J B Mulliken

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Repair of bilateral cleft lip and its variants
    John B Mulliken
    Department of Plastic and Oral Surgery, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    Indian J Plast Surg 42:S79-90. 2009
  2. ncbi request reprint Gustav Simon's band and the evolution of labial adhesion
    John B Mulliken
    Department of Plastic and Oral Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Craniofac Surg 24:108-14. 2013
  3. ncbi request reprint Fourth-dimensional changes in nasolabial dimensions following rotation-advancement repair of unilateral cleft lip
    John B Mulliken
    Department of Plastic and Oral Surgery, Children s Hospital Boston and Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 129:491-8. 2012
  4. ncbi request reprint Molecular analysis of patients with synostotic frontal plagiocephaly (unilateral coronal synostosis)
    John B Mulliken
    Craniofacial Center, Division of Plastic Surgery, Children s Hospital Boston, Mass 02215, USA
    Plast Reconstr Surg 113:1899-909. 2004
  5. ncbi request reprint Double unilimb Z-plastic repair of microform cleft lip
    John B Mulliken
    Craniofacial Center, Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Plast Reconstr Surg 116:1623-32. 2005
  6. ncbi request reprint Multifocal rapidly involuting congenital hemangioma: a link to chorangioma
    J B Mulliken
    Department of Plastic Surgery, Vascular Anomalies Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 143:3038-46. 2007
  7. ncbi request reprint Reticular infantile hemangioma of the limb can be associated with ventral-caudal anomalies, refractory ulceration, and cardiac overload
    John B Mulliken
    Department of Plastic Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Dermatol 24:356-62. 2007
  8. doi request reprint A craniofacial glossary
    John B Mulliken
    Department of Plastic Surgery and Craniofacial Centre, Children s Hospital, Harvard Medical School, Boston, Massachusettes 02115, USA
    J Craniofac Surg 19:705-12. 2008
  9. ncbi request reprint A novel association between RASA1 mutations and spinal arteriovenous anomalies
    R Thiex
    Department of Neurointerventional Radiology, Children s Hospital Boston, Harvard Medical School, Massachusetts 02115, USA
    AJNR Am J Neuroradiol 31:775-9. 2010
  10. ncbi request reprint The principle of rotation advancement for repair of unilateral complete cleft lip and nasal deformity: technical variations and analysis of results
    J B Mulliken
    Craniofacial Centre and Division of Plastic Surgery at Children s Hospital, Harvard Medical School, Boston, MA 021115, USA
    Plast Reconstr Surg 104:1247-60. 1999

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. pmc Repair of bilateral cleft lip and its variants
    John B Mulliken
    Department of Plastic and Oral Surgery, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    Indian J Plast Surg 42:S79-90. 2009
    ..These same principles also apply to the repair of the variants of bilateral cleft lip, although strategies and execution differ slightly...
  2. ncbi request reprint Gustav Simon's band and the evolution of labial adhesion
    John B Mulliken
    Department of Plastic and Oral Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Craniofac Surg 24:108-14. 2013
    ..Bilateral labial adhesion may also have a preparatory role in double cleft lip whenever dentofacial orthopedic manipulation is unavailable or unsuccessful...
  3. ncbi request reprint Fourth-dimensional changes in nasolabial dimensions following rotation-advancement repair of unilateral cleft lip
    John B Mulliken
    Department of Plastic and Oral Surgery, Children s Hospital Boston and Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 129:491-8. 2012
    ..Repair of unilateral cleft lip requires three-dimensional craftsmanship and understanding four-dimensional changes...
  4. ncbi request reprint Molecular analysis of patients with synostotic frontal plagiocephaly (unilateral coronal synostosis)
    John B Mulliken
    Craniofacial Center, Division of Plastic Surgery, Children s Hospital Boston, Mass 02215, USA
    Plast Reconstr Surg 113:1899-909. 2004
    ..Infants with either an identified or a suspected mutation usually need bilateral asymmetric advancement of the bandeau and may be more likely to require frontal revision in childhood...
  5. ncbi request reprint Double unilimb Z-plastic repair of microform cleft lip
    John B Mulliken
    Craniofacial Center, Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Plast Reconstr Surg 116:1623-32. 2005
    ..Microform unilateral cleft lip is characterized by 1) notched mucosal margin; 2) thin medial vermilion; 3) elevated medial peak of Cupid's bow; 4) furrowed philtral column; 5) hypoplastic orbicularis oris; and 6) minor nasal deformity...
  6. ncbi request reprint Multifocal rapidly involuting congenital hemangioma: a link to chorangioma
    J B Mulliken
    Department of Plastic Surgery, Vascular Anomalies Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 143:3038-46. 2007
    ..These placental vascular tumors can also occur in conjunction with solitary and multiple infantile hemangiomas...
