Hongmei Nan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:3551-7. 2008
  2. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
  3. pmc Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk
    H Nan
    Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Br J Dermatol 159:314-21. 2008
  4. pmc A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 20:171-9. 2009
  5. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
  6. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
  7. pmc Genetic variants in telomere-maintaining genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 129:247-53. 2011
  8. pmc Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 22:2948-59. 2013
  9. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
  10. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011

Detail Information

Publications25

  1. pmc Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:3551-7. 2008
    ..No associations were found for other SNPs with skin cancer risk. This study provides evidence for the contribution of the MMP9 Arg668Gln to SCC development...
  2. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
    ..Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers...
  3. pmc Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk
    H Nan
    Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Br J Dermatol 159:314-21. 2008
    ..The common p53 codon 72 polymorphism alters the protein's transcriptional activity, which may influence the UV radiation-induced tanning response...
  4. pmc A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 20:171-9. 2009
    ..05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07). These results provide evidence for the potential involvement of MDM2 SNP309 in pigmentary traits...
  5. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color...
  6. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
    ..Our study provides evidence for the contribution of pigmentation genetic variants, in addition to the MC1R variants, to variation in human pigmentary phenotypes and possibly the development of skin cancer...
  7. pmc Genetic variants in telomere-maintaining genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 129:247-53. 2011
    ..05). We did not observe significant associations for SCC or BCC risk. Our study provides evidence for the contribution of genetic variants in the telomere-maintaining genes to melanoma susceptibility...
  8. pmc Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 22:2948-59. 2013
    ..0 × 10(-8); P = 6.6 × 10(-7) in the discovery set and P = 3.0 × 10(-3) in the replication set) and rs8015138 upstream of GNG2 (P = 6.6 × 10(-8); P = 5.3 × 10(-7) in the discovery set and P = 0.01 in the replication set). ..
  9. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  10. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011
    ..21 (1.02-1.44); P= 0.03], were associated with an increased risk of SCC. These two variants were not associated with melanoma risk. We conclude that 6p25 and 13q32 are novel loci conferring susceptibility to non-melanoma skin cancer...
  11. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011
    ..5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin...
  12. pmc A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus
    Jiali Han
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:1533-9. 2011
    ..6 × 10(-3)). Given that the T allele was shown previously to be associated with increased expression of IRF4 locus, further studies are warranted to elucidate the role of the IRF4 gene in human pigmentation and skin cancer development...
  13. pmc ASIP genetic variants and the number of non-melanoma skin cancers
    Wen Lin
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 22:495-501. 2011
    ..32; 95% CI, 1.07-1.63). The OR increased to 1.45(1.18-1.78) for those with 2-4 NMSCs and 1.84(1.34-2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs...
  14. pmc Shorter telomeres associate with a reduced risk of melanoma development
    Hongmei Nan
    Channing Laboratory, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:6758-63. 2011
    ..43 (95% CI: 0.28-0.68; P(trend), 0.0003). Unlike findings for other tumors, shorter telomeres were significantly associated with a decreased risk of melanoma in this study, suggesting a unique role of telomeres in melanoma development...
  15. pmc Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations
    Hongmei Nan
    Affiliations of authors Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD HN Channing Division of Network Medicine, Department of Medicine HN, DJH, ELG, CSF, ATC and Department of Epidemiology DJH, PK, ELG, SO, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Center for Molecular Oncologic Pathology TM, YI, AK, MY, SO, Department of Medical Oncology TM, MS, YI, AK, MY, CSF, SO, MLF, and Department of Biostatistics and Computational Biology LW, Dana Farber Cancer Institute, Boston, MA Department of Epidemiology DJH, ELG, SO and Department of Nutrition, Harvard School of Public Health, Boston, Simancas 47130
    J Natl Cancer Inst 105:1852-61. 2013
    ....
  16. pmc Obesity-related genetic variants, human pigmentation, and risk of melanoma
    Xin Li
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 132:793-801. 2013
    ..But none of them was associated with obesity or in linkage disequilibrium with obesity-related variants. FTO locus may confer variation in human pigmentation and risk of melanoma, which may be independent of its effect on obesity...
  17. ncbi request reprint Association of colorectal cancer susceptibility variants with tumor subtypes in three large prospective cohorts
    Xabier Garcia-Albeniz
    Harvard School of Public Health, Boston, MA Dana Farber Cancer Institute, Boston, MA Harvard School of Public Health, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA Channing Laboratory, Brigham and Women s Hospital, Boston, MA Brigham and Women s Hospital, Boston, MA Massachusetts General Hospital, Boston, MA
    J Clin Oncol 30:445. 2012
    ..445 Background: Genome-wide association studies (GWAS) have identified 17 colorectal cancer (CRC) susceptibility variants. However, their association with specific tumor subtypes has not been fully defined...
  18. ncbi request reprint Known colorectal cancer susceptibility loci and survival after colorectal cancer diagnosis
    Amanda Phipps
    Fred Hutchinson Cancer Research Center, Seattle, WA Harvard School of Public Health, Boston, MA Dana Farber Cancer Institute, Boston, MA Massachusetts General Hospital, Boston, MA
    J Clin Oncol 30:394. 2012
    ..We examined 17 CRC susceptibility SNPs in relation to survival after CRC diagnosis...
  19. doi request reprint No association between telomere length-related loci and number of cutaneous nevi
    Xin Li
    Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA
    Oncotarget . 2016
    ....
  20. doi request reprint Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women
    Shasha Meng
    Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA
    Oncotarget . 2016
    ..To examine the association between leukocyte mitochondrial DNA copy number (mtCN) and different anthropometric indices as well as weight changes; and to compare mtCN and telomere length with respect to their associations with BMI and age...
  21. pmc Prospective study of alcohol consumption and the risk of colorectal cancer before and after folic acid fortification in the United States
    Hongmei Nan
    Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA
    Ann Epidemiol 23:558-63. 2013
    ..To evaluate the influence of alcohol consumption on the risk of colorectal cancer according to folic acid fortification period in the United States...
  22. pmc Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival
    Xabier Garcia-Albeniz
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 34:292-8. 2013
    ..These findings suggest that individuals with this SMAD7 variant that develop CRC are more probably to have tumors with greater invasiveness and methylation of RUNX3, which potentially contributes to their poorer observed survival...
  23. pmc Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States
    Andrew Rivera
    Harvard Medical School, Boston, Massachusetts
    Cancer Epidemiol Biomarkers Prev 25:1550-1558. 2016
    ..Alcohol consumption is associated with increased risk of numerous cancers, but existing evidence for an association with melanoma is equivocal. No study has evaluated the association with different anatomic locations of melanoma...
  24. pmc Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine
    Shuji Ogino
    From the aDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA bDivision of MPE Molecular Pathological Epidemiology, Brigham and Women s Hospital, Boston, MA cDepartment of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA dDepartment of Medical Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA eDepartment of Nutrition, Harvard T H Chan School of Public Health, Boston, MA fDepartment of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA gYale Institute for Network Science, Yale University, New Haven, CT hInstitute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom iDivision of Gastroenterology, Massachusetts General Hospital, Boston, MA jChanning Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA kDepartment of Epidemiology, Richard M Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN lDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School
    Epidemiology 27:602-11. 2016
    ..Given advances in biotechnology, bioinformatics, and computational/systems biology, there are wide open opportunities in MPE to contribute to public health. ..
  25. pmc Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women
    Hongmei Nan
    Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 8:e59455. 2013
    ..Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia...