B H Paw

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Cloning of the zebrafish retsina blood mutation: a genetic model for dyserythropoiesis and erythroid cytokinesis
    B H Paw
    Division of Hematology Oncology, Department of Pediatric Oncology, Children s Hospital, Dana Farber Cancer Institute, 320 Longwood Avenue, Enders 7, Boston, Massachusetts 02115, USA
    Blood Cells Mol Dis 27:62-4. 2001
  2. ncbi request reprint Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    A Donovan
    Department of Medicine, Children s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 403:776-81. 2000
  3. ncbi request reprint Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid beta-spectrin structure, and function in red cell morphogenesis and membrane stability
    E C Liao
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 127:5123-32. 2000
  4. ncbi request reprint Myelopoiesis in the zebrafish, Danio rerio
    C M Bennett
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:643-51. 2001
  5. ncbi request reprint Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia
    A Brownlie
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 20:244-50. 1998
  6. ncbi request reprint Zebrafish: a genetic model for vertebrate organogenesis and human disorders
    Gabriele E Ackermann
    Division of Hematology Oncology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Front Biosci 8:d1227-53. 2003
  7. ncbi request reprint Zebrafish ae2.2 encodes a second slc4a2 anion exchanger
    Boris E Shmukler
    Molecular and Vascular Medicine and Renal Units, Beth Israel Deaconess Medical Center E RW763, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1081-91. 2008
  8. ncbi request reprint Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency
    Barry H Paw
    Department of Medicine, Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nat Genet 34:59-64. 2003
  9. ncbi request reprint Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization
    Boris E Shmukler
    Molecular Medicine and Renal Units, Beth Israel Deaconess Med Ctr E RW763, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 289:F835-49. 2005
  10. pmc A GATA-1-regulated microRNA locus essential for erythropoiesis
    Louis C Dore
    Division of Hematology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:3333-8. 2008

Collaborators

  • Mitchell Weiss
  • C Brugnara
  • S Sassa
  • N C Andrews
  • P D Kingsley
  • J Palis
  • D M Langenau
  • LEONARD IRA ZON
  • Nikolaus S Trede
  • Seth L Alper
  • LUANNE PETERS
  • Nathan Bahary
  • Alister C Ward
  • KENNETH POSS
  • A C Oates
  • G J Lieschke
  • Iain Drummond
  • R Li
  • Yi Zhou
  • Gabriele E Ackermann
  • David Traver
  • Boris E Shmukler
  • Rebecca A Wingert
  • Alison Brownlie
  • Ebrahim Shafizadeh
  • George C Shaw
  • Helen Foott
  • John J Cope
  • Adriana Donovan
  • Shuo Lin
  • Seong Kyu Choe
  • Julio Amigo
  • Nathaniel B Langer
  • Andrew J Woo
  • Kimberly A Dooley
  • Abbhirami Rajagopal
  • J Tristan Dobson
  • Louis C Dore
  • Christine E Kurschat
  • Alan J Davidson
  • David H Vandorpe
  • Bettina Schmid
  • You Mie Lee
  • Jason N Berman
  • Jerry Kaplan
  • Kimberly Dooley
  • Hui Feng Lin
  • Bruce Barut
  • Candace Hersey
  • Hao Zhu
  • Karl Hsu
  • A Donovan
  • Stephen M Altmann
  • S J Pratt
  • Bruce A Barut
  • A Brownlie
  • C M Bennett
  • M D Fleming
  • A Zapata
  • E C Liao
  • Mark D Fleming
  • C Nusslein-Volhard
  • Yocheved L Schindler
  • U Langheinrich
  • C Metzger
  • Xiaowu Gai
  • Suji Uhm
  • Andrew K Stewart
  • J Hooge
  • T Nicolson
  • Jake Seibert
  • John W Tobias
  • Camila O Dos Santos
  • C Weiler
  • Julio D Amigo
  • G Vacun
  • Zhe Zhang
  • Paula G Fraenkel
  • M K Mathew
  • U Hagner
  • C Kaps
  • R Dahm
  • D Gilmour
  • C Seiler
  • Tyler B Moran
  • Caitlin Hall
  • Ann Hsu
  • Ken Chiang
  • E Busch-Nentwich
  • Yuko Fujiwara

