Henry M Kronenberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Genetically altered mice for bone research
    H M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Musculoskelet Neuronal Interact 5:348-9. 2005
  2. ncbi request reprint Developmental regulation of the growth plate
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Nature 423:332-6. 2003
  3. ncbi request reprint PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Biol 292:116-28. 2006
  4. pmc The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1334-43. 2004
  5. pmc Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    J Clin Invest 115:1734-42. 2005
  6. pmc Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 11:161-71. 2010
  7. pmc A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes
    Sylvain Provot
    Massachusetts General Hospital Harvard Medical School, Endocrine Unit, 50 Blossom Street, Thier 1101, Boston, MA 02114 2696, USA
    Mol Cell Biol 28:344-57. 2008
  8. pmc Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 151:3502-13. 2010
  9. pmc Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
    JOY Y WU
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Invest 121:3492-504. 2011
  10. pmc Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:1949-54. 2008

Detail Information

Publications61

  1. ncbi request reprint Genetically altered mice for bone research
    H M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Musculoskelet Neuronal Interact 5:348-9. 2005
  2. ncbi request reprint Developmental regulation of the growth plate
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Nature 423:332-6. 2003
    ..The past few years have seen an enormous increase in understanding of the signalling pathways and the transcription factors that control endochondral bone development...
  3. ncbi request reprint PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Biol 292:116-28. 2006
    ..These data indicate that the delayed hypertrophy induced by PTHrP is mediated by both Runx2-dependent and -independent mechanisms...
  4. pmc The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1334-43. 2004
    ..These studies suggest that the effects of PTHrP on both the rate and extent of chondrocyte proliferation are mediated, at least in part, through suppression of p57 expression...
  5. pmc Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    J Clin Invest 115:1734-42. 2005
    ..These results demonstrate that Ihh acts on periarticular chondrocytes to stimulate their differentiation, thereby regulating the columnar cell mass independently of PTHrP...
  6. pmc Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 11:161-71. 2010
    ..Our findings indicate that the full actions of PTH require intact Wnt signaling but that PTH can activate the Wnt pathway despite overexpression of Dkk1...
  7. pmc A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes
    Sylvain Provot
    Massachusetts General Hospital Harvard Medical School, Endocrine Unit, 50 Blossom Street, Thier 1101, Boston, MA 02114 2696, USA
    Mol Cell Biol 28:344-57. 2008
    ....
  8. pmc Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 151:3502-13. 2010
    ..Furthermore, PTH stimulated proliferation and increased mRNAs encoding cyclin D1 in primary osteoblasts derived from Wt but not from DSEL mice. Our data indicate that PLC signaling through the PTHR is required for skeletal homeostasis...
  9. pmc Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
    JOY Y WU
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Invest 121:3492-504. 2011
    ....
  10. pmc Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:1949-54. 2008
    ..Our results demonstrate the critical role of the Dicer-dependent pathway in the regulation of chondrocyte proliferation and differentiation during skeletal development...
  11. ncbi request reprint Expression of Stra13 during mouse endochondral bone development
    Helen E MacLean
    Endocrine Unit, WEL501, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
    Gene Expr Patterns 4:633-6. 2004
    ..Thus, there was a large degree of overlap in the expression patterns of Stra13 and VEGF in chondrocytes during embryonic development...
  12. pmc Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes
    Lige Song
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Bone Miner Res 27:2344-58. 2012
    ....
  13. ncbi request reprint Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation
    Sylvain Provot
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Development 133:651-62. 2006
    ..Taken together, these results suggest that PTHrP signals block chondrocyte hypertrophy by, in part, maintaining the expression of Nkx3.2/Bapx1, which in turn represses the expression of genes required for chondrocyte maturation...
  14. pmc Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration
    Dongsu Park
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 10:259-72. 2012
    ....
  15. pmc Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways
    JOY Y WU
    Endocrine Unit and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:16976-81. 2008
    ....