  7. ncbi request reprint Reticular infantile hemangioma of the limb can be associated with ventral-caudal anomalies, refractory ulceration, and cardiac overload
    John B Mulliken
    Department of Plastic Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Dermatol 24:356-62. 2007
    ....
  8. doi request reprint A craniofacial glossary
    John B Mulliken
    Department of Plastic Surgery and Craniofacial Centre, Children s Hospital, Harvard Medical School, Boston, Massachusettes 02115, USA
    J Craniofac Surg 19:705-12. 2008
  9. ncbi request reprint A novel association between RASA1 mutations and spinal arteriovenous anomalies
    R Thiex
    Department of Neurointerventional Radiology, Children s Hospital Boston, Harvard Medical School, Massachusetts 02115, USA
    AJNR Am J Neuroradiol 31:775-9. 2010
    ..Arteriovenous lesions have been reported in the brain, limbs, and the face in 18.5% of patients. We report a novel association between RASA1 mutations and spinal arteriovenous anomalies...
  10. ncbi request reprint The principle of rotation advancement for repair of unilateral complete cleft lip and nasal deformity: technical variations and analysis of results
    J B Mulliken
    Craniofacial Centre and Division of Plastic Surgery at Children s Hospital, Harvard Medical School, Boston, MA 021115, USA
    Plast Reconstr Surg 104:1247-60. 1999
    ..These improvements are attributable to technical refinements and experience, although dentofacial orthopedics may also have played a role...
  11. ncbi request reprint Complex spinal-paraspinal fast-flow lesions in CLOVES syndrome: analysis of clinical and imaging findings in 6 patients
    A I Alomari
    Division of Vascular and Interventional Radiology, Children s Hospital Boston, Massachusetts 02115, USA
    AJNR Am J Neuroradiol 32:1812-7. 2011
    ..We report the occurrence of spinal-paraspinal fast-flow lesions within or adjacent to the truncal overgrowth or a cutaneous birthmark in 6 patients with CLOVES syndrome...
  12. ncbi request reprint Anthropometric analysis of mandibular asymmetry in infants with deformational posterior plagiocephaly
    Dane St John
    Harvard School of Dental Medicine, Boston, MA, USA
    J Oral Maxillofac Surg 60:873-7. 2002
    ..We tested the hypothesis that mandibular asymmetry, associated with this condition, is secondary to anterior displacement of the ipsilateral temporomandibular joint. The response to molding helmet therapy was also evaluated...
  13. ncbi request reprint Incidence of cranial asymmetry in healthy newborns
    Wiebke K Peitsch
    Division of Plastic Surgery, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 110:e72. 2002
    ..The purpose of our study was to determine whether early signs of cranial flattening could be detected in healthy neonates and to document incidence and potential risk factors...
  14. ncbi request reprint Periorbital lymphatic malformation: clinical course and management in 42 patients
    Arin K Greene
    Vascular Anomalies Center, Division of Plastic Surgery, and the Department of Radiology, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 115:22-30. 2005
    ..Ocular proptosis was temporarily managed by tarsorrhaphy (n = 9), but expansion of the bony orbit was needed to correct persistent proptosis (n = 8). Orbital exenteration was necessary in two patients...
  15. ncbi request reprint Klippel-Trenaunay syndrome and spinal arteriovenous malformations: an erroneous association
    A I Alomari
    Division of Interventional Radiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    AJNR Am J Neuroradiol 31:1608-12. 2010
    ..KTS is a rare limb overgrowth disorder with slow-flow vascular anomalies. This study examines the presumed association between KTS and spinal AVMs...
  16. pmc Clonality and altered behavior of endothelial cells from hemangiomas
    E Boye
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:745-52. 2001
    ..We conclude that hemangiomas constitute clonal expansions of endothelial cells. This is consistent with the possibility that these tumors are caused by somatic mutations in one or more genes regulating endothelial cell proliferation...
  17. ncbi request reprint Anthropometric study of synostotic frontal plagiocephaly: before and after fronto-orbital advancement with correction of nasal angulation
    John G Meara
    Craniofacial Centre and Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 112:731-8. 2003
    ..Closing wedge nasal ostectomy results in improved nasal angulation and naso-orbital symmetry, without evidence of distortion or inhibition of nasal growth...
  18. ncbi request reprint Current management of hemangiomas and vascular malformations
    Jennifer J Marler
    Division of Plastic Surgery, Department of Surgery, Cincinnati Children s Medical Center, ML2020, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Clin Plast Surg 32:99-116, ix. 2005
    ..We describe the nomenclature, diagnosis, and management of the different types of anomalies. Specific indications for pharmacologic and surgical intervention are discussed...
  19. ncbi request reprint Autologous cranial particulate bone grafting reduces the frequency of osseous defects after cranial expansion
    Lin Lin Gao
    Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, Craniofacial Center, Boston, Massachusetts, USA
    J Craniofac Surg 21:318-22. 2010
    ..7% of group 1 patients and only 5.3% of those in group 2 (P = 0.04). Primary cranial particulate bone grafting significantly reduced the frequency of osseous defects and secondary cranioplasty following cranial remodeling...
