PETER D CARAVAN
Affiliation: Harvard University
- MR imaging probes: design and applicationsEszter Boros
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Dalton Trans 44:4804-18. 2015..Namely, we discuss methods to enhance the signal generating capacity of MR probes and how to achieve tissue specificity through protein targeting or probe activation within the tissue microenvironment. ..
- [Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complexEric M Gale
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Chem Commun (Camb) 49:8060-2. 2013..Gd(CyPic3A)(H2O)2](-) affords an r1 value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes...
- Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of actionPeter Caravan
A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Acc Chem Res 42:851-62. 2009..Through judicious molecular design, we show that high-relaxivity complexes with high target affinity can be realized...
- Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agentsPeter Caravan
A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 149 Thirteenth St, Charlestown, MA 02129, USA
Contrast Media Mol Imaging 4:89-100. 2009..Per ion relaxivities of 80, 45, and 18 mM(-1) s(-1) at 1.5, 3 and 9.4 T, respectively, are feasible for Gd(3+) and Mn(2+) complexes...
- Collagen-targeted MRI contrast agent for molecular imaging of fibrosisPeter Caravan
EPIX Pharmaceuticals, Inc 4 Maguire Road, Lexington, MA 02421, USA
Angew Chem Int Ed Engl 46:8171-3. 2007
- Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agentPeter Caravan
EPIX Pharmaceuticals, Cambridge, MA 02142, USA
Inorg Chem 46:6632-9. 2007..01-50 MHz at 5, 15, 25, and 35 degrees C in a 4.5% HSA in PBS solution for each isomer (0.1 mM). Differences in the relaxivity in HSA between the two isomers could be attributed to the differing water exchange rates...
- Structural, kinetic, and thermodynamic characterization of the interconverting isomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agentZoltan Tyeklar
EPIX Pharmaceuticals Inc, Cambridge, MA 02142, USA
Inorg Chem 46:6621-31. 2007..The rate of isomerization was highly pH dependent: k1 = (1.45 +/- 0.08) x 102[H+] + (4.16 +/- 0.30) x 105[H+]2; k-1 = (2.57 +/- 0.17) x 102[H+] + (7.54 +/- 0.60) x 105[H+]2...
- The interaction of MS-325 with human serum albumin and its effect on proton relaxation ratesPeter Caravan
EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
J Am Chem Soc 124:3152-62. 2002..0 x 10(8) s(-1) bound vs 1.1 x 10(9) s(-1) free) and an increase in the inner-sphere water residency time (tau(m) = 170 +/- 40 ns bound vs 69 +/- 20 ns free)...
- EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombusKirsten Overoye-Chan
EPIX Pharmaceuticals, 4 Maguire Road, Lexington, Massachusetts 02421, USA
J Am Chem Soc 130:6025-39. 2008..4 per Gd), about 25 times higher than that of GdDOTA measured under the same conditions. Strong fibrin binding, fibrin selectivity, and high molecular relaxivity enable EP-2104R to detect blood clots in vivo...
- Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325Harriet B Eldredge
EPIX Pharmaceuticals, Cambridge, Massachusetts 02142 1118, USA
Invest Radiol 41:229-43. 2006..We sought to determine whether there is a species dependence on plasma protein and serum album binding and/or relaxivity of the MR contrast agent MS-325...
- Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agentJeffrey S Troughton
EPIX Medical Inc, 71 Rogers Street, Cambridge, Massachusetts 02142, USA
Inorg Chem 43:6313-23. 2004..5 T. In a rabbit model of carotid artery injury, MnL1 clearly delineated both arteries and veins while also distinguishing between healthy tissue and regions of vessel damage...
- Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanideStephan G Zech
EPIX Pharmaceuticals, 67 Rogers Street, Cambridge, Massachusetts 02142, USA
Inorg Chem 46:3576-84. 2007..The approach of using surrogate lanthanides to identify specific molecular parameters influencing relaxivity is applicable to other protein-targeted GdIII contrast agents...
