Terry Strom

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Human CD4 memory T cells can become CD4+IL-9+ T cells
    Prabhakar Putheti
    Department of Medicine, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8706. 2010
  2. pmc Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    Silvia Deaglio
    Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 204:1257-65. 2007
  3. pmc Creating transplant tolerance by taming adverse intragraft innate immunity
    Dusan Hanidziar
    Departments of Medicine and Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E CLS 608 Boston, MA 02215 USA
    F1000 Biol Rep 2:83. 2010
  4. pmc Transplant rejection and paradigms lost
    Terry B Strom
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 123:2360-2. 2013
  5. pmc Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis
    Savithri Balasubramanian
    Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 23:674-86. 2012
  6. pmc 2006 Homer W. Smith Lecture: taming T cells
    Terry B Strom
    Harvard Medical School, Department of Medicine, Beth Israel Deaconess Medical Center, Division of Transplant Immunology, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 18:2824-32. 2007
  7. doi request reprint Recently discovered T cell subsets cannot keep their commitments
    Terry B Strom
    Departments of Medicine and Surgery, Harvard Medical School, Transplant Institute, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Am Soc Nephrol 20:1677-80. 2009
  8. pmc Can childhood viral infection protect from type 1 diabetes?
    Terry B Strom
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Invest 119:1458-61. 2009
  9. pmc Is transplantation tolerable?
    Terry B Strom
    Division of Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 113:1681-3. 2004
  10. pmc Saving islets from allograft rejection
    Terry B Strom
    Harvard Medical School and Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine 1, Room 026, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12651-2. 2005

Research Grants

Detail Information

Publications76

  1. pmc Human CD4 memory T cells can become CD4+IL-9+ T cells
    Prabhakar Putheti
    Department of Medicine, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8706. 2010
    ..IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+) T cells to commit to inflammatory IL-9 producing CD4(+) T cells...
  2. pmc Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    Silvia Deaglio
    Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 204:1257-65. 2007
    ..We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation...
  3. pmc Creating transplant tolerance by taming adverse intragraft innate immunity
    Dusan Hanidziar
    Departments of Medicine and Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E CLS 608 Boston, MA 02215 USA
    F1000 Biol Rep 2:83. 2010
    ..Hence, a reduction in adverse tissue inflammation may prove crucial in facilitating the induction and maintenance of a long-lasting state of transplant tolerance...
  4. pmc Transplant rejection and paradigms lost
    Terry B Strom
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 123:2360-2. 2013
    ..In this issue of the JCI, Walch et al. debunk two classical paradigms concerning transplant rejection, with important consequences for the design of antirejection therapeutics...
  5. pmc Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis
    Savithri Balasubramanian
    Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 23:674-86. 2012
    ..In summary, Nur77 promotes epithelial apoptosis after ischemia-reperfusion injury, and retinoic acid-mediated inhibition of Nur77 expression is a promising therapeutic strategy for the prevention of AKI...
  6. pmc 2006 Homer W. Smith Lecture: taming T cells
    Terry B Strom
    Harvard Medical School, Department of Medicine, Beth Israel Deaconess Medical Center, Division of Transplant Immunology, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 18:2824-32. 2007
  7. doi request reprint Recently discovered T cell subsets cannot keep their commitments
    Terry B Strom
    Departments of Medicine and Surgery, Harvard Medical School, Transplant Institute, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Am Soc Nephrol 20:1677-80. 2009
    ..Rather, Tregs and Th17(+) cells respond to cues provided by the inflammatory texture in which these cells reside. We review the important scientific and therapeutic implications of these differences herein...
  8. pmc Can childhood viral infection protect from type 1 diabetes?
    Terry B Strom
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Invest 119:1458-61. 2009
    ....
  9. pmc Is transplantation tolerable?
    Terry B Strom
    Division of Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 113:1681-3. 2004
    ..Pretreatment with this altered antigen produced transplant tolerance, generation of regulatory T cells, and a loss of many antigen-reactive T cells...
  10. pmc Saving islets from allograft rejection
    Terry B Strom
    Harvard Medical School and Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine 1, Room 026, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12651-2. 2005
  11. ncbi request reprint Transcriptional profiling to assess the clinical status of kidney transplants
    Terry B Strom
    Medicine and Surgery, Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Nat Clin Pract Nephrol 2:116-7. 2006
  12. pmc Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice
    Maria Koulmanda
    Departments of Surgery and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16242-7. 2008
    ..Indeed, the functional mass of beta cells expands in AAT-treated diabetic NOD mice...