  16. pmc Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels
    Christa Maes
    Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Dev Cell 19:329-44. 2010
    ..These findings reveal the specific involvement of immature osteoblast precursors in the coupled vascular and osteogenic transformation essential to endochondral bone development and repair...
  17. ncbi request reprint The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Dev Cell 3:183-94. 2002
    ....
  18. pmc Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo
    Murat Bastepe
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:14794-9. 2004
    ..These data suggest that Gsalpha is the primary mediator of the actions of PPR in growth plate chondrocytes and that there is haploinsufficiency of Gsalpha signaling in Gnas(+/E2-) chondrocytes...
  19. ncbi request reprint Localization of Indian hedgehog and PTH/PTHrP receptor expression in relation to chondrocyte proliferation during mouse bone development
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Growth Differ 47:59-63. 2005
    ..This study provides further evidence that in the developing growth plate, cell cycle exit and upregulation of Ihh and PPR mRNA expression are coupled...
  20. pmc Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow
    Gregor B Adams
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:103-7. 2009
    ..Galpha(s) governs specific aspects of HSPC localization under physiological conditions in vivo and may be pharmacologically targeted to improve transplantation efficiency...
  21. pmc Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development
    Sylvain Provot
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 177:451-64. 2007
    ..In addition, mutant mice show a striking impairment of joint development. Our study demonstrates a crucial, and previously unrecognized, role of Hif-1alpha in early chondrogenesis and joint formation...
  22. pmc G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes
    Andrei S Chagin
    1 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden 2 Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Nat Commun 5:3673. 2014
    ..Thus, G(s)α is the major mediator of the anti-differentiation action of the PPR, while activation of both G(s)α and Gq/11α is required for quiescence of stem-like chondrocytes...
  23. pmc Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
    Keertik Fulzele
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom St, Thier 1101, Boston, MA 02114, USA
    Blood 121:930-9. 2013
    ....
  24. pmc Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis
    Takao Hirai
    Endocrine Unit T H, T K, S N, H M K, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Sir Mortimer B Davis Jewish General Hospital A C K, McGill University, Montreal, Quebec, Canada H3T 1E2 and Royal Victoria Hospital of the McGill University Health Centre D G, Montreal, Quebec, Canada H3A 1A1
    Endocrinology 156:2774-80. 2015
    ..They also show that PTH-independent deposition of calcium in bone is the major controller of fetal blood calcium level. ..
  25. pmc Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage
    Noriaki Ono
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Cell 29:330-9. 2014
    ..These findings reveal an emerging complexity of stromal populations, accommodating Nes(+) cells as vasculature-associated early cells in the osteoblast and endothelial lineage. ..
  26. pmc Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 154:1680-9. 2013
    ..Our data indicate that PLC signaling at the PPR contributes to the long-term effect of PTH on Pi homeostasis but not to the regulation of 1,25 dihydroxyvitamin D3, fibroblast growth factor 23, or blood Ca(2+)...
  27. ncbi request reprint Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Biol 262:51-63. 2003
    ..5 in the c-maf-null. MMP-13 is known to be regulated by AP-1 and may also be a target of c-Maf. Thus, cartilage is a novel system in which c-Maf acts during development, where c-Maf is required for normal chondrocyte differentiation...
  28. pmc Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life
    Takao Hirai
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:191-6. 2011
    ..Moreover, chondrocyte apoptosis through the activation of a mitochondrial pathway may be involved in the process of premature disappearance of the growth plate by postnatal inactivation of the PPR in chondrocytes...
  29. pmc The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification
    Annie Moisan
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
    Dev Cell 20:583-96. 2011
    ..Furthermore, the constellation of anomalies in Wtx null mice suggests that this tumor suppressor broadly regulates MPCs in multiple tissues...
  30. pmc BMP signaling stimulates cellular differentiation at multiple steps during cartilage development
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, 02114, USA
    Proc Natl Acad Sci U S A 102:18023-7. 2005
    ..These results suggest that BMP signaling in prechondrogenic cells and in growth plate chondrocytes stimulates their chondrocytic differentiation and maturation toward hypertrophy, respectively...
