Xuebin Qin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The complement system in liver diseases
    Xuebin Qin
    Laboratory for Translational Research, Harvard Medical School, Cambridge, MA 02139, USA
    Cell Mol Immunol 3:333-40. 2006
  2. pmc Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Hematol 84:221-7. 2009
  3. pmc Generation and phenotyping of mCd59a and mCd59b double-knockout mice
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Hematol 84:65-70. 2009
  4. ncbi request reprint Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes
    X Qin
    Department of Medicine, Division of Hematology and Oncology, Brigham and Women s Hospital, Boston, MA, USA
    Genes Immun 7:287-97. 2006
  5. ncbi request reprint Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction
    Xuebin Qin
    Department of Medicine, Division of Hematology and Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 175:6294-302. 2005
  6. pmc Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice
    Gongxiong Wu
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 121:1338-46. 2010
  7. pmc Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis
    Weiguo Hu
    Department of Medicine, Brigham and Women s Hospital, and Laboratory for Translational Research, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Cancer Res 71:2298-307. 2011
  8. pmc Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex
    Gongxiong Wu
    Department of Medicine, Brigham and Women s Hospital, Laboratory forTranslational Research, Harvard Medical School, Cambridge, MA 02139, USA
    Circ Res 104:550-8. 2009
  9. ncbi request reprint Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin
    Weiguo Hu
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Nat Med 14:98-103. 2008
  10. ncbi request reprint Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Immunity 18:217-27. 2003

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The complement system in liver diseases
    Xuebin Qin
    Laboratory for Translational Research, Harvard Medical School, Cambridge, MA 02139, USA
    Cell Mol Immunol 3:333-40. 2006
    ..In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases...
  2. pmc Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Hematol 84:221-7. 2009
    ..These results indicate that the thrombotic diathesis of PNH patients could be due to a combination of increased complement-mediated platelet activation and reduced NO-bioavailability as a consequence of hemolysis...
  3. pmc Generation and phenotyping of mCd59a and mCd59b double-knockout mice
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Hematol 84:65-70. 2009
    ..We report here that total abrogation of mCd59 function in mCd59ab(-/-) mice results in complement-mediated hemolytic anemia that is rescued by the deficiency of C3 in compound mCd59ab(-/-)/C3(-/-) mice...
  4. ncbi request reprint Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes
    X Qin
    Department of Medicine, Division of Hematology and Oncology, Brigham and Women s Hospital, Boston, MA, USA
    Genes Immun 7:287-97. 2006
    ..Together these findings indicate that the mCd59 genes may have complex and perhaps different regulatory mechanisms in different tissues...
  5. ncbi request reprint Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction
    Xuebin Qin
    Department of Medicine, Division of Hematology and Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 175:6294-302. 2005
    ....
  6. pmc Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice
    Gongxiong Wu
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 121:1338-46. 2010
    ..However, the role of complement in the pathogenesis of abdominal aortic aneurysm, which is considered an immune and inflammatory disease, remains obscure...
  7. pmc Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis
    Weiguo Hu
    Department of Medicine, Brigham and Women s Hospital, and Laboratory for Translational Research, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Cancer Res 71:2298-307. 2011
    ..Furthermore, they suggest that preemptive elimination of CD59-overexpressing subpopulations along with rituximab treatment may be a useful approach to ablate or conquer rituximab resistance...
  8. pmc Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex
    Gongxiong Wu
    Department of Medicine, Brigham and Women s Hospital, Laboratory forTranslational Research, Harvard Medical School, Cambridge, MA 02139, USA
    Circ Res 104:550-8. 2009
    ..These combined results highlight the atherogenic role of MAC and the atheroprotective role of CD59 and suggest that inhibition of MAC formation may provide a therapeutic approach for the treatment of atherosclerosis...
  9. ncbi request reprint Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin
    Weiguo Hu
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Nat Med 14:98-103. 2008
    ....
  10. ncbi request reprint Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Immunity 18:217-27. 2003
    ..This work indicates that mCd59b is a key complement regulator in mice and that CD59 is critical in protecting self cells; it also provides a novel model to study complement regulation in human diseases...
  11. pmc The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model
    Weiguo Hu
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 116:1613-22. 2010
    ..These findings further highlight the importance of the inhibition of platelet activation and the enhancement of NO bioavailability for the treatment and prevention of hemolysis-associated (fatal) PAH...
  12. pmc The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury
    Jinyan Zhang
    Department of General Surgery, Shanghai First People s Hospital, Shanghai Jiaotong University, Shanghai, China
    Am J Pathol 179:2876-84. 2011
    ..Taken together, these results highlight the protective role of CD59 and pathogenic role of complement, including MAC, in the pathogenesis of hepatic IRI...
  13. pmc A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS
    Weiguo Hu
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 184:359-68. 2010
    ..These results indicate that rILYd4 may represent a novel therapeutic agent against HIV-1/AIDS...
  14. ncbi request reprint Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes
    Xuebin Qin
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes 53:2653-61. 2004
    ..We conclude that glycation inactivation of hCD59 that leads to increased MAC deposition may contribute to the extensive vascular pathology that complicates human diabetes...
  15. doi request reprint Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice
    Fengming Liu
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Diabetes Complications . 2016
    ..Our objective for this study is to assess experimentally how the deficiency of CD59 impacts the development of diabetic atherosclerosis in vivo...
  16. pmc Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1
    Gudrun Ziegeler
    Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:15408-19. 2010
    ..This is the first demonstration that HuR-dependent mRNA stability and HuR-independent mRNA translation plays a critical role in the regulation of post-transcriptional p27(Kip1) expression...
  17. ncbi request reprint Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b
    X Qin
    Harvard Medical School, Laboratory for Membrane Transport, 240 Longwood Ave, C1 607, Boston, Massachusetts 02115, USA
    Mamm Genome 12:582-9. 2001
    ..These results suggest that even though Cd59a and Cd59b are expressed in multiple tissues, they may play some different roles, particularly in reproduction...
  18. pmc Targeted mouse complement inhibitor CR2-Crry protects against the development of atherosclerosis in mice
    Fengming Liu
    Department of Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Atherosclerosis 234:237-43. 2014
    ..Here, we investigated whether complement inhibition represents a potential therapeutic strategy to treat/prevent atherogenesis using CR2-Crry, a recently described complement inhibitor that specifically targets to sites of C3 activation...
  19. ncbi request reprint Complement and complement regulatory proteins as potential molecular targets for vascular diseases
    Juan Acosta
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Curr Pharm Des 10:203-11. 2004
    ....
  20. pmc Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response
    M Wang
    Division of Dermatology, Department of Medicine, Barnes Jewish Hospital at Washington University Medical Center, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:6885-9. 1999
    ..These results indicate that stromelysin-1 and gelatinase B serve important functions in CHS. Stromelysin-1 is required for initiation of the response, whereas gelatinase B plays a critical role in its resolution...