  20. ncbi request reprint Repair of bilateral cleft lip: review, revisions, and reflections
    John B Mulliken
    Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Craniofac Surg 14:609-20. 2003
    ..The authors propose that nasolabial appearance and speech are the priorities in habilitation of the child with bilateral cleft lip/palate rather than the traditional emphasis on maxillary growth...
  21. ncbi request reprint Molecular diagnosis of bilateral coronal synostosis
    J B Mulliken
    Division of Plastic Surgery and the Craniofacial Centre at Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 104:1603-15. 1999
    ..Our data and those of other investigators suggest that we should begin integrating molecular diagnosis with phenotypic diagnosis of craniosynostoses in studies of natural history and dysmorphology and in analyses of surgical results...
  22. ncbi request reprint Children with repaired bilateral cleft lip/palate: effect of age at premaxillary osteotomy on facial growth
    B L Padwa
    Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA, USA
    Plast Reconstr Surg 104:1261-9. 1999
    ..Our findings that the early group had more significant change with premaxillary osteotomy than the late group suggest that premaxillary positioning can be done before completion of facial growth without compromise...
  23. ncbi request reprint Minor-form, microform, and mini-microform cleft lip: anatomical features, operative techniques, and revisions
    Shunsuke Yuzuriha
    Department of Plastic Surgery, Children s Hospital and Harvard Medical School, Boston, Mass, USA
    Plast Reconstr Surg 122:1485-93. 2008
    ..A smaller scar is possible in repair of limited forms of incomplete cleft lip. This retrospective study was undertaken to define the subgroups of lesser-form cleft lip, describe technical alternatives, and review results of repair...
  24. ncbi request reprint Combined push-pull distraction for correction of syndromic midfacial hypoplasia
    Alcuin Schulten
    Department of Orthodontics, Harvard School of Dental Medicine, Boston, MA, USA
    J Oral Maxillofac Surg 64:23-30. 2006
    ..We have used a combination of the 2 methods, called "push-pull," in an effort to control the distraction process. The purpose of this paper is to describe our push-pull distraction technique and summarize our early experience...
  25. ncbi request reprint Asymmetrical bilateral cleft lip: complete or incomplete and contralateral lesser defect (minor-form, microform, or mini-microform)
    Shunsuke Yuzuriha
    Department of Plastic Surgery, Children s Hospital and Harvard Medical School, Boston, Mass, USA
    Plast Reconstr Surg 122:1494-504. 2008
    ..Complete or incomplete cleft lip can be associated with a contralateral lesser form of incomplete cleft lip, constituting an asymmetrical bilateral malformation...
  26. ncbi request reprint Treatment of unilateral coronal synostosis by endoscopic strip craniectomy or fronto-orbital advancement: Ophthalmologic findings
    Sarah MacKinnon
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J AAPOS 13:155-60. 2009
    ..We compare the incidence and severity of V-pattern strabismus and aniso-astigmatism in children treated by these 2 procedures...
  27. pmc Cerebrofacial venous anomalies, sinus pericranii, ocular abnormalities and developmental delay
    B Macit
    Division of Vascular and Interventional Radiology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Interv Neuroradiol 18:153-7. 2012
    ..In addition, one child had a seizure disorder. Complex cerebrofacial slow-flow vascular anomalies may herald an underlying developmental aberration affecting the cerebrofacial and orbital regions...
  28. ncbi request reprint Soft-tissue vascular anomalies: utility of US for diagnosis
    H J Paltiel
    Department of Radiology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Radiology 214:747-54. 2000
    ..To determine the ultrasonographic (US) features that distinguish soft-tissue hemangioma from vascular malformation and one type of malformation from another...
  29. ncbi request reprint Infantile hemangiomas involving the neuraxis: clinical and imaging findings
    V Viswanathan
    Neuroradiology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    AJNR Am J Neuroradiol 30:1005-13. 2009
    ..Our purpose was to delineate the definition of infantile hemangiomas, determine their prevalence in the neuraxis, and describe their imaging characteristics and associations in this location...
  30. ncbi request reprint Repair of bilateral complete cleft lip: intraoperative nasolabial anthropometry
    J B Mulliken
    Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 107:307-14. 2001
    ....
  31. pmc Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK
    E Reichenberger
    Harvard Forsyth Department of Oral Biology, The Forsyth Institute, Harvard School of Dental Medicine, and Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 68:1321-6. 2001
    ..These results suggest that the mutated protein has a dominant negative effect on the function of ANK, since reduced levels of pyrophosphate in bone matrix are known to increase mineralization...
