Jarema J Malicki

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet
    J Malicki
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Bldg 149, Charlestown, MA 02129, USA
    Development 126:1235-46. 1999
  2. ncbi request reprint Forward and reverse genetic approaches to the analysis of eye development in zebrafish
    Jarema J Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02110, USA
    Vision Res 42:527-33. 2002
  3. ncbi request reprint Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning
    Jarema Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Dev Biol 259:95-108. 2003
  4. ncbi request reprint Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons
    Motokazu Tsujikawa
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02110, USA
    Neuron 42:703-16. 2004
  5. ncbi request reprint Approaches to study neurogenesis in the zebrafish retina
    Andrei Avanesov
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Methods Cell Biol 76:333-84. 2004
  6. ncbi request reprint Genetics of photoreceptor development and function in zebrafish
    Motokazu Tsujikawa
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02110, USA
    Int J Dev Biol 48:925-34. 2004
  7. ncbi request reprint Retinal pattern and the genetic basis of its formation in zebrafish
    Zac Pujic
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02110, USA
    Semin Cell Dev Biol 15:105-14. 2004
  8. pmc The role of crumbs genes in the vertebrate cornea
    Jill Beyer
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:4549-56. 2010
  9. ncbi request reprint Analysis of gene function in the zebrafish retina
    Jarema Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Methods 28:427-38. 2002
  10. pmc The apical complex couples cell fate and cell survival to cerebral cortical development
    Seonhee Kim
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Neuron 66:69-84. 2010

