Michael W Donnino

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Characterization of mitochondrial injury after cardiac arrest (COMICA)
    Michael W Donnino
    Beth Israel Deaconess Medical Center, Department of Emergency Medicine, Boston, MA, United States Beth Israel Deaconess Medical Center, Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Boston, MA, United States Electronic address
    Resuscitation . 2017
  2. pmc Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Crit Care 20:82. 2016
  3. pmc Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road West CC 2, Boston, MA, 02215, USA
    Crit Care 19:275. 2015
  4. pmc Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, W CC 2, MA, 02215, USA Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
    BMJ 348:g3028. 2014
  5. pmc APACHE II scoring to predict outcome in post-cardiac arrest
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Resuscitation 84:651-6. 2013
  6. pmc Performance of SAPS II and SAPS III scores in post-cardiac arrest
    J D Salciccioli
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Minerva Anestesiol 78:1341-7. 2012
  7. pmc A pilot study examining the severity and outcome of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitals
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 126:1478-83. 2012
  8. pmc Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
    Howard A Smithline
    Department of Emergency Medicine, Tufts University School of Medicine and Baystate Medical Center, Springfield, MA, USA
    BMC Clin Pharmacol 12:4. 2012
  9. doi request reprint Thiamine deficiency in critically ill patients with sepsis
    Michael W Donnino
    Department of Emergency Medicine and Internal Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Crit Care 25:576-81. 2010
  10. pmc Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, West Clinical Center 2, Boston, MA 02215, USA
    Crit Care 15:R189. 2011

Detail Information

Publications77

  1. doi request reprint Characterization of mitochondrial injury after cardiac arrest (COMICA)
    Michael W Donnino
    Beth Israel Deaconess Medical Center, Department of Emergency Medicine, Boston, MA, United States Beth Israel Deaconess Medical Center, Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Boston, MA, United States Electronic address
    Resuscitation . 2017
    ..We hypothesized that increased levels of mitochondrial biomarkers would be associated with mortality and neurological morbidity in post-cardiac arrest subjects...
  2. pmc Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Crit Care 20:82. 2016
    ..The purpose of this study was to determine whether the provision of corticosteroids improves time to shock reversal and outcomes in patients with post-cardiac arrest shock...
  3. pmc Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road West CC 2, Boston, MA, 02215, USA
    Crit Care 19:275. 2015
    ..The objective of the current study was to assess whether the provision of exogenous ubiquinol (the reduced form of CoQ10) could increase plasma CoQ10 levels and improve mitochondrial function...
  4. pmc Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, W CC 2, MA, 02215, USA Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
    BMJ 348:g3028. 2014
    ..To determine if earlier administration of epinephrine (adrenaline) in patients with non-shockable cardiac arrest rhythms is associated with increased return of spontaneous circulation, survival, and neurologically intact survival...
  5. pmc APACHE II scoring to predict outcome in post-cardiac arrest
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Resuscitation 84:651-6. 2013
    ..The goal of the current investigation was to assess the Acute Physiology and Chronic Health Evaluation II score in post-cardiac arrest...
  6. pmc Performance of SAPS II and SAPS III scores in post-cardiac arrest
    J D Salciccioli
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Minerva Anestesiol 78:1341-7. 2012
    ..Our objective was to determine if SAPS II and SAPS III scores predict outcomes in post-cardiac arrest patients...
  7. pmc A pilot study examining the severity and outcome of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitals
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 126:1478-83. 2012
    ..We tested whether hospital-independent factors would account for the difference in outcome between 2 geographically distinct hospitals...
  8. pmc Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
    Howard A Smithline
    Department of Emergency Medicine, Tufts University School of Medicine and Baystate Medical Center, Springfield, MA, USA
    BMC Clin Pharmacol 12:4. 2012
    ..The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects...
  9. doi request reprint Thiamine deficiency in critically ill patients with sepsis
    Michael W Donnino
    Department of Emergency Medicine and Internal Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Crit Care 25:576-81. 2010
    ..The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis...
  10. pmc Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, West Clinical Center 2, Boston, MA 02215, USA
    Crit Care 15:R189. 2011
    ..Moreover, statin therapy may decrease CoQ10 levels, but whether this occurs acutely remains unknown. We measured CoQ10 levels in septic shock patients enrolled in a randomized trial of simvastatin versus placebo...
  11. doi request reprint The development and implementation of cardiac arrest centers
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, WCC2, Boston, MA 02215, United States
    Resuscitation 82:974-8. 2011
    ..This paper may assist other potential clinical sites that are considering or actively developing cardiac arrest centers of their own...