  32. ncbi request reprint Simultaneous maxillary and mandibular distraction osteogenesis with a semiburied device
    B L Padwa
    Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Children s Hospital and Harvard School of Dental Medicine, Boston 02115, USA
    Int J Oral Maxillofac Surg 28:2-8. 1999
    ..The indications for bimaxillary distraction are reviewed, including its advantages, disadvantages and limitations...
  33. ncbi request reprint Congenital fenestration of the palate: A case of embryologic syzygy
    Gary F Rogers
    Harvard Medical School, Boston, Massachusetts, USA
    Cleft Palate Craniofac J 43:363-6. 2006
    ..Of the 26 putative cases in the literature, only 5 had confirmation of the cleft during the neonatal period. This report documents such a cleft in an infant and presents the likely pathogenesis...
  34. ncbi request reprint An association between hemifacial microsomia and facial clefting
    Wen S Fan
    Harvard School of Dental Medicine, Boston, MA, USA
    J Oral Maxillofac Surg 63:330-4. 2005
    ..We undertook a retrospective study of patients with HFM to document the prevalence of facial clefting. The hypothesis is that the coexistence of facial clefts and HFM suggests a common pathogenic mechanism...
  35. ncbi request reprint Infantile myofibroma or lymphatic malformation: differential diagnosis of neonatal cystic cervicofacial lesions
    Stephen C Merrell
    Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Craniofac Surg 21:422-6. 2010
    ..This report expands the clinical spectrum of infantile myofibromatosis and suggests its consideration in the differential diagnosis of neonatal cystic cervicofacial lesions...
  36. ncbi request reprint Frontonasal osteotomy to facilitate removal of an intracranial nasal dermoid
    Gary F Rogers
    Craniofacial Centre, Division of Plastic Surgery and Department of Neurosurgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Craniofac Surg 16:731-6. 2005
    ..Additionally unnecessary disruption of the nasal bones and facial scarring are avoided...
  37. ncbi request reprint Effect of a syndromic diagnosis on mandibular size and sagittal position in Robin sequence
    Gary F Rogers
    Department of Plastic and Oral Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Oral Maxillofac Surg 67:2323-31. 2009
    ..The purpose of this study was to determine mandibular length and position in patients with nonsyndromic versus syndromic Robin sequence...
  38. ncbi request reprint Nasomaxillary dermoid
    Edward W Swanson
    Department of Plastic Surgery, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Craniofac Surg 21:866-9. 2010
    ..Contralateral cleft lip and palate in our patient suggest a common pathogenesis involving abnormal formation of the maxillary prominences and failure of fusion and merging...
  39. ncbi request reprint Involvement of the basilar coronal ring in unilateral coronal synostosis
    Gary F Rogers
    Division of Plastic Surgery, Craniofacial Center, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 115:1887-93. 2005
    ..Possible fusion of the basilar sutures in unilateral coronal synostosis is poorly documented...
  40. ncbi request reprint Verrucous hemangioma revisited
    Lucile B Tennant
    Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Dermatol 23:208-15. 2006
    ..No firm conclusion seems possible as to whether verrucous hemangioma is a malformation or an indolent tumor, but clinical evidence favors the former category...
  41. ncbi request reprint Palatoplasty outcomes in nonsyndromic patients with cleft palate: a 29-year assessment of one surgeon's experience
    Stephen R Sullivan
    Department of Plastic Surgery, Craniofacial Centre, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Craniofac Surg 20:612-6. 2009
    ..001). Incidence of VPI was independent of surgeon experience (P = 0.2). In conclusion, the incidence of palatal fistula was low. Velopharyngeal insufficiency was associated with increasing age at palatoplasty and with the Veau hierarchy...
  42. ncbi request reprint The role of congenital muscular torticollis in the development of deformational plagiocephaly
    Gary F Rogers
    Department of Plastic Surgery, Craniofacial Center, Children s Hospital, Harvard Medical SchoolBoston, Massachussetts 02115, USA
    Plast Reconstr Surg 123:643-52. 2009
    ..Torticollis and sternocleidomastoid imbalance are implicated, but reporting is variable. The authors sought to determine the incidence of torticollis/sternocleidomastoid imbalance in deformational plagiocephaly...
  43. ncbi request reprint Comparison of a modifiable cranial cup versus repositioning and cervical stretching for the early correction of deformational posterior plagiocephaly
    Gary F Rogers
    Craniofacial Center, Department of Plastic Surgery, Children s Hospital, Boston, Mass 02115, USA
    Plast Reconstr Surg 121:941-7. 2008
    ..The authors assessed the effectiveness of a modifiable cranial cup compared to repositioning and cervical stretching to correct early deformational plagiocephaly...
  44. ncbi request reprint Facial asymmetry in unilateral coronal synostosis: long-term results after fronto-orbital advancement
    Albert K Oh
    Craniofacial Center, Division of Plastic Surgery, Children s Hospital Boston, Mass 02115, USA
    Plast Reconstr Surg 121:545-62. 2008
    ....