  13. ncbi request reprint Tracking the immunoregulatory mechanisms active during allograft tolerance
    Alberto Sanchez-Fueyo
    Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 168:2274-81. 2002
    ....
  14. ncbi request reprint Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 171:3878-85. 2003
    ..We concluded that the effector mechanisms in diabetic NOD hosts are inherently complex, and rejection in this model involves CD28/CD154/gammac-dependent and -independent mechanisms...
  15. pmc An antagonist mutant IL-15/Fc promotes transplant tolerance
    Xin Xiao Zheng
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Transplantation 81:109-16. 2006
    ..To inhibit IL-15 function and to target IL-15 receptor (IL-15R) bearing cells, we have generated a unique lytic antagonistic mutant IL-15/Fc fusion protein (mIL-15/Fc)...
  16. pmc On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes
    Yingyos Avihingsanon
    Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, USA
    J Am Soc Nephrol 16:1542-8. 2005
    ..The transcriptional profiling data provide absolutely essential data to the predictive models, particularly with respect to AR and renal function 6 mo posttransplantation...
  17. ncbi request reprint Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol
    Christoph Domenig
    Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 175:51-60. 2005
    ..In this model, both deletional and immunoregulatory mechanisms are active during the induction and/or maintenance of allograft tolerance through creation of MC using a potentially clinically applicable regimen...
  18. pmc On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 168:4382-90. 2002
    ....
  19. ncbi request reprint Activated intrarenal transcription of CTL-effectors and TGF-beta1 in children with focal segmental glomerulosclerosis
    Juergen Strehlau
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 61:90-5. 2002
    ..Based on the presence of elevated cytokine levels in peripheral blood, a T cell-induced injury could be postulated...
  20. pmc Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
    Sheng Xiao
    Center for Neurologic Diseases, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1691-702. 2007
    ..These data indicate that Tim-1 regulates T cell responses and that Tim-1 engagement can alter T cell function depending on the affinity/avidity with which it is engaged...
  21. pmc Cytokine related therapies for autoimmune disease
    Terry B Strom
    Harvard Medical School, Beth Israel Deaconess Medical Center, Center for Life Sciences Building, 3 Blackfan Circle, Boston, MA 02115, United States
    Curr Opin Immunol 20:676-81. 2008
    ..The ability of IFNgamma, IL-4, TNFalpha, and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in vivo may also enable translation into potent therapies...
  22. ncbi request reprint Allogeneic stem cell-derived "repair unit" therapy and the barriers to clinical deployment
    Terry B Strom
    Department of Medicine, Harvard Medical School, and Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1133-9. 2004
    ..Nonetheless, there are formidable barriers to the use of stem cells in the clinic. This review focuses on identifying and surmounting these barriers...
  23. ncbi request reprint Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size
    Masayuki Sho
    Department of Medicine, Children s Hospital, Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:3744-51. 2002
    ..These data demonstrate that cytokine regulation, CTLA-4 negative signaling, and T cell apoptosis play critical roles in regulating alloimmunity, especially under conditions where the alloreactive T cell clone size is relatively small...
  24. pmc Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts
    Maria Koulmanda
    Department of Surgery, Harvard Medical School, and Islet Transplantation Research Laboratory, Massachusetts General Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:13074-9. 2007
    ..Thus, this triple-therapy regimen, possessing both tolerance-inducing and select antiinflammatory properties, may represent a prototype for therapies able to restore euglycemia and self-tolerance in T1DM...
  25. ncbi request reprint Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
    Xin Xiao Zheng
    Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Immunity 19:503-14. 2003
    ....
  26. pmc CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein
    Sylvie Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Transplantation 82:1510-7. 2006
    ....
  27. ncbi request reprint Allogeneic stem cells, clinical transplantation and the origins of regenerative medicine
    Terry B Strom
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Opin Immunol 14:601-5. 2002
    ....
  28. ncbi request reprint Proteomic analysis of the allograft response
    Basset El Essawy
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Transplantation 82:267-74. 2006
    ..As transcriptional profiling techniques appear to provide a useful means to evaluate the allograft response, we have now initiated an attempt to use proteomics to examine the allograft response...
