M T Tsuang
Affiliation: Harvard University
- Genes, environment and schizophreniaM T Tsuang
Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
Br J Psychiatry Suppl 40:s18-24. 2001..Nevertheless, it remains clear that environmental factors both add to and interact with genetic factors to produce the disorder...
- Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes?S V Faraone
Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, USA
Am J Psychiatry 152:1286-90. 1995..However, most of these studies do not address a key measurement question: does the diagnostic accuracy of these spectrum classifications warrant their use in genetic linkage studies of schizophrenia?..
- Reduced subcortical brain volumes in nonpsychotic siblings of schizophrenic patients: a pilot magnetic resonance imaging studyL J Seidman
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston 02115, USA
Am J Med Genet 74:507-14. 1997..If replicated in a larger sample including both sexes, these results would suggest that the genetic liability to schizophrenia is also expressed as structural brain abnormalities...
- Impact of genetic vulnerability and hypoxia on overall intelligence by age 7 in offspring at high risk for schizophrenia compared with affective psychosesJ M Goldstein
Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
Schizophr Bull 26:323-34. 2000..Specificity of the effects for schizophrenia compared with affective psychoses and sex effects were also tested. Low IQ at age 7 was significantly associated with genetic vulnerability to psychoses, in particular with schizophrenia...
- Association of neuropsychological vulnerability markers in relatives of schizophrenic patientsR Toomey
Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA
Schizophr Res 31:89-98. 1998..We discuss how the use of multiple risk indicators may help us better identify those relatives that carry the schizophrenia genotype...
- The genetics of schizophreniaM T Tsuang
Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
Curr Psychiatry Rep 1:20-4. 1999..The potential importance of schizotaxia, or similar concepts, for use in genetic studies, is discussed...
- Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family StudiesL J Seidman
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
Psychol Med 43:119-31. 2013..We evaluated the specificity and impact of family history (FH) of psychosis on pre-morbid neuropsychological functioning...
- The Harvard Twin Study of Substance Abuse: what we have learnedM T Tsuang
Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
Harv Rev Psychiatry 9:267-79. 2001..Our results, thus far, indicate a complex pattern of genetic and environmental influences on substance use and abuse...
- The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal ProjectL J Seidman
Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
Schizophr Bull 26:309-21. 2000..Future studies will evaluate the effects of specific PPCs and genetic risk factors for psychosis on cognitive functioning in childhood...
- Prenatal maternal immune disruption and sex-dependent risk for psychosesJ M Goldstein
Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital, Boston, MA, USA
Psychol Med 44:3249-61. 2014..Previous studies suggest that abnormalities in maternal immune activity during pregnancy alter the offspring's brain development and are associated with increased risk for schizophrenia (SCZ) dependent on sex...
- Concurrent validation of schizotaxia: a pilot studyW S Stone
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
Biol Psychiatry 50:434-40. 2001....
- Impaired motor performance in adolescents at familial high-risk for schizophreniaT C Manschreck
Commonwealth Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Laboratory for Clinical and Experimental Psychopathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Fall River, MA, USA Electronic address
Schizophr Res 168:44-9. 2015..The present study assessed accuracy of motor performance and degree of lateralization in FHR adolescents and young adults...
- Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imagingJ M Goldstein
Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, MA 02115, USA
Cereb Cortex 11:490-7. 2001..These findings have implications for developmental studies that would directly test hypotheses about mechanisms relating sex steroid hormones to sexual dimorphisms in humans...
- A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demandsL J Seidman
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Neuropsychology 12:505-18. 1998..Performance and degree of activation was associated with an estimate of IQ. Further research should clarify the contributions of working memory and interference filtering to the activated network...
- Genetic association analysis of behavioral inhibition using candidate loci from mouse modelsJ W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet 105:226-35. 2001..This study illustrates the potential utility of using candidate genes derived from mouse models to dissect the genetic basis of BI, a possible intermediate phenotype for panic and phobic disorders...
- Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophreniaS J Glatt
Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, MA 02115, USA
Mol Psychiatry 8:911-5. 2003..Although more family-based studies are needed to confirm this relation, our results provide strong evidence that DRD2 influences susceptibility to schizophrenia...
- Neuropsychological consequences of regular marijuana use: a twin studyM J Lyons
Psychology Department, Boston University, Boston, MA 02215, USA
Psychol Med 34:1239-50. 2004..A major methodological limitation of prior studies is the inability to determine whether differences between users and non-users are due to differences in genetic vulnerability preceding drug use or due to the effects of the drug...
- Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium ConsortiumS V Faraone
Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, USA
Am J Med Genet 81:290-5. 1998..4, P = .0004) and its neighbor, D10S582 (NPL Z = 3.2, P = .0006)...