Yang D Teng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue
    Kook In Park
    Department of Pediatrics, Pharmacology, and Brain, Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 120 752, Korea
    Nat Biotechnol 20:1111-7. 2002
  2. pmc Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
    Yang D Teng
    Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3024-9. 2002
  3. ncbi request reprint Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    Regen Med 1:763-76. 2006
  4. doi request reprint Functional recovery in T13-L1 hemisected rats resulting from peripheral nerve rerouting: role of central neuroplasticity
    Deniz Konya
    Division of SCI Research, VA Boston Healthcare System, Boston, MA 02132, USA
    Regen Med 3:309-27. 2008
  5. pmc Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research
    Yang D Teng
    Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA, USA
    Curr Neuropharmacol 9:574-85. 2011
  6. ncbi request reprint Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School Children s Hospital Boston, MA, USA
    Neurosci Lett 397:155-8. 2006
  7. pmc Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School Children s Hospital Boston Brigham and Women s Hospital, Boston, and SCI Laboratory, VA Boston Healthcare System, MA, USA
    Proc Natl Acad Sci U S A 101:3071-6. 2004
  8. pmc Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells
    Christopher D Pritchard
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Neurosci Methods 188:258-69. 2010
  9. pmc Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuron 68:45-60. 2010
  10. ncbi request reprint Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats
    Howard Choi
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 25:4550-9. 2005

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue
    Kook In Park
    Department of Pediatrics, Pharmacology, and Brain, Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 120 752, Korea
    Nat Biotechnol 20:1111-7. 2002
    ..Inflammation and scarring were also reduced, facilitating reconstitution...
  2. pmc Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
    Yang D Teng
    Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3024-9. 2002
    ..These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problems...
  3. ncbi request reprint Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    Regen Med 1:763-76. 2006
    ....
  4. doi request reprint Functional recovery in T13-L1 hemisected rats resulting from peripheral nerve rerouting: role of central neuroplasticity
    Deniz Konya
    Division of SCI Research, VA Boston Healthcare System, Boston, MA 02132, USA
    Regen Med 3:309-27. 2008
    ....
  5. pmc Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research
    Yang D Teng
    Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA, USA
    Curr Neuropharmacol 9:574-85. 2011
    ..We suggest that embracing this view of the "multipotency" of the SCs is pivotal for correctly, efficiently, and optimally exploiting stem cell biology for therapeutic applications, including reconstitution of a dysfunctional CNS...
  6. ncbi request reprint Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School Children s Hospital Boston, MA, USA
    Neurosci Lett 397:155-8. 2006
    ..Overall, our data suggest that clenbuterol offers therapeutic effects on ALS-related neuromuscular degeneration...
  7. pmc Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School Children s Hospital Boston Brigham and Women s Hospital, Boston, and SCI Laboratory, VA Boston Healthcare System, MA, USA
    Proc Natl Acad Sci U S A 101:3071-6. 2004
    ..Minocycline, with its proven clinical safety, capability to cross the blood-brain barrier, and demonstrated efficacy during a clinically relevant therapeutic window, may become an effective therapy for acute SCI...
  8. pmc Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells
    Christopher D Pritchard
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Neurosci Methods 188:258-69. 2010
    ....
  9. pmc Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuron 68:45-60. 2010
    ..These findings provide insight into Nna1's role in neuronal development and why its absence renders Purkinje cells more vulnerable...
  10. ncbi request reprint Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats
    Howard Choi
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 25:4550-9. 2005
    ..p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT1A agonists for post-SCI respiratory disorders...
  11. pmc Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer
    Dou Yu
    Department of Neurosurgery, Harvard Medical School, The Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    Stem Cells 27:1212-22. 2009
    ..Our findings may provide a bioengineering approach for investigating mechanisms underlying the host microenvironment and donor NSC interaction and help formulate strategies for enhancing graft and host cell survival after SCI...
  12. pmc Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSC implantation
    Alexander E Ropper
    Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA 02130
    Proc Natl Acad Sci U S A . 2017
    ..The uncovered neural circuits and their molecular and cellular targets offer a biological underpinning for development of clinical rehabilitation therapies to treat disabilities and complications of SCI...
  13. ncbi request reprint Expression profile of an operationally-defined neural stem cell clone
    Mark A Parker
    Department of Otolaryngology, EN41, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Exp Neurol 194:320-32. 2005
    ..Furthermore, when operational definitions are employed, a common set of stem-like genes does emerge across both embryonic and somatic stem cells of various organ systems, including the nervous system...
  14. ncbi request reprint Single muscle fiber size and contractility after spinal cord injury in rats
    Walter R Frontera
    Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
    Muscle Nerve 34:101-4. 2006
    ..SCI thus appears to affect various contractile properties of single muscle fibers differently. Normal cage activity may partially restore function but new interventions are needed to restore muscle fiber quality...
  15. doi request reprint Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells
    Alexander E Ropper
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, Massachusetts Medical Research Institute, Chung Ang University College of Medicine, Seoul, Korea Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Stem Cell Center, Sanford Burnham Medical Research Institute, La Jolla, California Department of Medicine, University of British Columbia, Vancouver, BC, Canada Department of PM and R, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts
    Neurosurgery 79:481-91. 2016
    ..There are currently no satisfactory treatments or experimental models showing autonomic dysfunction for intramedullary spinal cord gliomas (ISCG)...
  16. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..CXCR4 expression within germinal zones suggests that NSC homing after injury and migration during development may invoke similar mechanisms...
