Genomes and Genes
Rhonda L Feinbaum
Affiliation: Harvard University
- Genome-wide identification of Pseudomonas aeruginosa virulence-related genes using a Caenorhabditis elegans infection modelRhonda L Feinbaum
Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Pathog 8:e1002813. 2012..elegans are biased towards evolutionarily conserved genes...
- Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureusJavier E Irazoqui
Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Pathog 6:e1000982. 2010..aeruginosa nor the S. aureus-triggered response requires canonical TLR signaling, they imply the existence of unidentified mechanisms for pathogen detection in C. elegans, with potentially conserved roles also in mammals...
- The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxificationRead Pukkila-Worley
Division of Infectious Diseases Massachusetts General Hospital Harvard Medical School Boston, Massachusetts, United States of America Department of Molecular Biology Massachusetts General Hospital Harvard Medical School Boston, Massachusetts, United States of America Department of Genetics Harvard Medical School Boston, Massachusetts, United States of America
PLoS Pathog 10:e1004143. 2014..These data define a central role for MDT-15/MED15 in the coordination of xenobiotic detoxification and innate immune responses. ..
- Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorialDaniel G Lee
Department of Molecular Biology, Massachusetts General Hospital, Cambridge Street, Boston, Massachusetts 02114, USA
Genome Biol 7:R90. 2006..We therefore sequenced a highly virulent strain of P. aeruginosa, PA14, and compared it with a previously sequenced (and less pathogenic) strain, PAO1, to identify novel virulence genes...