Genomes and Genes
Affiliation: Harvard University
- In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft responseZhigang Fan
Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:718-22. 2010..These results establish real-time cell tracking as a powerful means to probe the dynamic cellular interplay mediating immunologic rejection or transplant tolerance...
- The role of TNF-α in mice with type 1- and 2- diabetesMaria Koulmanda
Department of Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e33254. 2012....
- Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survivalMaria Koulmanda
Harvard Medical School, Beth Israel Deaconess Medical Center BIDMC, Boston, MA, USA
Proc Natl Acad Sci U S A 109:15443-8. 2012..The conclusions yielded by the systems-biology analysis were rigorously confirmed by QRT-PCR and immunohistology. These data suggest that short-term AAT treatment of human islet transplant recipients may be worthy of a clinical trial...
- Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term triple therapyM Koulmanda
Harvard Medical School, Department of Surgery, Transplant Institute at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, MA, USA
Am J Transplant 12:1296-302. 2012..Moreover slow progressive loss of islet function in some recipients was not associated with obvious pathologic evidence of rejection...
- Modification of adverse inflammation is required to cure new-onset type 1 diabetic hostsMaria Koulmanda
Department of Surgery, Harvard Medical School, and Islet Transplantation Research Laboratory, Massachusetts General Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:13074-9. 2007..Thus, this triple-therapy regimen, possessing both tolerance-inducing and select antiinflammatory properties, may represent a prototype for therapies able to restore euglycemia and self-tolerance in T1DM...
- Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD miceMaria Koulmanda
Departments of Surgery and Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:16242-7. 2008..Indeed, the functional mass of beta cells expands in AAT-treated diabetic NOD mice...
- Tissue expression of PD-L1 mediates peripheral T cell toleranceMary E Keir
Department of Pathology, Brigham and Women s Hospital and Children s Hospital Boston, MA 02115, USA
J Exp Med 203:883-95. 2006..These data provide evidence that PD-L1 expression on parenchymal cells rather than hematopoietic cells protects against autoimmune diabetes and point to a novel role for PD-1-PD-L1 interactions in mediating tissue tolerance...
- Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect responseMaria Koulmanda
Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Xenotransplantation 11:525-30. 2004....
- Inflammation and the balance of Treg and Th17 cells in transplant rejection and toleranceDusan Hanidziar
Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Curr Opin Organ Transplant 15:411-5. 2010..Hence, benefits of tilting Treg-Th17 equilibrium toward dominance of Tregs may promote transplant tolerance...
- Prediction of marginal mass required for successful islet transplantationKlearchos K Papas
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
J Invest Surg 23:28-34. 2010..Because human clinical islet preparations in a previous study had OCR/DNA...
- Pig islet xenografts are resistant to autoimmune destruction by non-obese diabetic recipients after anti-CD4 treatmentMaria Koulmanda
Islet Transplantation Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Xenotransplantation 10:178-84. 2003..The difficulty in obtaining indefinite islet xenograft survival in NOD recipients occurs independently from the development of destructive autoimmunity...
- Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primatesTimothy Millington
Massachusetts General Hospital Transplant Center, Massachusetts General Hospital, Boston, MA, USA
J Heart Lung Transplant 31:427-35. 2012..To tilt the immunologic balance toward tolerance and away from rejection, non-human primate recipients of cardiac allografts were treated with interleukin (IL)-2/Fc, mutant (m) antagonist type mIL-15/Fc, and sirolimus...
- A simple and cost-effective method for the isolation of islets from nonhuman primatesJohn J O'Neil
Joslin Diabetes Center, Boston, MA, USA
Cell Transplant 12:883-90. 2003..The technique yields sufficient numbers of pure and viable islets to support preclinical research to develop improved strategies to prevent the immune destruction of the transplanted islet graft...
- The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockadeLeila Makhlouf
Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Diabetes 51:3202-10. 2002..Our results may have implications for the design of future clinical trials in islet transplantation...