  45. ncbi request reprint Increased prevalence of left-handedness in hemifacial microsomia
    Gary F Rogers
    Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115
    J Craniofac Surg 20:690-4. 2009
    ..11%; P < 0.05). The frequency was higher, 36%, in those with bilateral involvement (P > 0.05). There was no correlation with predominant side or OMENS score. This study confirms that this disorder affects cerebral lateralization...
  46. ncbi request reprint Repair of transverse facial cleft in hemifacial microsomia: long-term anthropometric evaluation of commissural symmetry
    Gary F Rogers
    Craniofacial Center, Department of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Plast Reconstr Surg 120:728-37. 2007
    ....
  47. ncbi request reprint Astigmatism in unilateral coronal synostosis: incidence and laterality
    Richard Lawrence Levy
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 20115, USA
    J AAPOS 11:367-72. 2007
    ..The purpose of this study was to analyze the incidence and laterality of astigmatism in children with unilateral coronal synostosis...
  48. ncbi request reprint Sturge-Weber syndrome: soft-tissue and skeletal overgrowth
    Arin K Greene
    Department of Plastic and Oral Surgery, Vascular Anomalies Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Craniofac Surg 20:617-21. 2009
    ..0%), or skeletal overgrowth (11.0%). In conclusion, facial hypertrophy is a major component of SWS; these patients should be counseled about the risk of overgrowth and about the types of possible operative correction...
  49. ncbi request reprint Zygomaticotemporal synostosis: a rare cause of progressive facial asymmetry
    Gary F Rogers
    Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cleft Palate Craniofac J 44:106-11. 2007
    ..To our knowledge, this is the first description of this anomaly in the literature...
  50. ncbi request reprint Risk of vascular anomalies with Down syndrome
    Arin K Greene
    Vascular Anomalies Center and Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 121:e135-40. 2008
    ..We hypothesized that vascular anomalies, including infantile hemangioma, an angiogenesis-dependent vascular tumor, and vascular malformations might be similarly inhibited in patients with Down syndrome...
  51. ncbi request reprint The frequency of palatal anomalies in Saethre-Chotzen syndrome
    Joan M Stoler
    Division of Genetics, Department of Medicine, Harvard Medical School, Children s Hosptial, Boston, Massachusets, USA
    Cleft Palate Craniofac J 46:280-4. 2009
    ..Cleft palate can also occur, but there are few reports on its frequency. This study was undertaken to determine the prevalence of palatal anomalies in this population...
  52. ncbi request reprint Lesser forms of cleft lip associated with the branchio-oculo-facial syndrome
    Angela E Lin
    Genetics Unit, MassGeneral Hospital for Children, USA
    J Craniofac Surg 20:608-11. 2009
    ..Another possible pathogenic explanation is that failure of labial closure occurs earlier than in a major cleft when the primitive cells of ectoderm and mesoderm retain the capacity to "heal" the defect...
  53. ncbi request reprint Effect of midfacial distraction on the obstructed airway in patients with syndromic bilateral coronal synostosis
    Tyler E Nelson
    Harvard School of Dental Medicine, Boston, MA, USA
    J Oral Maxillofac Surg 66:2318-21. 2008
    ..This study aimed to document the effect of midfacial distraction-advancement on airway obstruction in patients with syndromic bilateral coronal synostosis...
  54. pmc Blue rubber bleb nevus syndrome: surgical eradication of gastrointestinal bleeding
    Steven J Fishman
    Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Ann Surg 241:523-8. 2005
    ..We report the largest clinical experience to date of surgically treated patients with blue rubber bleb nevus syndrome (BRBNS)...
  55. ncbi request reprint Circular excision of hemangioma and purse-string closure: the smallest possible scar
    John B Mulliken
    Division of Plastic Surgery and the Vascular Anomalies Center, Children s Hospital, Boston, MA 02115, USA
    Plast Reconstr Surg 109:1544-54; discussion 1555. 2002
    ..No other excision and closure technique results in a smaller scar. Another advantage of this method is minimal distortion of surrounding structures...
  56. ncbi request reprint The craniofacial surgeon as amateur geneticist
    John B Mulliken
    Craniofacial Center and Division of Plastic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Craniofac Surg 13:3-17. 2002
    ..As a member of the perinatal team, the craniofacial surgeon must be "cyber-savvy" to counsel parents and communicate with geneticists...
  57. ncbi request reprint Metastatic neuroblastoma mimicking infantile hemangioma
    Aladdin H Hassanein
    Department of Plastic and Oral Surgery, Vascular Anomalies Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 45:2045-9. 2010
    ..Deviation from the predictable clinical features of a deep infantile hemangioma should prompt consideration for other causes of a subcutaneous mass in infancy, including metastatic neuroblastoma...