Detail Information

Publications28

  1. ncbi request reprint Cloning of the zebrafish retsina blood mutation: a genetic model for dyserythropoiesis and erythroid cytokinesis
    B H Paw
    Division of Hematology Oncology, Department of Pediatric Oncology, Children s Hospital, Dana Farber Cancer Institute, 320 Longwood Avenue, Enders 7, Boston, Massachusetts 02115, USA
    Blood Cells Mol Dis 27:62-4. 2001
  2. ncbi request reprint Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    A Donovan
    Department of Medicine, Children s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 403:776-81. 2000
    ..We propose that Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload...
  3. ncbi request reprint Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid beta-spectrin structure, and function in red cell morphogenesis and membrane stability
    E C Liao
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 127:5123-32. 2000
    ..Further, we propose that the distinct mammalian erythroid morphology may have evolved from specific modifications of Sptb structure and function...
  4. ncbi request reprint Myelopoiesis in the zebrafish, Danio rerio
    C M Bennett
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:643-51. 2001
    ..The morphologic and molecular genetic evidence presented here supports the zebrafish as an informative model system for the study of normal and aberrant human myelopoiesis. (Blood. 2001;98:643-651)..
  5. ncbi request reprint Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia
    A Brownlie
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 20:244-50. 1998
    ..As mutations in ALAS2 cause congenital sideroblastic anaemia (CSA) in humans, sau represents the first animal model of this disease...
  6. ncbi request reprint Zebrafish: a genetic model for vertebrate organogenesis and human disorders
    Gabriele E Ackermann
    Division of Hematology Oncology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Front Biosci 8:d1227-53. 2003
    ..This review updates our knowledge of heart, vessel, blood and kidney organogenesis in zebrafish and extrapolates our insights to human disorders by assessing common genetic pathways...
  7. ncbi request reprint Zebrafish ae2.2 encodes a second slc4a2 anion exchanger
    Boris E Shmukler
    Molecular and Vascular Medicine and Renal Units, Beth Israel Deaconess Medical Center E RW763, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1081-91. 2008
    ..1 mRNA, or of both with nontoxic or minimally toxic levels of N-morpholino oligomers produced no grossly detectable morphological phenotype, and preserved normal structure of the head and the pronephric duct at 24 h postfertilization...
  8. ncbi request reprint Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency
    Barry H Paw
    Department of Medicine, Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nat Genet 34:59-64. 2003
    ..1R-binding domains. Our report establishes an evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis...
  9. ncbi request reprint Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization
    Boris E Shmukler
    Molecular Medicine and Renal Units, Beth Israel Deaconess Med Ctr E RW763, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 289:F835-49. 2005
    ..These results will inform tests of the role of Ae2 in zebrafish kidney development and function...
  10. pmc A GATA-1-regulated microRNA locus essential for erythropoiesis
    Louis C Dore
    Division of Hematology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:3333-8. 2008
    ..These results reveal a miRNA locus that is required for erythropoiesis and uncover a new regulatory axis through which GATA-1 controls this process...
  11. pmc Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
    Abbhirami Rajagopal
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Nature 453:1127-31. 2008
    ..Thus, uncovering the mechanisms of haem transport in C. elegans may provide insights into human disorders of haem metabolism and reveal new drug targets for developing anthelminthics to combat worm infestations...
  12. pmc montalcino, A zebrafish model for variegate porphyria
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Exp Hematol 36:1132-42. 2008
    ..The objective of this study was to identify the defective gene and characterize the phenotype of the zebrafish mutant...
  13. pmc Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110
    Nikolaus S Trede
    Institute of Biochemistry, Justus Liebig University, D 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 104:6608-13. 2007
    ..Together, our data demonstrate that a mutation in a general splicing factor can lead to distinct defects in organ development and cause disease...
  14. ncbi request reprint Mitoferrin is essential for erythroid iron assimilation
    George C Shaw
