A C Keates

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 119:972-82. 2000
  2. ncbi request reprint ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:43713-22. 2001
  3. ncbi request reprint cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells
    S Keates
    Division of Gastroenterology and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:48127-34. 2001
  4. ncbi request reprint Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori
    S Keates
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 163:5552-9. 1999
  5. pmc p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
    M Warny
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 105:1147-56. 2000
  6. ncbi request reprint Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes
    D Zhao
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:44464-71. 2001
  7. pmc Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease
    J H Kwon
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    Gut 51:818-26. 2002
  8. ncbi request reprint Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis
    S Keates
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol 273:G75-82. 1997
  9. pmc Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Infect Immun 76:3992-9. 2008
  10. pmc Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, MA 02215, USA
    Br J Pharmacol 136:271-9. 2002

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 119:972-82. 2000
    ..The aim of this study was to determine whether IL-16 production is increased in inflammatory bowel disease and whether IL-16 participates in trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice...
  2. ncbi request reprint ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:43713-22. 2001
    ..This study demonstrates that ENA-78 gene expression in Caco-2 intestinal epithelial cells is subject to complex regulation involving the coordinate binding of ZBP-89, Sp1, and nuclear factor-kappaB to the ENA-78 promoter...
  3. ncbi request reprint cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells
    S Keates
    Division of Gastroenterology and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:48127-34. 2001
    ..Transactivation of gastric epithelial cell EGF receptors may be instrumental in regulating both proliferative and inflammatory responses induced by cag+ H. pylori infection...
  4. ncbi request reprint Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori
    S Keates
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 163:5552-9. 1999
    ..pylori cag+ strains may be instrumental in inducing gastroduodenal inflammation, ulceration, and neoplasia...
  5. pmc p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
    M Warny
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 105:1147-56. 2000
    ..p38 MAP kinase also mediates intestinal inflammation and mucosal damage induced by toxin A...
  6. ncbi request reprint Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes
    D Zhao
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:44464-71. 2001
    ..We speculate that these NT-related proinflammatory pathways are important in the pathophysiology of colonic inflammation...
  7. pmc Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease
    J H Kwon
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    Gut 51:818-26. 2002
    ..The aim of this study was to determine whether colonic epithelial cells produce MIP-3alpha and whether its expression is upregulated in inflammatory bowel disease...
  8. ncbi request reprint Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis
    S Keates
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol 273:G75-82. 1997
    ..ENA-78 as an enterocyte-derived, neutrophil-activating chemokine may be especially important in neutrophil recruitment from the lamina propria into the epithelial layer...
  9. pmc Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Infect Immun 76:3992-9. 2008
    ..pylori-mediated PAI-1 upregulation. These findings suggest that the upregulation of PAI-1 in H. pylori-infected gastric epithelial cells may contribute to the carcinogenic process...
  10. pmc Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, MA 02215, USA
    Br J Pharmacol 136:271-9. 2002
    ..5. Our results indicate that in mice lacking the neurokinin - 1 receptor, substance P plays a protective role in prolonged experimental colitis...
  11. pmc Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells
    S Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gut 54:1363-9. 2005
    ....
  12. ncbi request reprint Development of chronic colitis is dependent on the cytokine MIF
    Y P de Jong
    Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nat Immunol 2:1061-6. 2001
    ..Because we found increased plasma MIF concentrations in patients with Crohn's disease, these data suggested that MIF is a new target for intervention in Crohn's disease...
  13. ncbi request reprint P-glycoprotein-170 inhibition significantly reduces cortisol and ciclosporin efflux from human intestinal epithelial cells and T lymphocytes
    R J Farrell
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Aliment Pharmacol Ther 16:1021-31. 2002
    ..To assess the role of P-glycoprotein-170 (P-gp) in transporting cortisol and ciclosporin from human intestinal epithelium and T lymphocytes...
  14. ncbi request reprint The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions
    G D Offner
    Departments of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 251:350-5. 1998
    ..The N-terminal D domains in MUC5B are likely to have important roles in both mucin assembly and in the protective functions of the secreted mucin...