Seigo Izumo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
    M Tanaka
    Cardiovascular Division, and Transgenic Core Facility, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Development 126:1439-50. 1999
  2. pmc Morphogenesis of the right ventricle requires myocardial expression of Gata4
    Elisabeth M Zeisberg
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:1522-31. 2005
  3. pmc Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure
    Egbert Bisping
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:14471-6. 2006
  4. ncbi request reprint Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
    Julie R McMullen
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Mass 02215, USA
    Circulation 109:3050-5. 2004
  5. ncbi request reprint Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase
    Antje Buerger
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Card Fail 12:392-8. 2006
  6. pmc Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy
    Julie R McMullen
    Beth Israel Deaconess Medical Center, Cardiovascular Division, 330 Brookline Ave, SL 408, Boston, MA 02215, USA
    Mol Cell Biol 24:6231-40. 2004
  7. pmc Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function
    Debra L Rigor
    Cardiovascular Division, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Rm 910, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 296:H566-72. 2009
  8. ncbi request reprint A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development
    Ivan P G Moskowitz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:1365-76. 2007
  9. pmc Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis
    Tomomi Ueyama
    Cardiovascular Division, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 23:9222-32. 2003
  10. ncbi request reprint Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats
    Sek Won Kong
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Physiol Genomics 21:34-42. 2005

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
    M Tanaka
    Cardiovascular Division, and Transgenic Core Facility, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Development 126:1439-50. 1999
    ....
  2. pmc Morphogenesis of the right ventricle requires myocardial expression of Gata4
    Elisabeth M Zeisberg
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:1522-31. 2005
    ..Our results demonstrate a general role of myocardial Gata4 in regulating cardiomyocyte proliferation and a specific, stage-dependent role in regulating the morphogenesis of the RV and the atrioventricular canal...
  3. pmc Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure
    Egbert Bisping
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:14471-6. 2006
    ..Our data demonstrate that Gata4 is essential for cardiac function in the postnatal heart. After pressure overload, Gata4 regulates the pattern of cardiomyocyte hypertrophy and protects the heart from load-induced failure...
  4. ncbi request reprint Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
    Julie R McMullen
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Mass 02215, USA
    Circulation 109:3050-5. 2004
    ..We recently reported that administration of rapamycin before exposure to ascending aortic constriction significantly attenuated the load-induced increase in heart weight by approximately 70%...
  5. ncbi request reprint Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase
    Antje Buerger
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Card Fail 12:392-8. 2006
    ..Conditional gene inactivation in mice using the bacteriophage P1 Cre-loxP recombination system requires transgenic expression of Cre-recombinase driven by a tissue-specific or inducible promoter...
  6. pmc Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy
    Julie R McMullen
    Beth Israel Deaconess Medical Center, Cardiovascular Division, 330 Brookline Ave, SL 408, Boston, MA 02215, USA
    Mol Cell Biol 24:6231-40. 2004
    ..These studies suggest that S6Ks alone are not essential for the development of cardiac hypertrophy...
  7. pmc Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function
    Debra L Rigor
    Cardiovascular Division, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Rm 910, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 296:H566-72. 2009
    ....
  8. ncbi request reprint A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development
    Ivan P G Moskowitz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:1365-76. 2007
    ..We conclude that a molecular pathway including Tbx5, Nkx2-5, and Id2 coordinates specification of ventricular myocytes into the ventricular conduction system lineage...
  9. pmc Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis
    Tomomi Ueyama
    Cardiovascular Division, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 23:9222-32. 2003
    ..These results suggest that myocardin expression is regulated by Nkx2.5 and that its function is required for cardiomyogenesis...
  10. ncbi request reprint Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats
    Sek Won Kong
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Physiol Genomics 21:34-42. 2005
    ..In addition, there were significant changes in glucose/insulin signaling, protein biosynthesis, and epidermal growth factor signaling during physiological hypertrophy but not during pathological hypertrophy...
