Bernard Rosner

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Blood pressure differences by ethnic group among United States children and adolescents
    Bernard Rosner
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Hypertension 54:502-8. 2009
  2. pmc Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk
    Ying Liu
    Affiliations of authors Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO YL, GAC Alvin J Siteman Cancer Center at Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO GAC Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA BR, CSB, WYC, RMT Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA LCC, SJS, JLC Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA WCW
    J Natl Cancer Inst 105:1571-8. 2013
  3. ncbi request reprint Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses
    Eliot L Berson
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Arch Ophthalmol 122:1306-14. 2004
  4. doi request reprint Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine and Tufts Medical Center, New England Eye Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:586-91. 2009
  5. pmc Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ophthalmology 117:1989-95. 2010
  6. doi request reprint Validation of a prediction algorithm for progression to advanced macular degeneration subtypes
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA 02111, USA
    JAMA Ophthalmol 131:448-55. 2013
  7. pmc One-carbon metabolism factors and leukocyte telomere length
    Jason J Liu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 97:794-9. 2013
  8. pmc Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:5818-27. 2009
  9. ncbi request reprint Unopposed estrogen therapy and the risk of invasive breast cancer
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Arch Intern Med 166:1027-32. 2006
  10. pmc Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, New England Eye Center, Boston, Massachusetts, USA
    Ophthalmology 118:2203-11. 2011

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. pmc Blood pressure differences by ethnic group among United States children and adolescents
    Bernard Rosner
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Hypertension 54:502-8. 2009
    ..Ethnic differences in prevalence rates of pediatric BP elevation that are not explained by obesity are present, primarily in boys. Whether these differences are attributable to genetic or environmental factors is unknown...
  2. pmc Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk
    Ying Liu
    Affiliations of authors Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO YL, GAC Alvin J Siteman Cancer Center at Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO GAC Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA BR, CSB, WYC, RMT Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA LCC, SJS, JLC Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA WCW
    J Natl Cancer Inst 105:1571-8. 2013
    ..No study has characterized the contribution of alcohol consumption during this interval to risks of proliferative benign breast disease (BBD) and breast cancer...
  3. ncbi request reprint Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses
    Eliot L Berson
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Arch Ophthalmol 122:1306-14. 2004
    ..To determine whether docosahexaenoic acid will slow the course of retinal degeneration in subgroups of patients with retinitis pigmentosa who are receiving vitamin A...
  4. doi request reprint Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine and Tufts Medical Center, New England Eye Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:586-91. 2009
    ..To evaluate the relationship between peripheral retinal drusen and reticular pigment changes and genotypes associated with age-related macular degeneration (AMD)...
  5. pmc Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ophthalmology 117:1989-95. 2010
    ..In this study, we evaluated whether LIPC is associated with serum lipids, and whether this gene and serum lipids are independently associated with AMD...
  6. doi request reprint Validation of a prediction algorithm for progression to advanced macular degeneration subtypes
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA 02111, USA
    JAMA Ophthalmol 131:448-55. 2013
    ....
  7. pmc One-carbon metabolism factors and leukocyte telomere length
    Jason J Liu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 97:794-9. 2013
    ..Dietary and genetic factors involved in the one-carbon metabolism pathway may affect telomere length through DNA methylation and synthesis, but this has not been comprehensively investigated in epidemiologic studies...
  8. pmc Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:5818-27. 2009
    ..This study was conducted to determine whether alterations in circulating levels of these markers of complement activation and regulation are also independently associated with advanced AMD and whether they are related to AMD genotypes...
  9. ncbi request reprint Unopposed estrogen therapy and the risk of invasive breast cancer
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Arch Intern Med 166:1027-32. 2006
    ..We sought to assess the relationship between longer-term use of unopposed estrogen and the risk of invasive breast cancer over an extended follow-up period...
  10. pmc Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, New England Eye Center, Boston, Massachusetts, USA
    Ophthalmology 118:2203-11. 2011
    ....
  11. pmc Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:180-90. 2010
    ..These results suggest that genetic variants and circulating levels of IGFBP-3 may play a role in the early stage of breast carcinogenesis...