  58. ncbi request reprint Binderoid complete cleft lip/palate
    John B Mulliken
    Division of Plastic and Oral Surgery, Craniofacial Centre, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Plast Reconstr Surg 111:1000-10. 2003
    ..The authors propose the term cleft lip/palate for these children. Early recognition of this entity is important for counseling parents and because alterations in standard operative methods and orthodontic protocols are necessary...
  59. ncbi request reprint The presentation and management of nasal dermoid: a 30-year experience
    Reza Rahbar
    Department of Otolaryngology, The Children s Hospital and the Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 129:464-71. 2003
    ..To review the presentation of nasal dermoid in children and present guidelines for its management...
  60. ncbi request reprint Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin
    Qing Li
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Pathol 201:296-302. 2003
    ..Furthermore, it is possible that antibodies against CD146 may be useful for separating haemangioma-derived endothelial cells from normal endothelial cells and pericytes...
  61. ncbi request reprint Endothelial progenitor cells in infantile hemangioma
    Ying Yu
    Program in Vacular Biology, Department of Surgery, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Blood 103:1373-5. 2004
    ..Our results suggest that EPCs contribute to the early growth of hemangioma. To our knowledge, this is the first study to show direct evidence of EPCs in a human vascular tumor...
  62. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-2004. A newborn girl with a large cutaneous lesion, thrombocytopenia, and anemia
    John B Mulliken
    Division of Plastic Surgery, Craniofacial Center, and Vascular Anomalies Center, Children s Hospital, Boston, USA
    N Engl J Med 350:1764-75. 2004
  63. ncbi request reprint Heterotopic neural nodules of the scalp
    Gary F Rogers
    Craniofacial Centre, Division of Plastic Surgery, Department of Pathology, Children s Hospital, and Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 115:376-82. 2005
    ..Preoperative imaging is essential to document possible intracranial involvement and thus minimize possible penetration of the dura during resection...
  64. ncbi request reprint Bilateral cleft lip
    John B Mulliken
    Harvard Medical School, Boston, MA 02115, USA
    Clin Plast Surg 31:209-20. 2004
    ..With expected improvements in the technology of distraction osteogenesis, maxillary advancement may someday become as acceptable as orthodontic treatment...
  65. ncbi request reprint Congenital hemangiomas and infantile hemangioma: missing links
    John B Mulliken
    Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Acad Dermatol 50:875-82. 2004
    ..We conclude that these infants exhibit "missing links" between the rare RICH and NICH, and the common infantile hemangioma...
  66. ncbi request reprint A sense of wonder
    John B Mulliken
    Division of Plastic Surgery, Children s Hospital, Boston, MA 02115, USA
    Plast Reconstr Surg 110:1353-9. 2002
  67. ncbi request reprint CLOVES syndrome with thoracic and central phlebectasia: increased risk of pulmonary embolism
    Ahmad I Alomari
    Division of Vascular and Interventional Radiology, Children s Hospital Boston and Harvard Medical School, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 140:459-63. 2010
    ..In this communication we studied the presence of central and thoracic phlebectasia in patients with CLOVES syndrome and its clinical implications...
  68. ncbi request reprint Primary repair of bilateral cleft lip and nasal deformity
    J B Mulliken
    Division of Plastic Surgery and Craniofacial Centre, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Plast Reconstr Surg 108:181-94; examination,195-6. 2001
    ..These pressures are not necessarily in conflict. Care by a subspecialized plastic surgeon and experienced team is in the best interests of the child and the third-party payer...
  69. ncbi request reprint Vascular tumors of the heart in infants and children: case series and review of the literature
    A S Mackie
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Cardiol 26:344-9. 2005
    ..Age at diagnosis appears to predict histologic type, tumor location, and clinical presentation...
  70. ncbi request reprint The role of matrix metalloproteinase activity in the maturation of human capillary endothelial cells in vitro
    B M Kräling
    Surgical Research Laboratory, Division of Plastic Surgery and Children s Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Sci 112:1599-609. 1999
    ..These data suggest that our cell culture assay provides a simple and feasible model system for the study of capillary endothelial cell differentiation and vessel maturation in vitro...
  71. ncbi request reprint Safety and clinical efficacy of Onyx for embolization of extracranial head and neck vascular anomalies
    R Thiex
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    AJNR Am J Neuroradiol 32:1082-6. 2011
    ..We review our experience and results with the use of Onyx for the treatment of fast-flow extracranial vascular lesions...
  72. ncbi request reprint Vascular anomalies. A primer for pediatricians
    S J Fishman
    Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Clin North Am 45:1455-77. 1998
    ..Next, animal models of vascular abnormalities will be engineered to elucidate pathogenesis, and these studies, in turn, should lead to development of novel therapies...
  73. ncbi request reprint The infant with a vascular tumor
    B U Mueller
    Department of Medicine, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Semin Perinatol 23:332-40. 1999
    ..Vascular lesions should be biopsied if there is any suspicion of malignancy...
