Alexey V Fedulov

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation
    Mohamed S Arredouani
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Immunol 178:5912-20. 2007
  2. pmc Maternal allergic contact dermatitis causes increased asthma risk in offspring
    Robert H Lim
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Respir Res 8:56. 2007
  3. ncbi request reprint Serum TGF-beta 1 and TNF-alpha levels and cardiac fibrosis in experimental chronic renal failure
    Alexey V Fedulov
    St Petersburg State Pavlov Medical University, Russia
    Immunol Invest 34:143-52. 2005
  4. ncbi request reprint Duration of allergic susceptibility in maternal transmission of asthma risk
    Alexey V Fedulov
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Reprod Immunol 58:120-8. 2007
  5. pmc Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility
    Alexey V Fedulov
    Harvard School of Public Health, Dept of Environmental Health, Molecular and Integrative Physiological Sciences Program, 665 Huntington Ave, HSPH 12, Room 1313, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:57-67. 2008
  6. pmc Allergy risk is mediated by dendritic cells with congenital epigenetic changes
    Alexey V Fedulov
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 44:285-92. 2011
  7. pmc Link between epigenomic alterations and genome-wide aberrant transcriptional response to allergen in dendritic cells conveying maternal asthma risk
    Lyudmila Mikhaylova
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e70387. 2013
  8. doi request reprint Customized PCR-array analysis informed by gene-chip microarray and biological hypothesis reveals pathways involved in lung inflammatory response to titanium dioxide in pregnancy
    Denise P Lamoureux
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Toxicol Environ Health A 73:596-606. 2010
  9. ncbi request reprint Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission
    Alexey Fedulov
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 175:4292-300. 2005
  10. ncbi request reprint Maternal stress during pregnancy increases neonatal allergy susceptibility: Role of glucocorticoids
    Robert Lim
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    Am J Physiol Lung Cell Mol Physiol 307:L141-8. 2014

Research Grants

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation
    Mohamed S Arredouani
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Immunol 178:5912-20. 2007
    ..The data identify a novel role for SR-As expressed on lung DCs in the down-regulation of specific immune responses to aeroallergens by the reduction of DC migration from the site of Ag uptake to the draining lymph nodes...
  2. pmc Maternal allergic contact dermatitis causes increased asthma risk in offspring
    Robert H Lim
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Respir Res 8:56. 2007
    ..The objective of this study was to determine whether maternal allergy at non-pulmonary sites can increase asthma risk in offspring...
  3. ncbi request reprint Serum TGF-beta 1 and TNF-alpha levels and cardiac fibrosis in experimental chronic renal failure
    Alexey V Fedulov
    St Petersburg State Pavlov Medical University, Russia
    Immunol Invest 34:143-52. 2005
    ....
  4. ncbi request reprint Duration of allergic susceptibility in maternal transmission of asthma risk
    Alexey V Fedulov
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Reprod Immunol 58:120-8. 2007
    ..Asthma has its origins in early-life. Maternal, not paternal asthma is an important risk factor, but the mechanisms and the duration of the maternal effect are unknown...
  5. pmc Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility
    Alexey V Fedulov
    Harvard School of Public Health, Dept of Environmental Health, Molecular and Integrative Physiological Sciences Program, 665 Huntington Ave, HSPH 12, Room 1313, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:57-67. 2008
    ....
  6. pmc Allergy risk is mediated by dendritic cells with congenital epigenetic changes
    Alexey V Fedulov
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 44:285-92. 2011
    ..Our findings suggest that maternal allergy results in an altered epigenetic profile in neonatal DCs that is independent of encounters with allergens and is linked to pro-allergic function...
  7. pmc Link between epigenomic alterations and genome-wide aberrant transcriptional response to allergen in dendritic cells conveying maternal asthma risk
    Lyudmila Mikhaylova
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e70387. 2013
    ..The findings are consistent with the emerging paradigm that asthma is a disease with underlying epigenetic changes. ..
  8. doi request reprint Customized PCR-array analysis informed by gene-chip microarray and biological hypothesis reveals pathways involved in lung inflammatory response to titanium dioxide in pregnancy
    Denise P Lamoureux
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Toxicol Environ Health A 73:596-606. 2010
    ....
  9. ncbi request reprint Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission
    Alexey Fedulov
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 175:4292-300. 2005
    ..Treatment with CpG just before OVA aerosol challenge also prevented allergic responses. The data support the potential for immunomodulatory therapy with CpG in early life to reduce susceptibility to asthma...
  10. ncbi request reprint Maternal stress during pregnancy increases neonatal allergy susceptibility: Role of glucocorticoids
    Robert Lim
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts
    Am J Physiol Lung Cell Mol Physiol 307:L141-8. 2014
    ..Because inflammation typically includes a stress hormone response, the results also suggest a common pathway by which various injurious exposures during pregnancy might increase offspring susceptibility to asthma. ..
  11. pmc MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway
    Ruoxi Hu
    1Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, 665 Huntington Ave, Room I 305, Boston, MA 02115, USA
    FASEB J 28:2347-57. 2014
    ..Hu, R., Pan, W., Fedulov, A. V., Jester, W., Jones, M. R., Weiss, S. T., Panettieri, R. A., Jr., Tantisira, K., Lu, Q. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. ..
  12. doi request reprint Immunotoxicologic analysis of maternal transmission of asthma risk
    Alexey V Fedulov
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunotoxicol 5:445-52. 2008
    ..We review here experimental models of maternal transmission of asthma risk, the progress to date in identifying mechanisms, and potential directions for future research...
  13. pmc Air pollution particles diminish bacterial clearance in the primed lungs of mice
    Samuel Sigaud
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Toxicol Appl Pharmacol 223:1-9. 2007
    ..The model reported here will allow further analysis of priming and CAPs exposure on lung sensitivity to infection...
  14. pmc Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice
    Alison S Williams
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41088. 2012
    ..In conclusion, T-cad does not mediate the protective effects of adiponectin. Instead, mice lacking T-cad have reduced allergic airways disease, likely because elevated serum adiponectin levels act on other adiponectin signaling pathways...
  15. pmc Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain
    David J Gregory
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epigenetics 7:344-9. 2012
    ..Specific reactivation of epigenetically silenced genes may thus be achievable by this approach, which provides a broadly useful strategy to further our exploration of biological mechanisms and to improve control over the epigenome...

Research Grants2

  1. Inhaled environmental particles, pregnancy and neonatal allergy
    Alexey Fedulov; Fiscal Year: 2007
    ..This research will provide novel insights into the basic question of early life origins of asthma and the applied question of how environmental agents mediate in utero effects. ..