A J Cole

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Is epilepsy a progressive disease? The neurobiological consequences of epilepsy
    A J Cole
    Epilepsy Service, Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Epilepsia 41:S13-22. 2000
  2. ncbi request reprint Neuroprotection and antiepileptogenesis: where are we now?
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 59:S36-8. 2002
  3. ncbi request reprint Initial individualized selection of long-term anticonvulsant drugs by neurologists
    Andrew J Cole
    Epilepsy Service, Massachusetts General Hospital, VBK 830, 55 Fruit Street, Boston, MA 02114, USA
    Neurology 63:S1-2. 2004
  4. ncbi request reprint Status epilepticus and periictal imaging
    Andrew J Cole
    MGH Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 45:72-7. 2004
  5. ncbi request reprint Are seizures harmful: what can we learn from animal models?
    Andrew J Cole
    Epilepsy Research Laboratory, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02114, USA
    Prog Brain Res 135:13-23. 2002
  6. doi request reprint Consideration of epilepsy surgery in adults should be independent of age
    D J Costello
    Epilepsy Service, Department of Neurology, Harvard Medical School, ACC 835, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Neurol Neurosurg 111:240-5. 2009
  7. ncbi request reprint Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation Summit
    Steven C Schachter
    Center for Integration of Medicine and Innovative Technology, Boston, MA, USA
    Epilepsy Behav 16:3-46. 2009
  8. ncbi request reprint Multimodal longitudinal imaging of focal status epilepticus
    Colin P Doherty
    Epilepsy Service, Neurology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Can J Neurol Sci 31:276-81. 2004
  9. pmc Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Epilepsy Res 85:279-86. 2009
  10. ncbi request reprint Treatment of acute seizures and status epilepticus
    Daniel J Costello
    Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Intensive Care Med 22:319-47. 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Is epilepsy a progressive disease? The neurobiological consequences of epilepsy
    A J Cole
    Epilepsy Service, Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Epilepsia 41:S13-22. 2000
    ....
  2. ncbi request reprint Neuroprotection and antiepileptogenesis: where are we now?
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 59:S36-8. 2002
  3. ncbi request reprint Initial individualized selection of long-term anticonvulsant drugs by neurologists
    Andrew J Cole
    Epilepsy Service, Massachusetts General Hospital, VBK 830, 55 Fruit Street, Boston, MA 02114, USA
    Neurology 63:S1-2. 2004
  4. ncbi request reprint Status epilepticus and periictal imaging
    Andrew J Cole
    MGH Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 45:72-7. 2004
    ..A framework is proposed for considering the relation between ictal duration and severity, the characteristics of imaging abnormalities, and the mechanism of their underlying pathophysiology...
  5. ncbi request reprint Are seizures harmful: what can we learn from animal models?
    Andrew J Cole
    Epilepsy Research Laboratory, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02114, USA
    Prog Brain Res 135:13-23. 2002
    ..In the future, we can anticipate that animal models will continue to be useful, especially when whole-animal preparations are used to generate material for detailed in vitro examination...
  6. doi request reprint Consideration of epilepsy surgery in adults should be independent of age
    D J Costello
    Epilepsy Service, Department of Neurology, Harvard Medical School, ACC 835, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Neurol Neurosurg 111:240-5. 2009
    ..Epilepsy surgery is performed less frequently in persons over 45 years of age than in younger individuals, probably reflecting biases among patients, referring physicians and neurologists...
  7. ncbi request reprint Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation Summit
    Steven C Schachter
    Center for Integration of Medicine and Innovative Technology, Boston, MA, USA
    Epilepsy Behav 16:3-46. 2009
    ..This article summarizes the discussions and demonstrates that cross-disciplinary interactions can catalyze collaborations between physicians and engineers to address and solve many of the pressing unmet needs in epilepsy...
  8. ncbi request reprint Multimodal longitudinal imaging of focal status epilepticus
    Colin P Doherty
    Epilepsy Service, Neurology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Can J Neurol Sci 31:276-81. 2004
    ..Little is understood about the evolution of structural and functional brain changes during the course of uncontrolled focal status epilepticus in humans...
  9. pmc Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Epilepsy Res 85:279-86. 2009
    ..Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy...
  10. ncbi request reprint Treatment of acute seizures and status epilepticus
    Daniel J Costello
    Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Intensive Care Med 22:319-47. 2007
    ....
  11. doi request reprint Debate: Should antiepileptic drugs be stopped after successful epilepsy surgery?
    Andrew J Cole
    Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 49:29-34. 2008
    ..The goal is to provide physicians with the best available data, a context in which to consider it, and a full understanding of its limitations. This article also highlights an area that is ripe for further prospective study...
  12. ncbi request reprint Neuroprotection and antiepileptogenesis: overview, definitions, and context
    Andrew J Cole
    MGH Epilepsy Service, Massachusetts General Hospital, Harvard Medical School, Fruit Street, Boston, MA 02114, USA
    Neurology 59:S1-2. 2002
  13. pmc Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: behavioral, physiological and histological studies
    Yi Zheng
    Epilepsy Research Laboratory, Epilepsy Service and Neurology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropharmacology 58:793-8. 2010
    ..We sought to determine the effect of LEV administered intravenously in a chemoconvulsant model of status epilepticus...