  29. pmc Requirements for induction and maintenance of peripheral tolerance in stringent allograft models
    Masayuki Sho
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13230-5. 2005
    ..These results provide insight into the mechanisms of tolerance in stringent models and provide a rational basis for innovative tolerogenic strategies in humans...
  30. ncbi request reprint Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
    ..Our data demonstrate a dichotomy in the generation of pathogenic (T(H)17) T cells that induce autoimmunity and regulatory (Foxp3+) T cells that inhibit autoimmune tissue injury...
  31. ncbi request reprint Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    Alberto Sanchez-Fueyo
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 4:1093-101. 2003
    ..Our data indicate that the Tim-3 pathway provides an important mechanism to down-regulate T(H)1-dependent immune responses and to facilitate the development of immunological tolerance...
  32. ncbi request reprint Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival
    Wenda Gao
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 76:994-9. 2003
    ..In the present study, the authors tested the hypothesis that stimulating programmed death 1 (PD-1)-triggered negative signals concurrent with blocking CD154 co-stimulatory signals would facilitate islet allograft tolerance...
  33. pmc Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance
    Koji Kishimoto
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:1471-9. 2002
    ..These data have implications for the design of tolerance strategies in transplant recipients with varying degrees of MHC mismatching...
  34. pmc Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice
    Nicolas Degauque
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:735-41. 2008
    ..The reciprocal effects of agonist Tim-1-specific mAbs upon effector T cells and Tregs serve to prevent allogeneic transplant tolerance...
  35. ncbi request reprint Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    Sylvie Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 173:5818-26. 2004
    ..Our study suggests that the effective targeting of IL-15R-triggered events with CRB-15 can be of therapeutic importance in the treatment of rheumatoid arthritis...
  36. ncbi request reprint Critical role of OX40 in CD28 and CD154-independent rejection
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, and Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 172:1691-8. 2004
    ..Our study revealed a key cellular mechanism of rejection and identified OX40 as a critical alternative costimulatory molecule in CD28/CD154-independent rejection...
  37. ncbi request reprint Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates
    Svjetlan Boskovic
    Department of Surgery, Transplantation Unit, Harvard Medical School at Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 82:819-25. 2006
    ....
  38. pmc Tim-2 regulates T helper type 2 responses and autoimmunity
    Sumone Chakravarti
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 202:437-44. 2005
    ..We propose that Tim-2, an orthologue of human Tim-1, is critical for the regulation of Th2 responses during autoimmune inflammation...
  39. pmc Gene expression profiling of the donor kidney at the time of transplantation predicts clinical outcomes 2 years after transplantation
    Gabor Bodonyi-Kovacs
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Immunol 71:451-5. 2010
    ..This post hoc analysis demonstrates that hypothesis-driven, targeted polymerase chain reaction profiling of gene expression in the donor kidney at the time of engraftment can predict 2-year post-transplantation clinical outcomes...
  40. pmc In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response
    Zhigang Fan
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:718-22. 2010
    ..These results establish real-time cell tracking as a powerful means to probe the dynamic cellular interplay mediating immunologic rejection or transplant tolerance...
  41. doi request reprint TIM-1: a new player in transplant immunity
    Christophe Mariat
    The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 87:S84-6. 2009
    ..The TIM-1 pathway might thus be a potential hurdle to the induction of tolerance in transplantation. Not unexpectedly, blocking the TIM-1 pathway is now emerging as a successful strategy to promote experimental peripheral tolerance...
  42. pmc IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    Thomas Korn
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 448:484-7. 2007
    ..We show that an IL-2 cytokine family member, IL-21, cooperates with TGF-beta to induce T(H)17 cells in naive Il6-/- T cells and that IL-21-receptor-deficient T cells are defective in generating a T(H)17 response...
  43. ncbi request reprint Expression of protective genes in human renal allografts: a regulatory response to injury associated with graft rejection
    Yingyos Avihingsanon
    Division of Immunology, Department of Medicine, Immunobiology Research Center, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 73:1079-85. 2002
    ..Little is known of the pattern of expression of such protective genes and the implication thereof in clinical transplantation...
  44. ncbi request reprint The balance of deletion and regulation in allograft tolerance
    Xin Xiao Zheng
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
    Immunol Rev 196:75-84. 2003
    ..Whilst in a model in which the regulation mechanism plays a critical role, e.g. donor-specific transfusion plus MR1-induced allograft tolerance, a deletional mechanism lowers the threshold for effective Treg action...
