J Ma

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    J Ma
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 94:2410-6. 1996
  2. ncbi request reprint Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
  3. ncbi request reprint Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
  4. ncbi request reprint Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
  5. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
  6. ncbi request reprint Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men
    J Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1330-6. 2001
  7. ncbi request reprint Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study
    J M Chan
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 74:549-54. 2001
  8. pmc Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study
    X Zhang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA
    Br J Cancer 106:1335-41. 2012
  9. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
  10. ncbi request reprint The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:743-8. 2001

Detail Information

Publications44

  1. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    J Ma
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 94:2410-6. 1996
    ..A common mutation in MTHFR recently has been identified...
  2. ncbi request reprint Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
    ..This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment...
  3. ncbi request reprint Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
    ..It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies...
  4. ncbi request reprint Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
    ..We therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer in a prospective case-control study nested in the Physicians' Health Study...
  5. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
    ....
  6. ncbi request reprint Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men
    J Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1330-6. 2001
    ..A high ratio of IGF-I to IGF-binding protein-3 (IGFBP-3) has been linked to an increased risk of colorectal cancer...
  7. ncbi request reprint Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study
    J M Chan
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 74:549-54. 2001
    ..The results of epidemiologic studies of this hypothesis are inconclusive...
  8. pmc Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study
    X Zhang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA
    Br J Cancer 106:1335-41. 2012
    ..Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive...
  9. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
    ..Moreover, the A870G genotype may enhance the protective effect of postmenopausal oestrogen use on the development of colorectal neoplasia...
  10. ncbi request reprint The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:743-8. 2001
    ..These results suggest that CYP17 genotype may possibly confer a small increased susceptibility to prostate cancer but is not a strong predictor of endogenous steroid hormone levels in men...
  11. pmc Effects of G/A polymorphism, rs266882, in the androgen response element 1 of the PSA gene on prostate cancer risk, survival and circulating PSA levels
    C Jesser
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Br J Cancer 99:1743-7. 2008
    ..Meta-analysis of 12 studies of rs266882 and overall prostate cancer risk was null...
  12. pmc Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
    B M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Cancer 97:98-104. 2007
    ..In four prospective cohorts, we found no association between the risk of pancreatic cancer and prediagnostic plasma levels of IGF-I, IGF-II, or IGFBP-3...
  13. ncbi request reprint Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction
    L M Hines
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    N Engl J Med 344:549-55. 2001
    ..We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study...
  14. ncbi request reprint A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma
    H Grasemann
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biochem Biophys Res Commun 272:391-4. 2000
    ..Total serum IgE was not associated with any allele of the polymorphism. These findings provide support, from case-control association analysis, for NOS1 as a candidate gene for asthma...
  15. ncbi request reprint Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators
    C Deal
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    J Clin Endocrinol Metab 86:1274-80. 2001
    ..The IGFBP3 promoter region deserves investigation as a locus where polymorphic variation occurs frequently and may influence GH responsiveness, somatic growth, and possibly cancer risk...
  16. ncbi request reprint A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice
    J F Chen
    Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 19:9192-200. 1999
    ....
  17. ncbi request reprint Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency
    N J Brown
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    Kidney Int 72:72-81. 2007
    ..We conclude that Ang II stimulates PAI-1 expression in part through the AT(1b) receptor in the kidney and liver. Further, norepinephrine induces PAI-1 expression in vivo with AT(1a) receptor deficiency modulating the effect...
  18. ncbi request reprint Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations
    J Ma
    Bio X Center, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Mol Psychiatry 11:479-87. 2006
    ..Overall, our data give further support to the existing evidence that G72/G30 genes are involved in conferring susceptibility to schizophrenia...
  19. ncbi request reprint Altered neurotrophin receptor function in the developing prefrontal cortex leads to adult-onset dopaminergic hyperresponsivity and impaired prepulse inhibition of acoustic startle
    N Rajakumar
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Biol Psychiatry 55:797-803. 2004
    ..Since neurotrophins play an important role in these events, behavioral effects relevant to schizophrenia were investigated in rats that had compromised neurotrophin function during prefrontal cortical development...