  12. ncbi request reprint Determining disease severity in severe sepsis and septic shock
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Road, West CC2, Boston, MA 02215, USA
    Intern Emerg Med 1:219-20. 2006
  13. pmc Coronary artery bypass graft surgery depletes plasma thiamine levels
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nutrition 26:133-6. 2010
    ..The stress of surgery and critical disease depletes electrolytes, minerals, and essential biochemical substrates. We hypothesized that critical illness (represented by major surgery) would result in decreased thiamine levels over time...
  14. doi request reprint Statin therapy is associated with decreased mortality in patients with infection
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acad Emerg Med 16:230-4. 2009
    ..The objective was to investigate the association between statin therapy and mortality in emergency department (ED) patients with suspected infection...
  15. ncbi request reprint Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Emerg Med 50:715-21. 2007
    ..Further, physician knowledge of this disease is vital because the failure to diagnose results in severe neurologic morbidity and possible mortality, but the treatment is safe and effective...
  16. ncbi request reprint Distinctive acid-base pattern in Wernicke's encephalopathy
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Emerg Med 50:722-5. 2007
    ..Observation of this acid-base disturbance should prompt clinicians to consider thiamine deficiency disorders as a possible cause...
  17. ncbi request reprint Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients
    Michael W Donnino
    Beth Israel Deaconess Medical Center, Department of Emergency Medicine, One Deaconess Road, CC2 Boston, MA, United States
    Resuscitation 75:229-34. 2007
    ..We investigated whether early, high lactate clearance was associated with reduced mortality in post-cardiac arrest patients...
  18. ncbi request reprint Inadequate blood volume collected for culture: a survey of health care professionals
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Hospital, One Deaconess Road, Boston, MA 02215, USA
    Mayo Clin Proc 82:1069-72. 2007
    ..Because volume remains the most important determinant for the optimal yield of organisms, these findings raise an important quality assurance issue...
  19. pmc Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study
    Michael W Donnino
    1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 2Department of Medicine, Division of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 3Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark 4Department of Medicine, Division of Pulmonary and Critical Care, Baystate Medical Center, MA 5Department of Medicine, Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 6Department of Emergency Medicine, Baystate Medical Center, MA 7Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Crit Care Med 44:360-7. 2016
    ..To determine if intravenous thiamine would reduce lactate in patients with septic shock...
  20. pmc The prevalence and significance of abnormal vital signs prior to in-hospital cardiac arrest
    Lars W Andersen
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
    Resuscitation 98:112-7. 2016
    ..The purpose of this study was to determine the prevalence of abnormal vital signs 1-4h before cardiac arrest, and to evaluate the association between these vital sign abnormalities and in-hospital mortality...
  21. pmc Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients
    Michael N Cocchi
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
    Resuscitation 83:991-5. 2012
    ..Therapeutic options are limited. Previous data suggest a benefit of coenzyme Q(10) (CoQ(10)) in post-arrest patients. We hypothesized that plasma CoQ(10) levels would be low after CA and associated with poorer outcomes...
  22. doi request reprint Association Between Tracheal Intubation During Pediatric In-Hospital Cardiac Arrest and Survival
    Lars W Andersen
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts2Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark3Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark
    JAMA 316:1786-1797. 2016
    ..Tracheal intubation is common during pediatric in-hospital cardiac arrest, although the relationship between intubation during cardiac arrest and outcomes is unknown...
  23. pmc Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial
    Lars W Andersen
    Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
    Crit Care 20:92. 2016
    ..The objective of this study was to determine if thiamine administration prior to coronary artery bypass grafting would decrease post-operative lactate levels as a measure of increased aerobic metabolism...
  24. ncbi request reprint Performance of severity of illness scoring systems in emergency department patients with infection
    Michael D Howell
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 14:709-14. 2007
    ....
  25. doi request reprint Cytochrome C in Patients with Septic Shock
    Lars W Andersen
    Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts Resuscitation Institute at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois Department of Medicine, Division of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Shock 45:512-7. 2016
    ....
  26. ncbi request reprint The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failure
    Katherine M Berg
    Department of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215 USA
    Respir Care 57:1548-54. 2012
    ..The rapid shallow breathing index (RSBI) is a validated tool for predicting readiness for extubation. We evaluated the ability of the RSBI to predict failure of NIV and mortality in ARF...
