Nader Rifai

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Population distributions of C-reactive protein in apparently healthy men and women in the United States: implication for clinical interpretation
    Nader Rifai
    Department of Laboratory Medicine, Children s Hospital, Boston, MA 02115, USA
    Clin Chem 49:666-9. 2003
  2. ncbi request reprint Clinical Chemistry journal has contributed to progress in lipid and lipoprotein testing for fifty years
    Nader Rifai
    Children s Hospital, Department of Laboratory Medicine, Boston, MA 02115, USA
    Clin Chem 50:1861-70. 2004
  3. ncbi request reprint High-sensitivity C-reactive protein: a useful marker for cardiovascular disease risk prediction and the metabolic syndrome
    Nader Rifai
    Children s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 51:504-5. 2005
  4. ncbi request reprint Apolipoprotein(a) size and lipoprotein(a) concentration and future risk of angina pectoris with evidence of severe coronary atherosclerosis in men: The Physicians' Health Study
    Nader Rifai
    Department of Laboratory Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 50:1364-71. 2004
  5. ncbi request reprint Inflammatory markers and coronary heart disease
    Nader Rifai
    Department of Laboratory Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Lipidol 13:383-9. 2002
  6. ncbi request reprint Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:386-91. 2004
  7. ncbi request reprint Clinical application of C-reactive protein across the spectrum of acute coronary syndromes
    Benjamin M Scirica
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02461, USA
    Clin Chem 53:1800-7. 2007
  8. ncbi request reprint Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Nutr 135:562-6. 2005
  9. ncbi request reprint Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction
    Esther Lopez-Garcia
    Department of Nutrition and the Division of Preventive Medicine, Harvard Medical School, Boston, USA
    Am J Clin Nutr 80:1029-35. 2004
  10. ncbi request reprint Synergistic relationship between hyperglycaemia and inflammation with respect to clinical outcomes in non-ST-elevation acute coronary syndromes: analyses from OPUS-TIMI 16 and TACTICS-TIMI 18
    Kausik K Ray
    The TIMI Study Group and Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 350 Longwood Avenue, Boston, MA 02115, USA
    Eur Heart J 28:806-13. 2007

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Population distributions of C-reactive protein in apparently healthy men and women in the United States: implication for clinical interpretation
    Nader Rifai
    Department of Laboratory Medicine, Children s Hospital, Boston, MA 02115, USA
    Clin Chem 49:666-9. 2003
  2. ncbi request reprint Clinical Chemistry journal has contributed to progress in lipid and lipoprotein testing for fifty years
    Nader Rifai
    Children s Hospital, Department of Laboratory Medicine, Boston, MA 02115, USA
    Clin Chem 50:1861-70. 2004
  3. ncbi request reprint High-sensitivity C-reactive protein: a useful marker for cardiovascular disease risk prediction and the metabolic syndrome
    Nader Rifai
    Children s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 51:504-5. 2005
  4. ncbi request reprint Apolipoprotein(a) size and lipoprotein(a) concentration and future risk of angina pectoris with evidence of severe coronary atherosclerosis in men: The Physicians' Health Study
    Nader Rifai
    Department of Laboratory Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 50:1364-71. 2004
    ..This study was designed to examine the ability of baseline Lp(a) concentration and apo(a) size to predict future severe angina pectoris in apparently healthy men...
  5. ncbi request reprint Inflammatory markers and coronary heart disease
    Nader Rifai
    Department of Laboratory Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Lipidol 13:383-9. 2002
    ..Because C-reactive protein is highly stable in stored frozen samples, and automated and robust analytical systems for its measurement are available, it has become the most widely examined inflammatory marker...
  6. ncbi request reprint Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:386-91. 2004
    ..Statins inhibit CD40L signaling in vitro, but there are no prospective studies of statins and sCD40L in acute coronary syndromes...
  7. ncbi request reprint Clinical application of C-reactive protein across the spectrum of acute coronary syndromes
    Benjamin M Scirica
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02461, USA
    Clin Chem 53:1800-7. 2007
    ..The ability to formulate recommendations regarding clinical use of hsCRP is limited by a paucity of data regarding several key issues. The purpose of this study was to evaluate hsCRP across the spectrum of ACS...
  8. ncbi request reprint Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Nutr 135:562-6. 2005
    ....