  11. ncbi request reprint Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02139, USA
    J Cardiovasc Electrophysiol 16:82-5. 2005
    ..Several observations support a model in which Msx2 negatively regulates formation of the conduction system and inappropriate Msx2 up-regulation causes the conduction defects associated with Nkx2-5 mutation...
  12. pmc Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy
    Ji Luo
    Division of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, 10th Floor, Boston, MA 02115, USA
    Mol Cell Biol 25:9491-502. 2005
    ..Our results therefore provide strong genetic evidence that class I(A) PI3Ks are critical regulators for the developmental growth and physiological hypertrophy of the heart...
  13. ncbi request reprint Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice
    Hiroko Wakimoto
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genesis 37:144-50. 2003
    ..5 also causes conduction abnormalities, although the onset is after the neonatal stage. Bradycardia and AV conduction failure may contribute to the lethal heart failure and early mortality...
  14. ncbi request reprint Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes
    Hideko Kasahara
    Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, SL201, Boston, MA 02215, USA
    J Mol Cell Cardiol 35:243-56. 2003
    ..5 overexpression but not due to heart failure phenotype in vivo. These studies indicate that overexpression of Nkx2.5 in terminally differentiated cardiomyocytes dramatically alters cardiac cell structure and function...
  15. ncbi request reprint The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway
    Julie R McMullen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:4782-93. 2004
    ..This study suggests that targeting the cardiac IGF1R-PI3K(p110alpha) pathway could be a potential therapeutic strategy for the treatment of heart failure...
  16. pmc Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
    Julie R McMullen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:12355-60. 2003
    ..PI3K(p110alpha) also appears essential for maintaining contractile function in response to pathological stimuli...
  17. pmc Development of heart valves requires Gata4 expression in endothelial-derived cells
    JOSE RIVERA-FELICIANO
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 133:3607-18. 2006
    ..First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling...
  18. ncbi request reprint Function follows form: cardiac conduction system defects in Nkx2-5 mutation
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:966-72. 2004
    ..Hypoplasia of the atrioventricular node, His bundle, and Purkinje system can explain in whole or in part specific conduction and electrophysiologic defects present in Nkx2-5 haploinsufficiency...
  19. ncbi request reprint Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies
    Oleg Tarnavski
    Cardiovascular Research Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Physiol Genomics 16:349-60. 2004
    ..The cardiac surgical techniques described have been, and will continue to be, important for elucidating the molecular mechanisms of cardiac hypertrophy and failure with high-throughput technology...
  20. pmc Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 113:1130-7. 2004
    ..Postnatal conduction defects in Nkx2-5 mutation may result at least in part from a defect in the genetic program that governs the recruitment or retention of embryonic cardiac myocytes in the conduction system...
  21. ncbi request reprint Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart
    Tomomi Ueyama
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:28750-7. 2003
    ..Furthermore, transient cotransfection analysis showed that Nkx2.5 transactivates the Csm promoter, suggesting that Nkx2.5 is essential for embryonic Csm expression...
  22. ncbi request reprint Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:952-61. 2007
    ..Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis...
  23. ncbi request reprint Rapamycin attenuates load-induced cardiac hypertrophy in mice
    Tetsuo Shioi
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Mass 02215, USA
    Circulation 107:1664-70. 2003
    ..The mammalian target of rapamycin (mTOR) is a component of the insulin-phosphoinositide 3-kinase pathway, which is known to play a critical role in the determination of cell, organ, and body size...
  24. ncbi request reprint Alterations in apoptosis regulatory factors during hypertrophy and heart failure
    Peter M Kang
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, SL 423C, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 287:H72-80. 2004
    ..Therefore, we speculate that this increased sensitivity to apoptotic stimulation along with proapoptotic changes in the apoptosis program may contribute to the development of heart failure seen in pathological cardiac hypertrophy...
