Amy Murphy

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
  2. ncbi request reprint Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
  3. pmc PRKCA: a positional candidate gene for body mass index and asthma
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:87-96. 2009
  4. pmc The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Pulm Med 11:17. 2011
  5. pmc An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes
    Jessica Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Eur J Hum Genet 18:720-5. 2010
  6. pmc Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 365:1173-83. 2011
  7. pmc Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:1084-90. 2009
  8. pmc Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
  9. pmc Polymorphisms in IL12A and cockroach allergy in children with asthma
    Michael Pistiner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Mol Allergy 6:6. 2008
  10. ncbi request reprint A common mitochondrial haplogroup is associated with elevated total serum IgE levels
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:351-8. 2007

Detail Information

Publications18

  1. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
    ..004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association...
  2. ncbi request reprint Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
    ..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity...
  3. pmc PRKCA: a positional candidate gene for body mass index and asthma
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:87-96. 2009
    ..6 x 10(-)(5)). PRKCA is a pleiotropic locus that is associated with both BMI and asthma and that has been identified via linkage analysis of BMI in a population ascertained on asthma...
  4. pmc The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Pulm Med 11:17. 2011
    ..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known...
  5. pmc An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes
    Jessica Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Eur J Hum Genet 18:720-5. 2010
    ..This program is available in the PBAT analysis package...
  6. pmc Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 365:1173-83. 2011
    ..We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids...
  7. pmc Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:1084-90. 2009
    ..Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma...
  8. pmc Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
    ..We compare the results from the PBAT analysis to that of quantitative linkage analysis on chromosome 4 using the Collaborative Study on the Genetics of Alcoholism data, as released through Genetic Analysis Workshop 14...
  9. pmc Polymorphisms in IL12A and cockroach allergy in children with asthma
    Michael Pistiner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Mol Allergy 6:6. 2008
    ..IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases...
  10. ncbi request reprint A common mitochondrial haplogroup is associated with elevated total serum IgE levels
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:351-8. 2007
    ..Mitochondria are inherited exclusively through the maternal line, raising the possibility that sequence variation in the mitochondrial genome contributes to the pathogenesis of asthma and atopy...
  11. ncbi request reprint Genome-wide association studies of family data in pharmacogenetics: a case study
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Pharm Des 15:3764-72. 2009
    ..In this manuscript, we discuss these considerations and provide concrete examples with GWAS data for an asthma clinical trial using parent-offspring trios...
  12. pmc IL1B polymorphisms modulate cystic fibrosis lung disease
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital, Boston, MA, USA
    Pediatr Pulmonol 44:580-93. 2009
    ....
  13. pmc The impact of self-identified race on epidemiologic studies of gene expression
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genet Epidemiol 35:93-101. 2011
    ....
  14. pmc On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Genet Epidemiol 34:582-90. 2010
    ..The advantages of the approach in practice are demonstrated by an application to a genome-wide association study for body mass index...
  15. pmc Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
    Amy Murphy
    Channing Laboratory, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 19:4745-57. 2010
    ..Population-based integrative genetic approaches can help identify such variation and enhance our understanding of the genetic basis of complex traits...
  16. doi request reprint Two-stage testing strategies for genome-wide association studies in family-based designs
    Amy Murphy
    Channing Laboratory, Center for Genomic Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 620:485-96. 2010
    ..In this chapter, we review the original Van Steen algorithm, its numerous extensions, and discuss its advantages and disadvantages...
  17. ncbi request reprint Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica
    Benjamin A Raby
    Channing Laboratory and Respiratory Disorders Program, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 16:243-53. 2007
    ..JAG1 is a hematopoetic cell growth factor that may regulate normal B-cell development. This is the first demonstration of a possible genetic basis for differences in total IgE between sexes...
  18. ncbi request reprint Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
    ..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...