  9. ncbi request reprint Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction
    Esther Lopez-Garcia
    Department of Nutrition and the Division of Preventive Medicine, Harvard Medical School, Boston, USA
    Am J Clin Nutr 80:1029-35. 2004
    ..Endothelial dysfunction is one of the mechanisms linking diet and the risk of cardiovascular disease...
  10. ncbi request reprint Synergistic relationship between hyperglycaemia and inflammation with respect to clinical outcomes in non-ST-elevation acute coronary syndromes: analyses from OPUS-TIMI 16 and TACTICS-TIMI 18
    Kausik K Ray
    The TIMI Study Group and Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 350 Longwood Avenue, Boston, MA 02115, USA
    Eur Heart J 28:806-13. 2007
    ..To investigate the relationship between diabetes and inflammation and the potentially synergistic relationship between hyperglycaemia and inflammation on clinical outcomes in non ST-elevation ACS...
  11. ncbi request reprint Inflammatory markers and the risk of coronary heart disease in men and women
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 351:2599-610. 2004
    ..The value of these inflammatory markers as independent predictors remains controversial...
  12. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  13. ncbi request reprint HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Massachusetts 02115, USA
    Diabetes 54:3567-72. 2005
    ..Our data indicate significant effects of H63D and C282Y on body iron stores and suggest a potential interaction between HFE genotypes and heme iron intake in relation to the risk of type 2 diabetes...
  14. ncbi request reprint Plasma fluorescent oxidation products as potential markers of oxidative stress for epidemiologic studies
    Tianying Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 166:552-60. 2007
    ..The association of fluorescent oxidation products with several indicators of oxidative stress suggests that this measure could be a useful global marker of oxidative stress for large epidemiologic studies...
  15. ncbi request reprint Multivariate assessment of lipid parameters as predictors of coronary heart disease among postmenopausal women: potential implications for clinical guidelines
    Iris Shai
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 110:2824-30. 2004
    ..Over the past decade, lipid measurements have been significantly improved and standardized. We evaluated the usefulness of multiple plasma lipid parameters in predicting coronary heart diseases (CHD) among women...
  16. ncbi request reprint Relationship between uncontrolled risk factors and C-reactive protein levels in patients receiving standard or intensive statin therapy for acute coronary syndromes in the PROVE IT-TIMI 22 trial
    Kausik K Ray
    Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 46:1417-24. 2005
    ..This study sought to evaluate what set of factors correlate with higher or lower C-reactive protein (CRP) levels in patients receiving standard and intensive statin therapy...
  17. ncbi request reprint Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction: a TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombo
    Stephen D Wiviott
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
    Circulation 109:580-6. 2004
    ..We sought to examine the relationship between gender and cardiac biomarkers in patients with unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI)...
  18. pmc Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...
  19. ncbi request reprint Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Obes Res 11:1055-64. 2003
    ..Furthermore, we examined the relationship between physical activity and insulin sensitivity (insulin, C-peptide, and hemoglobin A(1c) levels) and whether inflammatory markers mediate this association...
  20. ncbi request reprint A cross-sectional study of alcohol consumption patterns and biologic markers of glycemic control among 459 women
    Candyce H Kroenke
    Department of Epidemiology, Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes Care 26:1971-8. 2003
    ....
  21. pmc Plasma adiponectin and the risk of hypertension in white and black postmenopausal women
    Lu Wang
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 58:1438-45. 2012
    ..We conducted a prospective, nested case control study to investigate the relation between baseline plasma adiponectin, measures of adiposity, and subsequent risk of hypertension...
  22. pmc Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18
    David A Morrow
    TIMI Study Group Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 29:1096-102. 2008
    ....
  23. ncbi request reprint Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/l: an analysis of the PROVE-IT TIMI-22 trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 45:1644-8. 2005
    ..The aim of this research was to compare relative efficacy of different statin regimens in achieving the dual goals of low-density lipoprotein cholesterol (LDL-C) and C-reactive protein (CRP) reduction...
  24. ncbi request reprint Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  25. ncbi request reprint Is plasma oxidized low-density lipoprotein, measured with the widely used antibody 4E6, an independent predictor of coronary heart disease among U.S. men and women?
    Tianying Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 48:973-9. 2006
    ....
  26. ncbi request reprint Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Harvard Medical School, USA
    J Nutr 134:1806-11. 2004
    ....
  27. ncbi request reprint C-reactive protein levels and outcomes after statin therapy
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 352:20-8. 2005
    ..Statins lower the levels of low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP). Whether this latter property affects clinical outcomes is unknown...
