MICHAEL CRAIG CARROLL
Affiliation: Harvard University
- Identification of the target self-antigens in reperfusion injuryMing Zhang
CBR Institute for Biomedical Research, Inc, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 203:141-52. 2006..These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction...
- A protective role for innate immunity in systemic lupus erythematosusMichael C Carroll
CBR Institute of Biomedical Research, Inc, Harvard Medical School, 800 Huntington Avenue, Boston, Massachusetts 02115, USA
Nat Rev Immunol 4:825-31. 2004..In this way, the complement system and innate immunity protect against responses to SLE (self) antigens by enhancing the elimination of self-reactive lymphocytes...
- The complement system in regulation of adaptive immunityMichael C Carroll
The CBR Institute for Biomedical Research, Harvard Medical School, 800 Huntington Ave, Boston, Massachusetts 02115, USA
Nat Immunol 5:981-6. 2004....
- Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in micePhoebe H Yager
Department of Pediatric Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 2129, USA
J Cereb Blood Flow Metab 28:1030-9. 2008..The data suggest that MBL deficiency increases susceptibility to CCI through C3-independent mechanisms and that MBL-deficient patients may be at increased risk of poor outcome after traumatic brain injury...
- Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cellsMark A Brockman
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
J Virol 80:7111-7. 2006....
- T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient miceEva Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Virology 352:52-60. 2006..Thus, our studies revealed a profound dependence of TI and TD antiviral antibody responses on CR2-mediated signals in PyV-infected mice, where the viral antigen is abundant and persistent...
- Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammationChristian Taube
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 103:8084-9. 2006..These results demonstrate that in sensitized hosts complement activation through the alternative pathway after allergen exposure is critical to the development of AHR and airway inflammation...
- Transcriptional basis of lymphocyte toleranceMadhuri Borde
The CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Immunol Rev 210:105-19. 2006....
- Functional activity of natural antibody is altered in Cr2-deficient miceRussell R Reid
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
J Immunol 169:5433-40. 2002..These results suggest that complement receptors CD21/CD35 are important in maintenance of the B-1 cell repertoire to some, but not all, specificities...
- CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responsesRobert A Barrington
CBR Institute for Biomedical Research and Department of Pathology, Harvard University, Boston, MA 02115, USA
J Immunol 175:2859-67. 2005..Collectively, this study implies a mechanism for regulating B cell survival in vivo whereby the strength of BCR signaling (including coreceptor) determines c-FLIP levels and protection from CD95-induced death...
- Involvement of NFAT1 in B cell self-toleranceRobert A Barrington
CBR Institute for Biomedical Research, Harvard University, Boston, MA 02115, USA
J Immunol 177:1510-5. 2006..Taken together, these studies provide direct evidence that the transcription factor NFAT1 is involved in B cell anergy...
- Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritisNirmal K Banda
Divisions of Rheumatology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 177:1904-12. 2006..The mechanisms by which these target organ-specific mAbs bypass the requirements for engagement of the classical pathway remain to be defined but do not appear to involve a lack of alternative pathway regulatory proteins...
- Natural antibody mediated innate autoimmune responseMing Zhang
Department of Anesthesiology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Mol Immunol 44:103-10. 2007..Therefore, natural IgM mediated innate autoimmunity is likely responsible for the detrimental consequences in ischemic diseases...
- Natural IgM-mediated innate autoimmunity: a new target for early intervention of ischemia-reperfusion injuryMing Zhang
SUNY Downstate Medical Center, Department of Anesthesiology, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Expert Opin Biol Ther 7:1575-82. 2007..Moreover, ischemia-specific self-targets were identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention...
- The presence of MOMA-2+ macrophages in the outer B cell zone and protection of the splenic micro-architecture from LPS-induced destruction depend on secreted IgMMichael B Fischer
Department of Transfusion Medicine, Medical University of Vienna, Vienna, Austria
Eur J Immunol 37:2825-33. 2007..The consequence was a massive destruction of the microarchitecture of the spleen where marginal zones disorganized, lymphoid follicles and T cell zones disrupted and follicular DC (FDC) networks disappeared...
- Complement receptors CD21 and CD35 in humoral immunityRamon Roozendaal
Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
Immunol Rev 219:157-66. 2007..In recent unpublished work using multiphoton intravital imaging, we found that small protein antigens presented in the lymph drain rapidly into B-cell follicles and are taken up by FDCs in a complement-dependent manner...
