Steven E Hyman
Affiliation: Harvard University
- NeurotransmittersSteven E Hyman
Harvard University, Cambridge, Massachusetts 02138, USA
Curr Biol 15:R154-8. 2005
- The neurobiology of addiction: implications for voluntary control of behaviorSteven E Hyman
Harvard University, Cambridge, MA 02138, USA
Am J Bioeth 7:8-11. 2007..Possible mechanisms and implications are briefly reviewed...
- Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric DisordersSteven E Hyman
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA Electronic address
Cell Stem Cell 17:253-4. 2015..2015) combine gene targeting and stem cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was found to cause a defect in neurotransmitter release...
- The unconscionable gap between what we know and what we doSteven E Hyman
Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology MIT and Harvard, Cambridge, MA 02142, USA E mail
Sci Transl Med 6:253cm9. 2014..Here, I focus on possible reasons for the failure of policy-makers to respond effectively, and I suggest corrective approaches. ..
- How far can mice carry autism research?Steven E Hyman
Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02142, USA Electronic address
Cell 158:13-4. 2014..The open question is how much we can learn about human ills from such models...
- Might stimulant drugs support moral agency in ADHD children?Steven Edward Hyman
Stanley Center, Broad Institute of Harvard and MIT, 7 Cambridge Center 5015, Cambridge, MA 02142, USA
J Med Ethics 39:369-70; discussion 372-3. 2013..These findings are consistent with laboratory evidence that stimulant drugs in therapeutic doses improve cognitive control over thought and behavior...
- Revolution stalledSteven E Hyman
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Sci Transl Med 4:155cm11. 2012..In this Commentary, I develop a view of what has gone wrong scientifically and ask what can be done to address this parlous situation...
- Addiction: a disease of learning and memorySteven E Hyman
Department of Neurobiology, Harvard Medical School, Boston, MA, USA
Am J Psychiatry 162:1414-22. 2005..The author summarizes the converging evidence in this area and highlights key questions that remain...
- Public health contributionsSteven E Hyman
Schizophr Bull 33:1151-2. 2007
- How might cocaine interfere with brain development?Steven E Hyman
Harvard University, Cambridge, Massachusetts, United States of America
PLoS Med 5:e130. 2008
- Neural mechanisms of addiction: the role of reward-related learning and memorySteven E Hyman
Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Neurosci 29:565-98. 2006..Here we review progress in identifying candidate mechanisms of addiction...
- The diagnosis of mental disorders: the problem of reificationSteven E Hyman
Department of Neurobiology, Harvard Medical School, Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Clin Psychol 6:155-79. 2010..Insights that are beginning to emerge from psychology, neuroscience, and genetics suggest possible strategies for moving forward...
- Cognitive enhancement: promises and perilsSteven E Hyman
Office of the Provost, Massachusetts Hall, Harvard University, Cambridge, MA 02138, USA
Neuron 69:595-8. 2011..Here, I provide a context for discussions based on medical, regulatory, and ethical concerns that have been raised by the possibility that enhancers will emerge from current efforts to discover drugs for neuropsychiatric disorders...
- Can neuroscience be integrated into the DSM-V?Steven E Hyman
Harvard University, Massachusetts Hall, Cambridge, Massachusetts 02138, USA
Nat Rev Neurosci 8:725-32. 2007..It is thus timely to ask whether neuroscience has progressed to the point that the next editions of these manuals can usefully incorporate information about brain structure and function...
- How mice cope with stressful social situationsSteven E Hyman
Department of Neurobiology, Harvard Medical School, Massachusetts Hall, Cambridge, MA 02138, USA
Cell 131:232-4. 2007..As a step toward understanding the neural basis for these individual differences, Krishnan et al. (2007) reveal molecular changes in the brain's reward circuits that make some mice resistant to the effects of social defeat...
- Genome-scale neurogenetics: methodology and meaningSteven A McCarroll
1 Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA 2 Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Nat Neurosci 17:756-63. 2014..Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology. ..
