William S Stone

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Glucose effects on cognition in schizophrenia
    William S Stone
    Department of Psychiatry at Massachusetts Mental Health Center MMHC, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 62:93-103. 2003
  2. ncbi request reprint Evidence for linkage between regulatory enzymes in glycolysis and schizophrenia in a multiplex sample
    William S Stone
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 127:5-10. 2004
  3. ncbi request reprint Searching for the liability to schizophrenia: concepts and methods underlying genetic high-risk studies of adolescents
    William S Stone
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA 02115, USA
    J Child Adolesc Psychopharmacol 15:403-17. 2005
  4. pmc Auditory working memory impairments in individuals at familial high risk for schizophrenia
    Larry J Seidman
    Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neuropsychology 26:288-303. 2012
  5. pmc Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies
    Larry J Seidman
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
    Schizophr Bull 32:507-24. 2006
  6. pmc Toward a model of memory enhancement in schizophrenia: glucose administration and hippocampal function
    William S Stone
    Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Schizophr Bull 34:93-108. 2008
  7. doi request reprint Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS)
    William S Stone
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, MA 02215, USA
    Schizophr Res 128:102-10. 2011
  8. doi request reprint Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study
    Larry J Seidman
    Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, Massachusetts2Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston
    JAMA Psychiatry 73:1239-1248. 2016
  9. pmc Neurocognitive and clinical dysfunction in adult Chinese, nonpsychotic relatives of patients with schizophrenia: Findings from the Changsha study and evidence for schizotaxia
    William S Stone
    Department of Psychiatry, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA
    Asian J Psychiatr 5:83-92. 2012
  10. doi request reprint Factor structure and heritability of endophenotypes in schizophrenia: findings from the Consortium on the Genetics of Schizophrenia (COGS-1)
    Larry J Seidman
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, MA, United States Harvard Institute of Psychiatric Epidemiology and Genetic s, Boston, MA, United States Electronic address
    Schizophr Res 163:73-9. 2015