  28. doi request reprint Assessment of adiponectin and the risk of recurrent cardiovascular events in patients presenting with an acute coronary syndrome: observations from the Pravastatin Or atorVastatin Evaluation and Infection Trial-Thrombolysis in Myocardial Infarction 22 (PR
    Sean R Wilson
    TIMI Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 161:1147-55.e1. 2011
    ..Recent data have suggested a possible discordant adverse risk relationship in acute coronary syndrome (ACS). Therefore, we investigated the association between adiponectin and cardiovascular events in patients with ACS...
  29. doi request reprint Concentrations of C-reactive protein and B-type natriuretic peptide 30 days after acute coronary syndromes independently predict hospitalization for heart failure and cardiovascular death
    Benjamin M Scirica
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 55:265-73. 2009
    ....
  30. pmc Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial
    Julie Lin
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:2338-43. 2008
    ..Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated in part by chronic inflammation...
  31. pmc Plasma dehydroepiandrosterone and risk of myocardial infarction in women
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Chem 54:1190-6. 2008
    ..In this study we prospectively evaluated the relationships between plasma concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) and subsequent myocardial infarction in women...
  32. pmc High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women
    Debra A Schaumberg
    Division of Preventive Medicine, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Ophthalmol 125:300-5. 2007
    ..To investigate whether high-sensitivity C-reactive protein (hsCRP) and other biomarkers of inflammation predict age-related macular degeneration (AMD)...
  33. ncbi request reprint Soluble intercellular adhesion molecules, soluble vascular cell adhesion molecules, and risk of coronary heart disease
    Iris Shai
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 14:2099-106. 2006
    ....
  34. ncbi request reprint Relation between soluble intercellular adhesion molecule-1, statin therapy, and long-term risk of clinical cardiovascular events in patients with previous acute coronary syndrome (from PROVE IT-TIMI 22)
    Kausik K Ray
    Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:861-5. 2006
    ..In conclusion, in this large study of patients with ACS, we provide evidence that increased endothelial activation after ACS is independently associated with increased long-term risk of death, myocardial infarction, or recurrent ACS...
  35. ncbi request reprint Plasma fluorescent oxidation products: independent predictors of coronary heart disease in men
    Tianying Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 166:544-51. 2007
    ..The authors found that plasma fluorescent oxidation products significantly and independently predicted coronary heart disease incidence among men without previous cardiovascular events...
  36. ncbi request reprint Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women
    Tianying Wu
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 80:1043-9. 2004
    ..However, associations between fructose and the quantity and quality of total carbohydrate intake in relation to C-peptide concentrations have not been adequately examined...
  37. ncbi request reprint High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1560-6. 2003
    ..Although statins reduce inflammatory markers in asymptomatic adults or in patients with stable angina, the effect of statins on the markedly heightened inflammation in patients with acute coronary syndromes is unknown...
  38. ncbi request reprint B-type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction: an ENTIRE-TIMI-23 substudy
    Jessica L Mega
    TIMI Study Group, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 44:335-9. 2004
    ....
  39. ncbi request reprint Inflammatory markers and risk of developing type 2 diabetes in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 53:693-700. 2004
    ..001). These data support the role of inflammation in the pathogenesis of type 2 diabetes. Elevated CRP levels are a strong independent predictor of type 2 diabetes and may mediate associations of TNF-alphaR2 and IL-6 with type 2 diabetes...
  40. pmc Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Chem 57:729-36. 2011
    ..However, epidemiologic studies have yet to compare multiple corresponding biomarkers in relation to risk of hypertension, particularly in multiethnic populations...
  41. ncbi request reprint Lipoprotein (a) and coronary heart disease among women: beyond a cholesterol carrier?
    Iris Shai
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Eur Heart J 26:1633-9. 2005
    ..We assessed the role of Lp(a) in coronary heart diseases (CHD) by a recently developed assay that is not affected by the plasminogen-like Kringle-type-2 repeats...
  42. doi request reprint Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    JAMA 302:1186-94. 2009
    ..As diabetes is in part an inflammatory condition, the initiation of insulin and/or metformin may beneficially reduce levels of inflammatory biomarkers such as high-sensitivity C-reactive protein (hsCRP)...