- Medicine. What are the right targets for psychopharmacology?Steven E Hyman
Harvard University, Boston, MA 02138, USA
Science 299:350-1. 2003
- Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiologySteven A McCarroll
Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Electronic address
Neuron 80:578-87. 2013..We argue that technologies at the disposal of neuroscience are adequately advanced to begin to study the biology of common and devastating polygenic disorders. ..
- Decreased absolute amygdala volume in cocaine addictsNikos Makris
Motivation and Emotion Neuroscience Collaboration, Department of Radiology, Harvard Medical School, Boston, MA 02129, USA
Neuron 44:729-40. 2004..These findings argue for a condition that predisposes the individual to cocaine dependence by affecting the amygdala, or a primary event early in the course of cocaine use...
- A glimmer of light for neuropsychiatric disordersSteven E Hyman
Office of the Provost, Harvard University, Department of Neurobiology, Harvard Medical School, Massachusetts Hall, Cambridge, Massachusetts 02138, USA
Nature 455:890-3. 2008..Now, modern genomic technologies have begun to facilitate the discovery of relevant genes...
- Neuroscience, genetics, and the future of psychiatric diagnosisSteven E Hyman
Harvard University, Cambridge, MA 02138, USA
Psychopathology 35:139-44. 2002....
- Levels of analysis in psychiatric researchKathy L Kopnisky
NIH, National Institute of Mental Health, Bethesda, MD 20892 9619, USA
Dev Psychopathol 14:437-61. 2002..This article reviews how these different levels contribute to our understanding of a number of psychiatric disorders, including drug addiction, which has been the focus of much of our own work...
- Computational roles for dopamine in behavioural controlP Read Montague
Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
Nature 431:760-7. 2004..The application of such quantitative models has opened up new fields, ripe for attack by young synthesizers and theoreticians...
- Cognition in schizophreniaSteven E Hyman
Am J Psychiatry 165:312. 2008
- Can autism speak to neuroscience?Steven O Moldin
Department of Psychiatry and Office of the Vice Provost for Research Advancement, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 26:6893-6. 2006
- The human genome project and its impact on psychiatryW Maxwell Cowan
National Institute of Mental Health, Bethesda, Maryland 20892, USA
Annu Rev Neurosci 25:1-50. 2002....
- Recruiting and retaining future generations of physician scientists in mental healthDavid J Kupfer
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Arch Gen Psychiatry 59:657-60. 2002..A coalition of stakeholders--federal, academic, foundational, and in the pharmaceutical industry--is needed to meet these challenges...
- Regulation of ania-6 splice variants by distinct signaling pathways in striatal neuronsVéronique Sgambato
Molecular Plasticity Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
J Neurochem 86:153-64. 2003..These data suggest that different neuronal signals can differentially regulate splicing and that different intracellular pathways can be recruited to yield a given splice variant...
- Diagnosing disordersSteven E Hyman
Harvard Medical School
Sci Am 289:96-103. 2003
- Methylphenidate-induced plasticity: what should we be looking for?Steven E Hyman
Biol Psychiatry 54:1310-1. 2003
- Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neuronsPamela J Voulalas
Molecular Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 25:3763-73. 2005..Thus, signal transduction pathways activated by DR1/5 and mGluR5 interact to modify downstream events in striatal neurons while retaining numerous regulatory checkpoints...
- Introduction: the brain's special statusSteven E Hyman
Cerebrum 6:9-12. 2004
- Even chromatin gets the bluesSteven E Hyman
Nat Neurosci 9:465-6. 2006
- Managing emotional fallout. Parting remarks from America's top psychiatrist. Interview by Diane CoutuSteven E Hyman
Harv Bus Rev 80:55-60, 127. 2002..And he suggests that September 11, 2001, may come to be seen as a tipping point--the moment when managers started to think about dealing with mental health issues on a regular basis...