  12. pmc Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations...
  13. pmc Risk factors for mortality in the nurses' health study: a competing risks analysis
    Heather J Baer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 173:319-29. 2011
    ..In the future, this new model may be used to identify individuals at increased risk of mortality...
  14. pmc Diet quality indices and postmenopausal breast cancer survival
    Esther H J Kim
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nutr Cancer 63:381-8. 2011
    ..However, healthy dietary choices may be important because women are at risk of death from non-breast-cancer-related causes affected by diet...
  15. pmc Disease course in patients with autosomal recessive retinitis pigmentosa due to the USH2A gene
    Michael A Sandberg
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:5532-9. 2008
    ..To estimate the mean rates of ocular function loss in patients with autosomal recessive retinitis pigmentosa due to USH2A mutations...
  16. pmc Vegetable protein and vegetable fat intakes in pre-adolescent and adolescent girls, and risk for benign breast disease in young women
    Catherine S Berkey
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Breast Cancer Res Treat 141:299-306. 2013
    ..In conclusion, consumption of vegetable protein, fat, peanut butter, or nuts by older girls may help reduce their risk of BBD as young women...
  17. pmc Plasma vitamin D biomarkers and leukocyte telomere length
    Jason J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 177:1411-7. 2013
    ..05). Higher plasma 25(OH)D levels may be associated with longer telomeres, and this association may be modified by calcium intake...
  18. pmc C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmology 117:1560-6. 2010
    ..We evaluated their independent and combined effects on risk of AMD, as well as their interactions...
  19. ncbi request reprint Adult weight change and risk of postmenopausal breast cancer
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:193-201. 2006
    ..Endogenous hormones are a primary cause of breast cancer. Adiposity affects circulating hormones, particularly in postmenopausal women, and may be a modifiable risk factor for breast cancer...
  20. pmc Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration
    Eunyoung Cho
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 87:1837-43. 2008
    ..The association between lutein/zeaxanthin intake and age-related macular degeneration (AMD) risk may differ by smoking status, vitamin C and E intakes, and body fatness...
  21. pmc Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A
    Eliot L Berson
    Berman Gund Laboratory for Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 128:403-11. 2010
    ..To determine whether lutein supplementation will slow visual function decline in patients with retinitis pigmentosa receiving vitamin A...
  22. pmc Young women with family history of breast cancer and their risk factors for benign breast disease
    Catherine S Berkey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 118:2796-803. 2012
    ..The authors investigated childhood/adolescent risk factors for benign breast disease (BBD), a well-documented risk factor for BC, among girls with a family history...
  23. ncbi request reprint Prospective study of vitamins C, E, and A and carotenoids and risk of oral premalignant lesions in men
    Nancy Nairi Maserejian
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 120:970-7. 2007
    ..Vitamin C from dietary sources, but not supplements, was associated with a reduced risk of OPL. The observed increased risk for current smokers with high vitamin E or beta-carotene intake should be explored further...
  24. pmc Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2436-44. 2008
    ..These results suggest that women with certain genetic variants may have a higher risk of ovarian cancer associated with genital talc use. Additional research is needed on these interactions and the underlying biological mechanisms...
  25. pmc Flavonoid intake and ovarian cancer risk in a population-based case-control study
    Margaret A Gates
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 124:1918-25. 2009
    ..However, given the findings of previous studies and the biologic plausibility of this association, additional studies are warranted...
  26. pmc Assessing discrimination of risk prediction rules in a clustered data setting
    Bernard Rosner
    Channing Division of Network Medicine, Brigham and Women s Hospital Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Lifetime Data Anal 19:242-56. 2013
    ..Both data analyses based on progression of AMD and simulation studies show reasonable accuracy of this extended Mann-Whitney U test to assess discrimination of eye-specific risk prediction rules...
  27. pmc Breast cancer risk prediction with heterogeneous risk profiles according to breast cancer tumor markers
    Bernard Rosner
    Channing Division of Network Medicine, Brigham andWomen s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 178:296-308. 2013
    ..This approach provides a strategy for evaluating heterogeneity of risk factor associations by tumor marker levels while controlling for additional tumor markers. ..
