Ze Tian

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells
    Ze Tian
    Children s Hospital Informatics Program at Harvard MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 122:31-8. 2008
  2. pmc Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma
    Ze Tian
    Children s Hospital Informatics Program at Harvard MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    BMC Cancer 7:237. 2007
  3. ncbi request reprint Cytotoxicity of two triterpenoids from Nigella glandulifera
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, PR China
    Molecules 11:693-9. 2006
  4. ncbi request reprint Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    J Ethnopharmacol 114:227-33. 2007
  5. pmc A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
    Ze Tian
    Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA and
    Blood 123:706-16. 2014
  6. pmc Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
    Ze Tian
    LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 120:3958-67. 2012
  7. ncbi request reprint Anti-cancer activity and mechanisms of 25-anhydrocimigenol-3-O-beta-D-xylopyranoside isolated from Souliea vaginata on hepatomas
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Anticancer Drugs 17:545-51. 2006
  8. ncbi request reprint Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chemotherapy 53:257-62. 2007
  9. pmc A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
    Dharminder Chauhan
    Department of Medical Oncology, The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 22:345-58. 2012
  10. pmc Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells
    Ze Tian
    Informatics Program, MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cancer Chemother Pharmacol 63:1131-9. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells
    Ze Tian
    Children s Hospital Informatics Program at Harvard MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 122:31-8. 2008
    ..Dulxanthone A is therefore likely a promising preventive and/or therapeutic agent against Hepatoma...
  2. pmc Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma
    Ze Tian
    Children s Hospital Informatics Program at Harvard MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    BMC Cancer 7:237. 2007
    ..It is of great interest to examine the antiproliferative activity and mechanisms of total triterpenoid glycosides of C. dahurica and therefore might eventually be useful in the prevention or treatment of Hepatoma...
  3. ncbi request reprint Cytotoxicity of two triterpenoids from Nigella glandulifera
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, PR China
    Molecules 11:693-9. 2006
    ....
  4. ncbi request reprint Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    J Ethnopharmacol 114:227-33. 2007
    ..32% at 200 mg/kg. In conclusion, EAF may potentially find use as a new therapy for the treatment of hepatoma...
  5. pmc A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
    Ze Tian
    Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA and
    Blood 123:706-16. 2014
    ....
  6. pmc Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
    Ze Tian
    LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 120:3958-67. 2012
    ..Our results show that miR33b is a tumor suppressor that plays a role during MLN2238-induced apoptotic signaling in MM cells, and these data provide the basis for novel therapeutic strategies targeting miR33b in MM...
  7. ncbi request reprint Anti-cancer activity and mechanisms of 25-anhydrocimigenol-3-O-beta-D-xylopyranoside isolated from Souliea vaginata on hepatomas
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Anticancer Drugs 17:545-51. 2006
    ..Moreover, ACX also exhibited a dose-dependent inhibition of tumor growth on mice implanted with H22 in vivo. These findings implicate ACX as a promising anti-cancer agent for chemotherapy of certain cancers...
  8. ncbi request reprint Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chemotherapy 53:257-62. 2007
    ..Furthermore, proteolytic cleavage of poly-ADP-ribose polymerase (PARP), substrate of the caspase family, was detected and associated with apoptosis in HepG2 cells induced by the two compounds...
  9. pmc A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
    Dharminder Chauhan
    Department of Medical Oncology, The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 22:345-58. 2012
    ..Our preclinical study therefore supports clinical evaluation of USP7 inhibitor, alone or in combination, as a potential MM therapy...
  10. pmc Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells
    Ze Tian
    Informatics Program, MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cancer Chemother Pharmacol 63:1131-9. 2009
    ..The aim of the study is to dissect the cytotoxic mechanisms of 1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl)-4E-en-3-heptanone (compound 1) in SH-SY5Y cells and therefore to provide new insight into neuroblastoma chemotherapy...
  11. ncbi request reprint Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity
    Ning An
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Fitoterapia 79:27-31. 2008
    ..Compound 4 showed moderate cytotoxicity against human tumor cell lines, HepG2, MCF-7 and SF-268, while no significant effect were found for compounds 1-3...
