RAVI I THADHANI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Activated vitamin D sterols in kidney disease
    Ravi Thadhani
    Renal Unit and Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 371:542-4. 2008
  2. pmc Genetic variation in APOL1 associates with younger age at hemodialysis initiation
    Zahra Kanji
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 22:2091-7. 2011
  3. pmc Design and implementation of the Canadian Kidney Disease Cohort Study (CKDCS): A prospective observational study of incident hemodialysis patients
    Aminu K Bello
    Department of Medicine, University of Alberta, Edmonton, Canada
    BMC Nephrol 12:10. 2011
  4. doi request reprint Targeted ablation of the vitamin D 1alpha-hydroxylase gene: getting to the heart of the matter
    Ravi Thadhani
    Renal Unit and the Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 74:141-3. 2008
  5. pmc Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease
    Sahir Kalim
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, Department of Pathology, Division of Clinical Chemistry and, Department of Medicine, Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
    Clin J Am Soc Nephrol 8:1927-34. 2013
  6. pmc Changes in Kidney Function After Transjugular Intrahepatic Portosystemic Shunts Versus Large-Volume Paracentesis in Cirrhosis: A Matched Cohort Analysis
    Andrew S Allegretti
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA Electronic address
    Am J Kidney Dis 68:381-91. 2016
  7. pmc Does vitamin D modulate blood pressure?
    Hector Tamez
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 22:204-9. 2013
  8. pmc A Nationally Representative Study of Calcific Uremic Arteriolopathy Risk Factors
    Sagar U Nigwekar
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts
    J Am Soc Nephrol 27:3421-3429. 2016
  9. pmc Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice
    Ricardo C Cavalli
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America
    PLoS ONE 11:e0164353. 2016
  10. pmc Protein carbamylation in kidney disease: pathogenesis and clinical implications
    Sahir Kalim
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA
    Am J Kidney Dis 64:793-803. 2014

Research Grants

Collaborators

  • Sagar U Nigwekar
  • Hector Tamez
  • Ishir Bhan
  • Kevin E Chan
  • Hernan D Kopcow
  • Rhonda Bentley-Lewis
  • Charles A Herzog
  • Alexander Turchin
  • S Karumanchi
  • Richard J Johnson
  • Franklin W Maddux
  • Sahir Kalim
  • Andrew S Allegretti
  • Ana Sofia Cerdeira
  • Julia Wenger
  • Guillermo Ortiz
  • Ricardo C Cavalli
  • Raymond T Chung
  • Drucilla J Roberts
  • Jennifer Huynh
  • Augustine Rajakumar
  • Anders H Berg
  • Julia B Wenger
  • Elizabeth Ankers
  • Sarosh Rana
  • Aminu K Bello
  • Zahra Kanji
  • Marcello Tonelli
  • Winfred W Williams
  • Manoj Bhasin
  • Jie Cui
  • Dihua Xu
  • Dongsheng Zhang
  • Hui Yi Shan
  • Zubin Irani
  • Joshua Wibecan
  • Suzanne D Burke
  • Henri A Korkes
  • Elizabeth Pernicone
  • Deborah Wexler
  • Jessica Yamada
  • Catherine Beauharnais
  • Caitlin A Trottier
  • Joseph J Deferio
  • Zaheed Husain
  • Agnes Lo
  • Caroline M Royle
  • Vikas P Sukhatme
  • Steven J Ralston
  • Kee Hak Lim
  • Saira Salahuddin
  • Giulio Genovese
  • Natasha Wiebe
  • David Friedman
  • Mohammad Karkhaneh
  • Deborah Zimmerman
  • Dawn Opgenorth
  • Brenda Hemmelgarn
  • Salvatore Dibartolo
  • John Gill
  • Rafael Sibrian
  • Camille E Powe
  • Christopher Chan
  • Neil R Powe
  • Martin R Pollak
  • Dorothy A Sullivan
  • Andrea J Bernhardy
  • Sophanny Tiv
  • Daniel Holmes
  • Gina Collerone
  • Chunmei Huang
  • Scott Klarenbach
  • George Cembrowski
  • Jeffrey L Ecker
  • Aliyah Rahemtullah

