Eric H Holbrook

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Immunohistochemical characterization of human olfactory tissue
    Eric H Holbrook
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Laryngoscope 121:1687-701. 2011
  2. ncbi request reprint Abnormalities of axon growth in human olfactory mucosa
    Eric H Holbrook
    Department of Otolaryngology, MA Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 115:2144-54. 2005
  3. ncbi request reprint An updated review of clinical olfaction
    Eric H Holbrook
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    Curr Opin Otolaryngol Head Neck Surg 14:23-8. 2006
  4. pmc An Algorithm for Surgical Approach to the Anterior Skull Base
    Matthew R Naunheim
    Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, United States
    J Neurol Surg B Skull Base 77:364-70. 2016
  5. doi request reprint The impact of surgical trainee participation on sinus surgery outcomes
    Josh C Meier
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary
    Laryngoscope 126:316-21. 2016
  6. doi request reprint EQ-5D-derived health utility values in patients undergoing surgery for chronic rhinosinusitis
    Aaron K Remenschneider
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U S A
    Laryngoscope 125:1056-61. 2015
  7. doi request reprint Long-Term Outcomes in Sinus Surgery: A New Tool for Measuring Health-Related Quality of Life
    Aaron K Remenschneider
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 151:164-70. 2014
  8. doi request reprint The EQ-5D: a new tool for studying clinical outcomes in chronic rhinosinusitis
    Aaron K Remenschneider
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U S A
    Laryngoscope 125:7-15. 2015
  9. doi request reprint Syndrome of inappropriate antidiuretic hormone secretion in patients with olfactory neuroblastoma
    Stacey T Gray
    Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otolaryngol Head Neck Surg 147:147-51. 2012
  10. doi request reprint General antibiotic exposure is associated with increased risk of developing chronic rhinosinusitis
    Alice Z Maxfield
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U S A
    Laryngoscope . 2016