  25. ncbi request reprint Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia
    Zhiheng He
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:787-93. 2006
    ..This study characterized the role of insulin receptors and resistance on vascular endothelial growth factor (VEGF) expression and myocardial vascularization in physiological conditions and after ischemia...
  26. ncbi request reprint Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans
    Patrick Y Jay
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Novartis Found Symp 250:227-38; discussion 238-41, 276-9. 2003
    ..We propose that consideration of the two alternative hypotheses, in addition to the traditional ICC-centric model, should lead to a richer understanding of cardiac conduction defects and arrhythmogenesis...
  27. ncbi request reprint Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos
    Takahiro Ishiwata
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Circ Res 93:857-65. 2003
    ..Our study in normal mice forms the basis for future studies of embryonic cardiac function in genetically manipulated mice with abnormalities of the cardiovascular system...
  28. ncbi request reprint GATA4 is a dosage-sensitive regulator of cardiac morphogenesis
    William T Pu
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Dev Biol 275:235-44. 2004
    ..These data demonstrate that multiple aspects of embryonic cardiac morphogenesis and function are exquisitely sensitive to small changes in GATA4 expression levels...
  29. ncbi request reprint Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5
    Hiroko Wakimoto
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 13:682-8. 2002
    ....
  30. ncbi request reprint Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases
    Peter M Kang
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Trends Mol Med 9:177-82. 2003
    ..However, the significance of apoptosis to the overall pathogenesis of heart failure, and the relationship between cardiac hypertrophic signaling and apoptosis still needs further investigation...
  31. pmc Akt/protein kinase B promotes organ growth in transgenic mice
    Tetsuo Shioi
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 22:2799-809. 2002
    ..In conclusion, Akt is sufficient to induce a marked increase in heart size and is likely to be one of the effectors of the PI3K pathway in mediating heart growth...
  32. ncbi request reprint New insights into the role of apoptosis in cardiovascular disease
    Peter M Kang
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Circ J 66:1-9. 2002
  33. doi request reprint Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, PO Box 70575, TN 37614 0575, USA
    Cardiovasc Res 78:546-53. 2008
    ..We hypothesized that activation of PI3K/Akt signalling plays a critical role in LPS-induced cardioprotection...
  34. ncbi request reprint Elucidating the molecular and genetic interactions responsible for congenital heart disease
    Patrick Y Jay
    Pediatr Res 51:127. 2002
  35. ncbi request reprint Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system
    Sonia Meysen
    Institut de Biologie du Developpement de Marseille Luminy, IBDML, Universite de la Mediterranee, CNRS UMR6216, Campus de Luminy, Marseille, France
    Dev Biol 303:740-53. 2007
    ..Our results suggest that the formation of the peripheral conduction system is time- and dose-dependent on the transcription factor Nkx2.5 that is cell-autonomously required for the postnatal differentiation of Purkinje fibers...
  36. doi request reprint Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
    Kiwon Ban
    Department of Medicine and Physiology, University of Toronto, Ontario, Canada
    Circ Res 103:643-53. 2008
    ..These results demonstrate the importance of the PI3Kgamma-Akt-GSK3beta signaling pathway in IPC. Selective activation of myocardial PI3Kgamma may be an attractive target for the treatment of ischemic heart disease...
  37. pmc Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy
    Julie R McMullen
    Experimental Cardiology and Heart Failure Division, Baker Heart Research Institute, Melbourne 8008, Australia
    Proc Natl Acad Sci U S A 104:612-7. 2007
    ..Identification of genes important for hypertrophy in the athlete's heart could offer new strategies for treating heart failure...