  45. pmc TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
    William D Hastings
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 39:2492-501. 2009
    ..These results suggest that TIM-3 is a negative regulator of human T cells and regulates Th1 and Th17 cytokine secretion...
  46. pmc Specificity of CD4+CD25+ regulatory T cell function in alloimmunity
    Alberto Sanchez-Fueyo
    Department of Medicine, Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:329-34. 2006
    ..Taken together, our results indicate that in transplantation, TReg function is dependent on TCR stimulation, providing definitive evidence for their specificity in the regulation of alloimmune responses...
  47. pmc IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 9:1347-55. 2008
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation...
  48. ncbi request reprint Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells
    James McDaid
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 19:458-60. 2005
    ....
  49. ncbi request reprint Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
    Elizabeth Papathanassoglou
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:7745-52. 2006
    ..Taken together, our data further support the notion that nutritional status acting via leptin-dependent mechanisms may alter the nature and vigor of the immune response...
  50. ncbi request reprint Cytokines in the treatment and prevention of autoimmune responses-a role of IL-15
    Xin Xiao Zheng
    Beth Israel Deaconess Medical Centre, Boston, Massachusetts, USA
    Adv Exp Med Biol 520:87-95. 2003
  51. pmc Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6
    Wenda Gao
    The Transplant Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Cell Cycle 8:1444-50. 2009
    ..The implications for therapy are profound, harnessing endogenous immune regulation by paracrine delivery of LIF to CD4(+) cells in vivo...
  52. pmc Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation
    Christophe Mariat
    Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immunol 182:1379-85. 2009
    ....
  53. pmc The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression
    Alberto Sanchez-Fueyo
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 74:898-900. 2002
    ..In this study, we sought to test the role of complement dependent cytotoxicity (CDC) immune effector mechanism in MR1 anti-CD154 induced immunosuppression...
  54. pmc Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation
    Alberto Sanchez-Fueyo
    Department of Medicine and Surgery, Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transpl Int 20:534-41. 2007
    ..Hence, in the absence of indirect presentation, net CD4+CD25+ T cell-dependent immunoregulation is weak, and high ratios of CD4+CD25+ to CD4+CD25 T cells are required to ensure graft survival...
  55. ncbi request reprint Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    Catherine A Sabatos
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1102-10. 2003
    ..These data indicate that interaction of Tim-3 with Tim-3 ligand may serve to inhibit effector T(H)1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance...
  56. pmc Regulation of T cell dependent immune responses by TIM family members
    Christophe Mariat
    Department of Medicine, Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Philos Trans R Soc Lond B Biol Sci 360:1681-5. 2005
    ..In contrast, TIM-1 appears to be an activation molecule for all T cells, although the mechanisms through which TIM-1 activates T cells remain to be elicited...
  57. pmc Functional Th1 cells are required for surgical adhesion formation in a murine model
    Arthur O Tzianabos
    Department of Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:6970-6. 2008
    ..These data demonstrate that the CD4(+) T cells orchestrating adhesion formation are of the Th1 phenotype and delineate the central role of T-bet, Tim-3, IFN-gamma, and IL-16 in mediating this pathogenic tissue response...
  58. pmc TIM-4 expressed on APCs induces T cell expansion and survival
    ROSELYNN RODRIGUEZ-MANZANET
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:4706-13. 2008
    ..Tim-4 also induces the phosphorylation of signaling molecules LAT, Akt, and ERK1/2 in T cells. Tim-4, expressed on APCs, is a costimulatory molecule that promotes T cell expansion and survival by cross-linking Tim-1 on T cells...
  59. ncbi request reprint TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation
    Jennifer Hartt Meyers
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:455-64. 2005
    ..These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation...
  60. ncbi request reprint Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells
    Xuemei Zhong
    Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Eur J Immunol 37:2400-4. 2007
    ..Our findings suggest that B1 and B2 cell subsets play distinct roles in immune regulation by promoting reciprocal differentiation of T cell lineages...
  61. pmc Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    Thomas Korn
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 13:423-31. 2007
    ..Our data suggest that in order for CD4(+)Foxp3(+) T-reg to effectively control autoimmune reactions in the target organ, it may also be necessary to control tissue inflammation...