- Innate response to self-antigen significantly exacerbates burn wound depthFreeman Suber
Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:3973-7. 2007..We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response...
- Follicular exclusion of autoreactive B cells requires FcgammaRIIbElahna Paul
Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Int Immunol 19:365-73. 2007..The data further suggest that this FcgammaRIIb-dependent regulation is B cell autonomous...
- Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunityJerome P Jayasekera
CBR Institute for Biomedical Research, 800 Huntington Avenue, Boston, MA 02115, USA
J Virol 81:3487-94. 2007....
- B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cellsIchiro Shimizu
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Blood 109:1773-81. 2007..Our results suggest a possible role for follicular dendritic cells that pick up immune complexes via CR1/CR2 receptors in the tolerization of B-1b cells...
- Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injuryMing Zhang
CBR Institute of Biomedical Research Inc, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA
J Immunol 177:4727-34. 2006..The results reveal that IgM binds initially to ischemic Ag providing a binding site for mannan-binding lectin which subsequently leads to activation of complement and injury...
- Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscleJ Pablo Abonia
Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:7285-91. 2005..We now report a cytotoxic activity associated with a MC-specific protease and demonstrate that mMCP-5 is critical for irreversible IR injury of skeletal muscle...
- Defective B cell responses in the absence of SH2D1AMassimo Morra
Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 102:4819-23. 2005..Thus, both defective T and B cells exist in the absence of SH2D1A, which may explain the progressive dysgammaglobulinemia in a subset of X-linked lympho-proliferative disease patients without involvement of Epstein-Barr virus...
- A role for complement in feedback enhancement of antibody responses by IgG3Teresita Díaz de Ståhl
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
J Exp Med 197:1183-90. 2003..These findings demonstrate that IgG3 can induce feedback enhancement and that IgG3, in analogy with IgM, uses the complement system for this function...
- Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient miceOlga Pozdnyakova
Department of Pathology, Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:84-90. 2003..The normal immune response in wild-type mice may require localization of polysaccharide to marginal zone B cells with subsequent transfer of the Ag to follicular dendritic cells...
- Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient miceMihaela Gadjeva
Center for Blood Research, 221 Longwood Avenue, Boston, MA 02115, USA
J Immunol 169:5489-95. 2002..Cell-sorting experiments, followed by C4-specific RT-PCR, identified splenic macrophages (CD11b(+), CD11c(-)) as a cellular source for C4 synthesis within the spleen...
- B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptorsRobert A Barrington
Center for Blood Research and Department of Pathology, Harvard University, Boston, MA 02115, USA
J Exp Med 196:1189-99. 2002..These data suggest that CD21/CD35 on stroma, including follicular dendritic cells, is critical to the maintenance of long-term B lymphocyte memory...
- Anti-DNA autoreactivity in C4-deficient miceElahna Paul
Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Eur J Immunol 32:2672-9. 2002..These findings suggest that C4 normally helps prevent early stages of autoimmune disease and that C4 deficiency predisposes to abnormal regulation of autoreactive B cells...
- Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligoJiri Trcka
The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center and Weill Graduate School of Cornell University, New York, NY 10021, USA
Immunity 16:861-8. 2002..Thus, either complement or macrophages expressing activating Fc gamma R can independently and alternatively mediate disease in a model of autoimmune vitiligo...
- Arthritis critically dependent on innate immune system playersHong Ji
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Immunity 16:157-68. 2002..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
- Complement C4 is protective for lupus disease independent of C3Shirit Einav
Center for Blood Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:1036-41. 2002..Thus, complement C4 provides an important protective role against the development of SLE...
- Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha releaseOfer Levy
Division of Infectious Diseases, Children s Hospital, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Infect Immun 71:6344-53. 2003....
- Germinal center checkpoints in B cell tolerance in 3H9 transgenic miceElahna Paul
Department of Pediatrics, Harvard Medical School, Division of Nephrology, Children s Hospital and Center for Blood Research, Boston, MA 02115, USA
Int Immunol 16:377-84. 2004....
- B cell receptor signal strength determines B cell fateStefano Casola
CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 5:317-27. 2004..Furthermore, spontaneous germinal centers developed in gut-associated lymphoid tissue of LMP2A mice, indicating that microbial antigens can promote germinal centers independently of BCR-mediated antigen recognition...