  74. ncbi request reprint Primary grafting with autologous cranial particulate bone prevents osseous defects following fronto-orbital advancement
    Arin K Greene
    Craniofacial Center and Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 120:1603-11. 2007
    ..The authors hypothesized that corticocancellous cranial particulate bone placed over exposed dura at the time of fronto-orbital advancement would decrease the frequency of incomplete ossification...
  75. ncbi request reprint Validity and reliability of craniofacial anthropometric measurement of 3D digital photogrammetric images
    Julielynn Y Wong
    Craniofacial Centre, Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Cleft Palate Craniofac J 45:232-9. 2008
    ..Before morphometry using digital photogrammetry can be applied in clinical and research practice, it must be assessed against direct anthropometry...
  76. ncbi request reprint The molders of this plastic surgeon and his quest for symmetry
    John B Mulliken
    Craniofacial Center, Division of Plastic Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Craniofac Surg 15:898-908. 2004
  77. ncbi request reprint Professor Edmund Rose: his position in surgery
    Arin K Greene
    Department of Surgery and Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 111:383-6. 2003
  78. ncbi request reprint Frequency of Le Fort I osteotomy after repaired cleft lip and palate or cleft palate
    Phoebe M Good
    Harvard School of Dental Medicine, and Department of Plastic and Oral Surgery, Children s Hospital, Boston, MA 02115, USA
    Cleft Palate Craniofac J 44:396-401. 2007
    ..The goal of this study was to determine the frequency of maxillary hypoplasia as measured by need for Le Fort I...
  79. ncbi request reprint The effects of active infant orthopedics on occlusal relationships in unilateral complete cleft lip and palate
    Kathleen T Chan
    Department of Growth and Development, Harvard School of Dental Medicine, Boston, MA, USA
    Cleft Palate Craniofac J 40:511-7. 2003
    ..To evaluate the effects of active infant orthopedic treatment on dental arch relationships and determine the effect on maxillary growth in children born with unilateral complete cleft lip and palate (UCCLP)...
  80. ncbi request reprint Robin sequence: a retrospective review of 115 patients
    Adele Karen Evans
    Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, 243 Charles Street, Boston, MA 02114, USA
    Int J Pediatr Otorhinolaryngol 70:973-80. 2006
    ....
  81. pmc Evidence by molecular profiling for a placental origin of infantile hemangioma
    Carmen M Barnes
    Vascular Biology Program and Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:19097-102. 2005
    ..Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium...
  82. ncbi request reprint Prevention of temporal depression that follows fronto-orbital advancement for craniosynostosis
    Albert K Oh
    Craniofacial Centre, Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Craniofac Surg 17:980-5. 2006
    ..The temporalis muscle is rotated, advanced, and secured to the bandeau. Bone mush is used to fill the remaining superior coronal and donor site defects. Representative case examples are presented...
  83. ncbi request reprint Fast-flow lingual vascular anomalies in the young patient: is imaging diagnostic?
    Pek Lan Khong
    Department of Radiology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Radiol 33:118-22. 2003
    ..To describe the imaging findings (MR imaging and angiography) of high-flow vascular anomalies of the tongue, hemangiomas and arteriovenous malformations (AVMs), with emphasis on the discrepant imaging findings in lingual AVMs...
  84. ncbi request reprint Perioperative corticosteroid reduces hospital stay after fronto-orbital advancement
    James E Clune
    Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Craniofac Surg 21:344-8. 2010
    ..1%; group 2, 1.5%; P = 0.8).Perioperative corticosteroid shortens hospitalization after fronto-orbital advancement without increasing the incidence of postoperative infection. The cost of postoperative hospital care was reduced by 27.2%...
  85. ncbi request reprint Unilateral fusion of the frontosphenoidal suture: a rare cause of synostotic frontal plagiocephaly
    Gary F Rogers
    Craniofacial Centre, Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Plast Reconstr Surg 110:1011-21. 2002
    ..Proper diagnosis necessitates awareness of this uncommon entity and requires focused computed tomographic assessment...
  86. ncbi request reprint Prenatal diagnosis of cleft lip and cleft palate using MRI
    A Stroustrup Smith
    Harvard Medical School and Harvard MIT Division of Health Science and Technology, HMS TMEC 213, 260 Longwood Ave, Boston, MA 02215, USA
    AJR Am J Roentgenol 183:229-35. 2004
  87. ncbi request reprint Not all hemangiomas look like strawberries: uncommon presentations of the most common tumor of infancy
    D Martinez-Perez
    Division of Plastic Surgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02111, USA
    Pediatr Dermatol 12:1-6. 1995
    ..Telangiectatic (bossed) hemangiomas, however, involuted rapidly, usually before 1 year of age. Hemangiomas with persistent fast flow required either resection or sclerotherapy for complications in early childhood...