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 440:96-100. 2006
    ..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
  15. pmc Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish
    You Mie Lee
    Vascular Biology Program, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Dev Dyn 235:29-37. 2006
    ..Taken together, these data demonstrate a novel function for VEGF-Rs in the endocardial endothelium of the developing cardiac valve...
  16. ncbi request reprint Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis
    Rebecca A Wingert
    Stem Cell Program and Division Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 436:1035-39. 2005
    ..These findings uncover a connection between haem biosynthesis and Fe-S clusters, indicating that haemoglobin production in the differentiating red cell is regulated through Fe-S cluster assembly...
  17. pmc Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development
    Andrew J Woo
    Department of Pediatric Oncology, Children s Hospital Boston Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 28:2675-89. 2008
    ....
  18. pmc Analysis of thrombocyte development in CD41-GFP transgenic zebrafish
    Hui Feng Lin
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Blood 106:3803-10. 2005
    ..These studies have shown that it is possible to identify thrombocytes, thrombocyte precursors, and, possibly, early hematopoietic stem cells in zebrafish embryos and track their proliferation and maturation...
  19. ncbi request reprint Zebrafish as a model of human hematologic disorders
    Ebrahim Shafizadeh
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Hematol 11:255-61. 2004
    ....
  20. ncbi request reprint Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning
    Graham J Lieschke
    Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
    Dev Biol 246:274-95. 2002
    ....
  21. ncbi request reprint Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency
    Ebrahim Shafizadeh
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 USA
    Development 129:4359-70. 2002
    ..This work presents merlot/chablis as the first characterized non-mammalian vertebrate models of hereditary anemia due to a defect in protein 4.1R integrity...
  22. ncbi request reprint The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1)
    Adriana Donovan
    Department of Hematology Oncology, and Howard Hughes Medical Institute, Children s Hospital, Boston, MA 02115, USA
    Blood 100:4655-9. 2002
    ..Our studies further demonstrate the conservation of iron metabolism in vertebrates and suggest the existence of an alternative pathway of intestinal and red blood cell iron uptake...
  23. ncbi request reprint Characterization of embryonic globin genes of the zebrafish
    Alison Brownlie
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 255:48-61. 2003
    ..Our studies are the first to systematically evaluate the embryonic globins in the zebrafish and will ultimately be useful in evaluating zebrafish mutants with defects in hemoglobin production and switching...
  24. ncbi request reprint The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish
    Alister C Ward
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Blood 102:3238-40. 2003
    ..These TG(spi1:EGFP)pA301 transgenic zebrafish represent a valuable tool for further studies of myeloid development and its perturbation...
  25. ncbi request reprint Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
    David Traver
    Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1238-46. 2003
    ..Direct visualization of fluorescent donor cells in embryonic recipients allows engraftment and homing events to be imaged in real time. These results provide a cellular context in which to study the genetics of hematopoiesis...
  26. ncbi request reprint Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio
    Stephen M Altmann
    Department of Biochemistry, Microbiology, and Molecular Biology, University of Maine, Orono, ME 04469, USA
    Dev Comp Immunol 28:295-306. 2004
    ....
  27. ncbi request reprint The pu.1 promoter drives myeloid gene expression in zebrafish
    Karl Hsu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 104:1291-7. 2004
    ..These transgenic lines will be useful to dissect the cellular and molecular control of myeloid cell differentiation, and this promoter fragment may prove useful in the development of zebrafish models of acute myeloid leukemia...
  28. doi request reprint Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination
    J Tristan Dobson
    IWK Health Centre, Dalhousie University, Halifax, NS, USA
    Blood 112:2969-72. 2008
    ..1, but not gata-1 or fog-1, are necessary for early MC development. These studies validate the zebrafish as an in vivo tool for studying MC ontogeny and function with future capacity for modeling human MC diseases...