  27. pmc Etiology and therapeutic approach to elevated lactate levels
    Lars W Andersen
    Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    Mayo Clin Proc 88:1127-40. 2013
    ..The review ends with some general recommendations on the management of patients with elevated lactate levels. ..
  28. pmc Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients
    Justin D Salciccioli
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Resuscitation 84:1728-33. 2013
    ..Our objective was to determine whether neuromuscular blockade is associated with improved outcomes after out-of-hospital cardiac arrest...
  29. pmc Prevalence and characteristics of nonlactate and lactate expressors in septic shock
    Andrea Freyer Dugas
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Crit Care 27:344-50. 2012
    ..The study's objective was to determine the proportion and patient characteristics of patients in vasopressor-dependent septic shock who presented without lactatemia...
  30. doi request reprint Pyruvate Dehydrogenase Activity Is Decreased in Emergency Department Patients With Diabetic Ketoacidosis
    Lars W Andersen
    The Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    Acad Emerg Med 23:685-9. 2016
    ..The pyruvate dehydrogenase complex (PDH) is an essential enzyme in aerobic metabolism. Ketones are known to inhibit PDH activity, but the extent of this inhibition is unknown in patients with diabetic ketoacidosis (DKA)...
  31. doi request reprint Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients
    David W Callaway
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Trauma 66:1040-4. 2009
    ..No study has defined the role of these markers in the triage and management of the normotensive injured elderly patient...
  32. doi request reprint When to Stop CPR and When to Perform Rhythm Analysis: Potential Confusion Among ACLS Providers
    Brandon Giberson
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Intensive Care Med 31:537-43. 2016
    ..We hypothesized that this new ACLS algorithm may lead to uncertainty regarding the appropriate action following detection of a pulse during a cardiac arrest...
  33. doi request reprint The relationship between age and outcome in out-of-hospital cardiac arrest patients
    Lars W Andersen
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
    Resuscitation 94:49-54. 2015
    ..To determine the association between age and outcome in a large multicenter cohort of out-of-hospital cardiac arrest patients...
  34. pmc Prevalence and significance of lactic acidosis in diabetic ketoacidosis
    Kristin Cox
    Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA 02215, USA
    J Crit Care 27:132-7. 2012
    ..The objective of this study was to determine the prevalence of lactic acidosis in DKA and its association with intensive care unit (ICU) length of stay (LOS) and mortality...
  35. doi request reprint International validation of the out-of-hospital cardiac arrest score in the United States
    Sabina Hunziker
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Crit Care Med 39:1670-4. 2011
    ..The aim of this study is to externally validate this score in an independent patient population in the United States...
  36. doi request reprint Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection
    Todd A Seigel
    Department of Emergency Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 42:254-9. 2012
    ..The presence of systemic inflammatory response criteria aids in recognition of infection, although the reliability of these markers is variable...
  37. doi request reprint Postoperative Lactate Levels and Hospital Length of Stay After Cardiac Surgery
    Lars W Andersen
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA Department of Anesthesiology, Aarhus University Hospital, Denmark Electronic address
    J Cardiothorac Vasc Anesth 29:1454-60. 2015
    ..The objective of this study was to characterize the association between lactate levels and hospital length of stay (LOS) after cardiac surgery...
  38. pmc Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis
    Lars W Andersen
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Rosenberg Building, One Deaconess Road, Boston, MA 02215, USA Department of Anesthesiology, Aarhus University Hospital, Nørrebrogade 44, Bygn 21, 1 Aarhus 8000, Denmark Research Center for Emergency Medicine, Aarhus University Hospital, Trøjborgvej 72 74, Bygn 30, Aarhus 8200, Denmark
    BMJ 353:i1577. 2016
    ....
  39. doi request reprint Reasons for death in patients with sepsis and septic shock
    Ari Moskowitz
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    J Crit Care 38:284-288. 2016
    ..However, reasons for death in sepsis remain poorly understood. We sought to characterize reasons for in-hospital mortality in a population of patients with sepsis or septic shock...
  40. pmc Initial lactate and lactate change in post-cardiac arrest: a multicenter validation study
    Michael W Donnino
    1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 2Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 3Research Center for Emergency Medicine, Aarhus University, Aarhus, Denmark 4Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 5Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA 6Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 7Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Crit Care Med 42:1804-11. 2014
    ..This association has not been validated in a prospective multicenter study. The objective of the current study was to determine the association between percent lactate change and outcomes in post-cardiac arrest patients...