  17. doi request reprint Intra-amniotic delivery of amniotic-derived neural stem cells in a syngeneic model of spina bifida
    Christopher G Turner
    Department of Surgery, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Fetal Diagn Ther 34:38-43. 2013
    ..Neural stem cells (NSCs) may promote spinal cord repair in fetuses with experimental spina bifida. We sought to determine the fate of amniotic-derived NSCs (aNSCs) after simple intra-amniotic injection in a syngeneic model of spina bifida...
  18. doi request reprint Biological approaches to treating intervertebral disk degeneration: devising stem cell therapies
    Inbo Han
    Department of Neurosurgery, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Cell Transplant 24:2197-208. 2015
    ..Overall, the data suggest that when applied under a recovery neurobiology principle, multimodal regimens comprising ex vivo engineered stem cell-based disks hold a high potential promise for efficacious clinical translations. ..
  19. doi request reprint An efficient device to experimentally model compression injury of mammalian spinal cord
    Alexander E Ropper
    Department of Neurosurgery, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA Division of SCI Research, Veteran Affairs Boston Healthcare System, Boston, MA 02130, USA
    Exp Neurol 271:515-23. 2015
    ....
  20. doi request reprint Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis
    Yang D Teng
    Departments of Neurosurgery and PM and R, Brigham and Women s Hospital, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 4:165ra164. 2012
    ..We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases...
  21. pmc Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate target
    Dustin R Wakeman
    Graduate Program in Biomedical Sciences, University of California at San Diego, La Jolla, California, USA Program in Stem Cell and Regenerative Biology, Sanford Burnham Medical Research Institute, La Jolla, California, USA Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA Departments of Psychiatry, Neurosurgery, and Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA Department of Neurology, University of Colorado School of Medicine, Denver, Colorado, USA Department of Neurosurgery and Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA Gene Therapy Center and Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Stem Cells Transl Med 3:692-701. 2014
    ..We believe that transplantation of stem cells, specifically instructed ex vivo to yield DA neurons, could lead to reconstruction of some portion of the nigrostriatal pathway and prove beneficial for the parkinsonian condition. ..
  22. pmc Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7847-52. 2006
    ..We thus propose a molecular pathway by which the excessive tPA in nr cerebellum mediates PN degeneration...
  23. doi request reprint The amniotic fluid as a source of neural stem cells in the setting of experimental neural tube defects
    Christopher G Turner
    Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells Dev 22:548-53. 2013
    ..The amniotic fluid may be a practical source of autologous NSCs applicable to novel forms of therapies for spina bifida...
  24. ncbi request reprint Seeding neural stem cells on scaffolds of PGA, PLA, and their copolymers
    Erin Lavik
    Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Mol Biol 198:89-97. 2002
  25. doi request reprint Stemness enhancement of human neural stem cells following bone marrow MSC coculture
    Hariprakash Haragopal
    Department of Neurosurgery, Harvard Medical School and the Brigham and Women s Hospital, Boston, MA, USA
    Cell Transplant 24:645-59. 2015
    ....
  26. pmc Stem cells: cross-talk and developmental programs
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, MA4 02115, USA
    Philos Trans R Soc Lond B Biol Sci 359:823-37. 2004
    ..Understanding the relevant molecular pathways of stem cell repair phenotype should be a priority, in our view, for the entire stem cell field...
  27. pmc Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A
    Dou Yu
    Department of Neurosurgery, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E746-55. 2013
    ..Therefore, HUP-A may provide safe and effective management for chronic postneurotrauma pain by reestablishing homeostasis of sensory circuits...
  28. doi request reprint Neural stem cell delivery to the spinal cord in an ovine model of fetal surgery for spina bifida
    Dario O Fauza
    Department of Surgery and Advanced Fetal Care Center, Children s Hospital Boston, Boston, MA 02115, USA
    Surgery 144:367-73. 2008
    ..We introduce the notion of prenatal neural stem cell (NSC) delivery to the spinal cord as an adjuvant to fetal repair of spina bifida...
  29. doi request reprint Bladder and bowel dysfunction following small-volume epidural blood patch for spontaneous intracranial hypotension
    In Bo Han
    Department of Neurosurgery, CHA University, Bundang Cha Medical Center, Sungnam, Republic of Korea
    J Clin Neurosci 20:325-8. 2013
    ..We also discuss the possible pathophysiological mechanisms related to this complication in the postprocedure setting...
  30. pmc Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  31. ncbi request reprint Recombinant adenovirus vector-mediated functional expression of neurotropin-3 receptor (TrkC) in neural stem cells
    Jun Mei Wang
    Division of Neuroscience, Department of Histology and Embryology, Zhongshan Medical College, Sun Yat Sen University, Guangzhou, China
    Exp Neurol 203:123-7. 2007
    ..2% vs. 29.8%; P<0.05, chi(2) test). Thus, our rAd-TrkC vector can transfect NSCs and produce functional TrkC receptors to promote neuronal differentiation of NSCs...
  32. pmc Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    Kimberly B Bjugstad
    Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Exp Neurol 211:362-9. 2008
    ..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
  33. ncbi request reprint Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Transplant 14:183-92. 2005
    ..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
  34. ncbi request reprint Neural stem cell biology may be well suited for improving brain tumor therapies
    Stephen Yip
    The Burnham Institute, Program in Developmental and Regenerative Cell Biology, La Jolla, California 92037, USA
    Cancer J 9:189-204. 2003
    ..It is important to emphasize, however, that the use of NSCs is adjunctive and is not a replacement for other therapies that should be used in parallel...