- The gadolinium(III)-water hydrogen distance in MRI contrast agentsPeter Caravan
EPIX Medical, Inc, 71 Rogers Street, Cambridge, Massachusetts 02142, USA
Inorg Chem 42:3972-4. 2003..1 +/- 0.1 A. These distance estimates should aid in the design of new contrast agents, and in the interpretation of other molecular factors influencing relaxivity...
- Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopyStephan G Zech
EPIX Pharmaceuticals, Inc, 67 Rogers Street, Cambridge, MA 02142, USA
Chemphyschem 6:2570-7. 2005..These essential parameters directly correlate with the efficacy of MRI contrast agents and should therefore aid the development of novel, highly efficient compounds targeted to various proteins...
- Strategies for increasing the sensitivity of gadolinium based MRI contrast agentsPeter Caravan
EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA
Chem Soc Rev 35:512-23. 2006..It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging...
- Molecular MRI of intracranial thrombus in a rat ischemic stroke modelRitika Uppal
Department of Radiology, Massachusetts General Hospital East, 149 13th Street, Suite 2301, Charlestown, MA 02129, USA
Stroke 41:1271-7. 2010..In this study, we examined whether this fibrin-specific MR probe could noninvasively characterize intracranial arterial thrombi...
- When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivityPeter Caravan
EPIX Pharmaceuticals, Inc, 67 Rogers Street, Cambridge, MA 02142 1118, USA
Chemistry 11:5866-74. 2005..5 mM(-1) s(-1)) measured under the same conditions. Despite having two exchangeable water molecules, slow water exchange limits the potential efficacy of Gd-L1 as an MRI contrast agent...
- Multilocus binding increases the relaxivity of protein-bound MRI contrast agentsZhaoda Zhang
EPIX Pharmaceuticals, Inc 67 Rogers Street, Cambridge, MA 02142, USA
Angew Chem Int Ed Engl 44:6766-9. 2005
- On the philosophy of optimizing contrast agents. An analysis of 1H NMRD profiles and ESR lineshapes of the Gd(III)complex MS-325+HSAXiangzhi Zhou
Department of Bio physical Chemistry, Umea University, SE 901 87 Umea, Sweden
J Magn Reson 167:147-60. 2004..A computer program based on this theory is developed which calculates solvent water proton T1 NMRD profiles and the corresponding X-, Q-, U-, and W-bands ESR lineshapes...
- Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agentPatrick A Helm
Department of Radiology, University of Virginia, 409 Lane Rd, MR4 Bldg, Room 1186, Charlottesville, VA 22908, USA
Radiology 247:788-96. 2008..To prospectively evaluate a gadolinium-based collagen-targeting contrast agent, EP-3533, for in vivo magnetic resonance (MR) imaging of myocardial fibrosis in a mouse model of healed myocardial infarction (MI)...
- Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pHFerenc K Kalman
Department of Chemistry, University of Texas at Dallas, P O Box 803066, Richardson, Texas 75083, USA
Inorg Chem 46:5260-70. 2007....
- Determination of the hydration number of gadolinium(III) complexes by high-field pulsed 17O ENDOR spectroscopyArnold M Raitsimring
Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
Chemphyschem 7:1590-7. 2006..Under the experimental conditions used for the hydration number determination (30 mol % methanol), fewer than 15 % of the coordination sites were found to be occupied by methanol...
- Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agentM Meser Ali
Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083, USA
Chemistry 14:7250-8. 2008..8 mM(-1) s(-1) (pH 9) to 24.0 mM(-1) s(-1) (pH 6) per Gd(3+) ion. This more than doubles the relaxivity pH response, Deltar(1), of our agent from just 51 % for the original low molecular weight chelate to 122 % for the dendrimer...
- Monovalent and bivalent fibrin-specific MRI contrast agents for detection of thrombusShrikumar A Nair
Affinergy, Inc 617 Davis Drive, Suite 100, RTP, NC 27713, USA
Angew Chem Int Ed Engl 47:4918-21. 2008