O Kocher

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Automated detection of the G20210A prothrombin mutation using the LCx microparticle enzyme immunoassay
    A Gilchrist
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, East Campus, 330 Brookline Avenue, Boston, MA 02215, USA
    Clin Chim Acta 314:249-54. 2001
  2. pmc Targeted disruption of the PDZK1 gene by homologous recombination
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:1175-80. 2003
  3. ncbi request reprint PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein
    O Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 79:1161-70. 1999
  4. ncbi request reprint Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains
    O Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 78:117-25. 1998
  5. ncbi request reprint Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display
    Y Fu
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Gene 240:157-63. 1999
  6. ncbi request reprint Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique
    O Kocher
    Departments of Pathology and Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 1:1209-15. 1995
  7. ncbi request reprint Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis
    E Vasile
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 15:458-66. 2001
  8. ncbi request reprint H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo
    S W Lee
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Institutes of Medicine, Boston, MA 02115, USA
    Carcinogenesis 19:1157-9. 1998
  9. pmc Interaction between RGS7 and polycystin
    E Kim
    Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:6371-6. 1999
  10. pmc Identification and partial characterization of a novel membrane-associated protein (MAP17) up-regulated in human carcinomas and modulating cell replication and tumor growth
    O Kocher
    Department of Pathology, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    Am J Pathol 149:493-500. 1996

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Automated detection of the G20210A prothrombin mutation using the LCx microparticle enzyme immunoassay
    A Gilchrist
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, East Campus, 330 Brookline Avenue, Boston, MA 02215, USA
    Clin Chim Acta 314:249-54. 2001
    ..Several methods have been developed to detect the mutation; however, given the increased demand for this test in risk factor assessment, the development of simple and efficient screening methods has become necessary...
  2. pmc Targeted disruption of the PDZK1 gene by homologous recombination
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:1175-80. 2003
    ....
  3. ncbi request reprint PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein
    O Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 79:1161-70. 1999
    ....
  4. ncbi request reprint Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains
    O Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 78:117-25. 1998
    ..PDZK1 may represent the link between the cell membrane-where it interacts with MAP17-and other cytoplasmic proteins involved in biologic functions such as cell proliferation, differentiation, and ion transport...
  5. ncbi request reprint Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display
    Y Fu
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Gene 240:157-63. 1999
    ..M(r) 44330 with multiple potential protein kinase C and casein kinase II phosphorylation sites. Our data suggest that DLM-1 plays a role in such important processes as host response in neoplasia...
  6. ncbi request reprint Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique
    O Kocher
    Departments of Pathology and Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 1:1209-15. 1995
    ..These results suggest that DD96 may play a role in the early events associated with malignant transformation; however, its function remains to be determined...
  7. ncbi request reprint Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis
    E Vasile
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 15:458-66. 2001
    ..The reduced expression of thymosin beta-10 may contribute to the senescent phenotype by reducing EC plasticity and thus impairing their response to migratory stimuli...
  8. ncbi request reprint H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo
    S W Lee
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Institutes of Medicine, Boston, MA 02115, USA
    Carcinogenesis 19:1157-9. 1998
    ..These findings strongly suggest that H-cadherin could provide a possible target for corrective gene therapy against breast cancer...
  9. pmc Interaction between RGS7 and polycystin
    E Kim
    Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:6371-6. 1999
    ..Furthermore, membranous expression of C-terminal polycystin relocalized RGS7. Our results indicate that rapid degradation and interaction with integral membrane proteins are potential means of regulating RGS proteins...
  10. pmc Identification and partial characterization of a novel membrane-associated protein (MAP17) up-regulated in human carcinomas and modulating cell replication and tumor growth
    O Kocher
    Department of Pathology, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    Am J Pathol 149:493-500. 1996
    ..Although the precise function of MAP17 remains to be determined, our findings suggest that this protein may play an important role in tumor biology...
  11. ncbi request reprint Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy
    G Abu-Jawdeh
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 79:439-47. 1999
    ..These results indicate that frpHE functions as a regulator of the Wnt-frizzled signaling pathway and is involved in endometrial physiology and carcinogenesis...
  12. pmc Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis
    M Detmar
    Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215
    J Exp Med 180:1141-6. 1994
    ..Similar mechanisms may operate in tumors and in healing skin wounds which also commonly express both VPF and TGF-alpha...
  13. ncbi request reprint Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphoma
    M E Kadin
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Hum Pathol 32:1269-72. 2001
    ..This article supports the concept of a T-cell derivation for rare cases of Hodgkin's lymphoma and provides evidence of a novel mechanism of pathogenesis from chronic inflammation in the skin...
  14. pmc Influence of PDZK1 on lipoprotein metabolism and atherosclerosis
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochim Biophys Acta 1782:310-6. 2008
    ..They also define PDZK1 as a member of the family of proteins that is instrumental in preventing cardiovascular disease by maintaining normal lipoprotein metabolism...
