Shaoyong Chen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation
    Shaoyong Chen
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 287:8571-83. 2012
  2. pmc Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1
    Shaoyong Chen
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 284:25576-84. 2009
  3. doi request reprint Androgen ablation elicits PP1-dependence for AR stabilization and transactivation in prostate cancer
    Xiaming Liu
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
    Prostate 76:649-61. 2016
  4. pmc Androgen receptor expression in prostate cancer cells is suppressed by activation of epidermal growth factor receptor and ErbB2
    Changmeng Cai
    Cancer Biology Program Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:5202-9. 2009
  5. pmc Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    Changmeng Cai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:6027-32. 2009
  6. pmc Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation
    Xiaming Liu
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Oncotarget 7:1754-64. 2016
  7. pmc Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1
    Shaoyong Chen
    Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:15969-74. 2006
  8. pmc Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 20:457-71. 2011
  9. pmc Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein
    Shuai Gao
    Center for Personalized Cancer Therapy, University of Massachusetts, Boston, Boston, MA 02125, USA Hematology Oncology Division and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cell Rep 17:966-976. 2016
  10. pmc Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:6503-13. 2011

Collaborators

  • Steven P Balk
  • Liang Wang
  • Wei Li
  • Yang Wang
  • Ming Yang
  • Mark Pomerantz
  • Othon Iliopoulos
  • Daniel M Landis
  • Rupal S Bhatt
  • Elahe A Mostaghel
  • Changmeng Cai
  • Xiaming Liu
  • Yanfei Gao
  • Hongyun Wang
  • Jihong Liu
  • Shuai Gao
  • Nicholas I Simon
  • Housheng Hansen He
  • Myles Brown
  • Fen Ma
  • Xiaoping Zhang
  • Weiwei Han
  • Hongmei Yang
  • Sarah Gulla
  • Adam G Sowalsky
  • Glenn J Bubley
  • X Shirley Liu
  • Tong Sun
  • Peter S Nelson
  • Xin Yuan
  • Tengfei Zhang
  • Huihui Ye
  • Sean Gerrin
  • Joshua Russo
  • Yiming Wu
  • Amy Avery
  • Dong Han
  • Wanting Han
  • Jill A Macoska
  • Hao Zhao
  • Zheng Xia
  • Ziyang Yu
  • Roland Schüle
  • Musaddeque Ahmed
  • Eric Metzger
  • Mei Wei Chen
  • Jesse Zhang
  • Philip W Kantoff
  • Gwo Shu Mary Lee
  • Chen Lin Hsieh
  • Ilsa Coleman
  • Brett Marck
  • Zi Fang
  • Patrick Ng
  • Alvin M Matsumoto
  • Youyuan Xu
  • David C Portnoy
  • Xinnong Jiang

Detail Information

Publications15

  1. pmc Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation
    Shaoyong Chen
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 287:8571-83. 2012
    ....
  2. pmc Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1
    Shaoyong Chen
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 284:25576-84. 2009
    ..Moreover, AR may function as a PP1 regulatory subunit and mediate PP1 recruitment to chromatin, where it can modulate transcription and splicing...
  3. doi request reprint Androgen ablation elicits PP1-dependence for AR stabilization and transactivation in prostate cancer
    Xiaming Liu
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
    Prostate 76:649-61. 2016
    ..However, more systemic studies are needed to further define PP1 effects on AR, particularly in the settings of prostate cancer cells and under conditions mimicking androgen ablation...
  4. pmc Androgen receptor expression in prostate cancer cells is suppressed by activation of epidermal growth factor receptor and ErbB2
    Changmeng Cai
    Cancer Biology Program Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:5202-9. 2009
    ..These findings show that EGFR and ErbB2 can negatively regulate AR mRNA and may provide an approach to suppress AR expression in CRPC...
  5. pmc Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    Changmeng Cai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:6027-32. 2009
    ..These results show that expression of TMPRSS2:ERG, similarly to other AR-regulated genes, is restored in CRPC and may contribute to tumor progression...
  6. pmc Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation
    Xiaming Liu
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Oncotarget 7:1754-64. 2016
    ....
  7. pmc Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1
    Shaoyong Chen
    Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:15969-74. 2006
    ....
  8. pmc Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 20:457-71. 2011
    ..Androgen levels in CRPC appear adequate to stimulate AR activity on enhancer elements, but not suppressor elements, resulting in increased expression of AR and AR repressed genes that contribute to cellular proliferation...
  9. pmc Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein
    Shuai Gao
    Center for Personalized Cancer Therapy, University of Massachusetts, Boston, Boston, MA 02125, USA Hematology Oncology Division and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cell Rep 17:966-976. 2016
    ....
  10. pmc Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:6503-13. 2011
    ..Together, our results indicate that CRPCs resistant to CYP17A1 inhibition may remain steroid dependent and therefore responsive to therapies that can further suppress de novo intratumoral steroid synthesis...
  11. pmc Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity
    Changmeng Cai
    Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA Electronic address
    Cell Rep 9:1618-27. 2014
    ....
  12. doi request reprint Positive feedback loop mediated by protein phosphatase 1α mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer
    Xiaming Liu
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Nucleic Acids Res . 2017
    ..Collectively these findings reveal a mechanism involving PP1α, CDK9 and CDK1 that is used by AR to initiate and sustain P-TEFb activity, which may be exploited to drive AR in CRPC...
  13. pmc The altered expression of MiR-221/-222 and MiR-23b/-27b is associated with the development of human castration resistant prostate cancer
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer, Institute, Harvard Medical School, Boston, MA 02115, USA
    Prostate 72:1093-103. 2012
    ....
  14. pmc Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer
    Adam G Sowalsky
    Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
    Mol Cancer Res 13:98-106. 2015
    ..This inefficient coupling of transcription and mRNA splicing suggests an overall increase in transcription or defect in splicing...
  15. pmc Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor
    Rupal S Bhatt
    Division of Cancer Biology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    BJU Int 102:358-63. 2008
    ....