  28. pmc Evaluation of risk factors for cataract types in a competing risks framework
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ophthalmic Epidemiol 16:98-106. 2009
    ..One can compare the impact of risk factors on different types of cataract with methods of competing risk survival analysis that account for tied events...
  29. pmc Dairy intakes in older girls and risk of benign breast disease in young women
    Catherine S Berkey
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 22:670-4. 2013
    ..We conclude that dairy intakes by older girls have no strong relation with BBD risk in young women. Because of small number of cases, it is important to continue follow-up and re-examine later...
  30. pmc Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ophthalmology 120:1020-8. 2013
    ..To investigate associations between dietary omega-3 fatty acids and other fat intake, genes related to age-related macular degeneration (AMD), and progression to geographic atrophy (GA)...
  31. pmc Dietary flavonoid intakes and risk of type 2 diabetes in US men and women
    Nicole M Wedick
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 95:925-33. 2012
    ..Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes...
  32. ncbi request reprint Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts New England Medical Center, Boston, MA 02111, USA
    JAMA 297:1793-800. 2007
    ..Studies have reported that single-nucleotide polymorphisms in the genes CFH and LOC387715 are associated with age-related macular degeneration (AMD)...
  33. pmc Smoking, dietary betaine, methionine, and vitamin D in monozygotic twins with discordant macular degeneration: epigenetic implications
    Johanna M Seddon
    New England Eye Center, Tufts Medical Center, Boston, MA, USA
    Ophthalmology 118:1386-94. 2011
    ..We evaluated monozygotic twin pairs with discordant age-related macular degeneration (AMD) phenotypes to assess differences in behavioral and nutritional factors...
  34. ncbi request reprint Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration
    Johanna M Seddon
    Massachusetts Eye and Ear Infirmary and Channing Laboratory, Harvard Medical School, 243 Charles Street, Boston, MA, USA
    Arch Ophthalmol 124:995-1001. 2006
    ..To evaluate modifiable risk and protective factors for age-related macular degeneration (AMD) among elderly twins...
  35. pmc Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    JAMA 306:1884-90. 2011
    ..In addition, the role of drinking patterns (ie, frequency of drinking and "binge" drinking) and consumption at different times of adult life are not well understood...
  36. pmc Prospective study of growth and development in older girls and risk of benign breast disease in young women
    Catherine S Berkey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 117:1612-20. 2011
    ..The authors prospectively evaluated these childhood/adolescent characteristics and BBD risk...
  37. ncbi request reprint Extended work duration and the risk of self-reported percutaneous injuries in interns
    Najib T Ayas
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:1055-62. 2006
    ..Extended-duration work shifts are associated with increased risks of automobile crash, particularly during a commute from work. Interns may be at risk for other occupation-related injuries...
  38. pmc Physical activity and risk of breast cancer among postmenopausal women
    A Heather Eliassen
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 170:1758-64. 2010
    ..Although greater activity has been related to lower postmenopausal breast cancer risk, important details remain unclear, including type, intensity, and timing of activity and whether the association varies by subgroups...
  39. ncbi request reprint Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up
    Esther H J Kim
    Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 164:990-7. 2006
    ..These results suggest a reduction in breast cancer risk for women with insulin resistance syndrome who consume high-fat diets and no association between specific sources of fat during midlife and risk of postmenopausal breast cancer...
  40. pmc Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:2044-53. 2009
    ..The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed...
  41. pmc Seafood types and age-related cognitive decline in the Women's Health Study
    Dae Hyun Kim
    SM, Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115
    J Gerontol A Biol Sci Med Sci 68:1255-62. 2013
    ..However, benefits may vary by nutrient contents in different seafood types. We examined associations between total seafood consumption and cognitive decline and whether these associations differ by seafood types...
  42. pmc Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res Treat 131:159-67. 2012
    ..Identifying risk factors for less common subtypes such as luminal B, HER2-type and basal-like tumors has important implications for prevention of these more aggressive subtypes...
