Hajime Uno

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Stat Med 32:2430-42. 2013
  2. pmc Clinical consequences of road traffic injuries among the elderly in Japan
    Takashi Nagata
    Department of Emergency Medicine, Himeno Hospital, Fukuoka, Japan
    BMC Public Health 10:375. 2010
  3. pmc On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Stat Med 30:1105-17. 2011
  4. doi request reprint Dyssynchrony, contractile function, and response to cardiac resynchronization therapy
    Dorit Knappe
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Heart Fail 4:433-40. 2011
  5. doi request reprint Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with Darbepoetin Alfa: the trial to reduce cardiovascular events with Aranesp therapy (TREAT) experience
    Hicham Skali
    Brigham and Women s Hospital, Cardiovascular Division, 75 Francis St, Boston, MA 02115, USA
    Circulation 124:2903-8. 2011
  6. doi request reprint Hemoglobin stability in patients with anemia, CKD, and type 2 diabetes: an analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) placebo arm
    Hicham Skali
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Kidney Dis 61:238-46. 2013
  7. doi request reprint Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD
    Akshay S Desai
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Kidney Dis 58:717-28. 2011
  8. pmc Darbepoetin alfa impact on health status in diabetes patients with kidney disease: a randomized trial
    Eldrin F Lewis
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 6:845-55. 2011
  9. pmc Graphical procedures for evaluating overall and subject-specific incremental values from new predictors with censored event time data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biometrics 67:1389-96. 2011
  10. doi request reprint Prognostic assessment of estimated glomerular filtration rate by the new Chronic Kidney Disease Epidemiology Collaboration equation in comparison with the Modification of Diet in Renal Disease Study equation
    Hicham Skali
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 162:548-54. 2011