  43. ncbi request reprint Lack of association between soluble CD40L and risk in a large cohort of patients with acute coronary syndrome in OPUS TIMI-16
    Benjamin A Olenchock
    Department of Medicine, The Brigham and Women s Hospital, Boston, MA 02115, USA
    J Thromb Thrombolysis 26:79-84. 2008
    ..Recently, questions have been raised regarding the influence of pre-analytical and analytical conditions on measurement of sCD40L, and additional studies have had conflicting findings regarding the prognostic value of this marker...
  44. ncbi request reprint C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:750-5. 2006
    ..However, few studies have evaluated whether these factors are also associated with risk of colorectal adenoma, the main precursor lesion to colorectal cancer...
  45. pmc Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes
    Tricia Y Li
    Department of Nutrition, and 4Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 139:1333-8. 2009
    ..These data suggest that frequent nut and peanut butter consumption is associated with a significantly lower CVD risk in women with type 2 diabetes...
  46. ncbi request reprint Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Circulation 112:3375-83. 2005
    ....
  47. ncbi request reprint Non-HDL cholesterol and apolipoprotein B predict cardiovascular disease events among men with type 2 diabetes
    Rui Jiang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 27:1991-7. 2004
    ..To evaluate the role of non-HDL cholesterol and apolipoprotein (apo)B, markers of all potentially atherogenic lipoproteins, as predictors of cardiovascular disease (CVD) in comparison with LDL cholesterol in patients with type 2 diabetes...
  48. ncbi request reprint Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination Surveys
    Sarah D de Ferranti
    Department of Cardiology Division of Endocrinology, Children s Hospital, Boston, MA 02115, USA
    Clin Chem 52:1325-30. 2006
    ..Understanding of C-reactive protein (CRP) in adult metabolic syndrome is increasing; however, this relationship in children is less clear...
  49. doi request reprint Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 117:823-31. 2008
    ..Few large-scale prospective studies have critically assessed plasma-based factors as predictors of peripheral arterial disease (PAD), and comparative data between individual biomarkers and lipid levels are sparse, especially among women...
  50. pmc Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 58:275-8. 2009
    ..Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and the interactions between IL6R variants and CRP in relation to diabetes risk...
  51. ncbi request reprint Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    JAMA 291:1978-86. 2004
    ..Endothelial dysfunction occurs in diagnosed type 2 diabetes mellitus but may also precede development of diabetes...
  52. ncbi request reprint Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Am J Clin Nutr 82:163-73. 2005
    ..Endothelial dysfunction is one of the mechanisms linked to an increased risk of cardiovascular disease...
  53. pmc Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 117:1936-44. 2008
    ....
  54. ncbi request reprint Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease
    Marc S Sabatine
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 115:1528-36. 2007
    ....
  55. pmc Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 30:1747-52. 2007
    ..However, prospective data regarding its relation to diabetes risk in ethnically diverse populations are limited...
  56. pmc C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 118:2243-51, 4p following 2251. 2008
    ....
  57. pmc Comparison of LDL cholesterol concentrations by Friedewald calculation and direct measurement in relation to cardiovascular events in 27,331 women
    Samia Mora
    Division of Preventive Medicine, Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 55:888-94. 2009
    ....
  58. ncbi request reprint Alcohol consumption patterns and HbA1c, C-peptide and insulin concentrations in men
    Katie A Meyer
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Coll Nutr 22:185-94. 2003
    ..We examined the relations of alcohol consumption patterns-including average daily consumption, frequency of consumption and drinking with meals-to fasting insulin, fasting c-peptide and hemoglobin A1c (HbA1c)...
  59. ncbi request reprint Adiponectin and future coronary heart disease events among men with type 2 diabetes
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 54:534-9. 2005
    ..Our study suggests that increased adiponectin levels are associated with a moderately decreased CHD risk in diabetic men. This association seems to be mediated in part by effects of adiponectin on HDL cholesterol levels...
  60. pmc Early dynamic risk stratification with baseline troponin levels and 90-minute ST-segment resolution to predict 30-day cardiovascular mortality in ST-segment elevation myocardial infarction: analysis from CLopidogrel as Adjunctive ReperfusIon TherapY (CLAR
    Matthew W Sherwood
    TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am Heart J 159:964-971.e1. 2010
    ..The incremental prognostic use of the initial magnitude of troponin elevation and its value in conjunction with ST-segment resolution (STRes) in ST elevation myocardial infarction (STEMI) is less well defined...
  61. ncbi request reprint Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 28:1022-8. 2005
    ..Adiponectin may improve insulin sensitivity, reduce inflammation, and ameliorate glycemic control. However, few studies have evaluated dietary predictors of plasma adiponectin levels, especially among subjects with type 2 diabetes...