Detail Information

Publications21

  1. doi request reprint Activated vitamin D sterols in kidney disease
    Ravi Thadhani
    Renal Unit and Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 371:542-4. 2008
  2. pmc Genetic variation in APOL1 associates with younger age at hemodialysis initiation
    Zahra Kanji
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 22:2091-7. 2011
    ..In conclusion, genetic variations in APOL1 identify African Americans that initiate chronic hemodialysis at a younger age. Early interventions to prevent progression of kidney disease may benefit this high-risk population...
  3. pmc Design and implementation of the Canadian Kidney Disease Cohort Study (CKDCS): A prospective observational study of incident hemodialysis patients
    Aminu K Bello
    Department of Medicine, University of Alberta, Edmonton, Canada
    BMC Nephrol 12:10. 2011
    ..This study focuses on delineating potentially reversible determinants of adverse outcomes that occur in patients receiving dialysis for end-stage renal disease (ESRD)...
  4. doi request reprint Targeted ablation of the vitamin D 1alpha-hydroxylase gene: getting to the heart of the matter
    Ravi Thadhani
    Renal Unit and the Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 74:141-3. 2008
    ..In a study by Zhou et al., ablation of the 1alpha-hydroxylase gene led to hypertension, cardiac hypertrophy, and systolic dysfunction, and this cardiac phenotype was rescued with exogenous 1,25-dihydroxyvitamin D administration...
  5. pmc Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease
    Sahir Kalim
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, Department of Pathology, Division of Clinical Chemistry and, Department of Medicine, Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
    Clin J Am Soc Nephrol 8:1927-34. 2013
    ..The hypothesis of this study is that carbamylation burden is independently associated with erythropoietin resistance...
  6. pmc Changes in Kidney Function After Transjugular Intrahepatic Portosystemic Shunts Versus Large-Volume Paracentesis in Cirrhosis: A Matched Cohort Analysis
    Andrew S Allegretti
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA Electronic address
    Am J Kidney Dis 68:381-91. 2016
    ..Placement of a transjugular intrahepatic portosystemic shunt (TIPS) can reverse these changes and potentially improve kidney function. We sought to evaluate change in estimated glomerular filtration rate (eGFR) following TIPS placement...
  7. pmc Does vitamin D modulate blood pressure?
    Hector Tamez
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 22:204-9. 2013
    ..This article provides an overview of the data, with special emphasis on the work published in the last 2 years...
  8. pmc A Nationally Representative Study of Calcific Uremic Arteriolopathy Risk Factors
    Sagar U Nigwekar
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts
    J Am Soc Nephrol 27:3421-3429. 2016
    ..The presence of risk factors months to years before CUA development observed in this study will direct the design of preventive strategies and inform CUA pathobiology...
  9. pmc Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice
    Ricardo C Cavalli
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America
    PLoS ONE 11:e0164353. 2016
    ..When injected into immunocompromised pregnant mice with elevated uterine artery resistance, idNK cells homed to the uterus and reduced the uterine artery resistance index, suggesting improved placental perfusion...
  10. pmc Protein carbamylation in kidney disease: pathogenesis and clinical implications
    Sahir Kalim
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA
    Am J Kidney Dis 64:793-803. 2014
    ..This article reviews the biochemistry of the carbamylation reaction, its role in specific diseases, and the potential diagnostic and therapeutic implications of these findings based on recent advances. ..
  11. doi request reprint Vitamin D and hypertension: an update and review
    Hector Tamez
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 21:492-9. 2012
    ..Vitamin D deficiency and hypertension are highly prevalent. This review will discuss the association between vitamin D deficiency and blood pressure...
  12. pmc Siglec-7 as a Novel Biomarker to Predict Mortality in Decompensated Cirrhosis and Acute Kidney Injury