- T cell-independent somatic hypermutation in murine B cells with an immature phenotypeChangchuin Mao
Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, MA 02111, USA
Immunity 20:133-44. 2004..Mutation frequency was not diminished in the absence of T cells. Our results support the idea that somatic hypermutation can occur in murine immature B cells and may represent a mechanism for enlarging the V gene repertoire...
- Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgMWilliam G Austen
Department of Surgery, Harvard Medical School, The Brigham and Women s Hospital, Boston, MA 02115, USA
Surgery 136:401-6. 2004..Cr2-/- and wild type (WT) mice were studied to isolate the antibody or antibodies responsible for initiation of I/R...
- Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injuryMing Zhang
Natural Antibodies, Inc, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:3886-91. 2004..This finding opens an avenue for identification of I/R-specific self-antigen(s) and early prevention of injury...
- The complement system in B cell regulationMichael C Carroll
Department of Pediatrics, The CBR Institute for Biomedical Research Inc, Harvard Medical School, 800 Huntington Ave, Boston, MA 02115, USA
Mol Immunol 41:141-6. 2004..In this review, a role for complement is described in five distinct stages of B cell differentiation...
- Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infectionAdmar Verschoor
Center for Blood Research, Boston, MA 02115 Pathology, Pediatrics, and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Immunol 171:5363-71. 2003..This report offers insight into the generation of the adaptive immune response in the periphery and describes a unique role for a nonhepatic complement source...
- Innate autoimmunityMichael C Carroll
CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Adv Immunol 86:137-57. 2005....
- Immunoglobulin G monoclonal antibodies to Cryptococcus neoformans protect mice deficient in complement component C3Scott Shapiro
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 70:2598-604. 2002..Furthermore, we observed protection with IgG3 in the complement-deficient mice, suggesting that complement is involved in the lack of protection observed with IgG3 in other mouse models...
- Attenuation of skeletal muscle reperfusion injury with intravenous 12 amino acid peptides that bind to pathogenic IgMRodney K Chan
From the Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston
Surgery 139:236-43. 2006..In these experiments, we examine the properties of short peptide sequences, and their homologues, that bind to the antigen-combining site of this pathogenic IgM clone...
- Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse modelPaul A Monach
Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 56:2968-74. 2007..The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 synthesized within the synovium is important in promoting inflammation...
- Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4Zerong You
Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 27:1954-64. 2007..Thus, C4 contributes to motor deficits and brain tissue damage after CCI by mechanism(s) fundamentally different from those involved in experimental systemic ischemia-reperfusion injury...
- Emerging patterns in complement-mediated pathogen recognitionRamon Roozendaal
CBR Institute for Biomedical Research Inc, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA
Cell 125:29-32. 2006..Two recent Cell papers, including one in this issue, provide new insight into the role of the complement system in response to blood-borne pathogens...
- The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusionRodney K Chan
Department of Surgery and Pediatrics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 177:8080-5. 2006..Thus, the activation of both pathways is likely responsible for the full spectrum of injuries observed after skeletal muscle reperfusion injury...
- The role of natural IgM in myocardial ischemia-reperfusion injuryMing Zhang
The CBR Institute for Biomedical Research, Inc, Harvard Medical School, Boston, MA 02115, and Section of Cardiovascular Sciences, The Methodist Hospital, Houston, TX 77030, USA
J Mol Cell Cardiol 41:62-7. 2006..These results support a model in which natural IgM initiates the acute inflammatory response in the myocardium following ischemia and reperfusion...
- Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic miceMarcel Maier
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 28:6333-41. 2008..Our results suggest a beneficial role for complement C3 in plaque clearance and neuronal health as well as in modulation of the microglia phenotype...
- COMPLEMENT C3 AND ACQUIRED AND INNATE IMMUNITYMichael Carroll; Fiscal Year: 2003..Furthermore, elucidation of the mechanism of complement activation of mast cells is important for defining this important effector function of natural immunity. ..
- Role of complement C4 in immune toleranceMichael Carroll; Fiscal Year: 2006..abstract_text> ..
- MACROPHAGE PRODUCED COMPLEMENT IN HUMORAL IMMUNITYMichael Carroll; Fiscal Year: 2007..Moreover, it could lead to rational design of improved vaccines to pathogenic viruses, such as HSV, for which there is currently no cure. ..
- Regulation of immune response to influenza by innate immunity.Michael Carroll; Fiscal Year: 2009..ii) Examine the role of complement C3 in the development of memory B cells, (iii) Examine the role of natural IgM in host innate and adaptive response to influenza. ..