  31. ncbi request reprint Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactation
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Dev Dyn 233:794-803. 2005
    ..Reduced smooth muscle appears to underlie the majority of nipple deficiencies in mice with lower levels of the Ppr expression...
  32. pmc Loss of Gsα early in the osteoblast lineage favors adipogenic differentiation of mesenchymal progenitors and committed osteoblast precursors
    Partha Sinha
    Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    J Bone Miner Res 29:2414-26. 2014
    ..These findings have clinical implications for developing therapeutic approaches to direct the commitment of mesenchymal progenitors into the osteoblast lineage...
  33. pmc A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones
    Noriaki Ono
    1 Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA 2 Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA
    Nat Cell Biol 16:1157-67. 2014
    ..These cells are distinct from adult mesenchymal progenitors and thus provide opportunities for regulating the explosive growth that occurs uniquely in growing mammals. ..
  34. pmc Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation
    Wanida Ono
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Commun 7:11277. 2016
    ..These findings indicate that PPR signalling in dental mesenchymal progenitors is essential for tooth root formation, underscoring importance of the PTHrP-PPR system during root morphogenesis and tooth eruption. ..
  35. ncbi request reprint Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro
    Hong In Shin
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 145:1376-85. 2004
    ..These studies demonstrate the importance of gp130 signaling for osteoblast function and calcium homeostasis...
  36. pmc Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    Heather E Fleming
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 2:274-83. 2008
    ..Wnt pathway activation in the niche is required to limit HSC proliferation and preserve the reconstituting function of endogenous hematopoietic stem cells...
  37. ncbi request reprint PTHrP and skeletal development
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1068:1-13. 2006
    ..These pathways and undoubtedly others cooperate to regulate the pace of differentiation of growth plate chondrocytes in response to PTHrP...
  38. ncbi request reprint PTH regulates the hematopoietic stem cell niche in bone
    Henry M Kronenberg
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA
    Adv Exp Med Biol 602:57-60. 2007
  39. ncbi request reprint The role of the perichondrium in fetal bone development
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann N Y Acad Sci 1116:59-64. 2007
    ..Here I illustrate briefly examples of the complicated interactions between the perichondrium and the underlying growth cartilage...
  40. ncbi request reprint A novel transgenic mouse model to study the osteoblast lineage in vivo
    Christa Maes
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann N Y Acad Sci 1116:149-64. 2007
    ..Here, we developed a transgenic mouse system to study stage-specific subsets of osteoblast lineage cells. We believe that this system will prove to be a helpful tool in deciphering multiple aspects of osteoblast biology in vivo...
  41. doi request reprint Gs signaling in osteoblasts and hematopoietic stem cells
    Henry M Kronenberg
    Harvard Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1192:327-9. 2010
    ....
  42. ncbi request reprint Therapeutic targeting of a stem cell niche
    Gregor B Adams
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Biotechnol 25:238-43. 2007
    ..These data provide evidence that the niche may be an attractive target for drug-based stem cell therapeutics...
  43. pmc In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma
    Samantha Pozzi
    Massachusetts General Hospital Cancer Center, Boston, MA, USA
    Bone 53:487-96. 2013
    ..In conclusion, Dkk1 is a promising target for the treatment of both MM and bone disease, and ongoing clinical studies will help elucidate its efficacy...
  44. ncbi request reprint PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Development 129:2977-86. 2002
    ..Thus, chondrocyte differentiation is controlled at multiple steps by PTHrP and Ihh through the mutual regulation of their activities...
  45. pmc Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease
    Homare Eda
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 31:1225-34. 2016
    ..2016 American Society for Bone and Mineral Research. ..
