Claudia L Ordonez
Affiliation: Harvard University
- Effect of clarithromycin on airway obstruction and inflammatory markers in induced sputum in cystic fibrosis: a pilot studyC L Ordoñez
Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
Pediatr Pulmonol 32:29-37. 2001..We conclude that clarithromycin is not uniformly effective in improving airway obstruction or in decreasing airway inflammation in patients with CF...
- Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics in cystic fibrosisClaudia L Ordonez
Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA
Am J Respir Crit Care Med 168:1471-5. 2003..Seven of 127 (6%) sputum induction procedures showed a decrease in FEV1 of 20% or more. We conclude that markers in induced sputum may be useful, noninvasive outcome measures to assess response to therapies in cystic fibrosis studies...
- Variability of markers of inflammation and infection in induced sputum in children with cystic fibrosisClaudia L Ordonez
Department of Medicine and Clinical Research Program, Children s Hospital Boston, Massachusetts 02115, USA
J Pediatr 145:689-92. 2004..Neutrophil elastase concentration and bacterial cultures were reproducible. This study provides useful information for investigators designing trials of anti-inflammatory therapies in CF involving sputum induction...
- Ivacaftor in subjects with cystic fibrosis who are homozygous for the F508del-CFTR mutationPatrick A Flume
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Chest 142:718-24. 2012....
- Genome-wide study of Pseudomonas aeruginosa outer membrane protein immunogenicity using self-assembling protein microarraysWagner R Montor
Harvard Institute of Proteomics, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Boston Children s Hospital, Boston, MA 02115, USA
Infect Immun 77:4877-86. 2009..01). The study provides a list of potential candidates for the improvement of serological diagnostics and the development of vaccines...
- The treatment of spine and chest wall deformities with fused ribs by expansion thoracostomy and insertion of vertical expandable prosthetic titanium rib: growth of thoracic spine and improvement of lung volumesJohn B Emans
Department of Orthopaedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Spine (Phila Pa 1976) 30:S58-68. 2005..Prospective clinical trial of vertical expandable prosthetic titanium rib (VEPTR) in patients with combined spine and chest wall deformity with scoliosis and fused ribs...
- Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutationJ P Clancy
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Thorax 67:12-8. 2012..VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, has been shown to increase the cell surface density of functional F508del-CFTR in vitro...
- The role of epitope specificity in the human opsonic antibody response to the staphylococcal surface polysaccharide poly N-acetyl glucosamineCasie Kelly-Quintos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Infect Dis 192:2012-9. 2005..We investigated the human antibody response and specificity of binding and opsonic antibodies for different epitopes on PNAG in serum samples from patients with cystic fibrosis (CF) colonized and not colonized with Staphylococcus aureus...
- A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatusJoseph D Mougous
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Science 312:1526-30. 2006..Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions...