Daniel Tschumperlin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
    Fei Liu
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115
    J Cell Biol 190:693-706. 2010
  2. pmc A multiwell platform for studying stiffness-dependent cell biology
    Justin D Mih
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19929. 2011
  3. doi request reprint Mechanotransduction
    Daniel J Tschumperlin
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Compr Physiol 1:1057-73. 2011
  4. doi request reprint Biomechanical regulation of mesenchymal cell function
    Daniel J Tschumperlin
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115 6021, USA
    Curr Opin Rheumatol 25:92-100. 2013
  5. pmc Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness
    Aleksandar Marinkovic
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 303:L169-80. 2012
  6. ncbi request reprint Chronic effects of mechanical force on airways
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 68:563-83. 2006
  7. ncbi request reprint EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in
    Daniel J Tschumperlin
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Cycle 3:996-7. 2004
  8. pmc Recent advances and new opportunities in lung mechanobiology
    Daniel J Tschumperlin
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Biomech 43:99-107. 2010
  9. pmc Universal physical responses to stretch in the living cell
    Xavier Trepat
    Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 447:592-5. 2007
  10. ncbi request reprint Mechanotransduction through growth-factor shedding into the extracellular space
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 429:83-6. 2004

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
    Fei Liu
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115
    J Cell Biol 190:693-706. 2010
    ....
  2. pmc A multiwell platform for studying stiffness-dependent cell biology
    Justin D Mih
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19929. 2011
    ..The ability to deploy PA gels in multiwell plates for high throughput analysis of cells in tissue-relevant environments opens new opportunities for the discovery of cellular responses that operate in specific stiffness regimes...
  3. doi request reprint Mechanotransduction
    Daniel J Tschumperlin
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Compr Physiol 1:1057-73. 2011
    ....
  4. doi request reprint Biomechanical regulation of mesenchymal cell function
    Daniel J Tschumperlin
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115 6021, USA
    Curr Opin Rheumatol 25:92-100. 2013
    ....
  5. pmc Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness
    Aleksandar Marinkovic
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 303:L169-80. 2012
    ....
  6. ncbi request reprint Chronic effects of mechanical force on airways
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 68:563-83. 2006
    ....
  7. ncbi request reprint EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in
    Daniel J Tschumperlin
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Cycle 3:996-7. 2004
    ..Recent morphological and biochemical observations, bolstered by analytical modeling, support a new paradigm for mechanotransduction arising from constitutive growth factor shedding into a dynamically regulated interstitial volume...
  8. pmc Recent advances and new opportunities in lung mechanobiology
    Daniel J Tschumperlin
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Biomech 43:99-107. 2010
    ..We conclude with a brief summary of selected opportunities and challenges that lie ahead for the lung mechanobiology research community...
  9. pmc Universal physical responses to stretch in the living cell
    Xavier Trepat
    Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 447:592-5. 2007
    ..These laws seem to be both universal and primitive, and thus comprise a striking intersection between the worlds of cell biology and soft matter physics...
  10. ncbi request reprint Mechanotransduction through growth-factor shedding into the extracellular space
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 429:83-6. 2004
    ....
  11. pmc Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of receptor tyrosine kinases
    Francis Boudreault
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 43:64-73. 2010
    ..Our findings demonstrate that MAPKs are potently activated by stretch in lung fibroblasts, but, in contrast to stress responses observed in other cell types, RTKs are not necessary for stretch-induced MAPK activation in LFs...
  12. ncbi request reprint Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner
    Eric K Chu
    Department of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 32:373-80. 2005
    ..The response of all three EGFR ligands persisted long after the mechanical stimulus was removed. Taken together, these data suggest the possibility of a mechanically activated EGFR autocrine feedback loop involving selected EGFR ligands...
  13. pmc Cell elasticity determines macrophage function
    Naimish R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41024. 2012
    ..Taken together, these data demonstrate an unanticipated role for cell elasticity as a common pathway by which mechanical and biologic factors determine macrophage function...
  14. pmc Chronic intermittent mechanical stress increases MUC5AC protein expression
    Jin Ah Park
    Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, 665 Huntington Ave, SPH1 309, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 41:459-66. 2009
    ..We propose that the mechanical environment present in asthma may fundamentally bias the composition of airway epithelial lining in favor of mucin secretory cells...
  15. ncbi request reprint A new microrheometric approach reveals individual and cooperative roles for TGF-beta1 and IL-1beta in fibroblast-mediated stiffening of collagen gels
    Lester Y Leung
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    FASEB J 21:2064-73. 2007
    ..The microrheometry approach developed here should accelerate the discovery of biological pathways orchestrating cellular modulation of matrix mechanics...
  16. pmc Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells
    Eric K Chu
    Brigham and Women s Hospital, Department of Pulmonary and Critical Care Medicine, Harvard School of Public Health, Physiology Program and Children s Hospital Informatics Program, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 35:628-38. 2006
    ..Together these observations suggest an integrated response of airway epithelial cells to mechanical stimulation, acting through the plasminogen-activating system to modify the airway microenvironment...
  17. pmc The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress
    Jin Ah Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 285:29817-25. 2010
    ..In the asthmatic airway mechanical stress may contribute to enhanced YKL-40 levels...
  18. ncbi request reprint Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium
    Daniel J Tschumperlin
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 28:142-9. 2003
    ..These data are consistent with a primary pathogenic role for mechanical stress-induced release of both TGF-beta2 and ET in the subepithelial fibrosis that characterizes chronic asthma...
  19. pmc Computational modeling of extracellular mechanotransduction
    Nikola Kojic
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    Biophys J 90:4261-70. 2006
    ..These results underscore both the plausibility and complexity of the proposed extracellular mechanotransduction mechanism...

Research Grants2

  1. Molecular transduction of the mechanical environment in airway epithelium
    Daniel Tschumperlin; Fiscal Year: 2009
    ..These studies will provide a framework for understanding and modulating mechanical responses in the lung. ..
  2. A microrheometric assay of matrix mechanics
    Daniel Tschumperlin; Fiscal Year: 2007
    ..Understanding these processes will improve the engineering of replacement tissues, and the treatment of extracellular matrix diseases. [unreadable] [unreadable]..