- Towards cytoprotection in the peritransplant periodDusan Hanidziar
Harvard Medical School, Department of Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, 330 Brookline Ave, E CLS Room 609, Boston, MA 02215, USA
Semin Immunol 23:209-13. 2011....
- Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism With Combined Donor Bone Marrow TransplantationTetsu Oura
Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Cell Transplant 25:1331-41. 2016..However, unlike the kidney allograft, islet allograft tolerance was not induced with transient chimerism. Induction of more durable mixed chimerism may be necessary for induction of islet allograft tolerance. ..
- Cytokine related therapies for autoimmune diseaseTerry B Strom
Harvard Medical School, Beth Israel Deaconess Medical Center, Center for Life Sciences Building, 3 Blackfan Circle, Boston, MA 02115, United States
Curr Opin Immunol 20:676-81. 2008..The ability of IFNgamma, IL-4, TNFalpha, and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in vivo may also enable translation into potent therapies...
- Recently discovered T cell subsets cannot keep their commitmentsTerry B Strom
Departments of Medicine and Surgery, Harvard Medical School, Transplant Institute, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Am Soc Nephrol 20:1677-80. 2009..Rather, Tregs and Th17(+) cells respond to cues provided by the inflammatory texture in which these cells reside. We review the important scientific and therapeutic implications of these differences herein...
- Mechanisms underlying blockade of allograft acceptance by TLR ligandsPaige M Porrett
Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 181:1692-9. 2008..Instead, graft destruction results from the ability of CpG to drive Th1 differentiation and interfere with immunoregulation established by alloreactive natural CD4(+)Foxp3(+) Tregs...
- Innate immunity for better or worse govern the allograft responseLeo E Otterbein
aDepartment of Surgery bDepartment of Medicine, Harvard Medical School Transplant Institute, Beth Israel Deaconess Medical Center Boston, Massachusetts, USA
Curr Opin Organ Transplant 20:8-12. 2015..In addition, we review the information that a newly discovered, engraftment-promoting, and tolerance-inducing macrophage population is identified and characterized...
- Hand transplants and the mandate for toleranceMaria Koulmanda
aDepartment of Medicine, Harvard Medical School, Transplant Institute, Beth Israel Deaconess Medical Center bDivision of Plastic Surgery, Department of Surgery cDivision of Dermatopathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Organ Transplant 19:545-51. 2014..The field of vascularized composite allograft (VCA) to achieve its full potential will require induction of tolerance. This review will introduce a new method of potential inducing tolerance in hand transplantation...
- Creating transplant tolerance by taming adverse intragraft innate immunityDusan Hanidziar
Departments of Medicine and Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E CLS 608 Boston, MA 02215 USA
F1000 Biol Rep 2:83. 2010..Hence, a reduction in adverse tissue inflammation may prove crucial in facilitating the induction and maintenance of a long-lasting state of transplant tolerance...
- Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 DiabetesThomas B Thornley
Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
PLoS ONE 11:e0150792. 2016..Our findings suggest that maintenance of IRM abundance and their immunoregulatory phenotype may constitute a novel therapeutic strategy to prevent and/or cure T1D. ..
- Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant modelWeihua Gong
Department of Surgery and Medicine, Transplant International Research Centre TIRC, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People s Republic of China Departments of Medicine, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA Electronic address
Clin Immunol 153:8-16. 2014..Utilization of MDSC subset particularly CD11b+Gr1(-low) might provide a novel insight into improving graft outcome under such clinical scenarios...
- CD46 protects pig islets from antibody but not cell-mediated destruction in the mouseIan F C McKenzie
The Austin Research Institute, Heidelberg, Victoria, Australia
Xenotransplantation 10:615-21. 2003....
- Tolerance Induction for Primate Islet TransplantationMaria Koulmanda; Fiscal Year: 2006..abstract_text> ..