  46. pmc Role of G-proteins in the differentiation of epiphyseal chondrocytes
    Andrei S Chagin
    Department of Physiology and PharmacologyKarolinska Institutet, Nanna Svartz Vagen 2, Stockholm 17177, SwedenEndocrine UnitMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    J Mol Endocrinol 53:R39-45. 2014
    ....
  47. doi request reprint Overview of skeletal development
    Tatsuya Kobayashi
    Massachusetts General Hospital, Harvard University, Boston, MA, USA
    Methods Mol Biol 1130:3-12. 2014
    ..In this chapter, we overview the process of mouse skeletal development and discuss major regulators of skeletal cells at each developmental stage. ..
  48. ncbi request reprint Twist genes regulate Runx2 and bone formation
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA 02114, USA
    Dev Cell 6:317-8. 2004
    ..In this issue of Developmental Cell, show that Twist-1 and Twist-2 suppress the activity of Runx2 and thereby regulate bone formation...
  49. ncbi request reprint Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation
    Akio Sakamoto
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bone Miner Res 20:663-71. 2005
    ..These results show that G(s)alpha negatively regulates chondrocyte differentiation and is the critical signaling mediator of the PTH/PTH-rP receptor in growth plate chondrocytes...
  50. ncbi request reprint p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development
    Ferdinand Rossi
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA
    Dev Biol 247:271-85. 2002
    ..The results suggest that Cbfa1 links a p107- and p130-mediated cell cycle arrest to chondrocyte terminal differentiation...
  51. pmc The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 167:1113-22. 2004
    ..Thus, PTH/PTHrP signaling is a major regulator of the ontogeny of the bone marrow and its stromal tissue, and of the skeletal stem cell compartment...
  52. doi request reprint Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
    Kinglun Kingston Mak
    Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
    Development 135:1947-56. 2008
    ..In addition, we found that bone morphogenetic protein (Bmp) and Wnt/beta-catenin signaling in the cartilage may both mediate the effect of upregulated Ihh signaling in promoting chondrocyte hypertrophy...
  53. pmc Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34
    Dengshun Miao
    Calcium Research Laboratory and Department of Medicine, Royal Victoria Hospital of the McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Invest 115:2402-11. 2005
    ....
  54. ncbi request reprint Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    Fanxin Long
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 131:1309-18. 2004
    ..We suggest that Ihh acts in vivo on a potential progenitor cell to promote osteoblast and prevent chondrocyte differentiation...
  55. pmc Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorption
    Noriaki Ono
    Department of Molecular Pharmacology, Medical Research Institute, Graduate School, Tokyo Medical and Dental University, and Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
    J Biol Chem 282:25509-16. 2007
    ..These results indicated that constitutive activation of PTH/PTHrP receptor signaling in osteoblastic cells suppresses unloading-induced bone loss specifically through the regulation of osteoclastic activity...
  56. ncbi request reprint NPT2a--the key to phosphate homeostasis
    Henry M Kronenberg
    N Engl J Med 347:1022-4. 2002
  57. ncbi request reprint Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death
    Jin Qian
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Endocrinology 144:1053-61. 2003
    ..Taken together, these findings indicate that the PTH1R is required for the development of normal cardiomyocyte function...
  58. ncbi request reprint GCMB--another serendipitous gift from evolution to clinical investigators
    Henry M Kronenberg
    J Clin Endocrinol Metab 89:6-7. 2004
  59. ncbi request reprint Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein
    Lewis P Rubin
    Department of Pediatrics, Brown Medical School and Women and Infants Hospital, Providence, Rhode Island 02905 2499, USA
    Dev Dyn 230:278-89. 2004
    ....
  60. pmc Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts
    Noriaki Ono
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, 113 8510, Tokyo, Japan
    J Biol Chem 283:19400-9. 2008
    ..Thus, in addition to the well known calcemic feedback system for PTH, local feedback regulation by the bone matrix protein OPN also plays a significant role in the regulation of PTH actions...
  61. pmc Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    Matthew J Hilton
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:306-14. 2008
    ..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway...