Genomes and Genes
N S Trede
Affiliation: Harvard University
- Fishing for lymphoid genesN S Trede
Division of Hematology, Children s Hospital and Howard Hughes Medical Institute, 320 Longwood Avenue, Boston, MA 02115, USA
Trends Immunol 22:302-7. 2001..Studies of the zebrafish should improve our understanding of lymphoid development in vertebrates...
- Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysisMark Saltis
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
Immunogenetics 60:105-14. 2008..These findings reveal a very rapid evolution of certain regions of aire during vertebrate evolution and support the existence of an aire-dependent mechanism of T cell tolerance dating back at least to the emergence of bony fish...
- Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110Nikolaus S Trede
Institute of Biochemistry, Justus Liebig University, D 35392 Giessen, Germany
Proc Natl Acad Sci U S A 104:6608-13. 2007..Together, our data demonstrate that a mutation in a general splicing factor can lead to distinct defects in organ development and cause disease...
- Mitoferrin is essential for erythroid iron assimilationGeorge C Shaw
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 440:96-100. 2006..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
- Resolution of the novel immune-type receptor gene cluster in zebrafishJeffrey A Yoder
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Proc Natl Acad Sci U S A 101:15706-11. 2004..These studies resolve a complete immune gene cluster in zebrafish and indicate that the NITRs represent the most complex family of activating/inhibitory surface receptors thus far described...
- The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesisDavid G Ransom
Division of Hematology Oncology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
PLoS Biol 2:E237. 2004..Our results establish a major role for this transcriptional intermediary factor in the differentiation of hematopoietic cells in vertebrates...
- The use of zebrafish to understand immunityNikolaus S Trede
Division of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115 USA
Immunity 20:367-79. 2004..Here, we discuss the advent of the zebrafish as a powerful vertebrate model organism that promises to positively impact immunologic research...
- Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerioStephen M Altmann
Department of Biochemistry, Microbiology, and Molecular Biology, University of Maine, Orono, ME 04469, USA
Dev Comp Immunol 28:295-306. 2004....
- Myc-induced T cell leukemia in transgenic zebrafishDavid M Langenau
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Science 299:887-90. 2003..This transgenic model provides a platform for drug screens and for genetic screens aimed at identifying mutations that suppress or enhance c-myc- induced carcinogenesis...
- Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafishEric C Liao
Division of Hematology Oncology, Children s Hospital, Department of Pediatrics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Development 129:649-59. 2002..These observations demonstrate that the bls gene product is uniquely required in a non-cell autonomous manner for primitive hematopoiesis, potentially acting via regulation of scl...
- In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafishDavid M Langenau
Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115
Proc Natl Acad Sci U S A 101:7369-74. 2004..By contrast, whole kidney marrow permanently reconstituted the T lymphoid compartment of irradiated wild-type fish, suggesting that long-term thymic repopulating cells reside in the kidney...
- The zebrafish as a model organism to study development of the immune systemDavid Traver
Division of Hematology, Children s Hospital, 320, Longwood Avenue, Boston, MA 02115, USA
Adv Immunol 81:253-330. 2003
- Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiencyBarry H Paw
Department of Medicine, Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
Nat Genet 34:59-64. 2003..1R-binding domains. Our report establishes an evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis...
- Method for isolation of PCR-ready genomic DNA from zebrafish tissuesNathan D Meeker
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
Biotechniques 43:610, 612, 614. 2007..Given its speed and low cost, we anticipate that the adoption of this method will streamline DNA isolation for zebrafish research...
- Immunology and zebrafish: spawning new models of human diseaseNathan D Meeker
The Department of Pediatrics and the Huntsman Cancer Institute, University of Utah, Suite 4265, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
Dev Comp Immunol 32:745-57. 2008..Models of immune system malignancies are discussed that are either based on oncogene over-expression or on our own forward-genetic screen that was designed to identify new models of immune dysregulation...
- Views on four key questions about zebrafish researchKeith C Cheng
Jake Gittlen Cancer Research Foundation, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Zebrafish 5:9-24. 2008