Research Grants

  1. The Zebrafish Model of Microphthalmia
    Jarema Malicki; Fiscal Year: 2008

Collaborators

Detail Information

Publications24

  1. ncbi request reprint oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet
    J Malicki
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Bldg 149, Charlestown, MA 02129, USA
    Development 126:1235-46. 1999
    ..These cell-cell interactions may play a critical role in the patterning events that lead to differentiation of distinct neuronal laminae in the vertebrate retina...
  2. ncbi request reprint Forward and reverse genetic approaches to the analysis of eye development in zebrafish
    Jarema J Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02110, USA
    Vision Res 42:527-33. 2002
    ..These recent advances, combined with the genome project, have established the zebrafish as one of the leading models for studies of visual system development...
  3. ncbi request reprint Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning
    Jarema Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Dev Biol 259:95-108. 2003
    ..The late onset of mutant N-cadherin phenotypes may be due to the ability of classic cadherins to substitute each other's function...
  4. ncbi request reprint Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons
    Motokazu Tsujikawa
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02110, USA
    Neuron 42:703-16. 2004
    ..These studies reveal an essential role for IFT genes in vertebrate sensory neurons and implicate the molecular components of intraflagellar transport in degenerative disorders of these cells...
  5. ncbi request reprint Approaches to study neurogenesis in the zebrafish retina
    Andrei Avanesov
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Methods Cell Biol 76:333-84. 2004
    ..As new techniques are being introduced and improved at a rapid pace, the zebrafish will continue to be an important organism for the studies of the vertebrate visual system...
  6. ncbi request reprint Genetics of photoreceptor development and function in zebrafish
    Motokazu Tsujikawa
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02110, USA
    Int J Dev Biol 48:925-34. 2004
    ..These mutant strains are currently studied using both molecular and embryological tools and provide important insights into photoreceptor biology...
  7. ncbi request reprint Retinal pattern and the genetic basis of its formation in zebrafish
    Zac Pujic
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02110, USA
    Semin Cell Dev Biol 15:105-14. 2004
    ..Genetic analysis in zebrafish reveals mechanisms that are essential for the formation of this architecture...
  8. pmc The role of crumbs genes in the vertebrate cornea
    Jill Beyer
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:4549-56. 2010
    ..To evaluate the role of crumbs genes and related epithelial polarity loci in the vertebrate cornea...
  9. ncbi request reprint Analysis of gene function in the zebrafish retina
    Jarema Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Methods 28:427-38. 2002
    ..Some of these rely on the overexpression of a gene product, others take advantage of antisense oligonucleotides to block function of selected loci. Here we describe these methods in the context of the developing eye...
  10. pmc The apical complex couples cell fate and cell survival to cerebral cortical development
    Seonhee Kim
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Neuron 66:69-84. 2010
    ..These data highlight unexpected roles of the apical complex protein Pals1 in cell survival through interactions with mTOR signaling...
  11. pmc Zebrafish ale oko, an essential determinant of sensory neuron survival and the polarity of retinal radial glia, encodes the p50 subunit of dynactin
    Xiaotang Jing
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Development 136:2955-64. 2009
    ....
  12. ncbi request reprint nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina
    Xiangyun Wei
    Department of Ophthalmology, Harvard Medical School MEEI, 243 Charles Street, Boston, Massachusetts 02114, USA
    Nat Genet 31:150-7. 2002
    ..We propose that nok function in patterning of postmitotic neurons is mediated through neuroepithelial cells and is necessary for guiding neurons to their proper destinations in retinal laminae...
  13. pmc Mechanism of positioning the cell nucleus in vertebrate photoreceptors
    Motokazu Tsujikawa
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:14819-24. 2007
    ..These findings reveal an important mechanism that regulates nuclear position in vertebrate neurons...
  14. ncbi request reprint Mutations that affect the survival of selected amacrine cell subpopulations define a new class of genetic defects in the vertebrate retina
    Andrei Avanesov
    Department of Ophthalmology, Harvard Medical School MEEI, 243 Charles Street, Boston, MA 02114, USA
    Dev Biol 285:138-55. 2005
    ..These results indicate that environmental factors, possibly interactions among different subpopulations of amacrine neurons, are involved in the development of the amacrine cell class...
  15. ncbi request reprint Genetic analysis of photoreceptor cell development in the zebrafish retina
    Geoffrey Doerre
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Mech Dev 110:125-38. 2002
    ..These experiments identify distinct phenotypic categories of photoreceptor mutants and indicate that zebrafish photoreceptor defects involve both cell-autonomous and cell-nonautonomous mechanisms...
  16. ncbi request reprint Genetic defects of pronephric cilia in zebrafish
    Chengtian Zhao
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Mech Dev 124:605-16. 2007
    ..Mutants characterized in this study reveal intriguing genetic differences between subpopulations of embryonic cilia, and provide an opportunity to study several aspects of cilia structure and function...
  17. ncbi request reprint A screen for genetic defects of the zebrafish ear
    Andria Schibler
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Mech Dev 124:592-604. 2007
    ..As it proved to be the case in past screening efforts of this type, these mutant lines represent an asset in the studies of molecular mechanisms that regulate vertebrate ear development...
  18. ncbi request reprint oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo
    Yoshihiro Omori
    Department of Ophthalmology, Harvard Medical School, MEEI, R513, 243 Charles Street, Boston, Massachusetts 02114, USA
    Curr Biol 16:945-57. 2006
    ..In other tissues, apical specializations are responsible for the propagation of fluid flow. Despite its importance, the role of genetic determinants of apico-basal polarity in vertebrate embryogenesis remains poorly investigated...
  19. ncbi request reprint Reverse genetic analysis of neurogenesis in the zebrafish retina
    Zac Pujic
    Department of Ophthalmology, Harvard Medical School, MEEI, R513, 243 Charles Street, Boston, MA 02114, USA
    Dev Biol 293:330-47. 2006
    ..This approach very well complements forward genetic mutagenesis studies previously used to study retinal neurogenesis in zebrafish...
  20. ncbi request reprint Cell fate decisions and patterning in the vertebrate retina: the importance of timing, asymmetry, polarity and waves
    Jarema Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02110, USA
    Curr Opin Neurobiol 14:15-21. 2004
    ....
  21. ncbi request reprint High-throughput behavioral screening method for detecting auditory response defects in zebrafish
    Pascal I Bang
    Department of Otolaryngology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Neurosci Methods 118:177-87. 2002
    ..Nearly all of those showed abnormalities in conductive elements of the auditory system: the swim bladder or Weberian ossicles...
  22. doi request reprint Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8
    Yoshihiro Omori
    Department of Ophthalmology, Harvard Medical School, MEEI, R513, 243 Charles St Boston, MA 02114, USA
    Nat Cell Biol 10:437-44. 2008
    ..We show that Rabaptin5 binds to both Elipsa and Rab8, suggesting that these proteins provide a bridging mechanism between the IFT particle and protein complexes that assemble at the ciliary membrane...
  23. ncbi request reprint The zebrafish eye: developmental and genetic analysis
    Stephen S Easter
    Dept of Molecular, Cellular, and Developmental Biology, University of Michigan, 830N University Ave, Ann Arbor, Michigan 48109 1048, USA
    Results Probl Cell Differ 40:346-70. 2002
    ..Substantial though it is, this contribution will grow rapidly in the next few years as the advances of zebrafish genetics are accelerated by progress of genomics, especially the zebrafish genome project...

Research Grants1

  1. The Zebrafish Model of Microphthalmia
    Jarema Malicki; Fiscal Year: 2008
    ..These studies will provide insight into the genetic basis of this debilitating disorder that affects 1 in 5,000 children. [unreadable] [unreadable] [unreadable]..