Genomes and Genes
Yang D Teng
Affiliation: Harvard University
- The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissueKook In Park
Department of Pediatrics, Pharmacology, and Brain, Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 120 752, Korea
Nat Biotechnol 20:1111-7. 2002..Inflammation and scarring were also reduced, facilitating reconstitution...
- Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cellsYang D Teng
Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:3024-9. 2002..These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problems...
- Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cellsYang D Teng
Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
Regen Med 1:763-76. 2006....
- Functional recovery in T13-L1 hemisected rats resulting from peripheral nerve rerouting: role of central neuroplasticityDeniz Konya
Division of SCI Research, VA Boston Healthcare System, Boston, MA 02132, USA
Regen Med 3:309-27. 2008....
- Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational researchYang D Teng
Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA, USA
Curr Neuropharmacol 9:574-85. 2011..We suggest that embracing this view of the "multipotency" of the SCs is pivotal for correctly, efficiently, and optimally exploiting stem cell biology for therapeutic applications, including reconstitution of a dysfunctional CNS...
- Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosisYang D Teng
Department of Neurosurgery, Harvard Medical School Children s Hospital Boston, MA, USA
Neurosci Lett 397:155-8. 2006..Overall, our data suggest that clenbuterol offers therapeutic effects on ALS-related neuromuscular degeneration...
- Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injuryYang D Teng
Department of Neurosurgery, Harvard Medical School Children s Hospital Boston Brigham and Women s Hospital, Boston, and SCI Laboratory, VA Boston Healthcare System, MA, USA
Proc Natl Acad Sci U S A 101:3071-6. 2004..Minocycline, with its proven clinical safety, capability to cross the blood-brain barrier, and demonstrated efficacy during a clinically relevant therapeutic window, may become an effective therapy for acute SCI...
- Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cellsChristopher D Pritchard
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
J Neurosci Methods 188:258-69. 2010....
- Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signalingJianxue Li
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Neuron 68:45-60. 2010..These findings provide insight into Nna1's role in neuronal development and why its absence renders Purkinje cells more vulnerable...
- Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious ratsHoward Choi
Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 25:4550-9. 2005..p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT1A agonists for post-SCI respiratory disorders...
- Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymerDou Yu
Department of Neurosurgery, Harvard Medical School, The Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
Stem Cells 27:1212-22. 2009..Our findings may provide a bioengineering approach for investigating mechanisms underlying the host microenvironment and donor NSC interaction and help formulate strategies for enhancing graft and host cell survival after SCI...
- Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSC implantationAlexander E Ropper
Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA 02130
Proc Natl Acad Sci U S A . 2017..The uncovered neural circuits and their molecular and cellular targets offer a biological underpinning for development of clinical rehabilitation therapies to treat disabilities and complications of SCI...
- Expression profile of an operationally-defined neural stem cell cloneMark A Parker
Department of Otolaryngology, EN41, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Exp Neurol 194:320-32. 2005..Furthermore, when operational definitions are employed, a common set of stem-like genes does emerge across both embryonic and somatic stem cells of various organ systems, including the nervous system...
- Single muscle fiber size and contractility after spinal cord injury in ratsWalter R Frontera
Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
Muscle Nerve 34:101-4. 2006..SCI thus appears to affect various contractile properties of single muscle fibers differently. Normal cage activity may partially restore function but new interventions are needed to restore muscle fiber quality...
- Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem CellsAlexander E Ropper
Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, Massachusetts Medical Research Institute, Chung Ang University College of Medicine, Seoul, Korea Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Stem Cell Center, Sanford Burnham Medical Research Institute, La Jolla, California Department of Medicine, University of British Columbia, Vancouver, BC, Canada Department of PM and R, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts
Neurosurgery 79:481-91. 2016..There are currently no satisfactory treatments or experimental models showing autonomic dysfunction for intramedullary spinal cord gliomas (ISCG)...
- Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathwayJaime Imitola
Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:18117-22. 2004..CXCR4 expression within germinal zones suggests that NSC homing after injury and migration during development may invoke similar mechanisms...
- Intra-amniotic delivery of amniotic-derived neural stem cells in a syngeneic model of spina bifidaChristopher G Turner
Department of Surgery, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Fetal Diagn Ther 34:38-43. 2013..Neural stem cells (NSCs) may promote spinal cord repair in fetuses with experimental spina bifida. We sought to determine the fate of amniotic-derived NSCs (aNSCs) after simple intra-amniotic injection in a syngeneic model of spina bifida...
