Jonathan C Kagan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way
    Jonathan C Kagan
    Department of Pediatrics, Division of Gastroenterology and Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Enders 730 2, Boston, MA 02115, USA
    Immunity 33:578-80. 2010
  2. pmc Common mechanisms activate plant guard receptors and TLR4
    Jonathan C Kagan
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02446, USA Electronic address
    Trends Immunol 35:454-6. 2014
  3. doi request reprint Recognition for an innate explorer
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA 02115, USA
    Cell 154:261-4. 2013
  4. pmc Signaling organelles of the innate immune system
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 151:1168-78. 2012
  5. pmc Defining the subcellular sites of innate immune signal transduction
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Trends Immunol 33:442-8. 2012
  6. pmc Phagosome as the organelle linking innate and adaptive immunity
    Jonathan C Kagan
    Division of Gastroenterology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Enders 649, Boston, MA 02115, USA
    Traffic 13:1053-61. 2012
  7. doi request reprint "Complementing" toll signaling
    Jonathan C Kagan
    Division of Gastroenterology and Harvard Medical School, Department of Pediatrics, Children s Hospital Boston, Boston, MA 02115, USA
    Sci Signal 3:pe15. 2010
  8. pmc TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    Jonathan C Kagan
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 9:361-8. 2008
  9. pmc A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction
    Kevin S Bonham
    Division of Gastroenterology, Boston Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Cell 156:705-16. 2014
  10. ncbi request reprint Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    Jonathan C Kagan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 125:943-55. 2006