  62. pmc Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins
    Nicolas Degauque
    Division of Transplant Immunology, Harvard Medical School, and Transplant Research Center, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Transplantation 84:S12-6. 2007
    ..Likewise, it is tempting to speculate that Tim proteins might also modulate the function of other T helper cell subsets such as TH3, TR1 and TH17 cells, among others...
  63. ncbi request reprint CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance
    Lamis Z Jarvinen
    Department of Microbiology and Immunology, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Transplantation 76:1375-9. 2003
    ....
  64. ncbi request reprint Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation
    Sergio A Quezada
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Blood 102:1920-6. 2003
    ..Based on these observations, we conclude that DST and alphaCD154 preemptively tolerize the alloreactive T-cell compartment to prohibit subsequent responses to the immunogenic allograft...
  65. ncbi request reprint Clinical islet transplantation: advances and immunological challenges
    Camillo Ricordi
    University of Miami School of Medicine, Diabetes Research Institute, Miami, Florida 33136, USA
    Nat Rev Immunol 4:259-68. 2004
  66. ncbi request reprint Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes
    Marija Hleb
    Department of Pediatrics, Brown Medical School, Women and Infant s Hospital of Rhode Island, Providence, Rhode Island 02905, USA
    J Biol Chem 279:31948-55. 2004
    ..These results point to a critical role of cyclin D3 in rapamycin-mediated immunosuppressive effects in T cells and cell cycle regulation in lymphocytes in general...
  67. ncbi request reprint Rejection--more than the eye can see
    Terry B Strom
    N Engl J Med 353:2394-6. 2005
  68. pmc Mechanisms underlying blockade of allograft acceptance by TLR ligands
    Paige M Porrett
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 181:1692-9. 2008
    ..Instead, graft destruction results from the ability of CpG to drive Th1 differentiation and interfere with immunoregulation established by alloreactive natural CD4(+)Foxp3(+) Tregs...
  69. ncbi request reprint Mast cells are essential intermediaries in regulatory T-cell tolerance
    Li Fan Lu
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Nature 442:997-1002. 2006
    ..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
  70. ncbi request reprint Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance
    Yon Su Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int Immunol 18:1771-7. 2006
    ..These findings highlight the capacity of CD4(+)DC to modulate alloimmune responses, and suggest therapeutic approaches for the induction of donor-specific tolerance...
  71. ncbi request reprint Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells
    Qizhi Tang
    University of California San Francisco Diabetes Center, University of California, San Francisco, CA 94143, USA
    J Immunol 171:3348-52. 2003
    ..CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs...
  72. ncbi request reprint Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2
    Mariola Kurowska
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    J Immunol 169:1760-7. 2002
    ..Thus, we have demonstrated that a distinctive phenotype of RA FLS, i.e., persistent activation, proliferation, and resistance to apoptosis, is related to the autocrine activation of IL-15Rs by FLS-derived IL-15...
  73. pmc Routes to transplant tolerance versus rejection; the role of cytokines
    Patrick T Walsh
    University of Pennsylvania, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Immunity 20:121-31. 2004
    ..This review will focus on the role of these cytokines in influencing the progression of an alloimmune response leading ultimately to either allograft survival or rejection...
  74. ncbi request reprint Immunological tolerance and liver transplantation
    Alberto Sanchez-Fueyo
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic de Barcelona, Institut d Investigacions Biomédiques August PiSunyer, Universitat de Barcelona, Barcelona, Spain
    J Hepatol 41:698-705. 2004
  75. ncbi request reprint Mycophenolate mofetil is compatible with CD28/CD154 costimulatory blockade in preventing transplant rejection
    Minh Diem Vu
    Transplantation 79:736. 2005
  76. pmc In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3
    Poorni A D S Muthukumarana
    Department of Surgery, University of Cambridge, Cambridge, UK
    Transpl Int 21:593-7. 2008
    ..Thus, in an ex vivo model of in vivo tolerance to heart allografts, TIM-3-Ig therapy appears to reduce the stable tolerogenic environment by a rapid and specific repression of TGFbeta release...

Research Grants2

  1. NON T CELL PRODUCED NOVEL T CELL GROWTH FACTORS
    Terry Strom; Fiscal Year: 2002
    ....
  2. Novel Approaches To Achieve Allograft Tolerance
    Terry Strom; Fiscal Year: 2005
    ..6) determine whether an idealized therapeutic and diagnostic protocol can be established through knowledge gained from the combined efforts of each of the components of this project. ..