  62. ncbi request reprint Intercellular adhesion molecule 1 (ICAM1) Lys56Met and Gly241Arg gene variants, plasma-soluble ICAM1 concentrations, and risk of incident cardiovascular events in 23,014 initially healthy white women
    Robert Y L Zee
    Donald W Reynolds Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Stroke 38:3152-7. 2007
    ..However, to date, no large prospective, genetic-epidemiological data set is available that would allow evaluation of the degree of association of these gene variants with risk of CVD...
  63. ncbi request reprint Evaluation of the AccuTnI cardiac troponin I assay for risk assessment in acute coronary syndromes
    David A Morrow
    Department of Medicine and TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Clin Chem 49:1396-8. 2003
  64. ncbi request reprint Association between dietary factors and plasma adiponectin concentrations in men
    Tobias Pischon
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 81:780-6. 2005
    ..However, little is known about dietary predictors of plasma adiponectin concentrations in humans...
  65. ncbi request reprint Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women
    Edmund A Bermudez
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 22:1668-73. 2002
    ..Interleukin-6 (IL-6) and C-reactive protein (CRP) are markers of systemic vascular inflammation that herald atherothrombosis and may have important interrelationships with traditional cardiovascular risk factors...
  66. ncbi request reprint A prospective study of hemoglobin A1c concentrations and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2869-75. 2006
    ..These data suggest that higher HbA1c concentrations do not seem to increase risk of breast cancer among apparently healthy women...
  67. ncbi request reprint Hemodynamic significance of periprocedural myocardial injury assessed with N-terminal pro-B-type natriuretic peptide after percutaneous coronary intervention in patients with stable and unstable coronary artery disease (from the JUMBO-TIMI 26 trial)
    Marc P Bonaca
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 99:344-8. 2007
    ..This finding supports the physiologic relevance of procedural MI and the continued effort to define therapies that decrease the risk of this complication...
  68. ncbi request reprint Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 81:1429-35. 2005
    ....
  69. doi request reprint Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial
    Benjamin M Scirica
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 31:1993-2005. 2010
    ....
  70. ncbi request reprint Relation between markers of systemic vascular inflammation and smoking in women
    Edmund A Bermudez
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 89:1117-9. 2002
  71. ncbi request reprint C-reactive protein and cardiovascular disease: a review of risk prediction and interventions
    Sarah de Ferranti
    Department of Cardiology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Clin Chim Acta 317:1-15. 2002
    ..Increased C-reactive protein (CRP) has been associated with CVD, in those presenting after an acute coronary event, and also in apparently healthy individuals...
  72. ncbi request reprint Body iron stores and their determinants in healthy postmenopausal US women
    Jian meng Liu
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 78:1160-7. 2003
    ..Data on the determinants of body iron stores in middle-aged women are sparse...
  73. ncbi request reprint Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    JAMA 288:980-7. 2002
    ..Several inflammatory biomarkers, including CRP, are associated with increased cardiovascular risk. However, whether the effect of HRT on CRP represents a clinical hazard is unknown...
  74. ncbi request reprint Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and the development of symptomatic peripheral arterial disease in men
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115 1204, USA
    Circulation 106:820-5. 2002
    ..It is not certain, however, whether similar relationships exist for the development of early systemic atherosclerosis...
  75. ncbi request reprint Is C-reactive protein specific for vascular disease in women?
    Nader Rifai
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 136:529-33. 2002
    ..C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic individuals. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain...
  76. ncbi request reprint Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey
    Sarah D de Ferranti
    Department of Cardiology, Children s Hospital, Boston, Mass 02115, USA
    Circulation 110:2494-7. 2004
    ..Metabolic syndrome (MetS) is defined by the Third Report of the Adult Treatment Panel (ATP III) using criteria easily applied by clinicians and researchers. There is no standard pediatric definition...
  77. pmc Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass, USA
    Am J Med 120:720-7. 2007
    ..Whether mild elevations of this biomarker provide prognostic information for development of clinically evident type 2 diabetes and cardiovascular disease among individuals at usual risk for these disorders is uncertain...
  78. ncbi request reprint Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, LeDucq Center for Molecular and Genetic Epidemiology, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 294:326-33. 2005
    ....
  79. ncbi request reprint Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 105:1760-3. 2002
    ..Little is known, however, about the utility of these biomarkers in combination...