  12. ncbi request reprint The cytotoxicity of naturally occurring styryl lactones
    Ze Tian
    Institute of Medicinal Plant, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, PR China
    Phytomedicine 13:181-6. 2006
    ..Our results suggest that the three styryl lactones may be prospectively developed into anti-tumor drugs, especially on treating drug-resistance tumor after structure modification...
  13. pmc Cambogin is preferentially cytotoxic to cells expressing PDGFR
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    PLoS ONE 6:e21370. 2011
    ..These results suggest that cambogin is preferentially cytotoxic to cells expressing PDGFR. Our findings may provide a novel approach by targeting PDGFR signaling against MB...
  14. pmc Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells
    Erxi Wu
    Informatics Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3794. 2008
    ..Furthermore, some signaling is solely modulated through heterodimeric PDGFRalpha/beta...
  15. pmc Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana
    Ze Tian
    Department of Pharmacology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    World J Gastroenterol 12:874-9. 2006
    ..To investigate the anti-tumor activity of ursolic acid (UA) and its derivatives isolated from Aralia decaisneana on hepatocellular carcinoma both in vitro and in vivo...
  16. ncbi request reprint The constituents from the stems of Garcinia cowa Roxb. and their cytotoxic activities
    Jie Shen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    Pharmazie 62:549-51. 2007
    ..These structures were established on the basis of spectroscopic evidence. Twelve compounds isolated from the stems of Garcinia cowa were tested for cytotoxic activities...
  17. ncbi request reprint Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100094, PR China
    Fitoterapia 77:39-42. 2006
    ..Compounds (4) and (5) were inactive on all tested cell lines...
  18. ncbi request reprint Cytotoxicity of three cycloartane triterpenoids from Cimicifuga dahurica
    Ze Tian
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, People s Republic of China
    Cancer Lett 226:65-75. 2005
    ..In addition, inhibition of cdc2 protein expression correlates with mechanism of G(2)/M arrest...
  19. ncbi request reprint [Review of bioactivities of natural cycloartane triterpenoids]
    Ze Tian
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Zhongguo Zhong Yao Za Zhi 31:625-9. 2006
    ..This will be benefit for the further research and development of the compounds...
  20. ncbi request reprint Diterpenes from Helianthus annuus and their cytotoxicity in vitro
    Mao rong Suo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Yao Xue Xue Bao 42:166-70. 2007
    ..Compounds 1 and 2 are new compounds, some compounds showed cytotoxic activities on SF-268, MCF-7 and HepG2 cell lines...
  21. pmc In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
    Dharminder Chauhan
    The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 17:5311-21. 2011
    ..In the present study, we evaluated the efficacy of one such novel orally bioactive proteasome inhibitor MLN9708/MLN2238 in MM using well-established in vitro and in vivo models...
  22. doi request reprint Chemical constituents from the fruits of Hippophae rhamnoides
    Rui Xia Zheng
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People s Republic of China
    Nat Prod Res 23:1451-6. 2009
    ..Among them, 1 was a new compound, and 4-7 and 10 were obtained from the genus for the first time...
  23. pmc Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:121-31. 2011
    ..Targeting the CXCR4-CXCL12 axis thus mobilizes autologous HSCs and promotes long-term survival of islet allografts via a PD-L1-mediated mechanism...
  24. pmc TIM4 Regulates the Anti-Islet Th2 Alloimmune Response
    Andrea Vergani
    Transplantation Research Center, Division of Nephrology, Boston Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cell Transplant 24:1599-614. 2015
    ..The targeting of TIM4 could become a component of an immunoregulatory protocol in clinical islet transplantation, aiming at redirecting the immune system toward a Th2 response. ..
  25. pmc A practical platform for blood biomarker study by using global gene expression profiling of peripheral whole blood
    Ze Tian
    Informatics Program, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    PLoS ONE 4:e5157. 2009
    ..A practical platform needs to be established in order to obtain reliable and reproducible data to meet clinical requirements for biomarker study...
  26. pmc Targeting CD22 reprograms B-cells and reverses autoimmune diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:3013-24. 2008
    ..To investigate a B-cell-depleting strategy to reverse diabetes in naïve NOD mice...