Collaborators

Detail Information

Publications34

  1. doi request reprint Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way
    Jonathan C Kagan
    Department of Pediatrics, Division of Gastroenterology and Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Enders 730 2, Boston, MA 02115, USA
    Immunity 33:578-80. 2010
    ..In this issue of Immunity, Husebye et al. (2010) report that delivery of TLR4 to phagosomes occurs via a recycling endosome intermediate, which is controlled by the GTPase Rab11a...
  2. pmc Common mechanisms activate plant guard receptors and TLR4
    Jonathan C Kagan
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02446, USA Electronic address
    Trends Immunol 35:454-6. 2014
    ..In a recent study, Williams and colleagues report that plant Guard receptors can be activated by a mechanism remarkably similar to that of mammalian Toll-like Receptor 4. ..
  3. doi request reprint Recognition for an innate explorer
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA 02115, USA
    Cell 154:261-4. 2013
    ..But in reality, that time was not long ago. To mark this celebratory event, I highlight the conceptual revolution spurred by his work, which continues to inspire excitement today. ..
  4. pmc Signaling organelles of the innate immune system
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 151:1168-78. 2012
    ....
  5. pmc Defining the subcellular sites of innate immune signal transduction
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Trends Immunol 33:442-8. 2012
    ..Rather, a structurally unrelated class of proteins called 'sorting adaptors' functions in this capacity...
  6. pmc Phagosome as the organelle linking innate and adaptive immunity
    Jonathan C Kagan
    Division of Gastroenterology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Enders 649, Boston, MA 02115, USA
    Traffic 13:1053-61. 2012
    ..In this regard, we propose that at the subcellular level, phagosomes represent the smallest definable unit that links innate and adaptive immunity...
  7. doi request reprint "Complementing" toll signaling
    Jonathan C Kagan
    Division of Gastroenterology and Harvard Medical School, Department of Pediatrics, Children s Hospital Boston, Boston, MA 02115, USA
    Sci Signal 3:pe15. 2010
    ..A new study attempts to model such conditions in vitro and reveals that when macrophages encounter bacteria, two signal transduction pathways interact in a way that profoundly alters the cellular response to infection...
  8. pmc TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    Jonathan C Kagan
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 9:361-8. 2008
    ..Our data emphasize a unifying theme in innate immune recognition whereby all type I interferon-inducing receptors signal from an intracellular location...
  9. pmc A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction
    Kevin S Bonham
    Division of Gastroenterology, Boston Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Cell 156:705-16. 2014
    ..These data establish how promiscuity, rather than specificity, can be a beneficial means of diversifying the subcellular sites of innate immune signal transduction. ..
  10. ncbi request reprint Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    Jonathan C Kagan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 125:943-55. 2006
    ..TIRAP then functions to facilitate MyD88 delivery to activated TLR4 to initiate signal transduction. These results establish that phosphoinositide-mediated adaptor recruitment initiates a specific signal-transduction pathway...
  11. pmc A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, Room 354b, 295 Congress Avenue, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 102:826-31. 2005
    ..Thus, Legionella has the ability to engage synthesized substrate proteins and transfer them into host cells on contact, enabling Legionella to rapidly alter transport of the vacuole in which it resides...
  12. pmc A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4
    Charles V Rosadini
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA 02115, USA
    Cell Host Microbe 18:682-93. 2015
    ..This singular YopJ activity efficiently inhibits TLR4 transcription-inducing activities, thus illustrating a simple means by which pathogens impede innate immunity. ..
  13. pmc CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
    Ivan Zanoni
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 147:868-80. 2011
    ..This innate immune trafficking cascade illustrates how pathogen detection systems operate to induce both membrane transport and signal transduction...
  14. pmc Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria
    Yunhao Tan
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA 02115, USA
    Immunity 43:909-22. 2015
    ..We suggest that evasion of CD14-dependent endocytosis is an attribute that transcends the concept of pathogenesis and might be a fundamental feature of bacteria that inhabit eukaryotic hosts. ..
  15. pmc Innate immune pattern recognition: a cell biological perspective
    Sky W Brubaker
    Division of Gastroenterology, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115 email
    Annu Rev Immunol 33:257-90. 2015
    ..In this review, we highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol. ..
  16. pmc Peroxisomes and the antiviral responses of mammalian cells
    Charlotte Odendall
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA, 02115, USA
    Subcell Biochem 69:67-75. 2013
    ..This chapter will discuss the emerging evidence that indicates that in addition to their functions in cellular metabolism, peroxisomes play an important role in viral infections. ..
  17. pmc Diverse intracellular pathogens activate type III interferon expression from peroxisomes
    Charlotte Odendall
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, Massachusetts, USA
    Nat Immunol 15:717-26. 2014
    ..These findings highlight the importance of different intracellular organelles in specific innate immune responses. ..
  18. pmc Intracellular pathogen detection by RIG-I-like receptors
    Evelyn Dixit
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA, USA
    Adv Immunol 117:99-125. 2013
    ..RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction...
  19. pmc A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide
    Yunhao Tan
    Division of Gastroenterology, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 54:212-23. 2014
    ..By looking at both sides of the host-pathogen interaction equation, we hope to provide comprehensive insights into host defense mechanisms and bacterial pathogenesis...
  20. pmc Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    J Exp Med 199:1201-11. 2004
    ....
  21. ncbi request reprint Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    Gregory M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nat Immunol 7:49-56. 2006
    ..These data demonstrated that intracellular localization of TLR9 was not required for ligand recognition. Instead, localization of the nucleic acid-sensing TLRs is critical in discriminating between self and nonself nucleic acid...
  22. pmc Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila
    Lorri R Marek
    Division of Gasteroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Immunity 36:612-22. 2012
    ..We therefore propose that dMyD88 is the functional homolog of TIRAP and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors...
  23. pmc An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
    Ivan Zanoni
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA, USA Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy Unit of Cell Signalling and Innate Immunity, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Science 352:1232-6. 2016
    ..The cells and receptors of the innate immune system can therefore achieve different activation states, which may permit context-dependent responses to infection. ..
  24. pmc Microbe-inducible trafficking pathways that control Toll-like receptor signaling
    Yunhao Tan
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, Massachusetts
    Traffic . 2016
    ....
  25. doi request reprint Early innate immune responses to bacterial LPS
    Charles V Rosadini
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 44:14-19. 2016
    ..In this review, we discuss the importance of these receptor proximal activities in the spatiotemporal regulation of TLR4 signaling, and suggest interesting areas for future research...
  26. pmc The unique regulation and functions of type III interferons in antiviral immunity
    Charlotte Odendall
    Division of Gastroenterology, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Virol 12:47-52. 2015
    ..This review focuses on the distinctive features of type III IFNs in antiviral innate immunity. ..
  27. pmc PRRs are watching you: Localization of innate sensing and signaling regulators
    Jonathan Chow
    Division of Gastroenterology, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA Program in Immunology, Harvard Medical School, Boston, MA 02115, USA
    Virology 479:104-9. 2015
    ..Within this review, we discuss how several families of pattern recognition receptors act to provide a comprehensive surveillance network that has the potential to induce interferon expression in response to any viral infection. ..
  28. pmc Emerging principles governing signal transduction by pattern-recognition receptors
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, Massachusetts 02115
    Cold Spring Harb Perspect Biol 7:a016253. 2014
    ..In the future, cell biological analysis likely will rival pure genetic analysis as a tool to uncover fundamental principles that govern host-microbe interactions. ..
  29. pmc A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity
    Sky W Brubaker
    Division of Gastroenterology, Boston Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Cell 156:800-11. 2014
    ..This study therefore reveals the existence of a functionally important bicistronic antiviral mRNA and suggests a widespread role for polycistronic mRNAs in the innate immune system...
  30. pmc Endosomes as platforms for NOD-like receptor signaling
    Kevin S Bonham
    Boston Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02446, USA
    Cell Host Microbe 15:523-5. 2014
    ..Two recent studies provide important cell biological insights into the subcellular sites of NOD1- and NOD2-dependent signaling. ..
  31. pmc The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling
    Jin A Cho
    Department of Medicine, Division of GI Cell Biology, Boston Children s Hospital, Boston, MA 02115, USA
    Cell Host Microbe 13:558-69. 2013
    ..We propose IRE1α provides for a generalized mechanism of innate immune surveillance originating within the ER lumen...
  32. ncbi request reprint Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Nat Cell Biol 4:945-54. 2002
    ..These data indicate that L. pneumophila intercepts vesicular traffic from endoplasmic-reticulum exit sites to create an organelle that permits intracellular replication and prevents destruction by the host cell...
  33. pmc MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties
    Sen Wang
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:141-50. 2011
    ..Thus, MyD88-dependent TLR2 signals are necessary and sufficient to educate DC with gut-specific imprinting properties and contribute in vivo to the generation of gut-tropic T cells...
  34. pmc Peroxisomes are signaling platforms for antiviral innate immunity
    Evelyn Dixit
    Division of Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cell 141:668-81. 2010
    ..The interferon regulatory factor IRF1 plays a crucial role in regulating MAVS-dependent signaling from peroxisomes. These results establish that peroxisomes are an important site of antiviral signal transduction...