P J Utz
Affiliation: Harvard University
- The 72-kDa component of signal recognition particle is cleaved during apoptosisP J Utz
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 273:35362-70. 1998..The 72-kDa component of the SRP joins a growing list of autoantigens that undergo post-translational modifications during programmed cell death...
- Monoclonal antibodies derived from BALB/c mice immunized with apoptotic Jurkat T cells recognize known autoantigensT J Gensler
The Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA
J Autoimmun 16:59-69. 2001..These findings are consistent with the hypothesis that apoptosis can contribute to the development of autoimmunity...
- Death, autoantigen modifications, and toleranceP J Utz
Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Arthritis Res 2:101-14. 2000..This review will address the potential role played by death-specific modifications of autoantigens in bypassing tolerance to highly conserved autoantigens, including nucleic acids, lipids, and proteins...
- Life and death decisions: regulation of apoptosis by proteolysis of signaling moleculesP J Utz
Stanford University School of Medicine, Department of Medicine, Division of Immunology and Rheumatology, Stanford, CA 94305, USA
Cell Death Differ 7:589-602. 2000..By acting as executioners and as important 'molecular sensors' of the degree of cellular injury, the signaling proteins described in this review are strong candidates to mediate downstream events, both in condemned and in viable cells...
- Multiplexed assays for identification of biomarkers and surrogate markers in systemic lupus erythematosusP J Utz
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Lupus 13:304-11. 2004..Their potential and pitfalls for monitoring patients with SLE, particularly those enrolled in clinical trials testing novel therapeutics, will be discussed...
- Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndromeM Huang
First Department of Internal Medicine, Graduate School of Biochemical Sciences, Nagasaki University, Japan
Clin Exp Immunol 142:148-54. 2005..This is the first report describing autoantibodies in sera from primary SS patients that specifically recognize fragments of the La protein that are produced by the granzyme B protease...
- Autoantibodies in early arthritis: advances in diagnosis and prognosticationW Hueber
Department of Medicine, Division of Rheumatology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Clin Exp Rheumatol 21:S59-64. 2003....
- Unlocking the "PAD" lock on rheumatoid arthritisP J Utz
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Ann Rheum Dis 63:330-2. 2004
- Suppression of autoimmunity via microbial mimics of altered peptide ligandsL Steinman
Dept of Neurological Sciences and Interdepartmental Program in Immunology, Beckman Center for Molecular Medicine B002, Stanford University School of Medicine, CA 94305, USA
Curr Top Microbiol Immunol 296:55-63. 2005..Autoimmunity could therefore be modulated via microbial immunity, which may account for relapse and remission of ongoing disease...