Sutada Lotinun

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Activin receptor signaling: a potential therapeutic target for osteoporosis
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Curr Mol Pharmacol 5:195-204. 2012
  2. doi request reprint A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Bone 46:1082-8. 2010
  3. pmc Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH
    Vaibhav Saini
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 288:20122-34. 2013
  4. pmc Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
    Yanqiu Liu
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Clin Invest 122:3101-13. 2012
  5. pmc Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo
    Shriram Nallamshetty
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e71307. 2013
  6. pmc MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice
    Weiguo Zou
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 121:4383-92. 2011
  7. pmc Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Clin Invest 123:666-81. 2013
  8. pmc Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
    Keertik Fulzele
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom St, Thier 1101, Boston, MA 02114, USA
    Blood 121:930-9. 2013
  9. pmc Loss of BMPR2 leads to high bone mass due to increased osteoblast activity
    Jonathan W Lowery
    Department of Biomedical Science, Marian University College of Osteopathic Medicine, Indianapolis, IN 46222, USA Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Cell Sci 128:1308-15. 2015
  10. pmc Caloric restriction leads to high marrow adiposity and low bone mass in growing mice
    Maureen J Devlin
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:2078-88. 2010

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Activin receptor signaling: a potential therapeutic target for osteoporosis
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Curr Mol Pharmacol 5:195-204. 2012
    ..These data provide evidence of a dual anabolic antiresorptive effect of the soluble ActRIIA-Fc fusion protein in the skeleton. Therefore, targeting activin receptor signaling may be useful for therapeutic intervention in osteoporosis...
  2. doi request reprint A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Bone 46:1082-8. 2010
    ..Thus, soluble ActRIIA fusion protein may be useful in the prevention and/or treatment of osteoporosis and other diseases involving accelerated bone loss...
  3. pmc Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH
    Vaibhav Saini
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 288:20122-34. 2013
    ..Taken together, these data indicate that PPR signaling in osteocytes is required for bone remodeling, and receptor signaling in osteocytes is needed for anabolic and catabolic skeletal responses. ..
  4. pmc Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
    Yanqiu Liu
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Clin Invest 122:3101-13. 2012
    ..Importantly, our data support a model whereby VEGF regulates differentiation through an intracrine mechanism that is distinct from the role of secreted VEGF and its receptors...
  5. pmc Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo
    Shriram Nallamshetty
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e71307. 2013
    ..Collectively, these data implicate Aldh1a1 as a novel determinant of cortical bone density and marrow adiposity in the skeleton in vivo through modulation of BMP signaling. ..
  6. pmc MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice
    Weiguo Zou
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 121:4383-92. 2011
    ..Thus, our results provide a putative biochemical mechanism for the skeletal defects in human FGDY and suggest that modulating MAPK signaling may benefit these patients...
  7. pmc Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Clin Invest 123:666-81. 2013
    ..Our data provide genetic evidence that deletion of CTSK in osteoclasts enhances bone formation in vivo by increasing the generation of osteoclast-derived S1P...
  8. pmc Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
    Keertik Fulzele
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom St, Thier 1101, Boston, MA 02114, USA
    Blood 121:930-9. 2013
    ....
  9. pmc Loss of BMPR2 leads to high bone mass due to increased osteoblast activity
    Jonathan W Lowery
    Department of Biomedical Science, Marian University College of Osteopathic Medicine, Indianapolis, IN 46222, USA Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Cell Sci 128:1308-15. 2015
    ..As BMP and activin pathway modulation are of current therapeutic interest, our findings provide important mechanistic insight into the relationship between these pathways in human health...
  10. pmc Caloric restriction leads to high marrow adiposity and low bone mass in growing mice
    Maureen J Devlin
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:2078-88. 2010
    ..These results support the hypothesis that caloric restriction during rapid skeletal growth is deleterious to cortical and trabecular bone mass and architecture, in contrast to potential skeletal benefits of CR in aging animals...
  11. pmc Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus
    Glenn C Rowe
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    J Bone Miner Res 27:1649-58. 2012
    ..These findings may have physiological implications because ΔFosB is expressed and regulated in the hypothalamus...
  12. pmc The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
    Matthew B Greenblatt
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:2457-73. 2010
    ..These results also suggest that selective p38beta agonists may represent attractive therapeutic agents to prevent bone loss associated with osteoporosis and aging...
  13. pmc The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification
    Annie Moisan
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
    Dev Cell 20:583-96. 2011
    ..Furthermore, the constellation of anomalies in Wtx null mice suggests that this tumor suppressor broadly regulates MPCs in multiple tissues...