  20. ncbi request reprint Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury
    J Ma
    Division of Pediatric Nephrology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    Kidney Int 69:1064-72. 2006
    ..05). Aldosterone induced cardiac hypertrophy but not fibrosis in WT and PAI-1(-/-) mice. PAI-1 contributes to aldosterone-induced glomerular injury...
  21. ncbi request reprint Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis
    H C Yang
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 69:1756-64. 2006
    ..We conclude that treatment with PPARgamma agonist has protective effects on progression of glomerulosclerosis...
  22. pmc Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of Type 1 diabetes and diabetic nephropathy
    J Ma
    Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
    Diabet Med 23:1093-9. 2006
    ..ICAM-1 expression is related to development of T1D and diabetic nephropathy. The present study aims to evaluate the genetic influence of ICAM-1 gene polymorphisms on the development of T1D and diabetic nephropathy...
  23. ncbi request reprint Further evidence that the chromogranin B gene confers predisposition to schizophrenia: a family-based association study in Chinese
    S Wu
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
    J Neural Transm 114:641-4. 2007
    ..0018). Overall, our results suggest that at least one locus in or close to the CHGB gene confers risk of the disorder and strengthen the evidence that CHGB is a promising susceptibility gene for schizophrenia in Chinese population...
  24. ncbi request reprint Perfusion MRI before and after acetazolamide administration for assessment of cerebrovascular reserve capacity in patients with symptomatic internal carotid artery (ICA) occlusion: comparison with 99mTc-ECD SPECT
    J Ma
    Department of Neuroradiology, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany
    Neuroradiology 49:317-26. 2007
    ....
  25. ncbi request reprint Atomic force and confocal microscopy for the study of cortical cells cultured on silicon wafers
    J Ma
    Department of Material Science and Engineering, Tsinghua University, Beijing, PR China
    J Mater Sci Mater Med 18:851-6. 2007
    ..It is suggested that the porous structures are made of extracellular matrix (ECM) components and play an important role in the neuronal adhesion and neurite outgrowth on the inert silicon wafers...
  26. ncbi request reprint Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A
    J Ma
    Hollings Cancer Center at the Medical University of South Carolina, Charleston, SC 29425, USA
    Oncogene 26:5145-53. 2007
    ..On the basis of these observations, we hypothesize that phosphorylated Pim-1 binds Pin1 allowing the interaction of PP2A through B56beta. Dephosphorylation of Pim-1 then allows for ubiquitinylation and protein degradation of Pim-1...
  27. pmc No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk
    K Fall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Prostate 68:1416-20. 2008
    ..We assessed the influence of the most common IRS-1 gene polymorphism (Gly972Arg) on prostate cancer risk, alone and in combination with IGF-1 and other components in the IGF-1 signaling pathway...
  28. ncbi request reprint Protein kinase C expression in salivary gland acinar epithelial cells in non-obese diabetic mice, an experimental model for Sjögren's syndrome
    E K Tensing
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Rheumatol Int 25:28-32. 2005
    ..The lack of PKC alpha and beta isoforms found in Sjögren's syndrome was not reproduced in NOD mice, which discloses one more difference between the human disease and its NOD mouse model...
  29. ncbi request reprint Expression of proteasome subunit isoforms during spermatogenesis in Drosophila melanogaster
    J Ma
    Department of Biology, Syracuse University, Syracuse, New York, USA
    Insect Mol Biol 11:627-39. 2002
    ..These results suggest a possible role of a 'spermatogenesis-specific' proteasome in sperm differentiation and/or function...
  30. ncbi request reprint Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression
    J Ma
    Neurosurgical Services and Neurology Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Physiol 270:H1085-90. 1996
    ....