  43. pmc Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 53:1548-56. 2012
    ..Understanding the effect of genes on progression to different stages of age-related macular degeneration (AMD) may suggest stage-specific therapeutic targets and more precise prediction of the development of this disease...
  44. pmc Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 52:4663-70. 2011
    ..There is little information about which genes influence drusen accumulation. Discovery of genetic variants associated with drusen may lead to prevention and treatments of AMD in its early stages...
  45. pmc Risk prediction models with incomplete data with application to prediction of estrogen receptor-positive breast cancer: prospective data from the Nurses' Health Study
    Bernard Rosner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Breast Cancer Res 10:R55. 2008
    ..Although circulating levels of estradiol in postmenopausal women predict subsequent breast cancer risk, whether the addition of estradiol levels adds significantly to a model's predictive power has not previously been evaluated...
  46. pmc Dietary fat, fiber, and carbohydrate intake and endogenous hormone levels in premenopausal women
    Xiaohui Cui
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Horm Cancer 1:265-76. 2010
    ..The results suggest that a low-fat/high-fiber or carbohydrate diet is not associated with endogenous levels of sex steroid hormones, but it may modestly increase IGF-I and IGFBP-3 levels among premenopausal women...
  47. pmc Adolescent dairy product consumption and risk of type 2 diabetes in middle-aged women
    Vasanti S Malik
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 94:854-61. 2011
    ..Type 2 diabetes (T2D) prevention has generally focused on the identification of risk factors in adulthood. Dairy product consumption in adults has been associated with a lower risk of T2D...
  48. pmc Dietary fat, fiber, and carbohydrate intake in relation to risk of endometrial cancer
    Xiaohui Cui
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:978-89. 2011
    ..Macronutrients such as fat and fiber have been hypothesized to play a role in the etiology of endometrial cancer...
  49. pmc Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res Treat 128:243-50. 2011
    ..Further studies to confirm these findings are necessary...
  50. pmc Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, and Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02111, USA
    Mol Vis 16:2412-24. 2010
    ..We evaluated its association and interaction with previously identified genetic variants and modifiable factors...
  51. pmc Weight-control behaviors and subsequent weight change among adolescents and young adult females
    Alison E Field
    Division of Adolescent Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 91:147-53. 2010
    ..Little is known about the effectiveness of behavioral strategies to prevent long-term weight gain among adolescents and young adults...
  52. pmc Physical activity and incident urinary incontinence in middle-aged women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 179:1012-6; discussion 1016-7. 2008
    ..While strenuous, high impact activity may provoke urinary incontinence, little is known about relations with moderate physical activity. We examined recreational activity and incident urinary incontinence in middle-aged women...
  53. ncbi request reprint Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine and the Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 162:975-82. 2005
    ..CHD and stroke have broadly comparable risk factor profiles that differ widely from the profile for VTE...
  54. ncbi request reprint Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Ophthalmol 122:883-92. 2004
    ..To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM)...
  55. ncbi request reprint Serum lipids, lipid-lowering drugs, and the risk of breast cancer
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Arch Intern Med 165:2264-71. 2005
    ..The relation between serum cholesterol levels and breast cancer risk is itself unclear; because cholesterol is the precursor to sex steroid hormones, higher levels could plausibly increase risk...
  56. ncbi request reprint Fruit and vegetable intake and risk of major chronic disease
    Hsin Chia Hung
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 96:1577-84. 2004
    ..We evaluated the relationship between fruit and vegetable intake and the incidence of cardiovascular disease and cancer and of deaths from other causes in two prospective cohorts...
  57. ncbi request reprint Weight, weight gain, and survival after breast cancer diagnosis
    Candyce H Kroenke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    J Clin Oncol 23:1370-8. 2005
    ..To determine whether weight prior to diagnosis and weight gain after diagnosis are predictive of breast cancer survival...