Detail Information

Publications31

  1. ncbi request reprint Glucose effects on cognition in schizophrenia
    William S Stone
    Department of Psychiatry at Massachusetts Mental Health Center MMHC, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 62:93-103. 2003
    ..They also highlight the need to explore the extent to which glucose modulates nonmemory cognitive functions such as attention, and to understand more generally how glucose availability and regulation influence cognition...
  2. ncbi request reprint Evidence for linkage between regulatory enzymes in glycolysis and schizophrenia in a multiplex sample
    William S Stone
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 127:5-10. 2004
    ..More generally, they support the view that relationships between glucose dysregulation and schizophrenia are inherent to the disorder, and are not merely epiphenomena related to medication or other treatment factors...
  3. ncbi request reprint Searching for the liability to schizophrenia: concepts and methods underlying genetic high-risk studies of adolescents
    William S Stone
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA 02115, USA
    J Child Adolesc Psychopharmacol 15:403-17. 2005
    ....
  4. pmc Auditory working memory impairments in individuals at familial high risk for schizophrenia
    Larry J Seidman
    Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neuropsychology 26:288-303. 2012
    ..The goal of these studies was to develop new auditory continuous performance tests (ACPTs) and evaluate their effects in individuals with schizophrenia and their relatives...
  5. pmc Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies
    Larry J Seidman
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
    Schizophr Bull 32:507-24. 2006
    ..Ascertainment criteria for controls may markedly influence results and interpretation of group differences...
  6. pmc Toward a model of memory enhancement in schizophrenia: glucose administration and hippocampal function
    William S Stone
    Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Schizophr Bull 34:93-108. 2008
    ..More generally, the discussion underlines the promise of cognitive improvement in schizophrenia and the need to approach the issue in a programmatic manner...
  7. doi request reprint Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS)
    William S Stone
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, MA 02215, USA
    Schizophr Res 128:102-10. 2011
    ....
  8. doi request reprint Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study
    Larry J Seidman
    Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, Massachusetts2Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston
    JAMA Psychiatry 73:1239-1248. 2016
    ....
  9. pmc Neurocognitive and clinical dysfunction in adult Chinese, nonpsychotic relatives of patients with schizophrenia: Findings from the Changsha study and evidence for schizotaxia
    William S Stone
    Department of Psychiatry, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA
    Asian J Psychiatr 5:83-92. 2012
    ..These findings provide additional validity for a liability syndrome, and for its utility as an intervention target for strategies aimed at ameliorating both its core and its associated symptoms. ..
  10. doi request reprint Factor structure and heritability of endophenotypes in schizophrenia: findings from the Consortium on the Genetics of Schizophrenia (COGS-1)
    Larry J Seidman
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, MA, United States Harvard Institute of Psychiatric Epidemiology and Genetic s, Boston, MA, United States Electronic address
    Schizophr Res 163:73-9. 2015
    ..It may be possible to distill individual endophenotypes into composite measures that reflect dissociable, genetically informative elements...
  11. pmc Gating Deficit Heritability and Correlation With Increased Clinical Severity in Schizophrenia Patients With Positive Family History
    Tiffany A Greenwood
    From the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego the Department of Psychiatry, University of Pennsylvania, Philadelphia the Department of Psychiatry and Biobehavioral Sciences, UCLA, The Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif the Department of Psychiatry, University of Colorado Health Sciences Center, Denver the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J Peters VA Medical Center, New York
    Am J Psychiatry 173:385-91. 2016
    ..Here the authors investigated whether gating measures were more heritable in multiply affected families with a positive family history compared with families with only a single affected proband (singleton)...
  12. doi request reprint Open-label pilot study on vitamin D₃ supplementation for antipsychotic-associated metabolic anomalies
    Neelam Thakurathi
    Schizophrenia Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 28:275-82. 2013
    ....
  13. ncbi request reprint Medial temporal and prefrontal lobe activation during verbal encoding following glucose ingestion in schizophrenia: A pilot fMRI study
    William S Stone
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, USA
    Neurobiol Learn Mem 83:54-64. 2005
    ....
  14. ncbi request reprint Schizotaxia: current status and future directions
    Ming T Tsuang
    Department of Psychiatry at the Massachusetts Mental Health Center, Harvard Medical School, 74 Fernwood Road, Boston, MA 02115, USA
    Curr Psychiatry Rep 5:128-34. 2003
    ..In this review, the authors update the conceptual basis of schizotaxia, consider evidence for its validity, and look toward its likely evolution in the future...
  15. doi request reprint Declarative memory deficits and schizophrenia: problems and prospects
    William S Stone
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurobiol Learn Mem 96:544-52. 2011
    ....
  16. ncbi request reprint Understanding predisposition to schizophrenia: toward intervention and prevention
    Ming T Tsuang
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Can J Psychiatry 47:518-26. 2002
    ..In this paper, we consider some of the major obstacles that must be studied before prevention strategies become feasible...
  17. ncbi request reprint An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention
    Ming T Tsuang
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center MMHC, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 54:169-75. 2002
    ..25-2.0 mg). Thus, clinical deficits in schizotaxia may be identifiable, and to a significant extent, reversible. Implications for the conception of schizotypy and the prevention of schizophrenia will be discussed...
  18. pmc Are neurocognitive, clinical and social dysfunctions in schizotaxia reversible pharmacologically?: Results from the Changsha study
    William S Stone
    Department of Psychiatry, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA
    Asian J Psychiatr 5:73-82. 2012
    ....
  19. doi request reprint California Verbal Learning Test-II performance in schizophrenia as a function of ascertainment strategy: comparing the first and second phases of the Consortium on the Genetics of Schizophrenia (COGS)
    William S Stone
    Department of Psychiatry, Harvard Medical School, Boston, MA, United States Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States Electronic address
    Schizophr Res 163:32-7. 2015
    ..Demographically corrected data yield a consistent pattern of performance across the two studies in SZ. ..
  20. ncbi request reprint Treatment of nonpsychotic relatives of patients with schizophrenia: six case studies
    Ming T Tsuang
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
    Am J Med Genet 114:943-8. 2002
  21. pmc Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia
    Asli Demirtas-Tatlidede
    Harvard Medical School, Boston, MA, United States
    Schizophr Res 124:91-100. 2010
    ..This proof of principle study aimed to test this hypothesis using noninvasive brain stimulation, and to explore the safety of this protocol in schizophrenia...
  22. doi request reprint Healthy adolescent performance on the MATRICS Consensus Cognitive Battery (MCCB): Developmental data from two samples of volunteers
    William S Stone
    Department of Psychiatry, Harvard Medical School, Boston, MA, United States Massachusetts Mental Health Center Public Psychiatry Division of Beth Israel Deaconess Medical Center, Boston, MA, United States Electronic address
    Schizophr Res 172:106-13. 2016
    ..They also provide healthy comparison raw scores to facilitate clinical evaluations of adolescents, including those at risk for developing psychiatric disorders such as schizophrenia-related conditions. ..
  23. doi request reprint Development of liability syndromes for schizophrenia: where did they come from and where are they going?
    William S Stone
    Department of Psychiatry, Massachusetts Mental Health Center, Division of Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    Am J Med Genet B Neuropsychiatr Genet 162:687-97. 2013
    ..Finally, challenges to validation and future directions for research are considered...
  24. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  25. pmc The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes
    Raquel E Gur
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:49-68. 2007
    ....
  26. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  27. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  28. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  29. ncbi request reprint Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia
    Stephen J Glatt
    Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 920923, USA
    Br J Psychiatry 189:337-45. 2006
    ..Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness...
  30. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  31. ncbi request reprint Validating schizotaxia and its place in studies of preventing schizophrenia by psychopharmacological intervention
    Ming T Tsuang
    Department of Psychiatry, University of California, San Diego, USA
    Essent Psychopharmacol 6:91-103. 2005
    ..These may represent special vulnerability to schizophrenia. Five areas of deficit are enumerated and suggestions as to the potential value of pre-illness interventions are discussed...