  41. ncbi request reprint Relative adrenal insufficiency in post-cardiac arrest shock is under-recognized
    Joseph B Miller
    Henry Ford Hospital, Department of Emergency Medicine, 2799 West Grand Boulevard, Detroit, MI 48202, United States
    Resuscitation 76:221-5. 2008
    ..We sought to investigate current clinical practice pertaining to the evaluation for relative adrenal insufficiency in post-cardiac arrest shock...
  42. pmc The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity
    Teng J Peng
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, W CC 2, Boston, MA, 02215, USA
    Crit Care 19:160. 2015
    ..However, the incidence of dextrose administration during cardiac arrest and the association of dextrose administration with survival and other outcomes are unknown...
  43. pmc Fever after rewarming: incidence of pyrexia in postcardiac arrest patients who have undergone mild therapeutic hypothermia
    Michael N Cocchi
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Intensive Care Med 29:365-9. 2014
    ..We attempted to determine the incidence of fever after TH and hypothesized that those patients who were febrile after rewarming would have worse clinical outcomes than those who maintained normothermia in the postrewarming period...
  44. pmc The association between a quantitative computed tomography (CT) measurement of cerebral edema and outcomes in post-cardiac arrest-a validation study
    Cristal Cristia
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States Electronic address
    Resuscitation 85:1348-53. 2014
    ..2 reliably indicates poor survival post-cardiac arrest. We also sought to determine the inter-rater variability among reviewers, and examine the utility of a novel GWR measurement to facilitate easier practical use...
  45. pmc Sublingual microcirculation is impaired in post-cardiac arrest patients
    Yasser G Omar
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Resuscitation 84:1717-22. 2013
    ..We also assessed the association between microcirculatory dysfunction and inflammatory markers in the post-cardiac arrest state...
  46. doi request reprint Predictors of bacteremia in emergency department patients with suspected infection
    Maureen Chase
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Emerg Med 30:1691-7. 2012
    ..The goal of this study is to identify clinical variables associated with bacteremia. Such data could provide a rational basis for blood culture testing in emergency department (ED) patients with suspected infection...
  47. doi request reprint Neurologic recovery after therapeutic hypothermia in patients with post-cardiac arrest myoclonus
    Jason M Lucas
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
    Resuscitation 83:265-9. 2012
    ..The concept that early myoclonus heralds a uniformly poor prognosis may need to be reconsidered in the era of post-cardiac arrest mild therapeutic hypothermia...
  48. pmc The Association Between Admission Magnesium Concentrations and Lactic Acidosis in Critical Illness
    Ari Moskowitz
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Intensive Care Med 31:187-92. 2016
    ....
  49. pmc Intravenous thiamine is associated with increased oxygen consumption in critically ill patients with preserved cardiac index
    Katherine M Berg
    1 Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine
    Ann Am Thorac Soc 11:1597-601. 2014
    ..Oxygen consumption may be impaired in critically ill patients...
  50. doi request reprint Absolute lactate value vs relative reduction as a predictor of mortality in severe sepsis and septic shock
    Sharukh Lokhandwala
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA Harvard Medical School, Boston, MA Massachussetts Institute of Technology, Cambridge, MA Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle, WA Electronic address
    J Crit Care 37:179-184. 2017
    ..Among patients with an initial lactate >4mmol/L, we compared mortality prediction between a subsequent lactate ≥4mmol/L to a <10% and <20% decrease between initial and subsequent lactate values...
  51. doi request reprint Acute respiratory compromise on inpatient wards in the United States: Incidence, outcomes, and factors associated with in-hospital mortality
    Lars W Andersen
    Department of Medicine, Regional Hospital Holstebro, Aarhus University, Holstebro, Denmark Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark
    Resuscitation 105:123-9. 2016
    ..To estimate the United States' incidence and in-hospital mortality of acute respiratory events on inpatient wards and to identify factors associated with mortality...
  52. pmc The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis
    Ari Moskowitz
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA Electronic address
    J Crit Care 29:182.e5-8. 2014
    ..In the present study, we hypothesize that thiamine deficiency is associated with elevated lactate in patients with DKA...
  53. pmc Pyruvate Dehydrogenase Activity and Quantity Decreases After Coronary Artery Bypass Grafting: a Prospective Observational Study
    Lars W Andersen
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark and Division of Cardiothoracic Surgery and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Shock 43:250-4. 2015
    ..The main purpose of this study was to determine if PDH activity is affected by major stress in the form of coronary artery bypass grafting (CABG), which has previously been used as a model of critical illness...