  14. ncbi request reprint Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus
    Daniel J Costello
    Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Arch Neurol 63:895-901. 2006
    ..There have been few published reports of successful surgical treatment of focal status epilepticus. Surgical intervention is considered a last resort after medical strategies have been exhausted...
  15. ncbi request reprint Advancements in the treatment of epilepsy
    B A Leeman
    Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Annu Rev Med 59:503-23. 2008
    ..Patients with refractory seizures push for earlier surgical intervention, consider treatment with medical devices, and actively seek nonpharmacologic alternatives. We review some of these recent advances in the management of epilepsy...
  16. doi request reprint Periodic epileptiform discharges in hypoxic encephalopathy: BiPLEDs and GPEDs as a poor prognosis for survival
    O D San-Juan
    Neurophysiology Department, Massachusetts General Hospital, MA, USA
    Seizure 18:365-8. 2009
    ....
  17. doi request reprint Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults-Infectious or not?
    Daniel J Costello
    Epilepsy Service, Department of Neurology, ACC 835, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Neurol Sci 277:26-31. 2009
    ..They are usually presumed to be due to infectious encephalitis and typically have devastating consequences. We describe our experience with six adults who presented with NORSE and raise the possibility of non-infectious causes...
  18. doi request reprint Propofol and the electroencephalogram
    Daniel San-Juan
    Neurophysiology Service, Massachusetts General Hospital, MA 02114, USA
    Clin Neurophysiol 121:998-1006. 2010
    ..This paper presents a review of the effects of propofol in electroencephalograms and discusses proconvulsive, anticonvulsive proprieties and the EEG findings in different medical conditions...
  19. pmc Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy
    Claus Reinsberger
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 52:1238-42. 2010
    ..This finding may, in part, explain the unfavorable outcome in some MTLE patients after epilepsy surgery...
  20. ncbi request reprint Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brain
    Sookyong Koh
    MGH Epilepsy Service, Epilepsy Research Laboratory, Massachusetts General Hospital and Harvard Medical School, VBK 830, 55 Fruit Street, Boston, MA 02114, USA
    Exp Neurol 194:457-66. 2005
    ....
  21. ncbi request reprint Diffusion-weighted imaging abnormalities in the splenium after seizures
    Joel Oster
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 44:852-4. 2003
    ..Transient increased T2 signal in the splenium of the corpus callosum after seizures has been reported and sometimes attributed to a postulated toxicity of anticonvulsant medications (AEDs)...
  22. pmc Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice
    Natalia T Leach
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 80:792-9. 2007
    ..These findings implicate DGKD disruption by the t(X;2)(p11.2;q37)dn in the observed phenotype and support a more general role for DGKD in the etiology of seizures...
  23. doi request reprint Prognostic implications of periodic epileptiform discharges
    Daniel San Juan Orta
    Epilepsy Service, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Arch Neurol 66:985-91. 2009
    ..Periodic epileptiform discharges (PEDs) are an abnormal finding on electroencephalograms (EEGs), the significance of which is uncertain...
  24. ncbi request reprint Guidelines for new epilepsy drugs. New epilepsy drugs are safer and cause fewer adverse effects than their predecessors. But they're not more effective
    Andrew J Cole
    Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    Health News 10:6-7. 2004
  25. ncbi request reprint MRI changes in the rat hippocampus following proton radiosurgery
    James D Rabinov
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Stereotact Funct Neurosurg 82:156-64. 2004
    ..To define radiographic dose-response relationships for proton radiosurgery using a rat brain model...
  26. ncbi request reprint Hyperacute neuropathological findings after proton beam radiosurgery of the rat hippocampus
    Jonathan L Brisman
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 56:1330-7; discussion 1337-8. 2005
    ..To study the hyperacute histological and immunohistochemical effects of stereotactic proton beam irradiation of the rat hippocampus...
  27. ncbi request reprint Phosphorylation of P42/P44 MAP kinase and DNA fragmentation in the rat perforant pathway stimulation model of limbic epilepsy
    Jonathan L Brisman
    Epilepsy Research Laboratory, Neurosurgical Service, Massachusetts General Hospital, Boston, MA, USA
    Brain Res 933:50-9. 2002
    ..Populations displaying Erk1/2 activation appeared to differ from those showing DNA fragmentation and neuronal injury...
  28. ncbi request reprint Case records of the Massachusetts General Hospital. Case 24-2007. A 20-year-old pregnant woman with altered mental status
    Andrew J Cole
    Neurology Service, Massachusetts General Hospital, USA
    N Engl J Med 357:589-600. 2007
  29. ncbi request reprint Effects of noninvasive transcutaneous electrical stimulation via concentric ring electrodes on pilocarpine-induced status epilepticus in rats
    Walter G Besio
    Department of Biomedical Engineering, Louisiana Tech University, Ruston, Louisiana 71272, USA
    Epilepsia 48:2273-9. 2007
    ....