Collaborators

Detail Information

Publications26

  1. pmc Immunohistochemical characterization of human olfactory tissue
    Eric H Holbrook
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Laryngoscope 121:1687-701. 2011
    ..Furthermore, a comparison of the molecular phenotype of olfactory epithelial cells between rodents and humans will improve our ability to correlate human histopathology with olfactory dysfunction...
  2. ncbi request reprint Abnormalities of axon growth in human olfactory mucosa
    Eric H Holbrook
    Department of Otolaryngology, MA Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 115:2144-54. 2005
    ..However, detailed analysis of the subepithelial tissue with specific attention to the fascicles of the olfactory nerve and abnormalities of axonal growth may improve the correlation of histopathology with sensory function...
  3. ncbi request reprint An updated review of clinical olfaction
    Eric H Holbrook
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    Curr Opin Otolaryngol Head Neck Surg 14:23-8. 2006
    ..Disorders of the sense of smell can result through hundreds of different processes, but most commonly occur from upper-respiratory-tract infections, trauma, and chronic rhinosinusitis...
  4. pmc An Algorithm for Surgical Approach to the Anterior Skull Base
    Matthew R Naunheim
    Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, United States
    J Neurol Surg B Skull Base 77:364-70. 2016
    ..To characterize our experience with the surgical management of anterior skull base malignancy, and to propose an algorithm for surgical approach to anterior skull base malignancies...
  5. doi request reprint The impact of surgical trainee participation on sinus surgery outcomes
    Josh C Meier
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary
    Laryngoscope 126:316-21. 2016
    ..To determine the effect of otolaryngology trainee participation on clinical outcomes in patients who undergo endoscopic sinus surgery (ESS) for chronic rhinosinusitis...
  6. doi request reprint EQ-5D-derived health utility values in patients undergoing surgery for chronic rhinosinusitis
    Aaron K Remenschneider
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U S A
    Laryngoscope 125:1056-61. 2015
    ..The Euroqol 5-Dimension (EQ-5D) questionnaire is a widely used method for determining HUV, but it has not been applied for this purpose in patients with chronic rhinosinusitis (CRS) who undergo sinus surgery...
  7. doi request reprint Long-Term Outcomes in Sinus Surgery: A New Tool for Measuring Health-Related Quality of Life
    Aaron K Remenschneider
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 151:164-70. 2014
    ..It has not previously been applied to US patients undergoing endoscopic sinus surgery (ESS)...
  8. doi request reprint The EQ-5D: a new tool for studying clinical outcomes in chronic rhinosinusitis
    Aaron K Remenschneider
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U S A
    Laryngoscope 125:7-15. 2015
    ..To describe the role and applicability of the EuroQol 5-Dimension, 5-Level (EQ-5D-5L) questionnaire for the assessment of general health-related quality of life in patients with chronic rhinosinusitis...
  9. doi request reprint Syndrome of inappropriate antidiuretic hormone secretion in patients with olfactory neuroblastoma
    Stacey T Gray
    Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otolaryngol Head Neck Surg 147:147-51. 2012
    ..The purpose of this study was to review our experience with olfactory neuroblastoma and to identify all patients who had a history of SIADH prior to the diagnosis of ONB...
  10. doi request reprint General antibiotic exposure is associated with increased risk of developing chronic rhinosinusitis
    Alice Z Maxfield
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U S A
    Laryngoscope . 2016
    ..This study was undertaken to investigate whether antibiotic use may be an unrecognized risk factor for developing CRS...
  11. doi request reprint Impact of endoscopic dacryocystorhinostomy on sinonasal quality of life
    Marcel M Miyake
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Rhinol Allergy 30:189-91. 2016
    ..The purpose of this study was to determine whether patients who underwent eDCR experienced any decrement in sinonasal quality of life...
  12. doi request reprint Volumetric analysis of chronic maxillary atelectasis
    Giant C Lin
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Rhinol Allergy 29:166-9. 2015
    ..The relationship between orbit and maxillary sinus volumes in patients with chronic maxillary atelectasis (CMA), commonly known as silent sinus syndrome if enophthalmos is present, is poorly understood...
  13. doi request reprint Outcomes analysis in epistaxis management: development of a therapeutic algorithm
    Josef Shargorodsky
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 149:390-8. 2013
    ..This study explored the outcomes of epistaxis treatment modalities to optimize management and enable the development of a therapeutic algorithm...
  14. doi request reprint Diagnostic characteristics of sinonasal organizing hematomas: avoiding misdiagnosis
    Arthur W Wu
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    Int Forum Allergy Rhinol 3:598-602. 2013
    ..Diagnostic criteria for correctly identifying these lesions are not well known...
  15. doi request reprint A new model for collection of clinical outcomes data in patients with chronic rhinosinusitis
    Josh C Meier
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA Department of Otology and Laryngology, Harvard Medical School, Boston, MA
    Int Forum Allergy Rhinol 4:411-5. 2014
    ..The purpose of this study is to describe the implementation of an online model for collection of clinical outcomes data in patients with chronic rhinosinusitis (CRS)...
  16. pmc Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia
    Harry Pantazopoulos
    Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Schizophr Res 150:366-72. 2013
    ..Given the role CSPGs play in OE cell differentiation and axon guidance, we suggest that altered CSPG expression may contribute to ORN lineage dysregulation, and olfactory identification abnormalities, observed in SZ. ..
  17. pmc Office-based olfactory mucosa biopsies
    Eric H Holbrook
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Harvard Medical School, Boston, MA
    Int Forum Allergy Rhinol 6:646-53. 2016
    ..Confirmatory tissue staining analysis assures olfactory mucosa has been obtained, thereby strengthening clinical correlations and scientific conclusions...
  18. pmc Aseptic Meningitis with Craniopharyngioma Resection: Consideration after Endoscopic Surgery
    Jenny X Chen
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
    J Neurol Surg Rep 77:e151-e155. 2016
    ..b>Conclusions‚ÄÉConsideration of aseptic meningitis following craniopharyngioma resection is critical to avoid unnecessary surgical re-exploration and prolonged courses of antibiotics...
  19. doi request reprint Treatment outcomes and prognostic factors, including human papillomavirus, for sinonasal undifferentiated carcinoma: a retrospective review
    Stacey T Gray
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts Massachusetts Eye and Ear Infirmary Massachusetts General Hospital Cranial Base Center, Boston, Massachusetts
    Head Neck 37:366-74. 2015
    ..Low incidence and poor outcomes make identification of prognostic factors and treatment standardization difficult. Similarly, little is known regarding the association of human papillomavirus (HPV) with SNUC...
  20. pmc The regeneration of P2 olfactory sensory neurons is selectively impaired following methyl bromide lesion
    Eric H Holbrook
    Department of Otology and Laryngology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA, Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Chem Senses 39:601-16. 2014
    ....
  21. doi request reprint Management of severe epistaxis after Young's procedure: a case report
    Jonathan Y Ting
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Int Forum Allergy Rhinol 3:334-7. 2013
    ..While this procedure results in loss of smell and permanent nasal obstruction, proponents note significant improvement in patient symptomatology...
  22. doi request reprint Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitis
    Moshe Yamin
    Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Allergy Clin Immunol 122:1145-1153.e3. 2008
    ..Chronic rhinosinusitis (CRS) is characterized by persistent mucosal inflammation and frequent exacerbations...
  23. ncbi request reprint Olfactory loss as a result of toxic exposure
    Urmen D Upadhyay
    Tufts University School of Medicine, New England Medical Center, 750 Washington Street, NEMC 850, Boston, MA 02111, USA
    Otolaryngol Clin North Am 37:1185-207. 2004
    ..Furthermore, with increasing regulations of occupational environments and stricter policies on industrial air pollution, olfactory dysfunction secondary to toxicity should become less prevalent...
  24. ncbi request reprint Lack of significant correlation between rhinosinusitis symptoms and specific regions of sinus computer tomography scans
    Eric H Holbrook
    Department of Otolaryngology Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Rhinol 19:382-7. 2005
    ..The sinonasal computer tomography (CT) scan is frequently used to help confirm the diagnosis of rhinosinusitis. However, little data exist correlating patient symptoms with CT findings...
  25. ncbi request reprint Anosmia: diagnosis and management
    Eric H Holbrook
    Department of Otolaryngology Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 1225, USA
    Curr Opin Otolaryngol Head Neck Surg 11:54-60. 2003
    ..A detailed history and physical examination are the most powerful tools in the evaluation of smell disorders, whereas imaging studies are reserved for preoperative planning or detailed assessment of positive physical findings...
  26. pmc Matrix metalloproteinase expression in the olfactory epithelium
    Toshiaki Tsukatani
    Department of Physiology, School of Medicine, Kanazawa University, 13 1 Takaramachi Kanazawa 920 0934, Japan
    Neuroreport 14:1135-40. 2003
    ..The results show a correlation between MMP and TIMP levels and the stages of neural degeneration, regeneration and recovery of the olfactory epithelium following injury...