  31. ncbi request reprint L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice
    J Ma
    Department of Neurosurgery and Neurology, Massachusetts General Hospital, Charlestown, USA
    Am J Physiol 271:H1717-9. 1996
    ..L-NNA superfusion (1 mM) inhibited this increase by approximately 60% in both strains. Hence, synthesis of NO by the constitutively expressed type I NOS contributes to blood flow augmentation during hypercapnia...
  32. ncbi request reprint CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 50:1111-7. 1996
    ....
  33. ncbi request reprint Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
    Y Pan
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Nature 387:611-7. 1997
    ..Consequently we propose that neurotactin represents a new delta-chemokine family and that it may play a role in brain inflammation processes...
  34. ncbi request reprint CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 51:931-43. 1997
    ....
  35. pmc Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus
    S J Busfield
    Millennium Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 17:4007-14. 1997
    ..In contrast to those of neuregulin, high levels of expression of Don-1 are restricted to the cerebellum and dentate gyrus in the adult brain and to fetal tissues...
  36. ncbi request reprint Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
    J Li
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:917-27. 1997
    ..We discuss a pathogenic pathway for familial Alzheimer's disease in which defective presenilin function causes chromosome missegregation during mitosis, resulting in apoptosis and/or trisomy 21 mosaicism...
  37. ncbi request reprint Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4
    J Ma
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genomics 49:152-5. 1998
    ..3-p31.2 by fluorescence in situ hybridization analysis. The proximity of the Cyp2j cluster to the Cyp4a cluster suggests that these genes may be part of a cassette of P450 genes involved in the oxidation of fatty acids...
  38. ncbi request reprint Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men
    H Nishimura
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Mol Cell 3:1-10. 1999
    ....
  39. ncbi request reprint Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene
    R Y Nagaraj
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4963, USA
    Physiol Genomics 4:43-9. 2000
    ..Our results indicate that fatiguing affects the E-C components of the mutant EDL and SOL muscles, and the effect of fatigue in these mutant muscles could be primarily due to an alteration in the intracellular Ca homeostasis...
  40. ncbi request reprint Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study
    D Tang
    Division of Environmental Health Sciences, Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Res 61:6708-12. 2001
    ..The findings are of interest because they suggest that individuals who become cases have greater biological susceptibility to tobacco carcinogens, a biological difference, which manifests most clearly while exposure is ongoing...
  41. ncbi request reprint Telomerase activity and homozygous deletions of the p16 gene in liver metastases of colorectal carcinoma
    J Ma
    Department of Gastrointestinal and Pancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China
    Chin Med J (Engl) 114:1068-72. 2001
    ..However, telomerase activation and homozygous deletions of the p16 gene might not be the initiating event in liver metastases of colorectal carcinoma...
  42. ncbi request reprint [A case-control study on the risk factors of stomach cancer in Tianjin city]
    X Liu
    Department of Epidemiology, Tianjin Medical University, Tianjin 300070, China
    Zhonghua Liu Xing Bing Xue Za Zhi 22:362-4. 2001
    ..46, 95% CI: 1.05-2.02) were risk factors for stomach cancer. CONCLUSION: Frequent eating smoked food, cigarettes smoking, heavy salt intake and over intake of meats were risk factors for stomach cancer...
  43. ncbi request reprint [A case-control study of risk factors for type 2 diabetes mellitus]
    J Ma
    Public Health College, Tianjin Medical University, Tianjin 300070, China
    Zhonghua Liu Xing Bing Xue Za Zhi 22:365-7. 2001
    ..530 (95% CI: 1.234-1.896), 4.833 (95% CI: 1.966-11.703), 21.996 (95% CI: 5.461-88.593), respectively. CONCLUSION: Insulin resistance was risk factor causing type 2 diabetes mellitus, independent of other risk factors...
  44. ncbi request reprint Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses
    J Ma
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    J Immunol 157:417-26. 1996
    ..They also suggest that different mechanisms may be responsible for eliciting autoantibody responses in lpr/lpr mice...