Affiliation: Harvard University
- Effect of deletion of the major brain G-protein alpha subunit (alpha(o)) on coordination of G-protein subunits and on adenylyl cyclase activityU Mende
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Neurosci Res 54:263-72. 1998..We propose that alpha(o) and its associated betagamma are sequestered in a distinct pool of membranes that does not contribute to the regulation of adenylyl cyclase...
- Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein alpha(q)U Mende
Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circ Res 85:1085-91. 1999..It is likely that such changes occur in other model systems in which the activity of a single signaling component is increased, either due to an activating mutation or due to overexpression of the wild type...
- Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathwaysU Mende
Cardiovascular Division, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 95:13893-8. 1998..Treating HAalpha*q mice with CsA diminished some, but not all, aspects of the hypertrophic phenotype, suggesting that multiple pathways are involved...
- Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotypeU Mende
Department of Medicine, Cardiovascular Divison, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Mol Cell Cardiol 33:1477-91. 2001..The markedly different ages of disease onset in these two mouse lines provide a model for studying both genetic modifying factors and potential environmental influences in DCM...
- Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o)G J Greif
Department of Neurobiology, Harvard Medical School, Massachusetts 02115, USA
J Neurophysiol 83:1010-8. 2000..A likely possibility is that the very abundant Galpha(o) is normally used but, when absent, can readily be replaced by G proteins with different properties...