Ruth Luthi-Carter

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
    Alexandre Kuhn
    Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Hum Mol Genet 16:1845-61. 2007
  2. pmc Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood
    Heike Runne
    Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:14424-9. 2007
  3. ncbi request reprint Progress towards a vaccine for Huntington's disease
    Ruth Luthi-Carter
    Massachusetts General Hospital, Charlestown 02129, USA
    Mol Ther 7:569-70. 2003
  4. ncbi request reprint Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1927-37. 2002
  5. ncbi request reprint Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease
    Boris S Spektor
    Department of Neurology and Center for Aging, Genetics, and Neurodegeneration, Neurology B114 2001, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129 4404, USA
    Brain Res Mol Brain Res 102:118-28. 2002
  6. ncbi request reprint Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1911-26. 2002
  7. ncbi request reprint Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo
    Delphine Charvin
    Signalisation Neuronale et Régulations Géniques, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, UMR 7102, 9 quai Saint Bernard, 75005 Paris, France
    Neurobiol Dis 29:22-9. 2008
  8. ncbi request reprint Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation
    Ruth Luthi-Carter
    MassGeneral Institute for Neurodegenerative Diseases, B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
    Neurobiol Dis 14:624-36. 2003
  9. ncbi request reprint Modulation of nucleosome dynamics in Huntington's disease
    Edward C Stack
    Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford, MA 01730, USA
    Hum Mol Genet 16:1164-75. 2007
  10. ncbi request reprint Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease
    Edmond Y W Chan
    Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children s and Women s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, V5H 4H4
    Hum Mol Genet 11:1939-51. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
    Alexandre Kuhn
    Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Hum Mol Genet 16:1845-61. 2007
    ....
  2. pmc Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood
    Heike Runne
    Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:14424-9. 2007
    ..2005) Proc Natl Acad Sci USA 102:11023-11028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies...
  3. ncbi request reprint Progress towards a vaccine for Huntington's disease
    Ruth Luthi-Carter
    Massachusetts General Hospital, Charlestown 02129, USA
    Mol Ther 7:569-70. 2003
  4. ncbi request reprint Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1927-37. 2002
    ..These results demonstrate that some of the gene expression effects of expanded polyglutamine proteins occur independently of protein context...
  5. ncbi request reprint Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease
    Boris S Spektor
    Department of Neurology and Center for Aging, Genetics, and Neurodegeneration, Neurology B114 2001, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129 4404, USA
    Brain Res Mol Brain Res 102:118-28. 2002
    ..Understanding the functional bases for these effects may further elucidate the complex pathophysiology of Huntington's disease...
  6. ncbi request reprint Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1911-26. 2002
    ..The complete dataset is available at www.neumetrix.info...
  7. ncbi request reprint Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo
    Delphine Charvin
    Signalisation Neuronale et Régulations Géniques, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, UMR 7102, 9 quai Saint Bernard, 75005 Paris, France
    Neurobiol Dis 29:22-9. 2008
    ..These findings indicate that D2 receptors activation contributes to the deleterious effects of expHtt on striatal function and may represent an interesting early target to alter the subsequent course of neuropathology in HD...
  8. ncbi request reprint Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation
    Ruth Luthi-Carter
    MassGeneral Institute for Neurodegenerative Diseases, B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
    Neurobiol Dis 14:624-36. 2003
    ..Taken together, these data demonstrate multiple levels of NMDA receptor dysregulation, including abnormalities in mRNA expression levels, receptor stoichiometry, protein phosphorylation, and receptor trafficking...
  9. ncbi request reprint Modulation of nucleosome dynamics in Huntington's disease
    Edward C Stack
    Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford, MA 01730, USA
    Hum Mol Genet 16:1164-75. 2007
    ..These data show the ability of anthracycline compounds to rebalance epigenetic histone modification and, as such, may provide the rationale for the design of human clinical trials in HD patients...
  10. ncbi request reprint Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease
    Edmond Y W Chan
    Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children s and Women s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, V5H 4H4
    Hum Mol Genet 11:1939-51. 2002
    ..Furthermore, our findings suggest that short N-terminal fragments of mutant htt might be responsible for the gene expression alterations observed in human HD brain...
  11. ncbi request reprint Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice
    Edward C Stack
    Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA
    J Neurosci 27:12908-15. 2007
    ..Thus, modulation of synaptic influences continues to have therapeutic potential in HD...
  12. ncbi request reprint Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease
    Valérie Perrin
    Ecole Polytechnique Federale de Lausanne EPFL, Brain Mind Institute, Lausanne, Switzerland
    Mol Ther 15:903-11. 2007
    ..Finally, hsp104 induced the production of endogenous hsp27. These data demonstrate the protective effects of chaperones in mammalian models of HD...
  13. ncbi request reprint Regional and cellular gene expression changes in human Huntington's disease brain
    Angela Hodges
    Department of Psychological Medicine, Wales College of Medicine and School of Biosciences, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Hum Mol Genet 15:965-77. 2006
    ..These data from bona fide HD brains comprise an important reference for hypotheses related to HD and other neurodegenerative diseases...
  14. ncbi request reprint Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1
    Birgit Zucker
    Department of Neurology, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Hum Mol Genet 14:179-89. 2005
    ....
  15. ncbi request reprint Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice
    Robert J Ferrante
    Geriatric Research Education and Clinical Center, Bedford Veterans Affairs Medical Center, Bedford, Massachusetts 01730, USA
    J Neurosci 23:9418-27. 2003
    ....
  16. doi request reprint Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry
    Heike Runne
    Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Switzerland
    J Neurosci 28:9723-31. 2008
    ....