Kevin M Spencer
Affiliation: Harvard University
- Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalitiesKevin M Spencer
Department of Psychiatry, VA Boston Healthcare System, Brocton, Massachusetts, USA
Clin EEG Neurosci 39:65-8. 2008..The relationships between these abnormalities and neural circuitry abnormalities in schizophrenia are discussed...
- Baseline gamma power during auditory steady-state stimulation in schizophreniaKevin M Spencer
Research Service, Veterans Affairs Boston Healthcare System Boston, MA, USA
Front Hum Neurosci 5:190. 2011..These baseline increases could be the sign of NMDAR hypofunction on parvalbumin-expressing inhibitory interneurons, which would be consistent with acute NMDAR antagonism and genetic ablation models of schizophrenia...
- The functional consequences of cortical circuit abnormalities on gamma oscillations in schizophrenia: insights from computational modelingKevin M Spencer
Research Service, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
Front Hum Neurosci 3:33. 2009..Computational modeling may help to bridge the gaps between post-mortem studies, animal models, and experimental data in humans, and facilitate the development of new therapies for schizophrenia and neuropsychiatric disorders in general...
- Enhanced facilitation of spatial attention in schizophreniaKevin M Spencer
Veterans Affairs Boston Healthcare System Harvard Medical School, Research 151C, 150 S Huntington Avenue, Boston, MA 02130, USA
Neuropsychology 25:76-85. 2011..We tested this hypothesis with orienting tasks involving the cued detection of a laterally presented target stimulus...
- Sensory-evoked gamma oscillations in chronic schizophreniaKevin M Spencer
Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Brockton, Massachusetts 02301, USA
Biol Psychiatry 63:744-7. 2008..We investigated these issues by examining the VGO and AGO in chronic schizophrenic (SZ) and matched healthy control (HC) subjects...
- Hemispheric biases and the control of visuospatial attention: an ERP studyKevin M Spencer
Department of Psychiatry, Harvard Medical School, VA Boston Healthcare System, Brockton, Massachusetts, USA
BMC Neurosci 6:51. 2005....
- Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophreniaKevin M Spencer
Research Service, Veterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Research 151C, 150 S, Huntington Ave, Boston, MA 02130, USA
BMC Neurosci 10:85. 2009..A 5-dipole model was fit from the HC grand average ASSR, with 2 pairs of superior temporal dipoles and a deep midline dipole. Time-frequency decomposition was performed on the scalp EEG and source data...
- Gamma-band auditory steady-state responses are impaired in first episode psychosisKevin M Spencer
Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton 02301, USA
Biol Psychiatry 64:369-75. 2008..Here we examined whether gamma ASSR deficits are also present at first hospitalization for psychosis...
- Functional and structural deficits in brain regions subserving face perception in schizophreniaToshiaki Onitsuka
Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
Am J Psychiatry 163:455-62. 2006....
- Attentional networks and cingulum bundle in chronic schizophreniaPaul G Nestor
Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
Schizophr Res 90:308-15. 2007..In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration...
- Early and late stages of visual processing in individuals in prodromal state and first episode schizophrenia: an ERP studyNaoya Oribe
Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States
Schizophr Res 146:95-102. 2013..Therefore, in this study, we measured the P300 component as well as the P1/N1 in a visual oddball paradigm in prodromal subjects and first episode schizophrenia patients, and compared them with those of healthy controls...
- Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: a combined ERP and DTI studyThomas J Whitford
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, HarvardMedical School, Boston, MA 02215, USA
Neuroimage 54:2318-29. 2011..The present study investigated whether or not these IHTT abnormalities could be underpinned by structural damage to the visual fibers of the corpus callosum...
- Neural synchrony indexes disordered perception and cognition in schizophreniaKevin M Spencer
Department of Psychiatry, Veterans Affairs Boston Healthcare System, Harvard Medical School, Psychiatry 116A, 940 Belmont Street, Brockton, MA 02301, USA
Proc Natl Acad Sci U S A 101:17288-93. 2004..These data provide support for linking dysfunctional neural circuitry and the core symptoms of schizophrenia...
- Abnormal neural synchrony in schizophreniaKevin M Spencer
Department of Psychiatry, Harvard Medical School Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301, USA
J Neurosci 23:7407-11. 2003..These findings support the hypothesis that schizophrenia is associated with impaired neural circuitry demonstrated as a failure of gamma band synchronization, especially in the 40 Hz range...
- Clinical high risk and first episode schizophrenia: auditory event-related potentialsElisabetta C Del Re
VA Boston Healthcare System, Brockton, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Electronic address
Psychiatry Res 231:126-33. 2015..Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership. ..
- Electrophysiological assessment of auditory stimulus-specific plasticity in schizophreniaRyan P Mears
Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Boston, MA 02130, USA
Biol Psychiatry 71:503-11. 2012..We used event-related brain potentials (ERPs) to assay neuroplasticity after auditory conditioning in chronic schizophrenia patients (SZ) and matched healthy control subjects (HC)...