  58. pmc Prospective study of cigarette smoking and adult glioma: dosage, duration, and latency
    Crystal N Holick
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neuro Oncol 9:326-34. 2007
    ..These findings provide strong evidence that cigarette smoking is not associated with an appreciably elevated risk of adult glioma...
  59. pmc Healthful dietary patterns and type 2 diabetes mellitus risk among women with a history of gestational diabetes mellitus
    Deirdre K Tobias
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 172:1566-72. 2012
    ..Adherence to healthful dietary patterns has been inversely associated with T2DM in the general population; however, whether these dietary patterns are associated with progression to T2DM among a susceptible population is unknown...
  60. pmc Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave 3rd Floor, Boston, MA, 02115 USA
    Breast Cancer Res 14:R44. 2012
    ..Studies in animal models suggest that insulin-like growth factor-1 (IGF-1) may inhibit involution of lobules in the breast; however, this has not been studied in humans...
  61. pmc Application of the Rosner-Colditz risk prediction model to estimate sexual orientation group disparities in breast cancer risk in a U.S. cohort of premenopausal women
    S Bryn Austin
    Division of Adolescent and Young Adult Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 21:2201-8. 2012
    ..Lesbian and bisexual women may be at greater risk of breast cancer than heterosexual women during the premenopausal period due to disparities in risk factors...
  62. ncbi request reprint Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women
    Rulla M Tamimi
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:1483-9. 2006
    ..Given the increasing trend in the use of hormone therapies containing androgens, we evaluated the relation between the use of estrogen and testosterone therapies and breast cancer...
  63. pmc Urinary estrogens and estrogen metabolites and mammographic density in premenopausal women
    Kimberly A Bertrand
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res Treat 136:277-87. 2012
    ..If these profiles are associated with breast cancer risk, they may not act through influences on breast density...
  64. pmc Estrogen receptor positive tumors: do reproductive factors explain differences in incidence between black and white women?
    Erica T Warner
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 24:731-9. 2013
    ..In two large prospective cohorts, the Black Women's Health Study (BWHS) and the Nurses' Health Study II (NHSII), we investigated whether reproductive factors explain the difference...
  65. pmc Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence
    Xuehong Zhang
    Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory at Landmark Center, 401 Park Dr, Boston, MA 02115, USA
    J Clin Oncol 30:3468-77. 2012
    ..We examined these associations with breast cancer, both overall and by molecular subtype...
  66. pmc Dietary patterns during adolescence and risk of type 2 diabetes in middle-aged women
    Vasanti S Malik
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 35:12-8. 2012
    ..Preventive measures should be aimed at developing healthy dietary habits that begin in early life and continue through adulthood...
  67. pmc Dietary fat intake and cognitive decline in women with type 2 diabetes
    ELIZABETH E DEVORE
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:635-40. 2009
    ..We investigated whether dietary fat, which modulates glucose and lipid metabolism, might influence cognitive decline in older adults with diabetes...
  68. pmc Prospective study of adolescent alcohol consumption and risk of benign breast disease in young women
    Catherine S Berkey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 125:e1081-7. 2010
    ..To investigate prospectively, using alcoholic beverage consumption data collected in real time, the association between adolescent drinking and risk of biopsy-confirmed benign breast disease (BBD) in young women...
  69. pmc Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study
    Heather J Baer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Breast Cancer Res 7:R314-25. 2005
    ..We examined prospectively the relation between body fatness during childhood and adolescence and the incidence of breast cancer in premenopausal women...
  70. ncbi request reprint Rationale and design of the Optimal Macro-Nutrient Intake Heart Trial to Prevent Heart Disease (OMNI-Heart)
    Vincent J Carey
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Clin Trials 2:529-37. 2005
    ..Whether partial replacement of some carbohydrate (C) with either protein (P) or unsaturated fat (U) can further improve these and other cardiovascular (CVD) risk factors is unknown...
  71. ncbi request reprint Body mass index, weight gain, and incident urinary incontinence in middle-aged women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Obstet Gynecol 110:346-53. 2007
    ..To describe the relations between body mass index (BMI; kg/m(2)), weight gain, and incident urinary incontinence in middle-aged women...