  88. ncbi request reprint Vascular anomalies: classification, diagnosis, and natural history
    J J Marler
    Vascular Anomalies Center, Division of Plastic Surgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Facial Plast Surg Clin North Am 9:495-504. 2001
    ..Because of continued confusion about diagnosis and therapy, cyber-savvy parents will self-refer to specialists. Family support groups have arisen and provide commendable service to these patients...
  89. ncbi request reprint Prelaminated free flap reconstruction of complex central facial defects
    J J Pribaz
    Division of Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Plast Reconstr Surg 104:357-65; discussion 366-7. 1999
    ..A prelaminated free flap should be considered for a patient requiring reconstruction of a complex central facial defect...
  90. ncbi request reprint Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases
    S J Patrice
    Division of Plastic Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115
    Pediatr Dermatol 8:267-76. 1991
    ..The recurrence rate in 23 lesions treated by shave (intradermal) excision and cautery or cautery alone was 43.5%...
  91. ncbi request reprint Craniofacial, temporal bone, and audiologic abnormalities in the spectrum of hemifacial microsomia
    R Rahbar
    Department of Otolaryngology and Communication Disorders, The Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 127:265-71. 2001
    ....
  92. pmc Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells
    Y Yu
    Surgical Research Laboratory, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 159:2271-80. 2001
    ..These findings implicate Tie2 and its ligands Ang1 and Ang2 in the pathogenesis of hemangioma...
  93. ncbi request reprint Three-dimensional prenatal diagnosis of frontonasal malformation and unilateral cleft lip/palate
    T D Shipp
    Department of Obstetrics and Gynecology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ultrasound Obstet Gynecol 20:290-3. 2002
    ..Three-dimensional sonography with multiplanar reconstruction and surface-rendering were essential to establish the diagnosis of frontonasal malformation with severe nasal hypoplasia and unilateral complete cleft lip/palate...
  94. ncbi request reprint Facial infiltrating lipomatosis
    B L Padwa
    Craniofacial Centre and Division of Plastic and Oral Surgery at Children's Hospital, Harvard School of Dental Medicine and Harvard Medical School, Boston, MA 02115, USA
    Plast Reconstr Surg 108:1544-54. 2001
    ..Results of DNA analyses for these germline mutations were negative. It is more likely that this disorder is caused by a somatic mutation involving a local increase in growth factor(s)...
  95. ncbi request reprint Propranolol targets the contractility of infantile haemangioma-derived pericytes
    D Lee
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital, 300 Longwood Avenue, Boston, MA, 02115, U S A
    Br J Dermatol 171:1129-37. 2014
    ..Dramatic fading of cutaneous colour is often seen a short time after initiating propranolol therapy, with accelerated regression of IH blood vessels discerned after weeks to months...
  96. ncbi request reprint Hermann Friedberg's case report: an early description of CLOVES syndrome
    A I Alomari
    Division of Vascular and Interventional Radiology, Children s Hospital Boston, Boston, MA 02115, USA
    Clin Genet 78:342-7. 2010
    ..Careful analysis of the case report by the German physician Hermann Friedberg "gigantism of the right lower limb" published in 1867 revealed that the report probably represents one of the first written accounts of CLOVES syndrome...
  97. ncbi request reprint Vascular malformations of the upper limb: a review of 270 patients
    J Upton
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA, USA
    J Hand Surg Am 24:1019-35. 1999
    ..The complication rate was 22% for slow-flow lesions and 28% for fast-flow lesions...
  98. ncbi request reprint Unilateral coronal synostosis: a histomorphometric study
    H Vastardis
    Department of Growth and Development, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    Cleft Palate Craniofac J 41:439-46. 2004
    ..This histomorphometric study compared the open and prematurely fused side of the coronal suture in subjects with unilateral coronal synostosis (UCS)...
  99. ncbi request reprint Assignment of a locus for dominantly inherited venous malformations to chromosome 9p
    L M Boon
    Division of Plastic Surgery, Children s Hospital, Boston, MA
    Hum Mol Genet 3:1583-7. 1994
    ..Characterization of the gene responsible for this disorder should yield insights into the precise pathogenic mechanisms for venous malformations...
  100. ncbi request reprint Intracranial vascular anomalies in patients with periorbital lymphatic and lymphaticovenous malformations
    A Bisdorff
    Vascular Anomalies Center, Department of Radiology and Division of Plastic Surgery, Children s Hospital, Harvard Medical School, Boston, Mass, USA
    AJNR Am J Neuroradiol 28:335-41. 2007
    ..The purpose of this study was to determine the nature, incidence, and radiologic appearance of intracranial vascular anomalies that occur in association with periorbital lymphatic malformation (LM) and lymphaticovenous malformation (LVM)...
  101. ncbi request reprint Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
    M Vikkula
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 87:1181-90. 1996
    ..We conclude that an activating mutation in TIE2 causes inherited VMs in the two families and that the TIE2 signaling pathway is critical for endothelial cell-smooth muscle cell communication in venous morphogenesis...