    Andrew S Allegretti
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, GRB 1008, Boston, MA, 02114, USA
    Dig Dis Sci 61:3609-3620. 2016
    ..Patients with decompensated cirrhosis have high morbidity and are commonly hospitalized with acute kidney injury...
  13. pmc Calciphylaxis: risk factors, diagnosis, and treatment
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, MA Electronic address
    Am J Kidney Dis 66:133-46. 2015
    ..We hereby provide a summary of recommendations developed by a multidisciplinary team for patients with calciphylaxis. ..
  14. pmc Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors
    Ana Sofia Cerdeira
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 190:3939-48. 2013
    ..These findings have potential therapeutic applications for placental disorders associated with altered NK cell biology...
  15. pmc Type 1, type 2 and gestational diabetes mellitus differentially impact placental pathologic characteristics of uteroplacental malperfusion
    Jennifer Huynh
    Medicine Diabetes Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
    Placenta 36:1161-6. 2015
    ..During a pregnancy complicated by diabetes, the placenta undergoes a number of functional and structural pathologic changes. However, differences across studies may reflect pathophysiologic differences of diabetes types under investigation...
  16. pmc Quantifying a rare disease in administrative data: the example of calciphylaxis
    Sagar U Nigwekar
    Harvard Medical School, Boston, MA, USA
    J Gen Intern Med 29:S724-31. 2014
    ..This study was designed to develop an algorithm to accurately identify cases of calciphylaxis and to examine its incidence and mortality...
  17. pmc Dabigatran and rivaroxaban use in atrial fibrillation patients on hemodialysis
    Kevin E Chan
    From Nephrology Division, Massachusetts General Hospital, Waltham, MA K E C, J B W, R I T Clinical Research Division, Fresenius Medical Care North America, Waltham, MA K E C, F W M Massachusetts Institute of Technology, Harvard MIT Biomedical Engineering Center, Institute for Medical Engineering and Science, Cambridge, MA E R E and Cardiovascular Medicine Division, Brigham and Women s Hospital, Boston, MA E R E
    Circulation 131:972-9. 2015
    ..We wanted to determine whether prescription of dabigatran or rivaroxaban was occurring in the dialysis population and whether these practices were safe...
  18. pmc Plasma concentrations of soluble endoglin versus standard evaluation in patients with suspected preeclampsia
    Sarosh Rana
    Division of Maternal Fetal Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    PLoS ONE 7:e48259. 2012
    ....
  19. pmc Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 82:84-9. 2012
    ..Hence, bioavailable vitamin D levels are better correlated with measures of mineral metabolism than total levels in patients on hemodialysis...
  20. ncbi request reprint Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension
    Winfred W Williams
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 353:2590-600. 2005
  21. ncbi request reprint Hypertension during pregnancy: a disorder begging for pathophysiological support
    RAVI I THADHANI
    Hypertension 46:1250-1. 2005

Research Grants6

  1. Biological Measures and Hemodialysis Mortality
    Ravi Thadhani; Fiscal Year: 2006
    ..We have in place detailed plans for the protection of patient privacy, inclusion of all patients, and data/sample sharing with the larger research community. ..
  2. Gestational Diabetes and Preeclampsia Cytokine Profiles
    Ravi Thadhani; Fiscal Year: 2007
    ..abstract_text> ..
  3. ANDROGENS, LIPIDS, INSULIN AND HYPERTENSIVE PREGNANCIES
    Ravi Thadhani; Fiscal Year: 2005
    ..abstract_text> ..
  4. Antibody Microarray Predicting Pima Diabetic Nephropathy
    Ravi Thadhani; Fiscal Year: 2005
    ..This R21 proposal may provide insight into the pathogenesis of DN, provide useful biomarkers to predict DN, and suggest early targets for intervention for this devastating disorder. ..
  5. Vitamin D and Cardiovascular Disease
    Ravi Thadhani; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Ergocalciferol in ESRD Efficacy Safety and Biology
    Ravi Thadhani; Fiscal Year: 2010
    ..Our study is designed to determine safe and effective ways to raise vitamin D levels while monitoring effects on the immune system. ..