Collaborators

Detail Information

Publications26

  1. pmc A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Stat Med 32:2430-42. 2013
    ..The large sample properties of our procedures are theoretically justified. We illustrate the new proposal with data from a cancer study to evaluate a new gene score for prediction of the patient's survival...
  2. pmc Clinical consequences of road traffic injuries among the elderly in Japan
    Takashi Nagata
    Department of Emergency Medicine, Himeno Hospital, Fukuoka, Japan
    BMC Public Health 10:375. 2010
    ..Road traffic injuries among the elderly have recently become a public health issue; therefore, we investigated the clinical characteristics of such injuries among the elderly in Japan...
  3. pmc On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Stat Med 30:1105-17. 2011
    ..We provide a large sample approximation to the distribution of this estimator for making inferences about the concordance measure. Results from numerical studies suggest that the new procedure performs well in finite sample...
  4. doi request reprint Dyssynchrony, contractile function, and response to cardiac resynchronization therapy
    Dorit Knappe
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Heart Fail 4:433-40. 2011
    ..We hypothesized that a combined assessment of left ventricular (LV) dyssynchrony and contractile function by strain-based imaging would identify patients who would most benefit from CRT...
  5. doi request reprint Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with Darbepoetin Alfa: the trial to reduce cardiovascular events with Aranesp therapy (TREAT) experience
    Hicham Skali
    Brigham and Women s Hospital, Cardiovascular Division, 75 Francis St, Boston, MA 02115, USA
    Circulation 124:2903-8. 2011
    ..We sought to identify baseline characteristics and postrandomization factors that might explain this association...
  6. doi request reprint Hemoglobin stability in patients with anemia, CKD, and type 2 diabetes: an analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) placebo arm
    Hicham Skali
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Kidney Dis 61:238-46. 2013
    ..We intended to describe Hb level trends over time with no or minimal administration of erythropoiesis-stimulating agents...
  7. doi request reprint Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD
    Akshay S Desai
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Kidney Dis 58:717-28. 2011
    ..We examined the value of troponin T (TnT) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in assessing the risk of developing end-stage renal disease (ESRD) in diabetic patients with CKD...
  8. pmc Darbepoetin alfa impact on health status in diabetes patients with kidney disease: a randomized trial
    Eldrin F Lewis
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 6:845-55. 2011
    ..The objectives were to determine the longitudinal impact of anemia treatment on quality of life in patients with diabetes and chronic kidney disease and to determine the predictors of baseline and change in QOL...
  9. pmc Graphical procedures for evaluating overall and subject-specific incremental values from new predictors with censored event time data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biometrics 67:1389-96. 2011
    ....
  10. doi request reprint Prognostic assessment of estimated glomerular filtration rate by the new Chronic Kidney Disease Epidemiology Collaboration equation in comparison with the Modification of Diet in Renal Disease Study equation
    Hicham Skali
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 162:548-54. 2011
    ..We aimed to assess the incremental prognostic accuracy of eGFR(CKD-EPI) versus eGFR(MDRD) in subjects at increased risk for CV disease...
  11. pmc Mortality rates in trials of subjects with type 2 diabetes
    Ebrahim Barkoudah
    Cardiovascular Division, Dana Farber Cancer Institute, Boston, MA E B, H S, S D S, M A P General Medicine Division, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, MA E B
    J Am Heart Assoc 1:8-15. 2012
    ..In randomized controlled trials (RCTs) of subjects with type 2 diabetes mellitus, mortality rates vary substantially. We sought to examine the inclusion and exclusion criteria of these RCTs to explore relationships with mortality...
  12. pmc Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial
    Paul G Richardson
    Department of Adult Oncology, Harvard Medical School, Boston, MA, USA
    Biol Blood Marrow Transplant 16:1005-17. 2010
    ..In the absence of any differences in activity, toxicity or changes in PAI-1 level, defibrotide 25 mg/kg/day was selected for ongoing phase III trials in VOD...
  13. doi request reprint Baseline characteristics in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT)
    Marc A Pfeffer
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Kidney Dis 54:59-69. 2009
    ....
  14. doi request reprint Erythropoietic response and outcomes in kidney disease and type 2 diabetes
    Scott D Solomon
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 363:1146-55. 2010
    ..However, target-based strategies are confounded by each patient's individual hematopoietic response...
  15. pmc A versatile test for equality of two survival functions based on weighted differences of Kaplan-Meier curves
    Hajime Uno
    Department of Biostatistics and Computational Biology and Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, U S A
    Stat Med 34:3680-95. 2015
    ..The survival data from a recent cancer comparative study are utilized for illustrating the implementation of the process...
  16. doi request reprint Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension
    Anne Catherine Pouleur
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Renin Angiotensin Aldosterone Syst 12:483-90. 2011
    ..High circulating aldosterone levels stimulate myocardial fibrosis and left ventricular hypertrophy (LVH). However, it is not clear whether suppression of aldosterone directly contributes to LVH regression in hypertensive patients...
  17. doi request reprint Pathogenesis of sudden unexpected death in a clinical trial of patients with myocardial infarction and left ventricular dysfunction, heart failure, or both
    Anne Catherine Pouleur
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 122:597-602. 2010
    ....
  18. doi request reprint Relationship between improvement in left ventricular dyssynchrony and contractile function and clinical outcome with cardiac resynchronization therapy: the MADIT-CRT trial
    Anne Catherine Pouleur
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 32:1720-9. 2011
    ....
  19. pmc Financial hardship and the intensity of medical care received near death
    Reginald D Tucker-Seeley
    Dana Farber Cancer Institute, Boston, MA, USA Harvard School of Public Health, Boston, MA, USA
    Psychooncology 24:572-8. 2015
    ..The goal of this study was to determine the association between financial hardship and intensive care in the last week of life...
  20. pmc Derivation and validation of the SEER-Medicare myelodysplastic syndromes risk score (SMMRS)
    Hajime Uno
    Division of Population Sciences, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Leuk Res 38:1420-4. 2014
    ..Risk stratification by the SMMRS was comparable to the IPSS (net reclassification improvement index was 0.0), demonstrating that it is a useful research tool to stratify MDS patients in studies using SEER-Medicare. ..
  21. pmc Identification of potentially avoidable hospitalizations in patients with GI cancer
    Gabriel A Brooks
    All authors Dana Farber Cancer Institute, Boston, MA
    J Clin Oncol 32:496-503. 2014
    ..To identify and characterize potentially avoidable hospitalizations in patients with GI malignancies...
  22. pmc Monocyte activation markers in cerebrospinal fluid associated with impaired neurocognitive testing in advanced HIV infection
    Anupa Kamat
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 60:234-43. 2012
    ..To examine relationships of monocyte activation markers to HAND of varying severity, we compared plasma and cerebrospinal fluid (CSF) biomarker levels with neurocognitive test scores in HIV+ subjects...
  23. doi request reprint The inter-relationship of diabetes and left ventricular systolic function on outcome after high-risk myocardial infarction
    Amil M Shah
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02445, USA
    Eur J Heart Fail 12:1229-37. 2010
    ..Whether diabetes modifies the relationship between left ventricular ejection fraction (LVEF) and outcomes in the post-MI population is unknown...
  24. pmc Impact of high-risk classification by FISH: an eastern cooperative oncology group (ECOG) study E4A03
    Susanna J Jacobus
    Dana Farber Cancer Institute, Boston, MA, USA
    Br J Haematol 155:340-8. 2011
    ..FISH-based risk classification retained prognostic significance in patients receiving lenalidomide-based induction...
  25. doi request reprint Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo study
    Alessandra Meris
    Cardiovascular Division, Brigham and Women s Hospital, MA, USA
    Eur Heart J 30:56-65. 2009
    ..To assess the relationship between left atrial (LA) size and outcome after high-risk myocardial infarction (MI) and to study dynamic changes in LA size during long-term follow-up...
  26. doi request reprint Mechanical dyssynchrony after myocardial infarction in patients with left ventricular dysfunction, heart failure, or both
    Sung Hee Shin
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 121:1096-103. 2010
    ..Mechanical dyssynchrony is considered an independent predictor for adverse cardiovascular outcomes in patients with heart failure. However, its importance as a risk factor after myocardial infarction is not well defined...