J Sevigny

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase
    J Sevigny
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:5640-7. 2000
  2. ncbi request reprint Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
    K Sato
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 166:4185-94. 2001
  3. pmc Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection
    M Imai
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Mol Med 5:743-52. 1999
  4. ncbi request reprint Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae
    K Koziak
    Department of Medicine, Center for Immunobiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:2057-62. 2000
  5. ncbi request reprint Disordered cellular migration and angiogenesis in cd39-null mice
    C Goepfert
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:3109-15. 2001
  6. ncbi request reprint Identification and characterization of CD39/vascular ATP diphosphohydrolase
    E Kaczmarek
    Sandoz Center for Immunobiology, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:33116-22. 1996
  7. ncbi request reprint P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide
    M Warny
    Gastroenterology Divison, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:26051-6. 2001
  8. ncbi request reprint Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries
    S P Gangadharan
    Division of Vascular Surgery, Brigham and Women's Hospital and Harvard Institute for Human Genetics, Boston, MA 02115, USA
    Surgery 130:296-303. 2001
  9. pmc Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception
    H O Vongtau
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroscience 193:387-98. 2011
  10. ncbi request reprint Impact of therapeutic plasma exchange on cyclosporine kinetics during membrane-based lipid apheresis
    R A Balogun
    Division of Nephrology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Am J Kidney Dis 37:1286-9. 2001

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase
    J Sevigny
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:5640-7. 2000
    ..The different biochemical properties and localization of the hepatic ATPDase suggest pathophysiological functions that are distinct from the vascular ATPDase/cd39...
  2. ncbi request reprint Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
    K Sato
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 166:4185-94. 2001
    ..Additional mechanisms by which CO overcomes graft rejection may involve its ability to suppress endothelial cell apoptosis...
  3. pmc Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection
    M Imai
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Mol Med 5:743-52. 1999
    ..Studies were therefore conducted to evaluate the role of vascular NTPDase-1/cd39 in modulating platelet activation and vascular injury in cardiac xenografts...
  4. ncbi request reprint Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae
    K Koziak
    Department of Medicine, Center for Immunobiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:2057-62. 2000
    ..We suggest that palmitoylation could modulate the function of CD39 in regulating cellular signal transduction pathways...
  5. ncbi request reprint Disordered cellular migration and angiogenesis in cd39-null mice
    C Goepfert
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:3109-15. 2001
    ..Linked to these findings, chemotaxis of cd39-null monocyte/macrophages to nucleotides was impaired in vitro. This abnormality was associated with desensitization of nucleotide receptor P2Y-mediated signaling pathways...
  6. ncbi request reprint Identification and characterization of CD39/vascular ATP diphosphohydrolase
    E Kaczmarek
    Sandoz Center for Immunobiology, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:33116-22. 1996
    ..Because ATPDase activity is lost with endothelial cell activation, overexpression of the functional enzyme, or a truncated mutant thereof, may prevent platelet activation associated with vascular inflammation...
  7. ncbi request reprint P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide
    M Warny
    Gastroenterology Divison, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:26051-6. 2001
    ..Furthermore, lipopolysaccharide mediates IL-8 production at least in part by autocrine P2Y(6) activation. These findings indicate a novel role for P2Y(6) in innate immune defenses...
  8. ncbi request reprint Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries
    S P Gangadharan
    Division of Vascular Surgery, Brigham and Women's Hospital and Harvard Institute for Human Genetics, Boston, MA 02115, USA
    Surgery 130:296-303. 2001
    ..Further studies are required to determine whether targeted delivery of CD39 could convey thromboprotective properties to an injured vessel...
  9. pmc Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception
    H O Vongtau
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroscience 193:387-98. 2011
    ..We propose that NTPDase3 is a key regulator of nociceptive signaling that also makes an unexpected contribution to innocuous tactile sensation...
  10. ncbi request reprint Impact of therapeutic plasma exchange on cyclosporine kinetics during membrane-based lipid apheresis
    R A Balogun
    Division of Nephrology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Am J Kidney Dis 37:1286-9. 2001
    ..Despite substantial removal of lipoproteins, there is minimal impact of TPE on serum levels of cyclosporine, and dosage adjustment is not needed for patients undergoing this procedure...