Adrienne G Randolph
Affiliation: Harvard University
- The financial impact of underestimating personnel needs associated with implementing a computerized patient record in the intensive care unitAdrienne G Randolph
Department of Anesthesia, Children s Hospital, Boston, Boston, MA 02115, USA
J Crit Care 22:34-9. 2007..We tracked the cost of implementing a computerized patient record across 3 intensive care units at a large pediatric hospital...
- Pediatric sepsis: important considerations for diagnosing and managing severe infections in infants, children, and adolescentsAdrienne G Randolph
Harvard Medical School Boston, MA USA Department of Anesthesia, Perioperative and Pain Medicine Boston Children s Hospital Boston, MA USA
Virulence 5:179-89. 2014..Although children in developed countries are more likely to survive severe infections than adults, many survivors have chronic health impairments. ..
- Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational studyOliver Karam
Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
Crit Care 14:R57. 2010..No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children...
- Effect of lung compliance and endotracheal tube leakage on measurement of tidal volumeSami I Al-Majed
Pediatric pulmonary and Intensive Care, Dhahran Health Center, Saudi Aramco, Saudi Arabia
Crit Care 8:R398-402. 2004..The objective of this laboratory study was to measure the effect of decreased lung compliance and endotracheal tube (ETT) leakage on measured exhaled tidal volume at the airway and at the ventilator, in a research study with a test lung...
- Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypesAdrienne G Randolph
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Respir Crit Care Med 172:687-92. 2005..The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively...
- The unique challenges of enrolling patients into multiple clinical trialsAdrienne G Randolph
Children s Hospital, Harvard Medical School, Boston, MA, USA
Crit Care Med 37:S107-11. 2009..In conclusion, more vigorous promotion of thoughtful coenrollment policies could increase the efficiency of critical care research...
- Management of acute lung injury and acute respiratory distress syndrome in childrenAdrienne G Randolph
Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital, Boston, MA, USA
Crit Care Med 37:2448-54. 2009..Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are devastating disorders of overwhelming pulmonary inflammation and hypoxemia, resulting in high morbidity and mortality...
- Critically ill children during the 2009-2010 influenza pandemic in the United StatesAdrienne G Randolph
Children s Hospital Boston, Boston, MA 02115, USA
Pediatrics 128:e1450-8. 2011..Determining the roles of chronic conditions and bacterial coinfection in mortality is difficult because of the limited data for children with pH1N1-related critical illness...
- Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in childrenAdrienne G Randolph
Department of Anesthesia, Children s Hospital, Boston, MA, USA
Pediatr Crit Care Med 6:642-7. 2005..We sought to determine whether cumulative intake minus output (I-O) at the start of weaning predicted weaning duration and whether cumulative I-O at extubation predicted extubation failure...
- The feasibility of conducting clinical trials in infants and children with acute respiratory failureAdrienne G Randolph
Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 167:1334-40. 2003..6%), and the median duration of ventilation was 7 days. The design of clinical trials in critically ill children is feasible but must account for the diverse population, infrequent mortality, and short duration of mechanical ventilation...
- The IL12B gene is associated with asthmaAdrienne G Randolph
Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
Am J Hum Genet 75:709-15. 2004..IL12B may be an important asthma gene...
- IL10 gene polymorphisms are associated with asthma phenotypes in childrenHelen Lyon
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genet Epidemiol 26:155-65. 2004..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
- Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unitAdrienne G Randolph
Department of Anesthesia, Harvard Medical School, Boston, MA, USA
Pediatr Infect Dis J 23:990-4. 2004..To evaluate the risk of bacterial infection and use of antibiotics in otherwise healthy children infected with respiratory syncytial virus (RSV) admitted to the intensive care unit (ICU)...
- Assessment of hemoglobin threshold for packed RBC transfusion in a medical-surgical PICUStacey L Valentine
1Critical Care Division, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, MA 2Harvard Medical School, Boston, MA 3Department of Pediatrics, Division of Pediatric Critical Care, University of Massachusetts Children s Medical Center, Worcester, MA 4Department of Medicine, Boston Children s Hospital, Boston, MA 5Clinical Research Center, Boston Children s Hospital, Boston, MA 6Department of Laboratory and Transfusion Medicine, Boston Children s Hospital, Boston, MA 7Program for Patient Safety and Quality, Boston Children s Hospital, Boston, MA
Pediatr Crit Care Med 15:e89-94. 2014..We aimed to determine if wide dissemination of this evidence altered the hemoglobin threshold used for RBC transfusions in our pediatric medical-surgical ICU...
- Gender differences in research grant applications and funding outcomes for medical school facultySusan E Waisbren
Children s Hospital, Boston, Massachusetts, USA
J Womens Health (Larchmt) 17:207-14. 2008..To evaluate whether there were differences in acquisition of research grant support between male and female faculty at eight Harvard Medical School-affiliated institutions...
- Reorganizing the delivery of intensive care could improve efficiency and save livesAdrienne G Randolph
Departments of Pediatrics, Harvard Medical School and Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
J Eval Clin Pract 8:1-8. 2002..Given the growing evidence supporting the association between specific ICU characteristics and improved patient outcomes, we hope the future realizes broad implementation of these beneficial characteristics...
- Assessing the quality of case-control association studies on the genetic basis of sepsisSally H Vitali
Department of Anesthesia and the Division of Critical Care Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Pediatr Crit Care Med 6:S74-7. 2005..To define methodological standards that would improve the quality and reproducibility of case-control genetic association studies in sepsis...