  38. pmc Resistin, an adipocytokine, offers protection against acute myocardial infarction
    Jinping Gao
    Cecile Cox Quillen Laboratory of Geriatrics, James H Quillen College of Medicine East Tennessee State University, and James H Quillen Veterans Affairs Medical Center, Johnson City, TN 37614, USA
    J Mol Cell Cardiol 43:601-9. 2007
    ..There were significantly fewer in situ oligo ligation-positive myocyte nuclei in mice treated with resistin. Our results show that resistin can dramatically reduce apoptosis and infarct size, thus protecting the heart against I/R injury...
  39. pmc A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
    Brian T O'Neill
    Program in Human Molecular Biology and Genetics and Division of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Cell Metab 6:294-306. 2007
    ..Although PI3K signaling to Akt1 is required for cellular growth, Akt-independent pathways mediate the accompanying mitochondrial adaptations...
  40. ncbi request reprint Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
    Hiroki Aoki
    Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine, Minami Kogushi, Ube, Yamaguchi 755 8505, Japan
    J Biol Chem 277:10244-50. 2002
    ..These findings indicate that the JNK pathway is a direct activator of mitochondrial death machinery without other cellular components and provide a molecular linkage from oxidative stress to the mitochondrial apoptosis machinery...
  41. ncbi request reprint Role of the insulin-like growth factor 1 (IGF1)/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy
    Julie R McMullen
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Novartis Found Symp 274:90-111; discussion 111-7, 152-5, 272-6. 2006
    ..This review focuses largely on the role of the insulin-like growth factor 1 (IGF1)/phosphoinositide-3-kinase (PI3K) pathway in mediating physiological cardiac growth...
  42. ncbi request reprint Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo
    Tuanzhu Ha
    Department of Surgery, Campus Box 70575, East Tennessee State University, Johnson City, TN 37614, USA
    Free Radic Biol Med 39:1570-80. 2005
    ..Similar results were observed in aortic-banding-induced cardiac hypertrophy in mice. Our results suggest that both NFkappaB activation and the PI3K/Akt signaling pathway participate in the development of cardiac hypertrophy in vivo...
  43. ncbi request reprint Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes
    Patrick Y Jay
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    FASEB J 19:1495-7. 2005
    ..Any dependence of gene expression on Nkx2-5 gene dosage is affected by factors specific to the individual gene and the physiologic context...
  44. ncbi request reprint Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    Laurent Dupays
    Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Mol Cell Cardiol 38:787-98. 2005
    ..Direct or indirect effects of Nkx2-5 inactivation on the Cx45 gene expression could explain the absence of the endocardial cushions in the heart of Nkx2-5-/- embryos...
  45. ncbi request reprint Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    Michael A Crackower
    IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Cell 110:737-49. 2002
    ..These data show that PTEN has an important in vivo role in cardiomyocyte hypertrophy and GPCR signaling and identify a function for the PTEN-PI3Kgamma pathway in the modulation of heart muscle contractility...
  46. ncbi request reprint Transcriptional regulation of cardiac conduction system development: 2004 FASEB cardiac conduction system minimeeting, Washington, DC
    Brett S Harris
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:1036-45. 2004
    ..Thus, the precise spatiotemporal regulation of Nkx2.5 levels during development may be required for the progressive emergence of gene expression patterns specific to differentiated Purkinje fiber cells...
  47. pmc bcl-2 overexpression promotes myocyte proliferation
    Federica Limana
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:6257-62. 2002
    ..Taken together, these observations reveal a previously uncharacterized replication-enhancing function of Bcl-2 in myocytes in vivo in the absence of stressful conditions...
  48. ncbi request reprint Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor
    Joachim G Muller
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Mol Cell Cardiol 34:807-21. 2002
    ..5-SRF interactions are capable of producing different transcriptional responses in adult versus neonatal cardiomyocytes, implying important differences in NCX1 promoter tertiary complex formation dependent on developmental stage...
  49. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
    ..Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association...
  50. ncbi request reprint NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro
    William T Pu
    Division of Cardiovascular Research, Children s Hospital, Boston, Mass USA
    Circ Res 92:725-31. 2003
    ....