  54. doi request reprint Estimating duration of central venous catheter at time of insertion: Clinician judgment and clinical predictors
    Mathias J Holmberg
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215 Research Center for Emergency Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark Electronic address
    J Crit Care 30:1299-302. 2015
    ..The aim of this study was to investigate whether clinicians can estimate the length of time a central venous catheter (CVC) will remain in place and to identify variables that may predict CVC duration...
  55. pmc Neurologic outcome in comatose patients resuscitated from out-of-hospital cardiac arrest with prolonged downtime and treated with therapeutic hypothermia
    Won Young Kim
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States Department of Emergency Medicine, Ulsan University College of Medicine, Asan Medical Center, Seoul, Republic of Korea
    Resuscitation 85:1042-6. 2014
    ..The aim of this study was to determine the rate of good neurologic outcome based on the duration of resuscitation efforts in OHCA patients treated with TH...
  56. ncbi request reprint The utility of head computed tomography in the emergency department evaluation of syncope
    Nikhil Goyal
    Department of Emergency Medicine, Henry Ford Hospital, 2799 W Grand Blvd, CFP 2, Detroit, MI 48226, USA
    Intern Emerg Med 1:148-50. 2006
    ..We undertook the following investigation to determine whether HCT aids in the diagnostic investigation of syncope...
  57. ncbi request reprint Identification and resuscitation of the trauma patient in shock
    Michael N Cocchi
    Department of Emergency Medicine, Harvard Affiliated Emergency Medicine Residency, Beth Israel Deaconess Medical Center, One Deaconess Road, West Campus Clinical Center, 2nd Floor, Boston, MA 02215, USA
    Emerg Med Clin North Am 25:623-42, vii. 2007
    ..Resuscitation strategies (delayed resuscitation, damage control resuscitation), end points of resuscitation, and the role of blood products and pro-coagulants for resuscitation are discussed...
  58. doi request reprint Thiamine as a neuroprotective agent after cardiac arrest
    Kohei Ikeda
    Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    Resuscitation 105:138-44. 2016
    ..The objective of this study was to examine whether administration of thiamine improves outcomes after cardiac arrest in mice. Secondarily, we aimed to characterize the impact of cardiac arrest on PDH activity in mice and humans...
  59. doi request reprint Acute Respiratory Compromise in the Emergency Department: A Description and Analysis of 3571 Events from the Get With the Guidelines-Resuscitation® Registry
    Carl Mathias Karlsson
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark
    J Emerg Med . 2017
    ..Respiratory events requiring the use of assisted ventilation are relatively common in the emergency department (ED), and can be associated with substantial morbidity and mortality...
  60. doi request reprint The impact of downtime on neurologic intact survival in patients with targeted temperature management after out-of-hospital cardiac arrest: National multicenter cohort study
    Won Young Kim
    Department of Emergency Medicine, Ulsan University College of Medicine, Asan Medical Center, Seoul, Republic of Korea Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA Electronic address
    Resuscitation 105:203-8. 2016
    ..We investigated how downtime, defined as the interval from collapse-to-return of spontaneous circulation (ROSC), impacts on neurologic outcome in OHCA patients treated with targeted temperature management (TTM)...
  61. doi request reprint Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest
    Lars W Andersen
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts2Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
    JAMA 314:802-10. 2015
    ..Whether this association is true in the pediatric in-hospital cardiac arrest population remains unknown...
  62. pmc Disease heterogeneity and risk stratification in sepsis-related occult hypoperfusion: A retrospective cohort study
    Sharukh Lokhandwala
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    J Crit Care 30:531-6. 2015
    ..We sought to determine the practice patterns and outcomes of patients with sepsis-related occult hypoperfusion and introduce a potential method for risk stratification...
  63. pmc Immunocapture and microplate-based activity and quantity measurement of pyruvate dehydrogenase in human peripheral blood mononuclear cells
    Xiaowen Liu
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, W CC 2, Boston, MA 02215, USA
    Bioanalysis 7:583-92. 2015
    ..3% showed maximum yield. Sample protein concentration is correlated to PDH activity and quantity in human PBMCs from healthy subjects...
  64. pmc Septic shock and adequacy of early empiric antibiotics in the emergency department
    Sarah K Flaherty
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    J Emerg Med 47:601-7. 2014
    ..Antibiotic resistance is an increasing concern for Emergency Physicians...
  65. doi request reprint ED patients with vertigo: can we identify clinical factors associated with acute stroke?