- Identification of central venous catheter-related infections in infants and childrenAdrienne G Randolph
Department of Anesthesia, Division of Critical Care, Children s Hospital, Boston, MA, USA
Pediatr Crit Care Med 6:S19-24. 2005..To define central venous catheter-related infections in infants and children for the purpose of enrolling children in sepsis studies, for epidemiology and surveillance studies, and for clinical management...
- A practical approach to evidence-based medicine: lessons learned from developing ventilator management protocolsAdrienne G Randolph
Division of Critical Care, Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
Crit Care Clin 19:515-27. 2003..Finally, protocols must be tended to and updated when new evidence becomes available...
- A multinational study of thromboprophylaxis practice in critically ill childrenEdward Vincent S Faustino
1Department of Pediatrics, Yale School of Medicine, New Haven, CT 2Department of Pediatrics, Children s Hospital of Wisconsin, Milwaukee, WI 3Department of Pediatrics, Washington University at St Louis School of Medicine, St Louis, MO 4Department of Pediatrics, CHU Sainte Justine University of Montreal, Montreal, QC, Canada 5Division of Hematology Oncology BMT, Nationwide Children s Hospital, Columbus, OH 6Pediatric Intensive Care Unit, University of Santiago de Compostela, Santiago de Compostela, Spain 7Pediatric Intensive Care Unit, Women s and Children s Hospital, Adelaide, South Australia, Australia 8Department of Pediatrics, Children s Hospital and Medical Center, Omaha, NE 9Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT 10Department of Pediatrics, New York Medical College Maria Fareri Children s Hospital, Valhalla, NY 11Department of Anesthesia, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, MA
Crit Care Med 42:1232-40. 2014..We tested the hypothesis that thromboprophylaxis is infrequently used in critically ill children even for those in whom it is indicated...
- Vitamin D deficiency in critically ill childrenKate Madden
Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, Boston, MA 02115, USA
Pediatrics 130:421-8. 2012..We hypothesized that levels would be lower with increased illness severity and in children with serious infections...
- Potential for donation after cardiac death in a children's hospitalAmy L Durall
Division of Critical Care, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Pediatrics 119:e219-24. 2007..As part of this process, we sought to determine the number of potential kidney donation after cardiac death donors in our PICUs...
- Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantationJenifer R Lightdale
Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Biol Blood Marrow Transplant 18:813-7. 2012..004). Our initial experience suggests that implementation of a conservative transfusion strategy in otherwise stable children undergoing hematopoietic stem cell transplantation appears safe and lowers transfusion exposures...
- Fluid balance in critically ill children with acute lung injuryStacey L Valentine
Critical Care Division, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, and Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
Crit Care Med 40:2883-9. 2012....
- Real-time evaluation of patient monitoring algorithms for critical care at the bedsideYing Zhang
Harvard Medical School, MIT Division of Health Sciences and Technology, MIT Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
Conf Proc IEEE Eng Med Biol Soc 2007:2783-6. 2007....
- Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trialAdrienne G Randolph
Children s Hospital, MICU, FA 108, 300 Longwood Ave, Boston, MA 02115, USA
JAMA 288:2561-8. 2002..Ventilator management protocols shorten the time required to wean adult patients from mechanical ventilation. The efficacy of such weaning protocols among children has not been studied...
- Risk factors for central line-associated bloodstream infection in pediatric intensive care unitsMatthew C Wylie
From the Division of Critical Care Medicine, Department of Anesthesia, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Infect Control Hosp Epidemiol 31:1049-56. 2010..We sought to identify risk factors for central line-associated bloodstream infection (CLABSI) to describe children who might benefit from adjunctive interventions...
- Growth of pediatric intensive care units in the United States from 1995 to 2001Adrienne G Randolph
Department of Anesthesia, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Pediatr 144:792-8. 2004..To describe the growth and distribution of pediatric intensive care unit (PICU) beds in the United States from 1995 to 2001 and the characteristics of PICUs in 2001...
- Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysisCaroline Davison
Department of Anaesthesia, St George s Hospital, Tooting, London, UK
Pediatr Crit Care Med 5:482-9. 2004..Currently, the mainstay of treatment is supportive care. The effectiveness of treatments used for mechanically ventilated infants with bronchiolitis is unclear...
- How are children mechanically ventilated in pediatric intensive care units?Adrienne G Randolph
Intensive Care Med 30:746-7. 2004
- What underlies race and sex differences in acute respiratory distress syndrome-associated mortality?Adrienne G Randolph
Crit Care Med 30:1907-9. 2002
- Anemia, blood loss, and blood transfusions in North American children in the intensive care unitScot T Bateman
Department of Pediatrics, University of Massachusetts Medical Center, H5 524, 55 Lake Avenue, North Worcester, MA 01655, USA
Am J Respir Crit Care Med 178:26-33. 2008..Minimizing exposure of children to blood products is desirable...
- Mining for the genetic determinants of septic shock: when is it really gold?Adrienne G Randolph
Crit Care Med 30:1161-3. 2002
- Pediatric critical care medicine: planning for our research futureCarol E Nicholson
National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 2A03 MSC 7510, Bethesda, MD 20892, USA
Pediatr Crit Care Med 4:196-202. 2003..To introduce to the pediatric critical care medicine community a new program in pediatric critical care medicine at the National Institutes of Health...
- GENETIC EPIDEMIOLOGY OF RSV BRONCHIOLITIS AND ASTHMAAdrienne Randolph; Fiscal Year: 2004..Identifying the genes associated with the onset of childhood asthma could lead to targeted interventions aimed at prevention and treatment of this disorder that is increasing at a rate of 5 percent per year. ..