Genomes and Genes
Janet M Mullington
Affiliation: Harvard University
- Cardiovascular, inflammatory, and metabolic consequences of sleep deprivationJanet M Mullington
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Division of Cardiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
Prog Cardiovasc Dis 51:294-302. 2009..These studies show that insufficient sleep alters established cardiovascular risk factors in a direction that is known to increase the risk of cardiac morbidity...
- Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteersMonika Haack
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Sleep 30:1145-52. 2007..Sleep disturbances, pain, and inflammation co-occur in various medical conditions, but their interrelationships are poorly understood...
- Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous painMonika Haack
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Pain 145:136-41. 2009..Activation of the PGE2 system appears to be a potential mediator of increased spontaneous pain in response to insufficient sleep...
- Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular riskHans K Meier-Ewert
Department of Cardiology, Lahey Clinic Medical Center, Burlington, Boston, Massachusetts, USA
J Am Coll Cardiol 43:678-83. 2004..We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels...
- Sleep loss and inflammationJanet M Mullington
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Best Pract Res Clin Endocrinol Metab 24:775-84. 2010..Although the mechanism of this altered inflammatory status in humans undergoing experimental sleep loss is unknown, it is likely that autonomic activation and metabolic changes play key roles...
- Increasing sleep duration to lower beat-to-beat blood pressure: a pilot studyMonika Haack
Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
J Sleep Res 22:295-304. 2013....
- The contribution of sleep to improvements in working memory scanning speed: a study of prolonged sleep restrictionMelynda D Casement
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Biol Psychol 72:208-12. 2006..These results indicate that the efficiency of working memory scanning can improve with repeated practice given sufficient sleep, and that prolonged sleep restriction to 50% of habitual sleep prevents this improvement...
- Sustained sleep restriction reduces emotional and physical well-beingMonika Haack
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, East Campus, Dana 779, Boston, MA 02215, USA
Pain 119:56-64. 2005..Prolonged curtailment of nocturnal sleep has been studied for its adverse effect on cognitive functioning and subjective tiredness, but relatively little is known about its effect on mood and physical symptoms...
- Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteersMonika Haack
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, DA 779, Boston, MA 02215, USA
Brain Behav Immun 18:361-7. 2004..These diurnal variations in sTNF-Rs levels are consistent with the hypothesis that the TNF system plays a role in normal diurnal temperature regulation...
- Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortalityKiichiro Yano
Center for Vascular Biology Research, Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Exp Med 203:1447-58. 2006..Adenovirus-mediated overexpression of VEGF but not PlGF exacerbated the lipopolysaccharide-mediated toxic effects. Together, these data support a pathophysiological role for VEGF in mediating the sepsis phenotype...