- Biological approaches to treating intervertebral disk degeneration: devising stem cell therapiesInbo Han
Department of Neurosurgery, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
Cell Transplant 24:2197-208. 2015..Overall, the data suggest that when applied under a recovery neurobiology principle, multimodal regimens comprising ex vivo engineered stem cell-based disks hold a high potential promise for efficacious clinical translations. ..
- An efficient device to experimentally model compression injury of mammalian spinal cordAlexander E Ropper
Department of Neurosurgery, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA Division of SCI Research, Veteran Affairs Boston Healthcare System, Boston, MA 02130, USA
Exp Neurol 271:515-23. 2015....
- Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysisYang D Teng
Departments of Neurosurgery and PM and R, Brigham and Women s Hospital, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02115, USA
Sci Transl Med 4:165ra164. 2012..We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases...
- Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate targetDustin R Wakeman
Graduate Program in Biomedical Sciences, University of California at San Diego, La Jolla, California, USA Program in Stem Cell and Regenerative Biology, Sanford Burnham Medical Research Institute, La Jolla, California, USA Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA Departments of Psychiatry, Neurosurgery, and Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA Department of Neurology, University of Colorado School of Medicine, Denver, Colorado, USA Department of Neurosurgery and Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA Gene Therapy Center and Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Stem Cells Transl Med 3:692-701. 2014..We believe that transplantation of stem cells, specifically instructed ex vivo to yield DA neurons, could lead to reconstruction of some portion of the nigrostriatal pathway and prove beneficial for the parkinsonian condition. ..
- Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activatorJianxue Li
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:7847-52. 2006..We thus propose a molecular pathway by which the excessive tPA in nr cerebellum mediates PN degeneration...
- The amniotic fluid as a source of neural stem cells in the setting of experimental neural tube defectsChristopher G Turner
Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
Stem Cells Dev 22:548-53. 2013..The amniotic fluid may be a practical source of autologous NSCs applicable to novel forms of therapies for spina bifida...
- Seeding neural stem cells on scaffolds of PGA, PLA, and their copolymersErin Lavik
Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
Methods Mol Biol 198:89-97. 2002
- Stemness enhancement of human neural stem cells following bone marrow MSC cocultureHariprakash Haragopal
Department of Neurosurgery, Harvard Medical School and the Brigham and Women s Hospital, Boston, MA, USA
Cell Transplant 24:645-59. 2015....
- Stem cells: cross-talk and developmental programsJaime Imitola
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, MA4 02115, USA
Philos Trans R Soc Lond B Biol Sci 359:823-37. 2004..Understanding the relevant molecular pathways of stem cell repair phenotype should be a priority, in our view, for the entire stem cell field...
- Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine ADou Yu
Department of Neurosurgery, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 110:E746-55. 2013..Therefore, HUP-A may provide safe and effective management for chronic postneurotrauma pain by reestablishing homeostasis of sensory circuits...
- Neural stem cell delivery to the spinal cord in an ovine model of fetal surgery for spina bifidaDario O Fauza
Department of Surgery and Advanced Fetal Care Center, Children s Hospital Boston, Boston, MA 02115, USA
Surgery 144:367-73. 2008..We introduce the notion of prenatal neural stem cell (NSC) delivery to the spinal cord as an adjuvant to fetal repair of spina bifida...
- Bladder and bowel dysfunction following small-volume epidural blood patch for spontaneous intracranial hypotensionIn Bo Han
Department of Neurosurgery, CHA University, Bundang Cha Medical Center, Sungnam, Republic of Korea
J Clin Neurosci 20:325-8. 2013..We also discuss the possible pathophysiological mechanisms related to this complication in the postprocedure setting...
- Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cellsD Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:12175-80. 2007..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
- Recombinant adenovirus vector-mediated functional expression of neurotropin-3 receptor (TrkC) in neural stem cellsJun Mei Wang
Division of Neuroscience, Department of Histology and Embryology, Zhongshan Medical College, Sun Yat Sen University, Guangzhou, China
Exp Neurol 203:123-7. 2007..2% vs. 29.8%; P<0.05, chi(2) test). Thus, our rAd-TrkC vector can transfect NSCs and produce functional TrkC receptors to promote neuronal differentiation of NSCs...
- Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's diseaseKimberly B Bjugstad
Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Exp Neurol 211:362-9. 2008..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
- Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measuresKimberly B Bjugstad
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
Cell Transplant 14:183-92. 2005..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
- Neural stem cell biology may be well suited for improving brain tumor therapiesStephen Yip
The Burnham Institute, Program in Developmental and Regenerative Cell Biology, La Jolla, California 92037, USA
Cancer J 9:189-204. 2003..It is important to emphasize, however, that the use of NSCs is adjunctive and is not a replacement for other therapies that should be used in parallel...