  80. ncbi request reprint Low-density lipoprotein particle concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Gavin J Blake
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 106:1930-7. 2002
    ..Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL particle size...
  81. ncbi request reprint Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 123:774-82. 2005
    ..We previously found an association between AMD and CRP in a cross-sectional analysis, but the prospective relationships between AMD, CRP, and the other cardiovascular disease markers are unknown...
  82. ncbi request reprint Frequent intake of tropical fruits that are rich in beta-cryptoxanthin is associated with higher plasma beta-cryptoxanthin concentrations in Costa Rican adolescents
    Michael S Irwig
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 132:3161-7. 2002
    ..Intakes of beta-cryptoxanthin and papaya, a tropical fruit frequently consumed in Latin America, were the best predictors of beta-cryptoxanthin concentrations in plasma...
  83. doi request reprint Hormonal profile of diabetic men and the potential link to prostate cancer
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 19:703-10. 2008
    ..To investigate potential biological mechanisms, hormonal profiles of diabetic men and non-diabetic controls were compared...
  84. ncbi request reprint Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
    Hans K Meier-Ewert
    Department of Cardiology, Lahey Clinic Medical Center, Burlington, Boston, Massachusetts, USA
    J Am Coll Cardiol 43:678-83. 2004
    ..We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels...
  85. doi request reprint A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women
    Jan L Shifren
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    J Clin Endocrinol Metab 93:1702-10. 2008
    ....
  86. pmc Interleukin-18 and the risk of future cardiovascular disease among initially healthy women
    Brendan M Everett
    The Leducq Center for Molecular and Genetic Epidemiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, United States
    Atherosclerosis 202:282-8. 2009
    ..Elevated levels of interleukin (IL)-18 have been implicated in the development of atherosclerosis in animals. Data in humans are less clear, and data in women are particularly scarce...
  87. ncbi request reprint Mediating effects of inflammatory biomarkers on insulin resistance associated with obesity
    Deborah J Wexler
    Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Obes Res 13:1772-83. 2005
    ..We tested the hypothesis that these biomarkers mediate associations among obesity, IR, and risk of diabetes...
  88. ncbi request reprint Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  89. ncbi request reprint Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function
    Scott Kinlay
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 43:629-34. 2004
    ..We tested whether long-term administration of antioxidant vitamins C and E improves coronary and brachial artery endothelial function in patients with coronary artery disease (CAD)...
  90. ncbi request reprint Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    ..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis...
  91. pmc Dietary intake of trans fatty acids and systemic inflammation in women
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 79:606-12. 2004
    ..Systemic inflammation may be involved in the pathogenesis of such conditions; however, relations between TFA intake and systemic inflammation are not well established...
  92. ncbi request reprint Body iron stores in relation to risk of type 2 diabetes in apparently healthy women
    Rui Jiang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    JAMA 291:711-7. 2004
    ..Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload. However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a healthy population...
  93. ncbi request reprint Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes 56:3075-81. 2007
    ..To examine the associations between common variations in the IL6R gene and circulating interleukin (IL)-6 levels and diabetes risk...
  94. ncbi request reprint Point: high-sensitivity C-reactive protein and cardiac C-reactive protein assays: is there a need to differentiate?
    Nader Rifai
    Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 52:1254-6. 2006
  95. ncbi request reprint Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, United States
    Atherosclerosis 192:204-10. 2007
    ..006), whereas APOA4 +347T/A showed significant associations with lower levels of HDL-C (P=0.017). Our results indicate that the variability in APOA1/C3/A4/A5 gene cluster may affect TG and HDL levels in women with type 2 diabetes...
  96. pmc Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events
    Samia Mora
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 118:993-1001. 2008
    ..Whether fasting status alters associations of nontriglyceride lipids with CVD is unclear...
  97. ncbi request reprint Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:1262-9. 2005
    ..We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era...
  98. ncbi request reprint Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 347:1557-65. 2002
    ..Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are elevated in persons at risk for cardiovascular events. However, population-based data directly comparing these two biologic markers are not available...
  99. ncbi request reprint Low-grade albuminuria and the risks of hypertension and blood pressure progression
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 111:1370-6. 2005
    ....
  100. ncbi request reprint Association of markers of insulin and glucose control with subsequent colorectal cancer risk
    Sharon H Saydah
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 12:412-8. 2003
    ....
  101. ncbi request reprint CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the laboratory science discussion group
    Gary L Myers
    Circulation 110:e545-9. 2004