4 suppression leads to islet allograft survival
    Alyssa Goldberg
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    FASEB J 21:2840-8. 2007
    ..Our data suggest that TLR4 induction in beta cells is involved in beta cell death and graft rejection after transplantation. CO exposure protects islets from rejection by blocking TLR4 up-regulation...
  6. pmc Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation
    Huansheng Dong
    Department of Surgery H D, X Y, D S K, A s, K D C, D B A, H Wa, Medical University of South Carolina, Charleston, South Carolina 29425 Departments of Endocrinology, Diabetes, and Metabolism H H, Y B K and Surgery Y Y, L E O, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215 Department of Medicine H Wu, Section of Endocrinology, Tulane University, New Orleans, Louisiana 70112 and Department of Kinesiology and Physiology H H, East Carolina University, Greenville, North Carolina 27858
    Endocrinology 155:818-28. 2014
    ..Bilirubin or bilirubin-increasing drugs might be useful as an insulin sensitizer for the treatment of obesity-induced insulin resistance and type 2 diabetes based on its profound anti-ER stress and antiinflammatory properties. ..
  7. doi request reprint Activation of peroxisome proliferator-activated receptor γ prolongs islet allograft survival
    Hongjun Wang
    Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Transplant 21:2111-8. 2012
    ..Our data demonstrate that PPARγ plays a critical role in the survival and function of transplanted islets after transplantation in the recipient. The protective effects of CO are at least in part mediated by PPARγ...
  8. ncbi request reprint Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    Kenichiro Yamashita
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 20:776-8. 2006
    ....
  9. doi request reprint Cell-Permeable Peptide Blocks TLR4 Signaling and Improves Islet Allograft Survival
    Huansheng Dong
    Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
    Cell Transplant 25:1319-29. 2016
    ..This strategy for blocking TLR4 activity has potential utilization in the treatment of diseases where excessive TLR4 activation contributes to the pathologic cellular pathways such as islet transplantation. ..
  10. doi request reprint Carbon monoxide suppresses membrane expression of TLR4 via myeloid differentiation factor-2 in betaTC3 cells
    Fredy Rocuts
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 185:2134-9. 2010
    ..CO suppresses membrane activation of TLR4 via blocking its glycosylation and the physical interaction between TLR4 and MD-2...
  11. pmc Autotransplantation of culture-positive islet product: is dirty always bad?
    Crystal N Johnson
    Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
    HPB (Oxford) 16:665-9. 2014
    ..Little is known of the safety of transplanting islet cells with microbial contamination...
  12. pmc Prior surgery determines islet yield and insulin requirement in patients with chronic pancreatitis
    Hongjun Wang
    Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Transplantation 95:1051-7. 2013
    ..The purpose of this study is to compare islet yield and insulin requirement in the 76 patients who underwent different surgical procedures before TP-IAT at the Medical University of South Carolina between 2009 and 2011...
  13. pmc Quantitative analysis of minimal residual disease predicts relapse in children with B-lineage acute lymphoblastic leukemia in DFCI ALL Consortium Protocol 95-01
    Jianbiao Zhou
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 110:1607-11. 2007
    ....
  14. pmc Induction of protective genes leads to islet survival and function
    Hongjun Wang
    Division of General Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    J Transplant 2011:141898. 2011
    ..Such approaches are also appealing to islet autotransplantation in patients with chronic pancreatitis after total pancreatectomy, a procedure that currently only leads to 1/3 of transplanted patients being diabetes-free...
  15. ncbi request reprint Therapeutic applications of bilirubin and biliverdin in transplantation
    Robert Ollinger
    Department of Surgery, Medical University Innsbruck, Innsbruck, Austria
    Antioxid Redox Signal 9:2175-85. 2007
    ..This review attempts to summarize these protective roles as well as the molecular mechanisms by which biliverdin/bilirubin benefit IRI and solid-organ transplantation, including chronic rejection, and islet transplantation...
  16. ncbi request reprint Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice
    Liang Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing, China 100080
    J Leukoc Biol 81:1386-94. 2007
    ..The functional defects of CD4(+)CD25(+) Treg cells may shed light on the role of CD4(+)CD25(+) Treg cells in the increased sensitivity to autoimmune diseases of aged populations...
  17. ncbi request reprint A potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice
    Hongjun Wang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transplantation 82:1484-92. 2006
    ..The effects of cyclosporin A (CsA), a widely used immunosuppressive agent, on CD4CD25Treg cells in mice were investigated...