Genomes and Genes
Rachael Lee Neve
Affiliation: Harvard University
- A new wrestler in the battle between alpha- and beta-secretases for cleavage of APPRachael L Neve
Department of Psychiatry, Harvard Medical School, MRC 223, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Trends Neurosci 26:461-3. 2003....
- The cell cycle as a therapeutic target for Alzheimer's diseaseRachael L Neve
Department of Psychiatry, MRC 223, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
Pharmacol Ther 111:99-113. 2006..Drugs and peptides that can inhibit molecular steps leading to AD neurodegeneration by intervening in the activation of cell cycle re-entry in neurons represent an entirely new approach to the development of treatments for AD...
- Use of herpes virus amplicon vectors to study brain disordersRachael L Neve
Harvard Medical School, MA, USA
Biotechniques 39:381-91. 2005..The HSV amplicon virus is a user-friendly vector for the delivery of genes into neurons that has come of age for the study of brain function...
- Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosisRachael L Neve
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Biochim Biophys Acta 1772:430-7. 2007..In this article, we review the evidence that APP has the potential to activate aberrant neuronal cell cycle re-entry in AD, and we describe a signal transduction pathway that may mediate this abnormal activation of the cell cycle...
- Alzheimer's disease sends the wrong signals--a perspectiveRachael L Neve
McLean Hospital, Belmont, MA 02478, USA
Amyloid 15:1-4. 2008..Three recent papers highlight the potential importance of presenilin and APP signaling in the etiology of AD...
- APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1Yuzhi Chen
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Mol Neurodegener 2:3. 2007..Increased Abeta42/Abeta40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD). APP binds to APP-BP1, but the biological consequence is not well understood...
- cis-acting regulatory elements in the GAP-43 mRNA 3'-untranslated region can function in trans to suppress endogenous GAP-43 gene expressionR L Neve
Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA
Brain Res Mol Brain Res 65:52-60. 1999....
- Alzheimer's disease: a dysfunction of the amyloid precursor protein(1)R L Neve
Department of Psychiatry, Harvard Medical School, MRC 223 McLean Hospital, 115 Mill St, 02478, Belmont, MA, USA
Brain Res 886:54-66. 2000....
- Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defectsAnne M Cataldo
Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Am J Pathol 173:370-84. 2008....
- Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosisDaphna Laifenfeld
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 27:7141-53. 2007....
- APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brainYuzhi Chen
MRC 223, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
J Cell Biol 163:27-33. 2003..This translocation of APP-BP1 to lipid rafts is accompanied by a change in the subcellular localization of the ubiquitin-like protein NEDD8, which is activated by APP-BP1...
- ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosisYuzhi Chen
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
J Neurochem 85:801-9. 2003....
- DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3Donna L McPhie
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 23:6914-27. 2003..These data suggest that a normal signaling pathway mediated by the interaction of APP, PAK3, and Go is constitutively activated in neurons by FAD mutations in APP and that this activation causes cell cycle entry and consequent apoptosis...
- Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neuronsHelena Haberstock-Debic
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 2140, USA
J Neurosci 23:4324-32. 2003....
- Viral-mediated gene transfer to study the behavioral correlates of CREB function in the nucleus accumbens of ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA
Methods Mol Med 79:331-50. 2003
- Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behaviorRyan K Bachtell
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Eur J Neurosci 27:2229-40. 2008....
- Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behaviorThomas A Green
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 28:2025-32. 2008....
- Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responsesOlivier Berton
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Neuron 55:289-300. 2007..These results indicate that IS-induced accumulation of DeltaFosB in the vlPAG desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses...
- Brain reward regulated by AMPA receptor subunits in nucleus accumbens shellMark S Todtenkopf
Behavioral Genetics, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:11665-9. 2006..These data suggest that GluR1 and GluR2 in the NAc shell play opposing roles in the regulation of motivated behavior...
- Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviorsMing Hu Han
Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 26:4624-9. 2006....
- Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septumTeige P Sheehan
Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
Biol Psychiatry 54:540-51. 2003....
- Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neuronsJun Li Cao
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 107:17011-6. 2010....
- MOLECULAR MECHANISMS UNDERLYING GAP-43 FUNCTIONRachael Neve; Fiscal Year: 2001..The data obtained from the proposed studies will begin to provide unifying molecular mechanisms for the diverse functions in which GAP-43 is known to participate. ..
- APP-BP1, The Cell Cycle, and Alzheimer DiseaseRachael Neve; Fiscal Year: 2007..We will test whether these predictions are correct. [unreadable] [unreadable]..