    Maureen Chase
    Beth Israel Deaconess Medical Center, Department of Emergency Medicine, One Deaconess Road, West, Clinical Center 2, Boston, MA 02215, USA
    Am J Emerg Med 30:587-91. 2012
    ..Misdiagnosis of acute stroke may result in significant morbidity and mortality. Magnetic resonance imaging (MRI) is superior to computer tomography (CT) for diagnosis of acute stroke but is costly with limited availability...
  66. doi request reprint Cannabinoid hyperemesis: a case series
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 40:e63-6. 2011
    ..Traditionally, cannabinoids have been used recreationally or as antiemetics; however, recent reports suggest that chronic abuse can result in the paradoxical effect of a cyclic vomiting syndrome, termed cannabinoid hyperemesis...
  67. doi request reprint The role of cranial computed tomography in the immediate post-cardiac arrest period
    Michael N Cocchi
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Intern Emerg Med 5:533-8. 2010
    ..8% of patients had clinically significant abnormalities identified. The exact role of neuroimaging in this population is still in evolution, and further prospective evaluation is warranted...
  68. ncbi request reprint Prevalence of elevated troponin I in end-stage renal disease patients receiving hemodialysis
    Michael W Donnino
    Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA
    Acad Emerg Med 11:979-81. 2004
    ..The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis...
  69. doi request reprint Predicting Outcome With Diffusion-Weighted Imaging in Cardiac Arrest Patients Receiving Hypothermia Therapy: Multicenter Retrospective Cohort Study
    Seung Mok Ryoo
    1Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 2Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 3Department of Emergency Medicine, Ewha University College of Medicine, Seoul, Korea 4Department of Emergency Medicine, Chonnam National University College of Medicine, Gwangju, Korea 5Department of Emergency Medicine, College of Medicine, Chung Ang University, Seoul, Korea 6Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea 7Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    Crit Care Med 43:2370-7. 2015
    ....
  70. doi request reprint Prognostic value of B-type natriuretic peptide with the sequential organ failure assessment score in septic shock
    Seung Mok Ryoo
    Departments of Emergency Medicine SMR, WYK, and Respiratory and Critical Care Medicine JWH, S BH, C ML, YK, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea and Department of Emergency Medicine KMB, MWD, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Am J Med Sci 349:287-91. 2015
    ..The aim of this study was to evaluate the prognostic value of B-type natriuretic peptide (BNP) in combination with the sequential organ failure assessment (SOFA) score in patients with septic shock at the time of emergency department (ED)...
  71. ncbi request reprint Critical care and emergency medicine
    Emanuel P Rivers
    Department of Emergency Medicine, Henry Ford Hospital, Case Western Reserve University, Detroit, Michigan, USA
    Curr Opin Crit Care 8:600-6. 2002
    ....
  72. doi request reprint Rapid rewarming of hypothermic patient using arctic sun device
    Michael N Cocchi
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Intensive Care Med 27:128-30. 2012
    ..Clinicians may wish to consider the use of these devices when attempting to warm patients suffering from severe environmental hypothermia...
  73. pmc Increased plasma levels of microparticles expressing CD39 and CD133 in acute liver injury
    Moritz Schmelzle
    The Transplant Institute and Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA
    Transplantation 95:63-9. 2013
    ..Here, we tested whether CD133 MP might be shed in a CD39-dependent manner in a model of liver injury and could potentially serve as biomarkers of liver failure in the clinic...
  74. doi request reprint Pulmonary embolism presenting as flank pain: a case series
    Michael Amesquita
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Emerg Med 42:e97-100. 2012
    ..The current case series reveals the unexpected and initially unrecognized CT finding of a pulmonary infarct in two patients presenting with flank pain; a third patient presented with flank pain and was also found to have a PE...
  75. ncbi request reprint A central venous pressure goal of 8-12 mm Hg for all patients in septic shock
    Michael W Donnino
    Crit Care Med 35:1441. 2007
  76. ncbi request reprint Sepsis: the changing times
    Nathan I Shapiro
    Crit Care Med 33:2700-1. 2005
  77. ncbi request reprint Central venous-arterial carbon dioxide difference as an indicator of cardiac index
    Joseph Cuschieri
    Department of Surgery, Henry Ford Health Systems, Detroit, MI, USA
    Intensive Care Med 31:818-22. 2005
    ..A central venous pCO(2), which is easier to obtain, may provide similar information. The purpose of this study was to examine the correlation between the central venous-arterial pCO(2) difference and CI...