I Castagliuolo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Neurotensin is a proinflammatory neuropeptide in colonic inflammation
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 103:843-9. 1999
  2. pmc p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
    M Warny
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 105:1147-56. 2000
  3. pmc Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, MA 02215, USA
    Br J Pharmacol 136:271-9. 2002
  4. ncbi request reprint Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Hospital, Harvard Medical School, Boston 02215, USA
    Am J Physiol 271:G884-92. 1996
  5. ncbi request reprint Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Massachusetts, Boston 02215, USA
    Am J Physiol Gastrointest Liver Physiol 280:G539-45. 2001
  6. ncbi request reprint Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice
    B K Wershil
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital and Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 114:956-64. 1998
  7. ncbi request reprint Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 119:972-82. 2000
  8. pmc Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 101:1547-50. 1998
  9. ncbi request reprint Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells
    I Castagliuolo
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:26545-50. 2000
  10. ncbi request reprint Altered ion channel activity in murine colonic smooth muscle myocytes in an experimental colitis model
    H I Akbarali
    Center for Swallowing and Motility Disorders, West Roxbury, Massachusetts 02132, USA
    Biochem Biophys Res Commun 275:637-42. 2000

Detail Information

Publications11

  1. pmc Neurotensin is a proinflammatory neuropeptide in colonic inflammation
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 103:843-9. 1999
    ..We conclude that neurotensin plays a key role in the pathogenesis of C. difficile-induced colonic inflammation and mast cell activation...
  2. pmc p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
    M Warny
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 105:1147-56. 2000
    ..p38 MAP kinase also mediates intestinal inflammation and mucosal damage induced by toxin A...
  3. pmc Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, MA 02215, USA
    Br J Pharmacol 136:271-9. 2002
    ..5. Our results indicate that in mice lacking the neurokinin - 1 receptor, substance P plays a protective role in prolonged experimental colitis...
  4. ncbi request reprint Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Hospital, Harvard Medical School, Boston 02215, USA
    Am J Physiol 271:G884-92. 1996
    ..We conclude that CRF released during immobilization stress increases colonic transit via a neuronal pathway and stimulates colonic mucin secretion via activation of neurons and mast cells...
  5. ncbi request reprint Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Massachusetts, Boston 02215, USA
    Am J Physiol Gastrointest Liver Physiol 280:G539-45. 2001
    ..We conclude that C. difficile toxin A causes increased secretion of endogenous glucocorticoids, which diminish the intestinal secretory and inflammatory effects of toxin A...
  6. ncbi request reprint Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice
    B K Wershil
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital and Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 114:956-64. 1998
    ..The aim of this study was to define the contribution of mast cells to the fluid secretion and neutrophil infiltration associated with toxin A-induced enteritis...
  7. ncbi request reprint Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 119:972-82. 2000
    ..The aim of this study was to determine whether IL-16 production is increased in inflammatory bowel disease and whether IL-16 participates in trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice...
  8. pmc Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 101:1547-50. 1998
    ..These results demonstrate a major requirement for substance P receptors in the pathogenesis of acute inflammatory diarrhea...
  9. ncbi request reprint Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells
    I Castagliuolo
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:26545-50. 2000
    ..We suggest that this mechanism by which SP controls cell proliferation is an important pathway in tissue restoration and healing...
  10. ncbi request reprint Altered ion channel activity in murine colonic smooth muscle myocytes in an experimental colitis model
    H I Akbarali
    Center for Swallowing and Motility Disorders, West Roxbury, Massachusetts 02132, USA
    Biochem Biophys Res Commun 275:637-42. 2000
    ..19 +/- 1.17 pA/pF in DSS-treated colon. These currents were abolished by glibenclamide. The present results suggest that inflammation of the colon results in selective changes in ion channel activity of smooth muscle cells...
  11. ncbi request reprint Engineered E. coli delivers therapeutic genes to the colonic mucosa
    I Castagliuolo
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
    Gene Ther 12:1070-8. 2005
    ....