Rachel M McLoughlin
Affiliation: Harvard University
- Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammationRachel M McLoughlin
Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
J Clin Invest 112:598-607. 2003..These data emphasize a pivotal role for IFN-gamma in regulating innate immunity through control of both the recruitment and clearance phases of PMN trafficking...
- IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infectionRachel M McLoughlin
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:1323-32. 2008..aureus pathogenesis by facilitating bacterial survival within the neutrophil. These findings suggest avenues for novel immunomodulatory approaches to control S. aureus infections...
- Characterization of regulatory T cells in urban newbornsNgoc P Ly
Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
Clin Mol Allergy 7:8. 2009..The objective of this study was to compare Treg phenotype and function in cord blood (CB) of newborns to those in peripheral blood (PB) of a subset of participating mothers...
- A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2Qun Wang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 203:2853-63. 2006..fragilis. Commensal bacteria, using molecules like PSA, potentially modulate the Th1/Th2 cell balance and the response to infection by coordinating both the innate and adaptive pathways...
- CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infectionsRachel M McLoughlin
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:10408-13. 2006..aureus infections in controlling local CXC chemokine production, neutrophil recruitment to the site of infection, and subsequent bacterial replication...
- Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infectionJerry C Lee
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 78:4176-86. 2010..We propose a novel role for a HABP as an innate immunomodulator in the treatment of MSSA and MRSA surgical wound infection through enhancement of the local CXC chemokine-driven neutrophil response...
- Bacteroides fragilis-stimulated interleukin-10 contains expanding diseaseRonit Cohen-Poradosu
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Infect Dis 204:363-71. 2011..Deaths were due to exuberant proinflammatory responses, not increased bacterial burden. During infection or commensalism, induction of IL-10 by B. fragilis is critical to this microbe's interactions with the immune system...
- The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanismChristopher Weidenmaier
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e13227. 2010..An understanding of this novel T cell-dependent host response to staphylococcal abscess formation may lead to the development of new strategies to combat S. aureus skin and soft tissue infections...
- Hyaluronic acid binding peptides prevent experimental staphylococcal wound infectionKathleen J Zaleski
Shire Pharmaceuticals, 700 Main Street, Cambridge, MA 02139, USA
Antimicrob Agents Chemother 50:3856-60. 2006..These data suggest a novel approach for the treatment and prophylaxis of staphylococcal wound infections in the clinical setting...
- Viral IL-6 blocks neutrophil infiltration during acute inflammationCeri A Fielding
Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Wales, United Kingdom
J Immunol 175:4024-9. 2005..These data suggest that vIL-6 has the capacity to suppress innate immune responses and thereby influence the outcome of opportunistic infections in HHV8-associated disease...
- Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoformsRachel M McLoughlin
Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom
J Immunol 172:5676-83. 2004..These data confirm that sIL-6R-mediated signaling primarily limits neutrophil influx; however, induction of CXCL5 and CXCL6 may regulate other neutrophil responses...
- Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritisPeter J Richards
Cardiff University, Cardiff, UK
Arthritis Rheum 54:1662-72. 2006..The aim of this study was to evaluate the functional properties of gp130-RAPS...
- IL-6 regulates neutrophil trafficking during acute inflammation via STAT3Ceri A Fielding
Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
J Immunol 181:2189-95. 2008....
- IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammationRachel M McLoughlin
Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom
Proc Natl Acad Sci U S A 102:9589-94. 2005..Consequently, STAT3 plays a defining role in IL-6-mediated T cell migration...
- Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cellsSuzanne M Hurst
Cardiff School of Biosciences, Cardiff University, Institute of Nephrology, University of Wales College of Medicine, United Kingdom
J Immunol 169:5244-51. 2002..Thus suggesting that OSM and sIL-6R release from infiltrating neutrophils may contribute to the temporal switch between neutrophil influx and mononuclear cell recruitment seen during acute inflammation...