  15. pmc NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes
    Ayhan Cinar
    Hannover Medical School, Department of Gastroenterology and Hepatology, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Physiol 581:1235-46. 2007
    ..It leaves NHE3 inhibition by hyperosmolarity intact, suggesting an important and selective role for PDZK1 in the agonist-mediated regulation of intestinal NHE3 activity...
  16. ncbi request reprint Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice
    Jutta Hillesheim
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Pflugers Arch 454:575-86. 2007
    ..Lack of the PDZ-adapter protein PDZK1 in murine small intestine causes a mild reduction in maximal CFTR activation, but a severe defect in electroneutral Na(+) absorption...
  17. ncbi request reprint PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function
    Ayce Yesilaltay
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 281:28975-80. 2006
    ..Thus, PDZK1 is important for maintaining adequate steady state levels of SR-BI in the liver but is not essential for cell surface expression or function of hepatic SR-BI...
  18. pmc Role of PDZK1 in membrane expression of renal brush border ion exchangers
    R Brent Thomson
    Department of Internal Medicine and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Proc Natl Acad Sci U S A 102:13331-6. 2005
    ..In conclusion, the scaffolding protein PDZK1 is essential for the normal expression and function of Cl-anion exchanger CFEX in the proximal tubule of the mammalian kidney...
  19. ncbi request reprint Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1
    Ayce Yesilaltay
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Lipidol 16:147-52. 2005
    ..This review will focus on one of these lipoprotein receptor-adaptor pairs, the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and its adaptor PDZK1...
  20. ncbi request reprint Expression and regulation of the renal Na/phosphate cotransporter NaPi-IIa in a mouse model deficient for the PDZ protein PDZK1
    Paola Capuano
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Pflugers Arch 449:392-402. 2005
    ..However, under a P(i)-rich diet, loss of PDZK1 reduced NaPi-IIa abundance indicating that PDZK1 may play a role in the trafficking or stability of NaPi-IIa under these conditions...
  21. pmc Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization
    Sara A Fenske
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 283:22097-104. 2008
    ....
  22. ncbi request reprint Ligneous (pseudomembranous) inflammation involving the female genital tract associated with type-1 plasminogen deficiency
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Int J Gynecol Pathol 23:292-5. 2004
    ..We present a patient with ligneous inflammation of her genital, middle ear, and oral mucosa that was associated with type-1 homozygous plasminogen deficiency due to a novel missense mutation in the plasminogen gene...
  23. ncbi request reprint Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:52820-5. 2003
    ..The PDZK1-dependent regulation of hepatic SR-BI and, thus, lipoprotein metabolism supports the proposal that this adaptor may represent a new target for therapeutic intervention in cardiovascular disease...
  24. ncbi request reprint Down-regulation and antiproliferative role of C/EBPalpha in lung cancer
    Balazs Halmos
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:528-34. 2002
    ..Genetic analysis of the C/EBPalpha gene is in progress to fully evaluate its role as a novel tumor suppressor in lung cancer...
  25. ncbi request reprint Blood markers for vasculogenesis increase with tumor progression in patients with breast carcinoma
    Louis K Sussman
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Biol Ther 2:255-6. 2003
    ..Our data suggest increased circulating EPC markers in tumor patients, but further study of this cell population is needed to better define its role in tumor vasculogenesis...
  26. pmc Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: a correlative study of E3590
    Daniel B Costa
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Lung Cancer 56:97-103. 2007
    ..This is the first comprehensive study of this transcription factor in patients with NSCLC...
  27. ncbi request reprint Obstetric complications in patients with hereditary thrombophilia identified using the LCx microparticle enzyme immunoassay: a controlled study of 5,000 patients
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Pathol 127:68-75. 2007
    ..These results confirm the association between genetic thrombophilia and selected obstetric complications...
  28. ncbi request reprint Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice
    Shigeto Kubo
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, and Ireland Cancer Center, University Hospitals of Cleveland Case Western Reserve University, OH, USA
    Magn Reson Med 56:698-703. 2006
    ..This promising method is noninvasive and has the potential to eventually replace invasive histopathology because it obviates the need to kill groups of animals at multiple time points...
  29. ncbi request reprint Evaluation of p53 mutations in premalignant esophageal lesions and esophageal adenocarcinoma using laser capture microdissection
    Azita Djalilvand
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 17:1323-7. 2004
    ..Our results, using LCM, show that p53 gene mutations are relatively rare in esophageal preneoplastic and neoplastic conditions. Only point mutations were detected, but no deletions/insertions were identified...
  30. ncbi request reprint Analysis of 15 novel full-length BK virus sequences from three individuals: evidence of a high intra-strain genetic diversity
    YiPing Chen
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 213B, 330 Brookline Avenue, Boston, MA 02215, USA
    J Gen Virol 85:2651-63. 2004
    ..55 % of sites, implying a rate of nucleotide substitution of approximately 5 x 10(-5) substitutions per site per year, which is two orders of magnitude faster than estimated for the other human polyomavirus, JC virus...