  72. ncbi request reprint Disease course of patients with X-linked retinitis pigmentosa due to RPGR gene mutations
    Michael A Sandberg
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 48:1298-304. 2007
    ....
  73. ncbi request reprint A nonparametric test for observational non-normally distributed ophthalmic data with eye-specific exposures and outcomes
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ophthalmic Epidemiol 14:243-50. 2007
    ....
  74. ncbi request reprint The validity of self-reported weight change among adolescents and young adults
    Alison E Field
    Children s Hospital Boston, LO 649, 300 Longwood Avenue, Boston, MA 02115, USA
    Obesity (Silver Spring) 15:2357-64. 2007
    ..To assess the association of weight change based on serial self-reported vs. measured weights...
  75. pmc Incidence and remission of urinary incontinence in middle-aged women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 197:167.e1-5. 2007
    ..The objective of the study was to describe changes in urinary incontinence in middle-aged women...
  76. pmc Lung cancer and vehicle exhaust in trucking industry workers
    Eric Garshick
    Pulmonary and Critical Care Medicine Section, Medical Service, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    Environ Health Perspect 116:1327-32. 2008
    ..Interpretation of these studies specifically implicating diesel exhaust as a carcinogen has been limited because of limited exposure measurements and lack of work records relating job title to exposure-related job duties...
  77. pmc Physical activity and premenopausal breast cancer: an examination of recall and selection bias
    Sonia S Maruti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 20:549-58. 2009
    ..Compared with cohort studies, case-control investigations have tended to report clearer protective associations for the relationship between physical activity and premenopausal breast cancer risk...
  78. ncbi request reprint Extension of the rank sum test for clustered data: two-group comparisons with group membership defined at the subunit level
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biometrics 62:1251-9. 2006
    ..We also present comparisons between the clustered Wilcoxon test and each of the signed rank tests and mixed model approaches and show dramatic differences in power in favor of the clustered Wilcoxon test for some designs...
  79. ncbi request reprint Prospective study of fruits and vegetables and risk of oral premalignant lesions in men
    Nancy Nairi Maserejian
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 164:556-66. 2006
    ..7). The risk of oral premalignant lesions was significantly reduced with higher consumption of fruits, particularly citrus fruits and juices, while no consistent associations were apparent for vegetables...
  80. ncbi request reprint Epidemiology of urinary melatonin in women and its relation to other hormones and night work
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:936-43. 2004
    ..There is little information, however, about the interrelationships of night work, urinary melatonin levels, and levels of plasma steroid hormones in women...
  81. pmc Age at menopause: imputing age at menopause for women with a hysterectomy with application to risk of postmenopausal breast cancer
    Bernard Rosner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Ann Epidemiol 21:450-60. 2011
    ..Age at menopause, a major marker in the reproductive life, may bias results for evaluation of breast cancer risk after menopause...
  82. pmc Reproducibility of fifteen urinary estrogens and estrogen metabolites over a 2- to 3-year period in premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:2860-8. 2009
    ..Within-person reproducibility over time for most EM measures is comparable to or better than that for well-vetted biomarkers such as plasma cholesterol and, in postmenopausal women, estradiol...
  83. ncbi request reprint Job stress and breast cancer risk: the nurses' health study
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 160:1079-86. 2004
    ..87 (95% CI: 0.73, 1.04) for women in high-strain jobs, and 0.90 (95% CI: 0.76, 1.06) for women in passive jobs. Findings from this study indicate that job stress is not related to any increase in breast cancer risk...
  84. ncbi request reprint Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake
    Johanna M Seddon
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Harvard School of Public Health, Boston, Massachesetts 02114, USA
    Arch Ophthalmol 121:1728-37. 2003
    ..Evidence is sparse regarding modifiable factors that may decrease the risk of progression to the advanced forms of AMD...
  85. ncbi request reprint Differences in serum sex hormone and plasma lipid levels in Caucasian and African-American premenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:4516-20. 2005
    ..Risk of coronary heart disease is higher in African-American than in Caucasian women...