- Long-range synchrony of γ oscillations and auditory hallucination symptoms in schizophreniaC Mulert
Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Massachusetts, USA
Int J Psychophysiol 79:55-63. 2011..These results suggest that long-range synchrony of gamma oscillations is disturbed in schizophrenia and that this deficit is related to clinical symptoms such as auditory hallucinations...
- Spontaneous Gamma Activity in SchizophreniaYoji Hirano
Neural Dynamics Laboratory, Research Service, Veterans Affairs Boston Healthcare System, Boston, Massachusetts2Department of Psychiatry, Harvard Medical School, Boston, Massachusetts3Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyus
JAMA Psychiatry 72:813-21. 2015..Animal models of SZ based on hypofunction of the N-methyl-d-aspartate receptor (NMDAR) demonstrate increased spontaneous broadband gamma power, but this phenomenon has not been identified clearly in patients with SZ...
- Neurophysiological studies of auditory verbal hallucinationsJudith M Ford
Psychiatry Service, San Francisco Veterans Affairs Medical Center, Department of Psychiatry, University of California, San Francisco, CA, USA
Schizophr Bull 38:715-23. 2012..These problems are common to studies of other psychiatric symptoms and should be considered when attempting to understand the basic neural mechanisms responsible for them...
- Abnormal asymmetry of the face n170 repetition effect in male patients with chronic schizophreniaToshiaki Onitsuka
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA, USA
Brain Imaging Behav 3:240-5. 2009..01), whereas healthy subjects showed a significant decrease at the right occipitotemporal electrode (t = 2.36, p = 0.04). These results suggest abnormal asymmetry of the N170 face repetition effect in schizophrenia...
- The genetic and environmental influences of event-related gamma oscillations on bipolar disorderMei Hua Hall
Psychology Research Laboratory, Harvard Medical School, McLean Hospital Research Service, Boston, MA, USA
Bipolar Disord 13:260-71. 2011..The present study aimed to examine whether GBRs derived from two auditory tasks, the oddball task and the dual-click paradigm, are potential BPD endophenotypes...
- Abnormal pitch mismatch negativity in individuals with schizotypal personality disorderMargaret A Niznikiewicz
VA Boston Healthcare System Boston VA Healthcare System, Jamaica Plain VA and Brockton VA campuses, United States
Schizophr Res 110:188-93. 2009..Biological Psychiatry (2006); 59(8):762-772], in recent onset schizophrenia patients. To our knowledge no reports exist of MMN in SPD individuals...
- Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivoMei Hua Hall
Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA 02452, USA Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02452, USA Electronic address
Neuroimage 111:186-91. 2015....
- Did you or I say pretty, rude or brief? An ERP study of the effects of speaker's identity on emotional word processingAna P Pinheiro
Neuropsychophysiology Laboratory, Psychology Research Center CIPsi, School of Psychology, University of Minho, Braga, Portugal Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States Faculty of Psychology, University of Lisbon, Lisbon, Portugal Electronic address
Brain Lang 153:38-49. 2016..Together, these findings suggest that emotion and speaker's identity interact during speech processing, in line with observations of partially dependent processing of speech and speaker information...
- Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: a preliminary reportMei Hua Hall
Department of Psychiatry Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Boston, Massachusetts Department of Psychiatry Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Boston, Massachusetts Psychiatric and Neurodevelopmental Genetics Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts
Am J Med Genet B Neuropsychiatr Genet 168:151-61. 2015..This locus may influence P50 but not psychotic illness. Among patients with psychotic illness, PRS results indicated genetic overlap between SCZ loci and gamma oscillation and between BIP loci and P3 amplitude...
- Neurophysiological biomarkers for drug development in schizophreniaDaniel C Javitt
Nathan Kline Institute for Schizophrenia Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
Nat Rev Drug Discov 7:68-83. 2008..Moreover, many of these neurophysiological processes are phylogenetically conserved and can be modelled in preclinical studies, offering unique opportunities for use as translational biomarkers in schizophrenia drug discovery...
- Localization of the event-related potential novelty response as defined by principal components analysisJoseph Dien
Department of Psychology, University of Illinois, Urbana Champaign, IL, USA
Brain Res Cogn Brain Res 17:637-50. 2003..Source modeling on 129-channel data with BESA and BrainVoyager suggests the P300 has sources in the temporal-parietal junction whereas the Novelty P3 has sources in the anterior cingulate...
- The influence of stimulus deviance and novelty on the P300 and novelty P3Abraham Goldstein
Department of Psychology, Bar Ilan University, Ramat Gan, Israel
Psychophysiology 39:781-90. 2002....
- Parsing the late positive complex: mental chronometry and the ERP components that inhabit the neighborhood of the P300Joseph Dien
Department of Psychology, University of Illinois, Urbana Champaign, Urbana, USA
Psychophysiology 41:665-78. 2004..Conceptually, we dispute the proposed distinction between stimulus evaluation and response selection. We suggest a four-stage ERP model of information processing and place the P3a and the P300 in this framework...
- An EEG Study of Neural Dynamics in SchizophreniaKevin Spencer; Fiscal Year: 2006..This project seeks to further this goal by studying how brainwave synchronization is related to perception and thinking in people who are healthy, and in people who have schizophrenia. [unreadable] [unreadable] [unreadable]..