  86. ncbi request reprint Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men
    Pauline Koh-Banerjee
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 78:719-27. 2003
    ..Although it is known that abdominal obesity increases the risk of chronic diseases, prospective data examining the relation between lifestyle factors and the accumulation of abdominal adipose tissue are sparse...
  87. ncbi request reprint Breastfeeding during infancy and the risk of cardiovascular disease in adulthood
    Janet W Rich-Edwards
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Epidemiology 15:550-6. 2004
    ..Only 2 studies have evaluated the relation between having been breastfed and the risk of adult cardiovascular events...
  88. ncbi request reprint Prospective study of intake of fruit, vegetables, and carotenoids and the risk of adult glioma
    Crystal N Holick
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 85:877-86. 2007
    ..Studies examining fruit and vegetable consumption and brain tumors have relied on case-control study designs, with one exception, and results have been inconsistent...
  89. pmc Body mass index, physical activity, and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1474-8. 2007
    ..In conclusion, obesity seems to have an etiologic role in multiple myeloma, but the role of other correlates of energy balance remains uncertain...
  90. ncbi request reprint Functional impact of breast cancer by age at diagnosis
    Candyce H Kroenke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 22:1849-56. 2004
    ..To explore changes in physical and psychosocial function before and after breast cancer by age at diagnosis...
  91. pmc Measurement error correction for nutritional exposures with correlated measurement error: use of the method of triads in a longitudinal setting
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, MA, USA
    Stat Med 27:3466-89. 2008
    ....
  92. ncbi request reprint Correlates of bone and blood lead levels among middle-aged and elderly women
    Susan A Korrick
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 156:335-43. 2002
    ....
  93. ncbi request reprint Neonatal blood pressure and salt taste responsiveness
    Stephen H Zinner
    Department of Medicine, Mount Auburn Hospital, Cambridge, Mass 02138, USA
    Hypertension 40:280-5. 2002
    ..There was no relation of BP to sucking responses to sweet (sucrose) stimuli. Neonates can distinguish between dilute salt solutions and water. This response is related to BP and might be a potential risk factor for high BP later in life...
  94. ncbi request reprint Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Arch Ophthalmol 121:785-92. 2003
    ..To advise these high-risk patients regarding preventive measures, we evaluated anthropomorphic, behavioral, and medical factors associated with progression to the advanced stages of AMD associated with visual loss...
  95. ncbi request reprint Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women
    Simin Liu
    Division of Preventive Medicine and the Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 78:920-7. 2003
    ..Although increased consumption of dietary fiber and grain products is widely recommended to maintain healthy body weight, little is known about the relation of whole grains to body weight and long-term weight changes...
  96. ncbi request reprint Frequency of analgesic use and risk of hypertension in younger women
    Gary C Curhan
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 162:2204-8. 2002
    ..However, little prospective information is available on the association between analgesic use and the risk of hypertension...
  97. ncbi request reprint Breathing easy: a prospective study of optimism and pulmonary function in the normative aging study
    Laura D Kubzansky
    Department of Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Behav Med 24:345-53. 2002
    ..These data are the first to link optimism with higher levels of pulmonary function and slower rate of pulmonary function decline in older men, a protective effect that is independent of smoking...
  98. ncbi request reprint Antioxidant intake and primary open-angle glaucoma: a prospective study
    Jae H Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 158:337-46. 2003
    ..97 (95% CI: 0.62, 1.52) for vitamin E, and 1.11 (95% CI: 0.82, 1.51) for vitamin A. In conclusion, the authors did not observe any strong associations between antioxidant consumption and the risk of primary open-angle glaucoma...
  99. ncbi request reprint Moving forward with breast cancer prevention
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 109:2387-91. 2007
  100. ncbi request reprint Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 123:774-82. 2005
    ..We previously found an association between AMD and CRP in a cross-sectional analysis, but the prospective relationships between AMD, CRP, and the other cardiovascular disease markers are unknown...
  101. ncbi request reprint CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Hum Hered 61:157-65. 2006
    ....